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Discussion => Drug safety => Topic started by: sniper123 on December 07, 2012, 08:22 pm

Title: LSD ,Meth and MDMA Cross tollerance?
Post by: sniper123 on December 07, 2012, 08:22 pm
Do these have a cross over value?
Title: Re: LSD ,Meth and MDMA Cross tollerance?
Post by: Ballzinator on December 07, 2012, 10:58 pm
Do these have a cross over value?
LSD and MDMA have cross-tolerance because they both cause 5-HT2A receptors to downregulate themselves and Meth and MDMA have cross-tolerance because they both cause dopamine receptors to downregulate themselves.
I don't know if Meth and LSD have cross-tolerance but it's possible because Meth causes the serotonin transporter to reverse its direction of flow. I'm not sure if that results in cross-tolerance though.
Title: Re: LSD ,Meth and MDMA Cross tollerance?
Post by: sniper123 on December 07, 2012, 11:25 pm
Do these have a cross over value?
LSD and MDMA have cross-tolerance because they both cause 5-HT2A receptors to downregulate themselves and Meth and MDMA have cross-tolerance because they both cause dopamine receptors to downregulate themselves.
I don't know if Meth and LSD have cross-tolerance but it's possible because Meth causes the serotonin transporter to reverse its direction of flow. I'm not sure if that results in cross-tolerance though.
So that's why lsd and molly make a good combo?
Title: Re: LSD ,Meth and MDMA Cross tollerance?
Post by: Ballzinator on December 07, 2012, 11:45 pm
Do these have a cross over value?
LSD and MDMA have cross-tolerance because they both cause 5-HT2A receptors to downregulate themselves and Meth and MDMA have cross-tolerance because they both cause dopamine receptors to downregulate themselves.
I don't know if Meth and LSD have cross-tolerance but it's possible because Meth causes the serotonin transporter to reverse its direction of flow. I'm not sure if that results in cross-tolerance though.
So that's why lsd and molly make a good combo?
No. People just seem to enjoy the effects of MDMA and LSD at the same time :)
Title: Re: LSD ,Meth and MDMA Cross tollerance?
Post by: sniper123 on December 08, 2012, 01:42 am
Do these have a cross over value?
LSD and MDMA have cross-tolerance because they both cause 5-HT2A receptors to downregulate themselves and Meth and MDMA have cross-tolerance because they both cause dopamine receptors to downregulate themselves.
I don't know if Meth and LSD have cross-tolerance but it's possible because Meth causes the serotonin transporter to reverse its direction of flow. I'm not sure if that results in cross-tolerance though.
So that's why lsd and molly make a good combo?
No. People just seem to enjoy the effects of MDMA and LSD at the same time :)
Yes i enjoyed them very much.
Title: Re: LSD ,Meth and MDMA Cross tollerance?
Post by: Ballzinator on December 08, 2012, 02:32 am
i accidentally Od'd on m1 a while back and my tolerance is FUCKED. I can't really have a good experience even with long periods of abstinance. Its likely I fried something :)


wondering if this may effect my future experiments with lsd that I am hoping to do....
The only thing you can do is to simply try LSD after three months of abstinence from any MDxx and hope for the best.