Silk Road forums

Discussion => Drug safety => Topic started by: nabuchodonosor on January 06, 2013, 09:09 pm

Title: Diazepam solubility
Post by: nabuchodonosor on January 06, 2013, 09:09 pm
Hi,

A few days ago I bough 1g od diazepam, this was the fastest way. Previously I red that it dissolves in ethanol quite well. I tried it now and I was very surprised when I noticed that it did not dissolves at all (maybe a little). Can anyone tell me what is wrong? I know that there are others solvents, but they are beyond my hands. I have a scale up to milligrams, but I would not trust it. Profesional ones are to expensive. Any ideas what to do?
:(
Title: Re: Diazepam solubility
Post by: Ben on January 07, 2013, 02:07 am
It should dissolve quite readily in pure alcohol really, up to concentrations of about 50 grams per litre at room temperatures.

If you are attempting to dissolve tablets, however, there may be many other components in the tablets that do not dissolve well - filtering off whatever dissolved out of tablets ground to a powder should contain all the diazepam.

Note that readily doesn't mean rapidly though. Especially when dealing with tablets it may require mortaring those down to a fine powder and even some patience after that while stirring things to get the diazepam to actually dissolve.
Title: Re: Diazepam solubility
Post by: Mossberg on January 07, 2013, 07:19 am
Hi,

A few days ago I bough 1g od diazepam, this was the fastest way. Previously I red that it dissolves in ethanol quite well. I tried it now and I was very surprised when I noticed that it did not dissolves at all (maybe a little). Can anyone tell me what is wrong? I know that there are others solvents, but they are beyond my hands. I have a scale up to milligrams, but I would not trust it. Profesional ones are to expensive. Any ideas what to do?
:(

If you want to use ethanol, you can use a little heat and stir stir stir. No open flame! Use a water-bath or similar.
Or use Propylene Glycol, it is a very good solvent, but taste horrible. No heat, just stir.
Title: Re: Diazepam solubility
Post by: Sapper on January 10, 2013, 06:44 am
I too wish to dissolve my DZP such that one drop=1mg dose. (roughly 20mg per ml)
The goal being to fit 100mg into 5ml of fluid to put in a nice little amber glass eye dropper.