Silk Road forums
Discussion => Drug safety => Topic started by: fsgr on June 13, 2012, 09:44 am
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I was wondering if there are any serious interactions with Seroquel and recreational drugs, when taken daily at lose doses?
From what I can tell I cant see anything really bad with it, like say SSRI or MAOI anti-deressants, where people cannot use drugs like MDMA. However some people take it to end or coming off lsd, with mixed reports of effectiveness.
I am most interested in knowing how it would interact with cannabis, mxe, K and If it does have a impact, can it be avoided by skipping a dose because it has a half life of 6 hours.
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This may be advice you do not want to hear, but I'm going to say it anyway, for the sake of your health.
If you are on Seroquel, you should not be doing any drugs, especially since you're taking antipsychotics.
Cannabis (THC specifically), inhibits the formation of hepatic/intestinal enzyme CYP3A4, which breaks down metabolites produced by THC.
Seroquel and Ketamine both increase sedation, so the combination of those two could lead to respiratory depression.
As far as MDMA goes, you MIGHT be ok, but the seroquel is going to reduce your roll, if not totally prevent it, which is going to leave you with a super shitty hangover with nothing to show for it. Also, MDMA is metabolized by the same enzyme as cannabis (CYP3A4), which is inhibited by the Seroquel.
I don't know your situation or what you are willing to risk for a simple high, but I strongly suggest not stopping the Seroquel, regardless of why you are taking it.
Please PM me or talk to your doctor before doing anything that may put yourself or others at harm.
sdesu
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Thanks, I have set you a PM.
I was taking a SSRI and wanted to stop because of all the interactions it has with recreational drugs. Seroquel was just a preventative measure to stop rebound depression and other side effects from stopping SSRI, also a sleep aid.
I was manly concerned with things like "serotonin syndrome" that are life threatening.
With Ketamine, as long as I am not dosing them at the same time they should be safe? Missing one days dose of Seroquel isnt a big deal and I can just pick up from the next days dose.
The Cannabis, I honestly dont understand what you said means in laymans terms. I am trying to lay off the weed anyway because I am a smoke all the time or not at all person.
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Bit bummed that Seroquel seems to mess with other drugs but I still think it is improvement over SSRI type drugs and their interactions.
I am only on a starting dose of 25mg so hopefully I can just skip doses and get stoned, then resume normal dosage after. I cant find any "severe" interactions with other drugs. Apparently can be used to help lessen bad trips, so the only downside might be lessening of effect if you still have some in your system. I was only worried about the really bad reaction, like mdma and ssri, etc.
Still if people who know about what part of the brain drugs work, the process in which they effect you, etc etc I would still like hear it. (in basic layman terms)