Silk Road forums

Discussion => Newbie discussion => Topic started by: nameviolated on April 01, 2013, 10:02 pm

Title: MDMA and anti depressants
Post by: nameviolated on April 01, 2013, 10:02 pm
I'm currently prescribed anti depressants and anti psychotics and have no luck with LSD working.  Will this also be the case with MDMA?
Title: Re: MDMA and anti depressants
Post by: Smarties on April 02, 2013, 12:38 am
I know MDMA won't work when on SSRI based AD's and can be quite dangerous too.
Title: Re: MDMA and anti depressants
Post by: nuggets5 on April 02, 2013, 12:45 am
Be safe, I wouldn't do them both
Title: Re: MDMA and anti depressants
Post by: leavesbrown on April 02, 2013, 01:22 am
What antidepressants are you taking? Completely depends on what you're taking and also why you are taking them doesn't it?

drugsforum is a great place to ask questions like this.|
Title: Re: MDMA and anti depressants
Post by: BuysPaper on April 02, 2013, 01:29 am
Taking MDMA causes your brain to be flooded with Serotonin
Taking SSRIs prevents your brain from "taking back" the Serotonin

So basically if you take MDMA with an SSRI you're risking giving yourself serotonin syndrome

So don't do it. Stop taking your SSRIs for a couple of months and then you should be ok.

I don't know about how MDMA reacts with MAOIs but I would still be cautious.
Title: Re: MDMA and anti depressants
Post by: Fear.The.Reaper on April 02, 2013, 01:30 am
I would steer clear
Title: Re: MDMA and anti depressants
Post by: nameviolated on April 02, 2013, 01:56 am
Thanks for the info, I just checked and it's not a SSRI but an SNRI, not sure what the difference is but will research it further.  I've had MDMA before and didn't get much from it, though it probably wasn't the best.
Title: Re: MDMA and anti depressants
Post by: BuysPaper on April 02, 2013, 02:08 am
Thanks for the info, I take Pristiq and Abilify, I will have to do some checking around to see if they have SSRI in them.

SSRI refers to how the drug works, it's not something that's "in" the drug.

Desvenlafaxine(Pristiq) is an SNRI(Like an SSRI but it works for noradrenaline as well), for all intensive purposes, that means you should not take MDMA if you have taken Pristiq recently(A month or so).

Aripiprazole(Abilify) is a dopamine agonist, meaning it replicates dopamine(Probably inaccurate, so take this with a dose of skepticism), it would probably be a bad idea to take MDMA with this, because these drugs are generally used for people who do not have normal levels of dopamine.

If you are prescribed these drugs it would probably be safer to stick to cannabis for recreational use.
Title: Re: MDMA and anti depressants
Post by: nameviolated on April 02, 2013, 03:00 am
Thanks for the info, I take Pristiq and Abilify, I will have to do some checking around to see if they have SSRI in them.

SSRI refers to how the drug works, it's not something that's "in" the drug.

Desvenlafaxine(Pristiq) is an SNRI(Like an SSRI but it works for noradrenaline as well), for all intensive purposes, that means you should not take MDMA if you have taken Pristiq recently(A month or so).

Aripiprazole(Abilify) is a dopamine agonist, meaning it replicates dopamine(Probably inaccurate, so take this with a dose of skepticism), it would probably be a bad idea to take MDMA with this, because these drugs are generally used for people who do not have normal levels of dopamine.

If you are prescribed these drugs it would probably be safer to stick to cannabis for recreational use.

That's what I'm reading as well, considering tapering off the meds for a month before I use anything again.  Pristiq will be the pain in the ass as you have to slowly taper off or it bites you hard.
Title: Re: MDMA and anti depressants
Post by: leavesbrown on April 02, 2013, 03:11 am
Find out how long it takes for your meds to become completely eliminated from your system.
Drugs.com is a fantastic resource for info like this. My advice, stick to weed for the time being or until your doc takes you off at least on of those meds.
Title: Re: MDMA and anti depressants
Post by: Tabletter on April 02, 2013, 03:21 am
Wouldn't mix em. Serotonin syndrome is a real thing! Careful buddy!
Title: Re: MDMA and anti depressants
Post by: CRWHITLOCK on April 02, 2013, 09:36 pm
I would suggest doing a huge amount of research before you even consider it. After you've done the research I would suggest doing a lot of soul searching. If your being prescribed anti-depressants and anti-psychotics, you clearly have some emotional/mental issues troubling you. MDMA is a chemical that dramatically effects your brain chemistry. I would be very cautious with "mixing" multiple drugs that alter your brain chemistry when you are already having issues with balancing. If you want to try some sort of "drug" to assist you with your struggle, I would suggest looking into ibogaine. It would take a significant amount of research, time, and thought but it might be worth it for you. Ibogaine is a chemical that has shown huge results in helping people battling with emotional issues. The majority of attention is focused on it's use for opiate rehab, but it does a lot of miraculous things for people battling depression, anxiety, etc. Ibogaine is not a "party" drug like MDMA, it is more of a soul searching drug that helps you work through deep rooted emotional issues.
Title: Re: MDMA and anti depressants
Post by: nameviolated on April 03, 2013, 01:51 am
Thanks again for the replies, did some research yesterday and found that MDMA doesn't work with Pristiq.  Will have to stick to meth and coke I guess.
Title: Re: MDMA and anti depressants
Post by: Andrimion on April 03, 2013, 02:41 am
I have done this without knowing the consequences...

I am on 100mg Sertraline(SSRI) a day and popped 3 Nintendo's(600mg MDMA). I felt nothing only stay awake a bit longer and then come down on a Zopiclone.

So SSRI's and SRNI's dont work with XTC and LSD.