Silk Road forums
Market => Product requests => Topic started by: sharkonwhisky on April 27, 2012, 11:46 pm
-
The question mark was emphasized...Not being serious about the pineal by the way!! A massive long shot but wondering if anyone on here has ever encountered or could possibly somehow obtain pure, synthetic pinoline.
I'm afraid this is from Wikipedia, not much info out there...
Pinoline is a methoxylated tryptoline that occurs in the pineal gland during the metabolism of melatonin. Its chemical names are 5-methoxytryptoline and 6-methoxy-1,2,3,4-tetrahydro-β-carboline (6-MeO-THBC). The biological activity of this molecule is of interest as a potential free radical scavenger (antioxidant), similar to that function of melatonin.[1] It also acts as an endogenous MAOI.
A little info from TiHKAL...
6-Methoxytetrahydro-b-carboline (6-MeO-THbC, pinoline) is a naturally occurring component of human blood and cerebral spinal fluid. Like 6-MeO-THH, it is readily formed from 5-methoxytryptamine, but with formaldehyde rather than with acetaldehyde. The levels have been found to be similar in schizophrenics and psychiatrically healthy patients, suggesting that it is not a factor in the chemistry of mental illness. It is a natural component of the human pineal gland and is quite effective in binding to serotonin sites in human platelets. It has been suggested that the balanced interplay between melatonin and pinoline in the manipulation of serotonin levels, might be an explanation of the sleep/dream state. The carbolines just might play an endogenous role in creating dreams, our "asleep" visual tripping.
&...
I have decided to completely eliminate the dosage, duration and qualitative comments for this compound, and all related harman analogues. The reason is painfully obvious -- virtually nothing is known about their psychopharmacology. Despite their enormous potential for someday being understood as possible intermediates in brain chemistry, they remain almost unexplored.
Sounds like a very interesting frontier to be explored! Animal studies suggest it is psychoactive, and being an endogenous MOAI similar in structure to harmaline, this could be a really interesting chemical to experiment with, particularly for DMT explorers. Any thoughts?