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Discussion => Newbie discussion => Topic started by: Star Survivor on September 11, 2013, 05:12 am

Title: Psychedelics and Antidepressants
Post by: Star Survivor on September 11, 2013, 05:12 am
Hello Forum,

This is my first post and I look forward to joining the discussion. 

After a break of many years, I've decided to resume my psychonautic voyages I so enjoyed at university.  I guess its a better (and cheaper) way to deal with a mid-life crisis than a mistress or a menoPorsche.   ;D

My question, however, is about the ability to experience psychedelics when one is on antidepressants.  My personal cocktail is Zoloft and Welbutrin.  My reading suggests that their resulting boost to Serotonin and Dopamine levels compromise the primary levers of my old friend Sid significantly.  (They certainly do take the zip out of Charles.)

Some commentators suggest not taking your meds on the day you plan to dose.  Given that antidepressants work by saturation this strikes me as dubious advice.  Alternatively, an extended hiatus risks discontinuation syndrome which is not pretty.

Consequently I would welcome any experience or advice others may have. 

Take care and all the best!
Title: Re: Psychedelics and Antidepressants
Post by: ShpongleStarship on September 11, 2013, 06:14 am
If it's Sid it  should be fine, it might be a tiny bit toned -down, but only a tiny bit if there's any reaction between the two.
You shouldn't really skip a dose of meds, besides, SSRIs stay in your system for a long time, so skipping on the day won't have any effect on how much of it is in your system.
If you're taking a serotonin releasing agent however like MDMA with an SSRI (like zoloft) you'll be wasting your time and money, the effect of MDMA is just negated.
Title: Re: Psychedelics and Antidepressants
Post by: Belkamide on September 11, 2013, 06:47 am
I don't take ssri's so don't have direct evidence. My indirect evidence is a bit confusing - I know people on ssri's who have told me no discernible difference, and others that have told me no difference on some occassions, but that it notably dulled the effect of lsd on others - obviously, these reports are suspect.

Agian, not an ssri user - with mdma, the major risk is of http://en.wikipedia.org/wiki/Serotonin_syndrome

If you use yourself as a guinea pig, try to report the results somewhere.
Title: Re: Psychedelics and Antidepressants
Post by: tashkentsouk on September 11, 2013, 07:38 am
Just some anec-data: I was on both zoloft and welbutrin (separately, not together). While on welbuttrin I took both acid and shrooms and they had extremely attenuated effects (barely anything). Take a tester, then take a lot, maybe? While on zoloft I snorted a good amount (.25mg?) of mdma and got nothing. I wouldn't even bother. (Also, seeing the comedown my friends had made me very much not want to experience it.)

So, unfortunately, I think you're going to have a hard time tripping the light fantastic. You should probably stay on the meds and just smoke weed. FWIW, I've also found iv heroin to be pretty great, so there's always that (haha). Good luck!
Title: Re: Psychedelics and Antidepressants
Post by: monkusmaximus on September 11, 2013, 07:50 am
Did someone really just recommend IVing heroin? ::facepalm::

I don't care what you do, just don't go recommending that shit to people. Yeah sure it's great for pain yeah it gets you high but it also has the capacity to RUIN your LIFE. Almost ruined mine.

Anyway, I wouldn't expect much of a trip if you're taking SSRI meds or anything that affects dopamine/serotonin/norepinephrine levels. It's ok to have a benzo handy for the end of the trip but otherwise I wouldn't take any anti-depressant at least a day before the trip happens. It will make your experience a hell of a lot better
Title: Re: Psychedelics and Antidepressants
Post by: thatguynextdoor on September 11, 2013, 08:47 am
Wouldn't recommend anyone on antidepressants to use psychedelics. Took 2-CB while using a SSRI. Didn't experience any high but the days after i felt pretty bad.
Title: Re: Psychedelics and Antidepressants
Post by: Star Survivor on September 11, 2013, 09:42 pm
Thanks everyone!  Much appreciated advice!  I hadn't considered the impact on MDMA. 

I guess when in doubt, weed will always sort it out.   ;D

As an aside, while I doubt mainlining will ever be in my future, smoking opium in Laos proved unbelievably pleasant. 
Title: Re: Psychedelics and Antidepressants
Post by: ShpongleStarship on September 11, 2013, 09:51 pm
Disregard what  everyone says...
Everybodies' physiology and psychology is completely different

eg. someone posted they had little results with 2cb on antidepressants... i've tripped fucking amazingly on 2cb on both prozac and citalopram... mdma is the only one that definitely doesn't work....

Serotonin syndrome is not very understood however, the risk is that no-one actually knows who is susceptible.  You won't run into trouble with acid that's for sure I believe, 2-c-t-X drugs are a little more up  in the air though because of their MAO-inhibition

Simply put.... tryptamines and acid good - Phenethylamines up in the air
Title: Re: Psychedelics and Antidepressants
Post by: Rotaluc on September 11, 2013, 11:18 pm
If it's Sid it  should be fine, it might be a tiny bit toned -down, but only a tiny bit if there's any reaction between the two.
You shouldn't really skip a dose of meds, besides, SSRIs stay in your system for a long time, so skipping on the day won't have any effect on how much of it is in your system.
If you're taking a serotonin releasing agent however like MDMA with an SSRI (like zoloft) you'll be wasting your time and money, the effect of MDMA is just negated.
Zoloft (Sertraline) which the TS is taking is an SSRI.

Do not combine with a serotonin releasing agent (like MDMA) or 5-HTP: you risk serotonin syndrome. In the worst case, that ends in death.

Oxygen deprivation (also known as The Choking Game) supposedly also gives you a pretty good feeling. I've seen a TV presenter who went into a pressurized cabin from the millitary air force, they wanted to see what happened to his cognitive function when deprived of oxygen.

You saw him completely getting lost.. Not moving much, like a zombie, didn't talk, didn't respond, couldn't tell you his name.. Just sat there, eyes open.

Afterwards the operator told him that if they would have left him in for another 1-2 minutes, he would've been a goner. He just said he would be willing to pay as much as $250 for the experience he had. He saw colors and shit and everything.

Please note this was a guy who had already tried probably more than 50 well-known drugs, but this experience blew him away.

Mind you, I don't recommend it. I've never done it and it's pretty bloody dangerous, and surely going to kill brain cells. I just thought it was an interesting story. And relevant since I don't see how it could possibly interfere with the medication.