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Discussion => Drug safety => Topic started by: GoodShitExplorer on October 17, 2012, 03:49 pm

Title: Junk
Post by: GoodShitExplorer on October 17, 2012, 03:49 pm
Junk
Title: Re: Adderall and MDMA Cross Tolerance
Post by: microRNA on October 17, 2012, 04:28 pm
to answer your question no, it shouldnt - because taking adderall once isnt really going to produce a tolerance. but a tolerance to amp could slightly decrease the stimulating aspect/PNS response of the mdma experience - much of the positive mood is from serotonin efflux though so not likely to be effected much anyway though

why? because they both to a large extent work through the same mechanism on dopaminergic and adrenergic neural re-uptake . except that mdma has a strong serotonergic component not effected by amp. its a reasonable question