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Discussion => Drug safety => Topic started by: Purple_Hue000 on May 16, 2013, 01:38 am

Title: NBOMe & MDMA Tolerance question?
Post by: Purple_Hue000 on May 16, 2013, 01:38 am
If I take a 1mg blotter of 25b one night, Could I still roll off 200+ of MDMA the next night?
Title: Re: NBOMe & MDMA Tolerance question?
Post by: Naloxone on May 16, 2013, 03:41 pm
I experienced a bit of decreased effect a week later, although it may have been psychological since I was expecting some decreased effect. NBOMe acts on subset of serotonin receptors and MDMA obviously trys to release lots of serotonin and if you've already released some the previous night and the receptors are blocked the effect might be decreased.

Try searching on clearnet for someone who's done the same. They'll probably be a lot of results!
Title: Re: NBOMe & MDMA Tolerance question?
Post by: Ballzinator on May 16, 2013, 10:07 pm
NBOMes have extremely high selectivity for 5-HT2A receptors so those are the only receptors that downregulate themselves, causing tolerance. As Naloxone pointed out correctly, MDMA causes a release of serotonin, which then stimulates all 5-HT receptors. If you have a tolerance to NBOMes, there will theoretically be SOME cross-tolerance but I think that should be barely noticeable, if at all. MDMA also causes release of dopamine, which is completely unaffected by NBOMes.

TL;DR
MDMA's dopaminergic component will not be affected.
MDMA's serotonergic component is slightly affected, which will probably not be noticeable though.
Title: Re: NBOMe & MDMA Tolerance question?
Post by: Operation Shulgin on May 17, 2013, 12:40 am
NO! I have personal experience with this i took an stupid dose of multiple milligrams of 25i-NBOMe, and around a week later i went to a party and used big amount of MDMA i did not feel jack shit.

There is a cross tolerance between these substances, i don't know how but it exists.

~ O.S.