Silk Road forums
Discussion => Drug safety => Topic started by: caffeine_me on April 21, 2012, 05:56 am
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Deplin (l-methylfolate/levomefolic acid) Doctors are now using this to improve the efficacy of antidepressants (SSRI's, norepi inhibit) with very impressive results. So far, from my early/brief review of the literature, this molecule could have some benefit in the post-MDMA recovery stage and even more excitingly may enhance the overall experience with a pre-peri-load; even more so than 5-htp (Which I avoid the day of) with it's notable enhancement of making new neurotransmitters. Particularly the portion of people of people who report the loss of the "magic" very quickly or have the mid-week wall of depression post roll; even if they have a proper intake of folate (most do) they may be the "Approximately 10% of the general population (homozygous TT) lack the enzymes needed to receive any benefit from folic acid.[citation needed] Another 40% of the population (heterozygous CT) appear to convert only a limited amount of folic acid into levomefolic acid. They cannot fully process supplemental folic acid at RDA or higher dose levels.[citation needed] The remaining population do not have a known MTHFR polymorphism and can therefore metabolize folic acid more efficiently." taken from https://en.wikipedia.org/wiki/L-methylfolate
At a minimum I will be taking folate post roll (I don't think I fall in the group lacking the enzyme--- over ten years of 10-30/year still with all the magic and little recovery), but I will also be testing this with a pre-load, pre-load with day of, and just day of. What makes this more promising is there appears to be no negative side-effects from consuming this molecule (pretty rare).
More info
http://www.deplin.com/deplin-and-depression/how-deplin-works/
Any other biochem nerds like myself, what are your thoughts?
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Very interesting post!
I've got nothing to add here for now, but posting to subscribe to the thread