Silk Road forums
Market => Product requests => Topic started by: 2c shaman on November 28, 2012, 02:15 am
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is there a good source for this chemical? i've tried it numerous times and its as good or better than h.
the stuff ive tried back when research chemical websites and marketplaces were still around had me unable to drive and coulkd barely walk, it was great... if anyone has a source or would like to make some money id like to start stocking this
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How close is that stuff to regular tramadol, because frankly tramadol sucks ass. Saying tramadol is almost as good as heroin is like saying. The captain of the JV basketball team is almost as good as Michael Jordan.
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o-dezmethyltramadol is a metabolite of tramadol that gives tramadol most of its effects though the conversion is very low. tramadol does suck, but this chemical is a gem
O-Desmethyltramadol (O-DT) is an opioid analgesic and the main active metabolite of tramadol.[1]
(+)-O-Desmethyltramadol is the most important metabolite of tramadol produced in the liver after tramadol is consumed. This metabolite is considerably more potent as a μ opioid agonist than the parent compound.[2]
Tramadol is demethylated by the liver enzyme CYP2D6[3] in the same way as codeine, and so similarly to the variation in effects seen with codeine, individuals who have a less active form of CYP2D6 ("poor metabolisers") will tend to get reduced analgesic effects from tramadol.
The two enantiomers of O-desmethyltramadol show quite distinct pharmacological profiles;[4] both (+) and (-)-O-desmethyltramadol are inactive as serotonin reuptake inhibitors,[5] but (-)-O-desmethyltramadol retains activity as a noradrenaline reuptake inhibitor[6] and so the mix of both the parent compound and metabolites produced contributes significantly to the complex pharmacological profile of tramadol.