I recently used some deductive reasoning based on my own DNA to hypothesize that some unusual #4 gear I got a few weeks ago is likely a fentanyl analog.
Although it's lame and a normal customer has every right to be pissed, I'm not very upset about it which you will see below.. And to be fair, there are no hot spots or anything. If it really isn't H, it's mixed quite well and/or the analog is less potent and much safer than fentanyl..
OK, so I have a heterozygous mutation in my CPY2D6 gene/enzyme (P450 genes) which, if expressed in my body (seems very likely), means a decreased function by the ezyme to break down so many different medicines including certain opitaes..
I've recently been prescribed Wellbutrin (going to kick soon) and in general, my blast offs with I.V. H have been pretty lackluster. The rush and legs are there, but not as intense as pre-Wellbutrin. This is because that gene and enzyme are used in the metabolism of dope (and Wellbutrin fwiw, so not the best med choice but so it's really the only dopamine med in its class) which puts a lot of strain on the enzyme and it can't hang with all of its duties.. The metabolism of dope is actually pretty complex and involves mutliple enzymes, has primary and secondary stages, etc..etc.. The REAL Dope is from who many of us consider the best guy here, so I know that is solid PLUS I had this same stash before I started the med.
Still following? So, I decided to try another stash that I shelved because it cooks up sort of blackish and has strange super noddy/tired legs.
<FUCKING BOOOOOOOM!!!> The rush nearly knocked me over! It wasn't reduced at all from what I can tell. Now, fentanyl and it's analogs I assume, are NOT metabolized by CPY2D6. Parts of it's metabolism are not understood so well, but a different enzyme P45034A is definitely in the mix.
I'm going to continue conducting research within this important scientific study (aka getting high every day, heh) but it seems likely to me that there is somethig in that dope getting me high that is NOT H..
Any science minds in here want to offer some insight? We'd love to learn! Oh, and for some reading fun, goto your favorite search engine and type in Addiction Inbox The CYP2D6 Factor.
At this time, I don't feel comfortable naming the vendor but will continue testing. He likely has a different batch by now anyway. Plus, I bet many of you have figured out who both of them are by now..
Genetic testing rocks
No shade, but you guys LOVE your smack.