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Market => Rumor mill => Topic started by: gyarados1169 on August 15, 2012, 08:17 pm

Title: Dextro-MDMA vs. Levo-MDMA
Post by: gyarados1169 on August 15, 2012, 08:17 pm
This has been puzzling me for a really long time. I posted something a while back about who has the firest mdma, because each batch is different from every vendor, and I got mostly people saying that all molly is the same if it's the same purity. However, I don't think this is the case. Most MDMA is racemic, a mixture of the dextro and levo isomers. But, as in the case of its cousin Methamphetamine, the levo isomer probably has all the negative side effects while the dextro isomer has all the positive ones. If someone were to create a pure Dextro-MDMA batch, would that be the ultimate roll that everyone always seeks? Would it be the ever-elusive ElixerOfSex that so many people crave? It's hard enough to find Dextromethamphetamine, now imagine Dextro-MDMA.  8)

What are you guys opinions on this?
Title: Re: Dextro-MDMA vs. Levo-MDMA
Post by: remoulade on August 15, 2012, 09:08 pm
I believe the correct prefix in this case is R(-) and S(+), rather than dextro- and levo-. Wiki says - "The R and S prefixes are different from the preceding ones [d- and l-] in that the labels R and S characterize a specific stereocenter, not a whole molecule. A molecule with just one stereocenter can be labeled R or S, but a molecule with multiple stereocenters needs more than one label, for example (2R,3S)."

From http://countyourculture.com/2011/05/23/mirrored-magic-mdma/ - all your questions are answered here: "In general, R(-)-MDMA appears to produce psychedelic effects and has a longer duration relative to the more stimulating effects of S(+)-MDMA. MDMA is an incredibly unique compound, where each stereoisomer has a distinct and centrally active mode of action. Unlike other compounds where one stereoisomer is more potent or responsible for the majority of effects, each stereoisomer of MDMA contributes to produce a full and complex experience."
Title: Re: Dextro-MDMA vs. Levo-MDMA
Post by: gambino on August 15, 2012, 09:12 pm
The topic was addressed by Shulgin in PIHKAL:

Quote from: PIHKAL
(with 100 mg of the "R" isomer) There were the slightest of effects noted at about an hour (a couple of paresthetic twinges) and then nothing at all.

(with 160 mg of the "R" isomer) A disturbance of baseline at about forty minutes and this lasts for about another hour. Everything is clear by the third hour.

(with 200 mg of the "R" isomer) A progression from an alert at thirty minutes to a soft and light intoxication that did not persist. This was a modest +, and I was at baseline in another hour.

(with 60 mg of the "S" isomer) The effects began developing in a smooth, friendly way at about a half-hour. My handwriting is OK but I am writing faster than usual. At the one hour point, I am quite certain that I could not drive, time is slowing down a bit, but I am mentally very active. My pupils are considerably dilated. The dropping is evident at two hours, and complete by the third hour. All afternoon I am peaceful and relaxed, but clear and alert, with no trace of physical residue at all. A very successful ++.

(with 100 mg of the "S" isomer) I feel the onset is slower than with the racemate. Physically, I am excited, and my pulse and blood pressure are quite elevated. This does not have the 'fire' of the racemate, nor the rush of the development in getting to the plateau.

(with 120 mg of the "S" isomer) A rapid development, and both writing and typing are impossible before the end of the first hour. Lying down with eyes closed eliminates all effects; the visual process is needed for any awareness of the drug's effects. Some teeth clenching, but no nystagmus. Excellent sleep in the evening.

It seems the S isomer is the more active of the two, but that the racemate may be more pleasurable than either enantiomer.  So it's certainly not worth the effort to do an enantiomeric separation, which, by the looks of what's been going around, is certainly beyond the skill level of most underground MDMA labs.
Title: Re: Dextro-MDMA vs. Levo-MDMA
Post by: 12345 on August 16, 2012, 03:19 pm
so there is a difference between 80% MDMA and 80%MDMA ....mmmmh

The more I learn the more I notice I dont know shit....
Title: Re: Dextro-MDMA vs. Levo-MDMA
Post by: gyarados1169 on August 17, 2012, 04:08 am
Thank you guys very very much! Very interesting pieces of information to read. I learn something new every day  :)