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Discussion => Newbie discussion => Topic started by: synthamesc2 on February 17, 2013, 07:24 pm

Title: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 17, 2013, 07:24 pm
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?q=all&cid=50922681#ec

What are the odds I could get this compound synthesized by a garage/blackmarket chemist? It's an antidepressant currently in FDA trials that works by causing neurogenesis (birth of new brain cells). There's some interest in the depression community for it already, and probably more in the nootropic/brain enhancement folks (who are into racetams etc.).

Has anyone had a custom compound synthesized?
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 17, 2013, 07:29 pm
(Getting up to 50...)

Here's an article on it, ctrl-f for "antidepressant" to get to the part about this compound, NSI-189
http://seekingalpha.com/article/859871-why-neuralstem-could-provide-a-10x-return?source=email_rt_article_readmore&ifp=0
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 17, 2013, 07:36 pm
1
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 17, 2013, 07:39 pm
aoeu
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 17, 2013, 07:40 pm
da shit
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: Proper on February 17, 2013, 08:25 pm
lol
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: DrNakaMats on February 17, 2013, 09:29 pm
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?q=all&cid=50922681#ec

What are the odds I could get this compound synthesized by a garage/blackmarket chemist? It's an antidepressant currently in FDA trials that works by causing neurogenesis (birth of new brain cells). There's some interest in the depression community for it already, and probably more in the nootropic/brain enhancement folks (who are into racetams etc.).

Has anyone had a custom compound synthesized?

I think DrV is the only person with access and the skills to accomplish this.
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: Yoda on February 17, 2013, 11:09 pm
(Getting up to 50...)

Here's an article on it, ctrl-f for "antidepressant" to get to the part about this compound, NSI-189
http://seekingalpha.com/article/859871-why-neuralstem-could-provide-a-10x-return?source=email_rt_article_readmore&ifp=0

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?q=all&cid=50922681#ec

What are the odds I could get this compound synthesized by a garage/blackmarket chemist? It's an antidepressant currently in FDA trials that works by causing neurogenesis (birth of new brain cells). There's some interest in the depression community for it already, and probably more in the nootropic/brain enhancement folks (who are into racetams etc.).

Has anyone had a custom compound synthesized?
I'm no Orgo Dr.  but...

For one, that compound isn't illegal... so you don't need go to a black-market chemist.  (have millions laying around to fund a team to compete with Neuralstem?)
Two... That is not NSI-189 (the first link you gave).  I'm not seeing any mention of that specific compound on Thomson Reuters Pharma's or Neuralstem Inc.'s press releases etc...  nothing explicitly saying that this is the compound behind neurogenisis drug NSI-189... but I did find something else. 

Also of possible interest:
In related patent 7560553 I found:
Quote
"Interestingly, chronic administration of either the antidepressant fluoxetine, an SSRI or the antidepressant rolipram, a phosphodiesterase IV inhibitor, promoted neurogenesis in normal animals (Malberg et al., 2000; Nakagawa et al., 2002)"
  Why not start downing these?

I don't see a patent listed for synthesis of NSI-189.  Maybe I'm just not finding it, overlooking it perhaps... but my first guess is that they are keeping the info a proprietary secret.  Yet at the same time, they aren't shy/have no qualms about publishing NSI-189's actual structure.   What this tells me is that this probably isn't an easy synthesis... it's so difficult even, that they aren't worried about someone else filing the patent and stealing away it's rights... losing years and years worth of research/money.  If they were worried, wouldn't it make sense that they file a patent explicitly on the drug (synthesis) itself?  I've looked for it to no avail.  Maybe it's not even synthesized, just "harvested".   

If you read through the patents associated with this research... until they start mass production of NSI-189 (if they ever do), your best bet is to basically eat brains.  :o
Do what they did to look for the nootropic compounds...  well, and maximize them.
-Raise rats
-Dose them up with SSRI's
-Keep them stress free and happy
-Kill them young
-Eat their brains

You could also do this with other mammals... I'm guessing human infant brains wold probably have the most amount of these compounds.  Us being smarter than rats, bigger brains etc.  Not only that, I imagine each mammal brain produces slightly different stuff (specific to that species)... just like it's healthier to drink human milk, it'd probably be better to eat human brain if you didn't have to worry about cretzfeldt jakob disease (human version of mad cow disease).  Yet I don't think prions/the cause of this disease are really understood... so I'm not sure if cannibalism can be blamed by itself.  Infants may be prion free.  http://en.wikipedia.org/wiki/Creutzfeldt_Jakob_Disease#Transmission

Really makes ya think.  Maybe zombies aren't so stupid.  Or those tales of ET's harvesting/eating humans brains etc., maybe they aren't so far fetched :)




Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:26 am
bumping
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:31 am
da bomb
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:32 am
da maui maui
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: ZoomZoom on February 18, 2013, 03:32 am
So basically eating stem cells lol. Merika!
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:34 am
da sweet mary jane
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:37 am
about 30 sec per reply so 25 min for 50 posts

ugh
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:37 am
uegtyw
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:38 am
ktydhm
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:40 am
fegkth
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:42 am
I'm honestly putting off suicide until NSI-189 hits the market. I've been through every mainstream antidepressant without any of them being effective.
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:43 am
GGRBbk
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:44 am
yehbmy
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: ZoomZoom on February 18, 2013, 03:44 am
Damn halfway to 50! whatchu know bout dattt
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:44 am
ahnyht
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:45 am
rynrrm
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:45 am
vhuukm
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:48 am
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Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:49 am
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Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: galwithpants on February 18, 2013, 03:49 am
sweet
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:51 am
hfkbkn
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:53 am
bdwedk
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:55 am
bahxgu
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 03:59 am
vyewak
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:00 am
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Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:01 am
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Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:02 am
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Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:03 am
hymhur
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:04 am
btacav
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:05 am
gdrxpt
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:09 am
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Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:09 am
hktfeu
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:12 am
bpunhk
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:13 am
uavhmf
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:17 am
5 more
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:27 am
ypbfax
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:28 am
kdhnum
Title: Re: Organic chemists in the house? Having a compound synthesized
Post by: synthamesc2 on February 18, 2013, 04:30 am
tada!