Silk Road forums

Discussion => Drug safety => Topic started by: Virmo on November 02, 2012, 09:16 pm

Title: Combining fentanyl with other drugs same for ghb
Post by: Virmo on November 02, 2012, 09:16 pm
I've read that both fentanyl and ghb should not be used with alcohol. And F and G not with eachother.

I have a way too gigh tolerance for G, and can drink with it (though I did it a few times and never do it again since it can be lethal).

Im just clueless as to why fentanyl and ghb cant be combined. I read that F is used together with benzo's in hospitals. GHB is a barbirature (like benzo but older and stronger, as far as I know (although the effects feel different). Correct me if I'm wrong...

Title: Re: Combining fentanyl with other drugs same for ghb
Post by: microRNA on November 03, 2012, 12:03 am
GHB most certainly is not a barbituate, its most similar to the neurotransmitter GABA

barbs have a specific chemical backbone and gamma hydroxybutyrate has a different structure

GHB effects GABA-B receptor, while alcohol and benzos effect GabaA receptor

also, GHB specifically targets its own receptor

therefore the effects are potentiated when you mix two drugs that alter the activity of the same transmitter

opiates are dangerous to mix because they too impact GABAergic transmission, just at the mu receptor increasing gaba which then effects the gabaA receptor...

 so basically it causes much greater respiratory depression and can result in death if mixed with alcohol or opiates - which is why its not recommended...
Title: Re: Combining fentanyl with other drugs same for ghb
Post by: Ben on November 03, 2012, 02:38 am
Indeed. Even if you factor out alcohol, taking ghb and fentanyl at the same time is risky arealdy.

Combining drugs that affect different receptors simultaneously is a very tricky business. It can be very enjoyable to do so, but also very dangerous. Getting advise from a forum like this may be useful to avoid the worst problems.
Title: Re: Combining fentanyl with other drugs same for ghb
Post by: BlueGiraffe on February 05, 2013, 09:04 pm
GHB most certainly is not a barbituate, its most similar to the neurotransmitter GABA

barbs have a specific chemical backbone and gamma hydroxybutyrate has a different structure

GHB effects GABA-B receptor, while alcohol and benzos effect GabaA receptor

also, GHB specifically targets its own receptor

therefore the effects are potentiated when you mix two drugs that alter the activity of the same transmitter

opiates are dangerous to mix because they too impact GABAergic transmission, just at the mu receptor increasing gaba which then effects the gabaA receptor...

 so basically it causes much greater respiratory depression and can result in death if mixed with alcohol or opiates - which is why its not recommended...

Perfectly in agreement with this post. Thanks for communicating so clearly on the matter.

BG
Title: Re: Combining fentanyl with other drugs same for ghb
Post by: Oirudeboy73 on February 05, 2013, 11:16 pm
I've read that both fentanyl and ghb should not be used with alcohol. And F and G not with eachother.

I have a way too gigh tolerance for G, and can drink with it (though I did it a few times and never do it again since it can be lethal).

Im just clueless as to why fentanyl and ghb cant be combined. I read that F is used together with benzo's in hospitals. GHB is a barbirature (like benzo but older and stronger, as far as I know (although the effects feel different). Correct me if I'm wrong...

Back in my rave days of the late 80's and 90's we would take G & F and mdma and then roofies to come down. Deadly mixture doing G with anything hence the tag of it being a date rape drug. Due to people blackingout and some overdosing
Title: Re: Combining fentanyl with other drugs same for ghb
Post by: flicky42 on February 06, 2013, 03:48 am
This thread made me curious about GHB  did you guys know its a naturally occurring substance :o   Pretty cool stuff.

What is an average dose of GBL? I may buy some.
Title: Re: Combining fentanyl with other drugs same for ghb
Post by: moonflower on February 06, 2013, 11:22 pm
This thread made me curious about GHB  did you guys know its a naturally occurring substance :o   Pretty cool stuff.

What is an average dose of GBL? I may buy some.
yeah, ghb is also endogenous to the human body! i wouldn't do gbl if i were you, it's a solvent used as a superglue remover and paint thinner. that can't possibly be good for your health. i suggest you stick to ghb instead. bluegiraffe seems to have the best on the road.
Title: Re: Combining fentanyl with other drugs same for ghb
Post by: flicky42 on February 06, 2013, 11:24 pm
This thread made me curious about GHB  did you guys know its a naturally occurring substance :o   Pretty cool stuff.

What is an average dose of GBL? I may buy some.
yeah, ghb is also endogenous to the human body! i wouldn't do gbl if i were you, it's a solvent used as a superglue remover and paint thinner. that can't possibly be good for your health. i suggest you stick to ghb instead. bluegiraffe seems to have the best on the road.

Mostly looking for domestic, have you heard good things of Juno's?
Title: Re: Combining fentanyl with other drugs same for ghb
Post by: BlueGiraffe on February 26, 2013, 08:54 pm
This thread made me curious about GHB  did you guys know its a naturally occurring substance :o   Pretty cool stuff.

What is an average dose of GBL? I may buy some.
yeah, ghb is also endogenous to the human body! i wouldn't do gbl if i were you, it's a solvent used as a superglue remover and paint thinner. that can't possibly be good for your health. i suggest you stick to ghb instead. bluegiraffe seems to have the best on the road.

Mostly looking for domestic, have you heard good things of Juno's?

I've not tried his product yet, but we've spoken and he sounds like a professional - so you'll probably have a good experience all in all.

BG