Silk Road forums
Discussion => Drug safety => Topic started by: hamtaro on September 23, 2012, 02:34 am
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I just took 8 x 5mg Oxycodone HCL (small round blue pills), and was feeling really good, had a nap, and woke up with a bit of nausea and feel really lightheaded, no good feelings however.
I got 20 of these suckers for like $18.
If they are the same, then boy, I think I rather smoke weed, don't know what all the rave is about.
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Oxycodone is the active ingredient in Oxycontin.
Oxycontin is just a brand name given by Purdue Pharma for their time release oxycodone.
The active ingredient in Percocet is also Oxycodone, in other words, oxycodone is the drug, oxycontin is the brand name.
I'll gladly buy em off you if you don't want em :)
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I'm in the same boat as you. I can't get hooked on opiates. It's also if I try or not try to get hooked on them.... i can't no matter what. The high isn't all that awesome, I've snorted close to pure H, parachuted oxys etc, it's really all the same shit to me but I'm in the same boat as you. Not everyone will react the same, some like the high so much that they, yes, become addicted. "I'd rather smoke weed",. is the thought that always comes when I do opiates.
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You really made this thread? Really? Do you know what google is? Wow...
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I'm in the same boat as you. I can't get hooked on opiates. It's also if I try or not try to get hooked on them.... i can't no matter what. The high isn't all that awesome, I've snorted close to pure H, parachuted oxys etc, it's really all the same shit to me but I'm in the same boat as you. Not everyone will react the same, some like the high so much that they, yes, become addicted. "I'd rather smoke weed",. is the thought that always comes when I do opiates.
heh, that's exactly what I mean...weed is way cheaper, safer, cleaner, and better high for me.
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I'm in the same boat as you. I can't get hooked on opiates. It's also if I try or not try to get hooked on them.... i can't no matter what. The high isn't all that awesome, I've snorted close to pure H, parachuted oxys etc, it's really all the same shit to me but I'm in the same boat as you. Not everyone will react the same, some like the high so much that they, yes, become addicted. "I'd rather smoke weed",. is the thought that always comes when I do opiates.
I gotta agree with you on this. If I do an amount just over my tolerance limit I get hit with the worse headache and nausea. It's the shittiest feeling. However the only opiate which didn't bother me was oxymorphone. I do love to speedball though :)
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Weed is obviously, objectively speaking the least harmful, least risky euphoria you can get from a drug. However, some people don't enjoy being baked out all the time it definitely effects the sharpness of your mental capacity (either a little bit or a whole lot depending on the individual and their tolerance). Opiates on the other hand (especially oxy), are euphoric and extremely functional and productive. That is the main difference, but no one's gonna argue with you about weed as far as avoiding addiction and avoiding bodily harm (other than the tar of the smoke) and still getting high, yeah nothing compares...
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I'm in the same boat as you. I can't get hooked on opiates. It's also if I try or not try to get hooked on them.... i can't no matter what. The high isn't all that awesome, I've snorted close to pure H, parachuted oxys etc, it's really all the same shit to me but I'm in the same boat as you. Not everyone will react the same, some like the high so much that they, yes, become addicted. "I'd rather smoke weed",. is the thought that always comes when I do opiates.
I gotta agree with you on this. If I do an amount just over my tolerance limit I get hit with the worse headache and nausea. It's the shittiest feeling. However the only opiate which didn't bother me was oxymorphone. I do love to speedball though :)
Thats pretty interesting that the strongest, gnarliest opioid is the only one that you tolerated well. Opana is fuckin gnarly, I don't like it all because of the strength and dopiness. But to each his own I guess, but thats pretty weird. OXY/HYDRO - CODONE is the bomb to me (Perc/Vic), I strongly dislike the MORPHONE aka dilaudid and opana.
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Dlaudid (Hydromorphone) is the only one I hate, it gives me nausea as soon as I take it and doesn't really do the job. Any other opiate though and mmm mmm good, dunno why that is, but it caused my doc to switch my script from dilaudid to tylenol #3's of all things !!! He wouldn't even give me percs but he's give me dilaudid ..... lol.
The reason some people don't enjoy opiates is because there's a range of slow to fast cytochrome P450 metabolizer's (eg. CYP3A4, CYP3D6, etc. etc. etc.) amongst a given race in a population, which roughly follows a bell curve. Slow metabolizer's will end up with an accumulation of the opiate and very slow metabolism into active metabolites that infer u-opioid induced 'euphoria', they will typically only feel the analgesic effects (treat the pain but not get you high).
Fast metabolizer's will get high and less pain relief but they will need to redose much more frequently. Since it typically follows a bell curve like distribution most people fall under the same 'moderate' metabolizer pharmacokinetics.
If you don't 'enjoy' them and feel sick/headache/nausea you are one of the 1-5% unlucky few whose liver cytochrome P450 enzyme system just isn't quite up to par in terms of metabolic rate. Most people fall into the center (bell curve) though, that's why you hear about many more people enjoying opiates for recreation then those that don't.
Opiates were not designed for recreational 'euphoria', it's just an 'unfortunate' (in medicine) side effect. They were actually designed to treat analgesia. Greedy practitioner's have for decades looked past their own responsibilities (to treat disease) for the profit to be had in distributing them because of the high demand for the euphoria SIDE-EFFECT of opiate's. I'm sure that most will agree that the crap that went down in Florida before they finally created a centralized database is a prime example of how easy it is for those that care for us (Doctors) to be blinded by their own responsibilities when dollar signs are waiving in their face.
Those saying weed is PHYSIOLOGICALLY safer then opiates are ... full of crap. Opiates are meant to treat chronic pain, and do so extraordinarily well with little to no PHYSIOLOGICAL damage, it's when people seek them out for their side-effect's (euphoria) illicitly that excessive use occurs and physiological damage can occur (though it's still fairly rare). PSYCHOLOGICALLY, however, opiates are far more dangerous in terms of addiction and relapse, mostly due to misuse. But on the same note weed is not even remotely as close to treating chronic analgesia as opiates are. It's true that weed has pronounced effectiveness over opiates on a few dozen chronic pain related diseases, but opiates have a pronounced effectiveness on a few THOUSAND chronic pain related diseases.
It's the RESPONSIBILITY of both the Practitioner and the Patient to use Opiates (and weed) appropriate to their condition that dictates the risks and dangers associated with Opiates. You don't blame the drug, you blame the person intentionally misusing the drug for recreation to acheive one of it's SIDE-EFFECTS.
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^Droppin some knowledge in that post. DEfinitely true about its only 5% or less of people don;t experience the ephoric "side-effect" hah. I would say THC and Rx opioids are pretty much equally safe, the con of weed health wise is the smoke, and maybe some mental health stuff. As for opiates, its basically just the physical addiction thing, but thats such a big one. Nevertheless, neither are harmful to your body on occasion, besides from the smoking part of smoking weed hah. When I had a grip of Vics after one of my many shoulder dislocations I ate some brownies with like 15-20mg of hydro, DA BOMB! hah
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Analgesia is the reduction of, or lessening of pain. That is why opiates are referred to as "opiate analgesics" or "narcotic analgesics". That's why aspirin are referred to as analgesics. You are using the word analgesia in the exact opposite context of how it should be used. Saying "But on the same note weed is not even remotely as *close to treating chronic analgesia* as opiates are " makes no sense at all because chronic analgesia would be the same as being in a chronic state of feeling no pain. Most of your info here is right on the money except for your use and definition of analgesia. Don't mean to sound arrogant, just trying to help
(Although your info on liver enzymes is also correct, I have my doubts about the only reason some people don't enjoy opiates is because they're slow metabolizers. That has not been proven to be a fact at all. Some people just don't like the woozy, tired feeling they get from opiates. Or they don't like the nausea. Some people just prefer the feeling of stimulants. In fact, the first few times I tried percocet, that's exactly what I said to a tee. "What's the big deal??!! I"d rather smoke a joint" Except I tried them again. Felt the same way. Then again (don't ask me why) and this time, I noticed I was in a very good mood, and was talking to everyone around me. I did't put two and two together though and didn't even realize it was the percs making me feel that way. The next time I tried opiates I took hydrocodone. About double the amount of percocet I had taken before (there were no oxys back then) and I got very drowsy and was having weird dreams just by closing my eyes. I couldn't believe how good I felt though. I thought it felt wonderful. After that I really enjoyed opiates....too much! Now I've been taking them for thirty years.
Many people think opiates are going to get them ripped out of their skull. Opiates aren't really like that. (well unless you take a lot, or are using IV) I always say they're sort of a learned high. You don't get to know how they affect you until you take them four or five times
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^Yea, they're good. Hah.
The perfect balance of relaxation and stimulation+euphoria in one drug.
+analgesia
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Analgesia is the reduction of, or lessening of pain. That is why opiates are referred to as "opiate analgesics" or "narcotic analgesics". That's why aspirin are referred to as analgesics. You are using the word analgesia in the exact opposite context of how it should be used. Saying "But on the same note weed is not even remotely as *close to treating chronic analgesia* as opiates are " makes no sense at all because chronic analgesia would be the same as being in a chronic state of feeling no pain. Most of your info here is right on the money except for your use and definition of analgesia. Don't mean to sound arrogant, just trying to help
(Although your info on liver enzymes is also correct, I have my doubts about the only reason some people don't enjoy opiates is because they're slow metabolizers. That has not been proven to be a fact at all. Some people just don't like the woozy, tired feeling they get from opiates. Or they don't like the nausea. Some people just prefer the feeling of stimulants. In fact, the first few times I tried percocet, that's exactly what I said to a tee. "What's the big deal??!! I"d rather smoke a joint" Except I tried them again. Felt the same way. Then again (don't ask me why) and this time, I noticed I was in a very good mood, and was talking to everyone around me. I did't put two and two together though and didn't even realize it was the percs making me feel that way. The next time I tried opiates I took hydrocodone. About double the amount of percocet I had taken before (there were no oxys back then) and I got very drowsy and was having weird dreams just by closing my eyes. I couldn't believe how good I felt though. I thought it felt wonderful. After that I really enjoyed opiates....too much! Now I've been taking them for thirty years.
Many people think opiates are going to get them ripped out of their skull. Opiates aren't really like that. (well unless you take a lot, or are using IV) I always say they're sort of a learned high. You don't get to know how they affect you until you take them four or five times
There are several medications that BLACK people CANNOT take because the C 450 isoform that most people are completely apsent in them, it's a genetic and evolitionary phenomenon and can KILL them very easily.
That's why there is an entire branch of medical sciences called epidemiology. Epidemiologists study the rate of metabolism amonsgt various populations, in various environments. They specifically look at the 'race', or to be more specific the groups of a sub-population with very similar genetic profiles, sattelite DNAs and isoforms of encoded proteins.
With ever growing multiculturalism and interactial offspring the distribution of slow to fast metabolizer's has conformed closer and closer to a smooth bell curve. Furthermore, you must understand that opiate narcotics that contain NSAIDS (percocet, vicodin, etc.) will NOT react with COX1 and COX2 inhibition of 'normal metabolizer's' and thus sequester in the body over time increasing leveels of prostoglandin (and it's analogs), which among other biochemical pathway's (though PGE is the primary biochemical cascade) regulate inflammation. The two primary and almost 90% of perceived pain is due to inflammation and anxiety. So go nut's looking on wikipedia for the definition of analgesia when you clearly have no knowledge of the processes that produce the sensation of pain.
I will not continue in a reciprocal argument because I stated VERY CLEARY the role of cytochrome catalyzed metaboilic rate and speciaiclly that withing a specific sub-domain of prostoglandin synthesis. If you have any legitimate statement's to make about prostaglandin biosynthesis and neurologically mediated anxiety (you get more anxious when you are hurt) then by all mean's I would love to hear it, because everything you've said is incorrect within modern medicine.
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Everyone reacts differently to different drugs. I have a couple friends who love opiates, and recently tried heroin. They say it's the best thing ever, and I fear they're heading down a dark road.
I myself used heroin frequently for a year or so, but eventually stopped. I greatly enjoyed the nod, and shooting it gave a nice rush, but it paled in comparison the feelings I got from smoking pot or the rush I got from taking MDMA. Plus, it occasionally made me throw up for hours at a time. It's just not for everyone.
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o go nut's looking on wikipedia for the definition of analgesia when you clearly have no knowledge of the processes that produce the sensation of pain.
Ya, okay. Whatever you say doc. ::) I guess I'm just not as smart as you. :( You're spouting off words like prostaglandin and cox inhibitors which don't impress me when you can't use the word analgesia correctly. Yes I Know NSAID's work through COX 2 inhibition to reduce inflammation which is caused by prostaglandin E2. What does me having knowledge of the processes by which the sensation of pain is produced (in this case it's inflammation) have to do with using a word correctly? I was simply trying to provide *correct* information. I didn't realize you would be so touchy about it. My, quite a touchy ego you have there. ??? I clearly stated I wasn't trying to be arrogant, but obviously you were offended anyway. If everyone on the Road was as touchy as you about someone trying to correct a mistake, this place would be full of flaming and arguing like many other forums are.
I don't have "go nuts looking on wikipedia for the definition of analgesia" Merriam Webster dictionary states the definition quite clearly. Maybe you should look it up :) ANALGESIA: insensibility to pain without loss of consciousness. Simply, opiates can produce anagesia. They aren't used to stop "chronic analgesia" or whatever it was you said that shows your ignorance of the definition of the word.
Do you feel better after giving me some negative karma? ;D lol
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"The two primary and almost 90% of perceived pain is due to inflammation and anxiety."
Saying that you are overstating the case there would be way too nice of a way of putting it. That is an obnoxious claim. I would replace '90% of perceived pain' with 'the majority of very mild pain that people commonly experience' (headaches, stomach aches, tooth aches, mild soreness) and yes some of those minor ailments can be caused or exacerbated by anxiety that creates psycho-somatic pain. But anyone who has experienced moderate to severe pain from actual physical injury knows that NSAIDs are a joke in treating that type of pain, which is why prescription opioids exist... and are used so frequently.
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Quote from: quinone Quote from: dillydod on September 27, 2012, 02:55 AM <blockquote> The two primary and almost 90% of perceived pain is due to inflammation and anxiety.
</blockquote>
Saying that you are overstating the case there would be way too nice of a way of putting it. That is an obnoxious claim. I would replace '90% of perceived pain' with 'the majority of very mild pain that people commonly experience' (headaches, stomach aches, tooth aches, mild soreness) and yes some of those minor ailments can be caused or exacerbated by anxiety that creates psycho-somatic pain. But anyone who has experienced moderate to severe pain from actual physical injury knows that NSAIDs are a joke in treating that type of pain, which is why prescription opioids exist... and are used so frequently. </blockquote>
Hi Bob;
Yup, I have to agree with you. That is a pretty far out claim although the sentence doesn't really make sense. He seems to be forgetting about simple nerve endings responding to stimuli. That's one of our bodies built in protection mechanism. When we touch a hot stove we aren't responding to inflammation and anxiety. We are simply responding to our bodies protection mechanism, pain from nerve endings. If we had to wait for inflammation, or anxiety before we responded to pain everyone would be walking around with broken bones, burns and all kinds of injuries! Thing is that wasn't my quote. :) Just wanted to point that out. I think that came from that quinone fellow, not me
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Yeah I know the quoting system is fucked on this forum.
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You're information was incorrect, what's why I was so adament about correcting you