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Discussion => Drug safety => Topic started by: metacontxt on September 26, 2013, 03:06 pm

Title: Modafinil/dexamphetamine (Adderall) cross-tolerance?
Post by: metacontxt on September 26, 2013, 03:06 pm
Does anyone know about this?

After using Modafinil on and off over a period of about 4 months, I now need to take about twice as much as I did when I first took it.

It seems that my tolerance to dexamphetamine or dextroamphetamine (which I use much much more infrequently) has also increased by a similar amount even though the small amounts I've been taking and the months-long breaks between using don't really explain to me why my dex tolerance would have gone up so much.

I know they're different drugs, but it seems to me that is some relation between their mechanism of action or whatever it is in the brain that they tweak. If I use dexies two days in a row, on the second day I don't get much of a buzz and they're less effective for concentration. If I take modafinil on one day and dexies the next, I get the same reduced effectiveness of dexies the day after taking modafinil.

Anyone else have any experience with these two drugs?
Title: Re: Modafinil/dexamphetamine (Adderall) cross-tolerance?
Post by: fakename709 on September 27, 2013, 10:50 am
I have no access to Adderall but speed, and taking Modafinil quite regularly.
I experienced the same thing, the same dose of amp does less to you if you have taken Modafinil even some days before.
I get the same with Cannabis. I get a weaker effect on Modafinil (less couch locky and I like it more), but this is another story and I guess it's quite obvious given the effects of Modafinil. What a great invention it is!
Title: Re: Modafinil/dexamphetamine (Adderall) cross-tolerance?
Post by: mrguymann on September 27, 2013, 10:26 pm
Its kinda in the amphetamine family's nature to build tolerance quicly.As for modafanil, I took it for 30 days and count stand it.
Title: Re: Modafinil/dexamphetamine (Adderall) cross-tolerance?
Post by: metacontxt on September 28, 2013, 08:54 am
Sure but not during 30+ day breaks.

"I get the same with Cannabis. I get a weaker effect on Modafinil (less couch locky and I like it more)"

I can see why that would be a good thing with gunga - less so with dex when you're taking it to power through some work but it's not quite giving you that familiar kick in the arse to get you going :)
Title: Re: Modafinil/dexamphetamine (Adderall) cross-tolerance?
Post by: MrMates on September 28, 2013, 01:05 pm
My tolerance has me puzzled I just asked the Dr about it.

I don't do any during the week only weekends and when I had the phosphate salt other people were up all night and day on 80mg I was up all night too but it took me 500mg.

I used to really bash it a Decade ago and wondering if my brain is still remembering those days or something as I think a lot of people in the amphet thread think they would be dead on half a gram of that in say 18 hours - just don't understand why I seem to need 4 x the amount everyone else is taking love to just take 100mg and that is that.