Silk Road forums
Market => Rumor mill => Topic started by: falucka on August 04, 2012, 01:52 am
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A study came out only like two months ago that states that low dose Ketamine was found to help people suffering from bipolar depression who have not responded well to other normal SSRIs, with a 79% success rate as compared to a 0% success rate with placebo. This is huge for people like me who suffer a milld form of bipolar depression, or even for people with severe bipolar depression. The best part is that one single small dose could provide medical advantages to the consumer up to 10 days after consumption, and over 50% of the subjects felt subjectively "better" after only 40 minutes after intake (SSRIs can take weeks). The article states that the test subjects were given 0.5 mg Ketamine IV for every KG over the course of 40 minutes through IV. I weigh about 187 lbs, which is 85 kg, so I should take between 40 and 50 mg over the course of 40 minutes. So, I have two questions:
1. Is there a difference between nasal and IV intake of Ketamine as far as bioavailability is concerned? If there is, what does 40-50 mg IV Ketamine translate to nasally?
2. Do you think the reason why they spread out the IV course over 40 minutes was because they didn't want patients getting "high" off of the Ketamine, or was it medically beneficial? I am not a huge druggy and I didn't buy this Ketamine to get "high," but instead to try its medical properties, but I wouldn't mind a little head rush. So, essentially, if I take 10-13 mg every 10 min for 40 min, will I feel anything beyond the medicinal benefits? If I take all 40-50 mg at once, what will I feel?
Thanks for your time!
Article URL: http://www.sciencedaily.com/releases/2012/05/120530100247.htm
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To me, ketamine has anxiety killing properties at lower dosages. However, the point of K is to K-Hole, during the K-hole the ego is usually destroyed, allowing you to think with the soul, or however you want to look at it. I specifically use K if I have been binging on a weekend, and I get some wicked after depression while my brain rebalances it's chemicals, I dive deep into the k-hole, and when I come out, I feel at least more apathetic to the comedown. Other than post-binge related issues, I've also dived into the K-Hole with many great successes in finding inspiration to what seemed like a dull, routine life.
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Yeah, I don't plan to IV it, as I said. I was wondering actually if anyone knew about the differences in bioavailability. Any help on that subject would be very helpful!
I understand that for you, the point of Ketamine is to K-hole, but I looked at the effects of a K-hole and I definitely do NOT want to K-hole or get anywhere close to being in a k-hole. So if anyone could answer my two questions, that would be great!
Thanks guys!
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Thanx for the great thread falucka, I'm going to read the article as well as share it with a friend who is bipolar. I've been doing my own research for dayz after my life changing experience with DMT.
Thanx for sharing, I'm sure you'll find the answers here in the community that you are looking for.
~Peace
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Hi,
I have been suffering from mild depression for many years, and K really helped me, after I had to give up alcohol.
Together with some other changes in my life it has worked wonders, now I cannot say of course what exactly played the most important role if that can be said at all, but the K (low and high dosaged) helped a lot, just keep in mind the easy tolerance build-up, and of course it is also liver-toxic, so probably not a wise choice to treat alcohol withdrawal with it, but in my case it helped getting my liver function to normal levels back again.
As with so many other things it's probably widely different for different persons, but if you have a doctor you trust I'd say give it a chance.
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Hey falucka,
Not sure if you're still around, cause this post is old, but we're hoping you are!
From what we've done on our own, and from what we can tell in the literature, you're looking for around 95mg of K if done nasally, since there is a difference in bio-availability, for sure. This would be considered a "strong" dose if railed all at once, but members of the ILF who weigh less than you have sniffed this much *in one go* and not K-Holed, so that concern of yours can be put to rest.
For the kind of experience you're looking for, we suggest weighing out the total amount, crushing the crystal into fine powder to increase bio-availability, and putting it on a plate. Then do little "bumps" (lines) over the course of 90 mins to two hours -- K insufflated will last longer, and you will feel the effects start to build even if you were to only sniff every 10 mins or so. You will be able to self-titrate pretty well; you'll feel each dose within 5 mins, though it'll take another 10-20 to get the full effects. Might want to alternate nostrils to reduce irritation.
You'll probably want to be able to lie, or at least sit, during the experience. Running around (and dancing!) on low doses of K can be so much fun, but if you find yourself getting vertigo or nausea, you'll want to be able to chill for a minute.
Some music that you find relaxing and calming can be ace.
You may even find that you want the experience to be stronger, so you'll just go for it at some point, rather than spreading it out evenly.
It'll be a weird, though fun and enlightening experience, and it will help with the depression. There's some other threads in the forums if you search for them on some of the specific psychological advantages of doing K.
Hell yeah and good luck! Also, we'd love to hear you report back on how it went.