Silk Road forums

Market => Product requests => Topic started by: loladol on March 05, 2012, 12:51 pm

Title: S-isomer ketamine
Post by: loladol on March 05, 2012, 12:51 pm
Would really love to get my hands on this, rather than plain racemic I've grown weary of. I saw there is a 50/50 mix on offer, wonder how that is. Would like to pick up 14-28g of the right stuff! I know somebody else surely wants some, too.
Title: Re: S-isomer ketamine
Post by: mju7 on March 05, 2012, 03:14 pm
Racemic is actually much much better imo.
Title: Re: S-isomer ketamine
Post by: spacewasp on March 05, 2012, 06:29 pm
anyone care to explain the difference?
Title: Re: S-isomer ketamine
Post by: gustono on March 05, 2012, 08:12 pm
anyone care to explain the difference?
Isomers are chemicals which have the same molecular formula, but different structural formula, meaning they act differently with receptors, sometimes better sometimes worse.

Thalidomide tragedy was down to one isomer being a relatively good birth control chemical, but the other having a horrible deformity affect on newborns. The other isomer also degraded in to the bad isomer so it was a bad chemical overall.

S-R isomers are enantiomers where some of the atoms are attached differently on to the carbon chain, usually with a C=C bond as atoms can attack from either side.

Anyway yeah, I imagine the S-isomer of ketamine has higher bioavailability or producs better effects, but seperating isomers from each other can take time and money so is probably why racemic (50/50 S-R isomers) is much more common.
Title: Re: S-isomer ketamine
Post by: QTC on March 06, 2012, 12:38 am
The s-isomer is more potent at the opiate and NDMA receptors, and the racemic has more of an effect on the heart, see http://www.ncbi.nlm.nih.gov/pubmed/658124

Unless you're well connected though s-isomer is harder to find than hen's teeth so get used to the racemic stuff. :/
Title: Re: S-isomer ketamine
Post by: tordemon on March 06, 2012, 02:07 am
The s-isomer is more potent at the opiate and NDMA receptors, and the racemic has more of an effect on the heart, see http://www.ncbi.nlm.nih.gov/pubmed/658124

Unless you're well connected though s-isomer is harder to find than hen's teeth so get used to the racemic stuff. :/
My experience with the S-isomer indicated that it was approximately twice as potent as the racemic mixture, but that may have only been due to an increase in quality correlated with the chemical experience needed to separate the two isomers.

Overall, I'm not sure it was worth the increase in price.
Title: Re: S-isomer ketamine
Post by: loladol on March 06, 2012, 01:50 pm
I appreciate all of the chemical insight. Speaking from anecdotal experience, I can only say that I found the s-isomer to be a lot more liberating of the mind -- not to mention downright psychedelic. Potency was definitely higher and there was less of a drunk feeling. The K-hole was fabulous but even small doses improved my cognitive functions, both creatively and critically.

Regardless, it would be nice to revisit these experiences and see if they hold up after a year.
Title: Re: S-isomer ketamine
Post by: tordemon on March 06, 2012, 08:41 pm
I appreciate all of the chemical insight. Speaking from anecdotal experience, I can only say that I found the s-isomer to be a lot more liberating of the mind -- not to mention downright psychedelic. Potency was definitely higher and there was less of a drunk feeling. The K-hole was fabulous but even small doses improved my cognitive functions, both creatively and critically.

Regardless, it would be nice to revisit these experiences and see if they hold up after a year.
Well, if somebody were to list it up, I'd probably be willing to give the S-isomer another go, just to make sure it wasn't a fluke. Worst case scenario I have a special reserve of SPECIAL K to dip into on occasion. =]