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Discussion => Drug safety => Topic started by: DMtryptamine285 on July 02, 2013, 06:15 pm

Title: Lets talk about the narcotic properties of myrrh
Post by: DMtryptamine285 on July 02, 2013, 06:15 pm
Investigating the narcotic effects of myrrh

myhrr causes analgesia that is reversed by naloxone...
 
The isolate of myrhh mostly responsible for it's analgesic properties is a furosesquiterpene, called furanoedesma-1,3-diene. It's supposedly 4X as powerful as morphine on a weight/weight basis with both the hot plate and acetic acid writhing tests.
 
FED also displaces (3H)diprenorphine from central opioid receptors, but with "high inhibition constant", whatever that means.<<
 
"Myrrh, described in Greek medicine, Plinius and the Gospel, was
used as a perfume and as a general remedy. It is a resinous
compound from Commphorae myrrha, scrubs typical of the
Middle East. It was given to Jesus by the Magi Kings and proposed
as a drink (vinum myrratum) before crueifictinn, a potion that he
refused. We eharacterlzed ehemieaUy the components of the
hexane extract of myrrh by flash chromatography with hexane on
silica. The hexane extract had four main sesquiterpenoid
components (furanodiene, lindestrene, furanoeudesma-l,3-diene
and eurzarene, MWs ranging from 214 to 216). The mixture of
these four compounds at a dose of 50 mg/kg, increased leak
latency time in the mouse hot plate test (from 15_+0.8 s to 22_+2
s, P<0.05) and decreased the number of stretehings in the mouse
writhing test from 43+4 to 26_+2, I,_+ SE, P<0,05. These responses
were blocked by 1 mg/kg of naloxone and by the 8 specific
antagonist naltrindole (1 mg/Kg), which did not block the effect of
5 mg/kg morphine p.o. We studied the structure of curzarene and
furanoeudesma with computer molecular modelling, comparing
hem with the ~ opiod specific agonist D-Pen2D-Pen 5 (DPDPE)
and we found a good overlapping of the three steric structures. We
also characterized the binding of the sesquiterpenes of myrrh to
CNS opiod receptors with 3H-diprenorphine. Furanoeudesma was
able to displace the specific binding of diprenorphine to opioid
receptors. Myrrh contains agonists of/t oplod receptors, effective
orally, which explain its popularity in the folk medicine in the past."

Notes from my experience with myrrh essential oil

Consumed eight drops diluted with water so as not to irritate the lining of my stomach. 10:00 am

Feeling rather stimulated now, typing faster than normal, mind clear but dreamlike...still feel a bit removed, nausea is settling down. 11:00am

Pupils constricted, not quite pinpoint but smaller than normal, wasnt really expecting opiate like effects from the essential oil as the aromatic compounds are more indicative of a sedative effect, I didnt think the opiate compounds where present in the oil. Perhaps I was wrong. 11:19 am

Opiate like effects fading, stimulant effects diminishing 12:30 pm

baseline 1:00