Silk Road forums
Discussion => Drug safety => Topic started by: DoctorX on 14 April 2013, 01:16:45
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Hello,
I am a Spanish Family Physician working in fields like
risk reduction associated to drug use, club drugs, new synthetic drugs,
cannabis therapeutic and steroids since 1999. I would like to contribute
to this forum offering professional advice in topics related to drug
use and health: pharmacological interactions, risks of drug use in
particular conditions (specific diseases, problems of health…),
contraindications, adverse effects and toxicity, risk reduction
measures…
This advice cannot replace a complete face-to-face
medical evaluation, but I know how difficult can be to talk frankly
about these things. You can see my CV in my personal web-page
http://www.doctorcaudevilla.com/
You can also use PM for personal questions or video-conference in my web.
I will try to answer all your questions (if I know the answers) but I have limited time
DoctorX
(03/05/13)
Please use only PM and PGP for personal questions. Most of the
questions can be answered in general forum and can be useful to other
people
(05/07/13) Thanks to user cleansober, who is helping me editing my awful English
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Hey doctor thanks so much for offering your advice! I have type 1
diabetes and i am wondering if there is any information connected to
MDMA and its effect on blood sugar? I have never done MDMA but am
interested in exploring it. Would i have enough control over myself to
realize "i need to test" or should a trip sitter be there to remind me?
Secondly, I have tripped in the past on LSD and mushrooms but that was
before my diagnosis...now that i know i have to monitor my sugar levels
to avoid issues im afraid i might become afraid or paranoid of my
glucometer or my insulin injections under the influence..any
recommendations on how to deal with this?
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In non-diabetic persons MDMA does not have a significant effect on
glucose blood levels. There are no specific studies on diabetic persons
but, according to MDMA pharmacology, dramatic changes in glucose are not
expected.
In fact, alcohol is the most altering glucose drug in
diabetics. For the rest of substances, it is more important “what are
you doing” that “what substance did you take”. If you are dancing, doing
exhausting exercise or you forget to eat are important aspects that can
affect glycaemia. Some drugs make you hungry (cannabis), other diminish
appetite (stimulants).
Most people feel like, on MDMA, it is easy
to keep control on what you feel, what you think and what you do (or at
least easier than other drugs). But the positive mood could make you
feel forgetful and carefree. As MDMA effects last for 4-6 hours, one
possible strategy is to set an alarm clock in hour 2-4 to remind you of
test your sugar. I think with that it should be enough. If you are with
some friends that know what you are doing it should be great. You should
use moderate doses first times (60-80 mg) and be cautious with dosage
in general (not over 120 mg) as diabetes can affect cardiovascular
health. One important thing to remember is that MDMA decreases appetite:
you should keep with you sweat soft food as milkshakes or fruit.
Some
diabetic MDMA users have told me that MDMA makes them feel more
conscious about their own body, so they can notice better if there is
hyper or hypoglycaemias. On the other hand, ketamine is a drug not
recommendable for diabetics, as it alters self-perception of body.
I
don´t know how long have you been diagnosed of diabetes, but if it is a
recent diagnosis you should wait to know well how to use insulin and
“get used” to your condition and then after experiment with substances. I
think worries and paranoias are less probable with MDMA than
psychedelics. But as you learn to live a normal life with diabetes
worries will disappear.
DoctorX
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Do you have any information on the Dissociative Fugue experienced by
those on prescription Lithium or Tricyclics with LSD? Is it unpleasant,
and should it be avoided?
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dar la bienvenida Dr Caudevilla!
It's fantastic that you've joined us and are offering your knowledge towards harm reduction, thank you! +1
I
noticed on your page that you accept bitcoin donations, so I hope
anybody that's financially able and who also takes benefit from your
information to donate as a token of thanks.
estoy agredecido
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A dissociative fugue is a kind of amnesia in which, the person who
suffers it, experiments an "escape" of his own personality, and so he is
not able to remember a part or the whole of his previous life. He is
not able to remember who he or she is and, in some times, it produces
the creation of a new identity. In most cases it is a temporal state,
lasting hours to days or months.
In relation to LSD, lithium and
tricyclics I only know some reports in Internet forums, but, as far as I
know there are no scientific data about it. I think very high doses of
LSD or other psychedelics could rarely trigger dissociative states in
predisposed individuals. I don´t know if lithium or triciclycs raise
this probability. From a medical point of view, dissociative fugue is
considered a psychiatric condition and, in my personal opinion, is an
unpleasant and non-adaptative state. Some psychonauts like to explore
these mind-states but I would not personally recommend that.
DoctorX
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Thank you! If i could it would definitely be +1!
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Hi Doc,
Great that you are giving out advice.
What are your thoughts on the neuro toxicity of 2C-B and other 2C drugs?
Cheers
FH
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Hey doc after tapering my lexapro down to zero how long should i wait before taking MDMA to feel its full effects?
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Hi Doc,
Great that you are giving out advice.
What are your thoughts on the neuro toxicity of 2C-B and other 2C drugs?
Cheers
FH
Bumping this question. ^
Also:
What suggestions would you have for stimulant users (never more than 25
mg meth or 30 mg dextroamphetamine used at a time) that want to avoid
weight loss or want to re-gain the weight that was lost during routine
stimulant use? I am prescribed an extended-release form of
dextroamphetamine and sometimes take low doses of methamphetamine on
days that I wake up too late to take the meds and need to keep up
productivity. The doctor hasn't wanted to prescribe an instant release
form in addition to my extended-release. I have lost some notable body
mass and I'm already slim/athletic build to begin with. What are your
suggestions for re-gaining weight while still on the medication?
Thank you for providing this to the community!
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2C-B and 2C-X
Amphetamines and ring substituted
methylenedioxyamphetamines are known to be neurotoxic in animals in high
doses. This is a problem with MDMA, MDA or meth and has been studied
and described for decades. 2C-B is structurally related to mescaline,
not to MDMA or amphetamines. And mescaline is a molecule known since a
century and there are no studies showing neurotoxicity in animals or
humans. So it is not likely that 2C-B has significant neurotoxic
potential.
Our working team published last year the first study on
subjective effects of 2C-B users. The sample was small but we did not
find any adverse effects or toxicity ( motor problems, memory complains)
suggestive of neurotoxicity.
http://www.slideshare.net/fernandocaudevilla/2cb
On
the other hand, and in terms of general toxicity, 2C-B is known since
the 70s and has been widely used. Adverse effects seem well known and
not important. It is a well known molecule. But there are some other
derivatives with atoms that are not typical in human pharmacology (2C-F,
2C-C...). Maybe any of these lesser-known drugs are potentially more
dangerous
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MDMA and Lexapro
In theory, two or three weeks after
finishing escitalopram, your neurorreceptors would be in a state similar
to how you felt before Lexapro. But life is much more complex than
neurochemistry. It depends also on your expectations, feelings, mood,
personal experiences...I suppose that you have been taking Lexapro for
a mental health or psychological condition. The best way to have a
positive experience with any drug is to be in good state of mind before
taking it. Until you are feeling 100% and able to abandon your
medication it will be difficult for you to feel the full effects of
MDMA.
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Stimulants and weight loss
Like therapeutic effects, some adverse
effects of drugs are inherent to them and difficult to avoid.
Loss of appetite is a well-known effect of amphetamines, in fact some
people take them to lose weight , the opposite as you wish. The only way
I think you could win or re-win some weight is increasing protein and
carbohydrates intake. I think many formula used in bodybuilding (50%
protein + 50% carbohydrate, for example) could make you gain some weight
if you get used to use it daily.
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I love this thread! Thank you!
So my question is..... Whats your favorite drug and why? Which one do you consider the most harmless and why?
Which one do you consider the most dangerous?
Which one causes the most problems?
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Dangers of drugs.
All drugs are absolutely harmless. If you
leave cocaine, MDMA, meth or 4-AcO-DMT on a table, they won´t try to
assault you, rape you or hit your balls.
To consider potential of
harm of psychoactives you should keep in mind factors as individual,
doses, patterns of use, frequency, motivation and context of use. This
seems obvious but it is very important, it is no sense talking about
harms of drugs in abstract.
From an objective point of view and in a
Public Health perspective, legal drugs (alcohol and tobacco) causes much
more problems (health, familiar, social...) than all the other illegal
together.
Scientific studies trying to answer this question point that alcohol, heroin and crack cocaine are the most harmful substances
http://www.fcaglp.unlp.edu.ar/~mmiller/espanol/Variedades,%20politica/drogas_Journal.pdf
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As an 18 year old with a still developing brain, what do you think
the possible consequences of frequent psychedelic use could be?
About
mid-December, I took MDMA for the first and only time and absolutely
loved it. I plan on doing it once or twice more this summer, but have
not come back to it yet due to it's known neurotoxicity. Since that time
though, I have done LSD, mushrooms, threshold doses of DMT, and
4-aco-DMT a handful of times, tripping an average of 2-3 times a week,
but even more so in the last two weeks. I've also tried 25-I twice but
the iodine molecule scares me so I won't be going back to that.
I've
decided that I'll be spacing my trips out more now. I'm taking LSD on
the 19th for Bicycle Day and waiting until a concert on May 4th to trip
again. From there, I'll try to space out trips by at least a week over
the summer, and then stop for a few months or more when school starts
back up.
So what I'm wondering is, do you know what sort of
effects, long or short-term, on the brain my frequent use of
psychedelics over the last four months may have caused? And would you
suggest waiting longer than a week between trips over the summer?
Any
info you have would be really appreciated, as I do care about myself
and don't want to continue tripping like this if it means something
serious could come from it. Thank you.
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I was wondering if it is more harmful if say taking .3 of MDMA or
MDA and then take anther .2 say 3 hours later? or would it be more
dangerous to take the .5 all at once
ive heard that redosing is bad and i know .5 seems like a lot but idk i roll balls every once in a while :)
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Dangers of drugs.
All
drugs are absolutely harmless. If you leave cocaine, MDMA, meth or
4-AcO-DMT on a table, they won´t try to assault you, rape you or hit
your balls.
To consider potential of harm of psychoactives you
should keep in mind factors as individual, doses, patterns of use,
frequency, motivation and context of use. This seems obvious but it is
very important, it is no sense talking about harms of drugs in abstract.
From
an objective point of view and in a Public Health perspective, legal
drugs (alcohol and tobacco) causes much more problems (health, familiar,
social...) than all the other illegal together.
Scientific studies trying to answer this question point that alcohol, heroin and crack cocaine are the most harmful substances
http://www.fcaglp.unlp.edu.ar/~mmiller/espanol/Variedades,%20politica/drogas_Journal.pdf
yeah
but powder sold as heroin which is carfentanil is definetely dangerous
because how the hell does one cut up evenly such potent substance as
carfentanil ? just saying it because it was seized ready for the
streets. You might buy 1 dose and not get high , you might buy 3 doses
don't get high, you might buy 1 dose once more and OD. Still pure
carfentanil 100x more potent than fentanyl I wonder if media didn't blew
out this of proportion.
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ModalSoul:
In my opinion tripping 2-3 times a week is too much,
regardless of your age and any other factor. "Classical" psychedelics
(LSD, mushrooms, DMT...) have a very low organic toxicity, but are
substances that can make feel very strong changes in the way we perceive
the world and reality. I think it is good to have enough time to
integrate these experiences. Some people that take psychedelics with
frequency they finally wonder if is this world real or the psychedelic
one. Or have difficulties to handle with real world. Or, simply, get
bored of psychedelics (when you repeat the same thing a lot of times you
finally get bored of it). I think once a month could be a reasonable
pattern of use for psychedelics. Too frequent use will lead to
tolerance, and you will need to increase dose. You should think about
the objective of your psychedelic use (fun?, self-knowledge?,
experimentation?,
If you are worried about negative effects, I
strongly advise you against new synthetic psychedelics (bromo dragonfly,
25-I-NBOME...) We know almost everything about LSD, ayahuasca, DMT,
mushrooms... but these new substances have not been studied in humans
and risks are unknown and potentially high.
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ThisSHITScrazyman
0.5 gr of MDMA is too much MDMA in any
case. Studies in human pharmacology and studies of psychoterapeutic use
of MDMA in the 1970s show that 120-150 mg is the highest rank. A re-dose
of the half (60-75 mg) 2-3 hours later extends the experience with not
too many adverse effects. If you take higher doses or frequencies you
will multiply adverse and negative after effects. Women and first time
users should use smaller quantities (70-100 mg).
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Grdr
You are right, I agree with you. One of the
conditionants for the dangerousness of drugs is the fact that they are
legal or not. Illegal drugs are far more dangerous because they are not
sanitary controlled. Some scientist have criticized that study in the
same way you´ve done.
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Illegal drugs are far more dangerous because they are not sanitary controlled.
[/quote
**NOT**
come on now "Doctor" (rolls eyes)
look at public records...alcohol related accidents..compared to marijuana related accidents...
personally..i've never seen anyone smoke a joint..freak out and have to kill someone for another hit...
oh well .. i'm no "Doctor" :P
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ChemCat:
The original question was "Which one do you consider the
most harmless and why? Which one do you consider the most dangerous?". I
tried to explain that harms and dangers not depend only on the
substance but other factors like individuals, patterns of use and
context of use. And it depends on the kind of danger we consider. If we
measure "accidents" alcohol would be more harmul than marijuana,
obviously. If we measure "effects on short time memory" cannabis would
be more dangerous than tobacco, for example. And I answered "Illegal
drugs are far more dangerous because they are not sanitary controlled"
in response to a remark about heroin adulterants (carfentanil)
By the
way, I don´t underestimate your comments by the fact you are a "doctor"
or not. So I ask you to do the same with me, please ;D ;D ;D
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No Worries :)
debates and goos conversation is welcomed :)
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Studies
in human pharmacology and studies of psychoterapeutic use of MDMA in
the 1970s show that 120-150 mg is the highest rank. A re-dose of the
half (60-75 mg) 2-3 hours later extends the experience with not too many
adverse effects.
This has been my formula for a long time, except I do 180 followed by 120. :)
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"All drugs are absolutely harmless. If you leave cocaine, MDMA, meth
or 4-AcO-DMT on a table, they won´t try to assault you, rape you or hit
your balls."
Priceless. you know the movie Torrente? ;)
Thanks for the answer!
So you don't use anything? (no favorite) thats cool.
I got another one. What do you think about the current synthetic (rc) scene?
(bigone i know. Im thinking nbome-s, cathiones, mdpv, etc)
How long can we play this grey area game? there seems to be no end to it. New substances pop up every 2 years.
What do you think about legalization? Decriminalization? (not just cannabis)
I'm gonna send some more karma your way when i can ;)
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Valakki
Torrente rules!
I don´t think my personal use of
drugs has any interest, but, if you insist, I´ll tell that MDMA is my
favourite, although now I do it only 3-4 times a year.
I think the
new synthetic scene can be very problematic. During all the nineties,
media and antidrug scientists used the images of "Russian roulette" or
"laboratory guinea pigs" to talk about risks of MDMA and other syntethic
drugs. And that was absolutely false, as drugs like MDMA, psilocibin,
ketamine, GHB, amphetamines, LSD, mescaline, MDA, DMT, opiates,
cocaine...have been studied during decades and we know almost everything
about their pharmacology and risks.
Otherwise, these new synthetic
drugs have not been tested in human or animals in most cases. Their
risks are unknown but potentially much greater than classic drugs. As
you say new substances appear because older are fiscalized. But, in
terms of chemistry and pharmacology, they are even more bizarre and
dangerous than previous. But they are "legal", and some people can think
that, if they are legal it is because they are harmless. It is curious
the fact that, in SR, they are rarely among the "bestselling", probably
because SR users have better information about drugs than general
population.
I think that legalization of all substances is the only solution to the called "drug problem"
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Loving this thread!!! ;D
To all the members asking questions I
would be careful posting specifics. We might have a doctor in the
house, but there are 15 more LEO to go with him!
Doc, let me ask it like this.
If
you had a 21 year old son who had never experimented with any drugs but
was bound to dabble in them no matter what, and he asked your opinion
which would you approve/suggest of him experimenting/using
recreationally?
Meaning what drugs sold here on SR would you suggest as far as his health being the main concern.
Top 5 please?
Sorry if this sounds odd I am just curious to hear a Doc's personal standpoint not his professional.
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As
an 18 year old with a still developing brain, what do you think the
possible consequences of frequent psychedelic use could be?
My
own personal thoughts on the matter- as an adolescent / young adult,
you literally get high off of getting high- when you use drugs,
regardless of their method of action, your brain releases excess
dopamine not found in adults.
Furthermore, most studies of illicit drugs and side effects (if any) were done on adults.
But,
given how you're on Silk Road coupled with the mannerism of your
speaking- be careful and I feel you'll be fine. Stick to psychedelics,
give your self time between drug use, and especially give yourself a
barrier between use of MDMA or Ecstasy pills; they can be neurotoxic and
multiple uses can result in bad mood swings from serotonin depletion.
I'm sure you know this from your own research; stay careful.
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White Out:
I understand your question but it seems very difficult
to me to answer it in a general way. Most 21 years old persons have
tried alcohol and tobacco, it would be very strange to find such a
person. But I believe that, in drugs, advice should always be
personalized. Why does this person want to try drugs? How is his
personality? What are his motivations? What does he think/beleive/know
about drugs? How does he work in his personal/familiar/social life? Is
he looking for stimulants/depressors/psychedelics? Why? One important
thing is to have access to objective, true, reliable information about
positive and negative possible consequences and the way to handle it (in
English, www.erowid.org is the gold standard, in my opinion).I´m not
trying to avoid to answer your question but I think is impossible to
have a "Top 5" for everyone. I would avoid all "research chemicals" and
"legal highs" as I explained in previous messages. Intravenous route and
high-potential dependence drugs as opiates or tobacco would not be
recommended for beginners, also.
In general, I agree with the advices of zvp1014
And
I didn´t understand the meaning of this sentence "We might have a
doctor in the house, but there are 15 more LEO to go with him!" (What
does LEO mean, sorry my English is limited)
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White Out:
I
understand your question but it seems very difficult to me to answer it
in a general way. Most 21 years old persons have tried alcohol and
tobacco, it would be very strange to find such a person. But I believe
that, in drugs, advice should always be personalized. Why does this
person want to try drugs? How is his personality? What are his
motivations? What does he think/beleive/know about drugs? How does he
work in his personal/familiar/social life? Is he looking for
stimulants/depressors/psychedelics? Why? One important thing is to have
access to objective, true, reliable information about positive and
negative possible consequences and the way to handle it (in English,
www.erowid.org is the gold standard, in my opinion).I´m not trying to
avoid to answer your question but I think is impossible to have a "Top
5" for everyone. I would avoid all "research chemicals" and "legal
highs" as I explained in previous messages. Intravenous route and
high-potential dependence drugs as opiates or tobacco would not be
recommended for beginners, also.
In general, I agree with the advices of zvp1014
And
I didn´t understand the meaning of this sentence "We might have a
doctor in the house, but there are 15 more LEO to go with him!" (What
does LEO mean, sorry my English is limited)
I
am referring to a male, non addictive genetics, average weight &
height, average life, job, class, good health, no other variables. I
just was curious your opinion on what drugs are the purest. Though, Now
that I read your post it makes more sense to me. I think the only way we
can judge what is ok for us to do is by knowing our own structure and
limitations.... Like you have said.
Would you put Cannabis at #1
on every list though? Or is there something out there less harmful but
with just as nice a mind alternate.
Also I was referring to LEO
meaning Law Enforcement Officials, I was just warning members not to
post too much specific info because this makes it that much easier to
single them out.
Can I get your take on Adderall being used to
treat adult ADD? I'm talking about only dealing with around 10mg of
instant release per day, every other day or so. Can you forsee any short
or long term consequences other than it being an addictive stimulant? I
just hate the fact that I am basically taking meth (no hate on those
that do) But is it really that bad, I know it is pharmaceutically
promoted but that doesn't mean shit for health safety.
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Hello Doctor!
Does modern science know the way (or any
recommendation) to restore the sensitivity of serotonin receptors? I
mean the consequences of taking MDMA: depression and 'lost of magic'.
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White Out:
I wouldn´t put cannabis in that list, I wouldn´t
reject it, neither. But I think, in general, some risks of cannabis are
underestimated. In fact I consider it as a "minor psychedelic" with all
the inconveniences (and properties) of these group. People who like
cannabis enjoy it very much, but there are some other people that find
their effects not pleasant. It also has effects on short time memory
(reversible with weeks of abstinence) and I don´t think it is a drug for
people who have to study or do hard intellectual work (there are
exceptions to this rule). As with any other substances, it all depends
on persons and patterns of use.
I´m not concerned about LEOs, as
I´m not doing any illegal activity here. I´m offering my professional
experience to assess people who take drugs in a risk reduction
perspective. For that I have decided to make my identity public. But I
understand perfectly your worries. All the personal data I receive in my
work (in Spain and outside) are confidential and restrained to Spanish
Personal Data Laws. Anyway I will create a PGP key if anyone wants to
contact me privately.
I´m sorry but I didn´t understand your question about Adderall and meth :P
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Yellowmattercustard:
The only way I know to avoid loss of
magic and depressive symptoms is to be moderate in dosage, frequency and
contexts. To leave MDMA for special occasions and not to make it an
habit. This could sound obvious, but I think it is not only a question
of neurorreceptors. It is much easier.
Suppose that you like
Disneyworld. The first time you go you will think it is fantastic but,
if you go every weekend you will finally get fed up of White Snow and
Donald Duck. Properties of MDMA are so specific that if you use it too
frequently it makes you bored. I think it is also important not to
expect too much from it, I mean, some people get obsessed with "getting
high" as the first times and that conditions the experience. It is also
important, in my opinion, to realize and think about some effects of
MDMA that can be learn during the experience, but applicable to everyday
life.
Someone told me that the first time you take MDMA is similar
to "learn to read". Once you have done it, your perception of reality
(and your perceptions of further MDMA experiences) changes. You can´t
learn to read twice, and, in this sense, the first experiences will be
different to the rest. But you can still enjoy the substance if you are
cautious in the way of use and don´t expect too much.
Combinations with SSRI, Prozac, triptophan and all that stuff don´t have a scientist basis.
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No mate, you had me twisted. I was worried about those replying with
specific illness's & age's that can make them easy to single out
lol! Your perfectly fine my friend!
Keep doing what you are doing...
For my adderall question, I was basically asking is Adderall really basically the same as meth?
I have heard this from many people.
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There are some differences but, basically, they are compounds very
similar. Methamphetamine is 2,5 times more potent than amphetamine on
their effects, but therapeutical and clinical uses are the same. In
fact, meth is marketed in some countries as Desoxyn, anda approved for
ADD and obesity as short time medication. As a prescription drug,
methamphetamine is used at 5 mg dose and only by oral route
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The
only way I know to avoid loss of magic and depressive symptoms is to be
moderate in dosage, frequency and contexts. To leave MDMA for special
occasions and not to make it an habit. This could sound obvious, but I
think it is not only a question of neurorreceptors. It is much easier.
Suppose
that you like Disneyworld. The first time you go you will think it is
fantastic but, if you go every weekend you will finally get fed up of
White Snow and Donald Duck. Properties of MDMA are so specific that if
you use it too frequently it makes you bored.
Excellent answer ! +1, doc.
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You look like you are in it for the soul. Unlike that "Tim" guy....
Nice website.....
My
next q is: Do you think lsd or mdma can permanently change body
language? I cant get this out of my head.. Scientist posted a
thread about it and i cant get it out of my head. Do you think People
can see drug use on you after you have sobered up?
How easy is it to notice an ex drug addict? Could you tell what i used from the way i walk or talk? (after i have stopped using)
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Well...I think it basically depends on the impact on MDMA or
psychedelics in your life. For many people these drugs only mean a
little while of fun on a limited experience. But, in other cases, these
substances can have a significative psychological impact and make long
lasting changes in personality. For example, if someone learns through
MDMA, to be more open-minded or less shy, I think this will change his
"body language" in some way. But in this sense drugs can change
body language as many other important things that happen in your life.
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Yellowmattercustard:
The
only way I know to avoid loss of magic and depressive symptoms is to be
moderate in dosage, frequency and contexts. To leave MDMA for special
occasions and not to make it an habit. This could sound obvious, but I
think it is not only a question of neurorreceptors. It is much easier.
Suppose
that you like Disneyworld. The first time you go you will think it is
fantastic but, if you go every weekend you will finally get fed up of
White Snow and Donald Duck. Properties of MDMA are so specific that if
you use it too frequently it makes you bored. I think it is also
important not to expect too much from it, I mean, some people get
obsessed with "getting high" as the first times and that conditions the
experience. It is also important, in my opinion, to realize and think
about some effects of MDMA that can be learn during the experience, but
applicable to everyday life.
Someone told me that the first time you
take MDMA is similar to "learn to read". Once you have done it, your
perception of reality (and your perceptions of further MDMA experiences)
changes. You can´t learn to read twice, and, in this sense, the first
experiences will be different to the rest. But you can still enjoy the
substance if you are cautious in the way of use and don´t expect too
much.
Combinations with SSRI, Prozac, triptophan and all that stuff don´t have a scientist basis.
Doesn't combining MDMA with an SSRI lead to an increased risk of serotonin syndrome?
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Doesn't combining MDMA with an SSRI lead to an increased risk of serotonin syndrome?
There
have been many clinical trials in humans co-administrating different
SSRIs (paroxetine, citalopram, sertraline...) to study pharmacological
properties. There is a theoretical risk but it is probably
overestimated. Anyway, combination of MDMA and SSRI is not recommended.
First because, in general, it lowers MDMA effects. Second because people
under SSRI treatment usually suffer problems as depression or anxiety
disorders and, MDMA is not recommended because of these problems.
In
animal models combination of MDMA and some SSRI showed lower
neurotoxicity.But doses and patterns of administration make that these
results can´t be extrapolated to humans. It is not likely that SSRIs
have a neuroprotective effect in humans at doses available.
In my
opinion risk of neurotoxicity associated to MDMA is sometimes
exagerated. There is no evidence that occasional moderate doses (lower
than 120-150 mg) have any neurotoxic effects. In fact at least four
investigation teams have been administrating MDMA to healthy human
volunteers in clinical trials with the approval of sanitary authorities
and ethical comitees of clinical trials. In this case neuroprotective
drugs are unnecessary. People who take large doses during long time are
probably more exposed to this risks, and in this case there are no
neuroprotective measures that have shown efficacy.
Substances that
inhibit monoamine oxidase (MAOI: phenelzine, moclobemide) are most
likely to lead to serious increases in serotonin when used with ecstasy,
and develop a serotonin syndrome. In people who use these drugs MDMA is
absolutely not recommended.
-
Hey DoctorX!
Thank you for your nice offer here.
I have a question about opiats and mental health issues.
Again
and again I find sources that tell that opiats are the "better
antipsychotics" (and were used for that in the past), also partially
anti-depressant because of mood lifting... and many pain patients tell,
that their mental health issues were almost gone completely since they
started taking their prescribed opiats/opioids. Also some therapists and
doctors suggest that the use of opiats would be far better, especially
because of better mood and less harm to your body.
I have to deal with OCD (obsessive-compulsive-disorder), GAD (generalized anxiety disorder) and kind of schizophrenia.
I
take highly potent antipsychotics atm and they don't work like I would
them to work... (they just sedate... thats it... than you have to deal
with side effects like very hard depressions, and dissociative mental
states).
So I don't have much to loose, I have to weigh up -
perhaps life long - antipsychotic treatment with all the side effects
and feeling like a zombie - on the other hand a much better quality of
life with opiates.
So I'm going to try this path anyway, but would thank you a lot, if you could tell me something about mental health and opiates.
Can they be used as medication while a panic attack takes place? Or is set&setting important?
I need something for my emergencies to come down - and I need something for stabilization in long term.
I don't want to use benzos - as I know they are more dangerous than opiats (for the body) and don't have mood "support" ...
above all - sometimes they make it worse...
Perhaps you can tell me a little bit about it
and...
are there dangerous interactions between antipsychotics and
opiates?`(Of course both sedating, so I'm talking about low doses)
Thank you
-
from time to time (3 or 4 times a year) i like to do a few large
bumps of cocaine, maybe 3 166mg bumps within a hour, when I am starting
to come down I like to snort a small 25mg line of #4 heroin. what are
the dangers of doing this? I am a 24 year old male in good shape about
220 pounds. I do not smoke or drink alcohol just wondering if there is
immediate danger. I know it is not safe but would like more info.
thanks!
-
I have a question about amphetamine usage.
I am in the age
bracket of 20 - 40 and in good health. I use pure amphetamine between 15
- 70mg, depending on what I am using it for.
Is 70mg of pure
amphetamine safe to use in one go? I have low tolerance and I do not go
on "binges." Sometimes I may have a small top up, but I never go for
more than 12-16 hours at a time.
Also, how frequently can I use
it without causing harm to myself? I don't normally use it more than
once a fortnight, but sometimes I do and I was wondering if it is
damaging to use it weekly, or even more than that?
Thanks for your time and effort, and +1.
Dingo
-
Bastian:
There are some scientific data that point that some
opiates can relieve symptoms of schizophrenia. Some authors believe that
use of opiates by persons with schizophrenia is so common because of
self-medication. But in fact this is only a hypothesis and it is a
matter of discussion. The role of opiates in schizophrenia is
documented, but there are many less data in OCD and anxiety dissorder.
I´m not sure if they can be useful for these diseases. Anxiety
dissorders are better controlled with SSRIs better than benzodiacepines.
As
any other psychoactives , we should consider unwanted effects and
problems: first of all the dependence potential (more important than
antipsychotics and antideppresives). Also adverse effects (constipation,
nausea, stinging...), farmacological tolerance (need to increase dose
over time) and problems to have a continous supply of non-sanitary
controlled products.
In any case, I think medication alone
(antidepressives, antipsychotics, opiates or whatever...) should never
be the only base of mental health issues. Psychological support is
always as important as pills and helps to improve results.
-
agrowersstory
Estimate risks from concrete practices is one
of the most common questions, and one of the most difficult to answer.
Some risks are east to estimate, but most are not. If you drink 4 gr of
GHB and 3 cups of whiskey the risk of falling asleep in high. If you
take 100 mg of pure MDMA in a controlled environment , the risk of a
heatstroke is extremely low.
But the risk of the combination you
propose is difficult to calculate. When we talk about risks we have to
difference between "adverse effects" (frequent and common at normal
doses and, in general, mild) and "toxicity" (serious problems, but rare
at normal doses/more possible at high doses). It is important to
consider the probability that a particular event happens.
In general,
combinations of drugs have more risks than drugs alone. Dose is also
important, and doses you are using seems to be higher than recommended.
Half a gram of cocaine in an hour seems a high dose. The possibility of
toxic effects is relatively low but these effects, if happen, could be
serious (cardiovascular or cerebrovascular problems). The heroin dose it
seems also high (you don´t have tolerance if you do this 3-4 times a
year),and it is particularly important to be prudent if you don´t know
the exact purity of the batch of heroin you are using. If purity raises a
clinical overdose it is possible.
-
Therapeutic dosage of amphetamine as prescription drugs is 15-60 mg
oral route. The 60 mg dose is used for people with pharmacological
tolerance, after some weeks/months of treatment.
So the doses you
are using seem high from a pharmacological point of view (particularly
if you were using intranasal route). Obviously , risks should be lower
at the 15 than at the 60 mg rank. But even at these doses, in "real
world" the chance of serious problems for health is relatively low in
young healthy persons. (Please, read the difference between "adverse
effects" and "toxicity" in previous answer).
The more frequent it is
the use, the possibilities of problems is higher. It is not a good idea
to associate too many activities of your life to amphetamine use. Most
amphetamine health problems are related to regular use, so the more
sporadic is your use, the probability of risks gets reduced. I regret
some advice seem too obvious, but objectively is all I can say.
-
from
time to time (3 or 4 times a year) i like to do a few large bumps of
cocaine, maybe 3 166mg bumps within a hour, when I am starting to come
down I like to snort a small 25mg line of #4 heroin. what are the
dangers of doing this? I am a 24 year old male in good shape about 220
pounds. I do not smoke or drink alcohol just wondering if there is
immediate danger. I know it is not safe but would like more info.
thanks!
I do a similar thing with tokes of freebase.. but I use short acting benzo's instead of the H. ..
-
Andrewbud420:
In a risk perspective we can consider freebase
more dangerous than cocaine clorhidrate (absorption surface, dependence
potential, organic repercussion). On the other hand, there is no risk of
overdose and respiratory depression with short acting benzodiacepines
and, in this sense, is far more than intranasal heroin.
-
Hi DoctorX
In summer I'm going to apply for admission test at
university and I'm considering using ritalin to improve my focus an so
my score too:
the test has a lot of gmat 600-type logical questions
e.g.
http://gmatclub.com/forum/critical-reasoning-question-directory-topic-and-difficulty-128861.html
in particular Assumptions,Conclusion,Strengthen,Argument Weaken,Argument ,Numbers and Percents,Logical Flaw.
I've
already applied once to a similar test,and I was disturbed by the
noises of other people,by the feeling of time running out...I performed
worse in class than I would have performed at my home.
I'm planning to ingest a 10mg pill - therapeutic dosage - about 30 minutes before the test.
The
problem is that where I live generally the summer is hot (25-29 C) and
during the test there will be some stress (hundrends of people waiting
outside the university to take the test and eventually not much space).
Also I have some general anxiety,I could fear to look "drugged" to others or my voice altered.
Of
course the anxiety will probably get worse,but I'll see if I can manage
it testing ritalin in social situations few days before taking the
admission test.
Methylphenidate is anfetamine,a stimulant,so the
question is: could the hot and the stress cause problem to my
circulatory system during the test?
I will take and ECG check
much before taking ritalin however to minimize the risks,but I have
already used cocaine an mdma some time ago.
Sorry for crossposting.
Thank you.
-
Thank you for your reply DoctorX
SSRI or other antidepressant medicine - I already tried...
Enough studies show, that these are all placebo related... so ... :(
-
Devoidest
Methylphenidate is a drugs relatively close to
amphetamine in their mechanism of action, but it is not an amphetamine.
If you mean with "problems for your circulatory system" symptoms like
mild tachycardia, palpitations, sweating...they are possible but
probably related to situations. If you mean severe problems like angina,
psychosis, stroke...they are highly unlikely. I think no one will
notice "that you are drugged".
But one important thing is "is it
methylphenidate effective for that use?". Studies have shown some
cognitive improvement in children with ADD, but there is a considerable
neuropsychological profile heterogeneity among diagnosed children, as
well as variable response to treatment. And in healthy volunteers the
effect of methylphenidate is only shown on short term memory, and the
quality of studies is weak.
I don´t think that there is evidence enough that methylphenidate will be effective for the kind of complex-tests you are facing.
-
DoctorX, I appreciate this thread.
As I posted elsewhere in
this section, I have experienced asthma symptoms/respiratory tightness
multiple times after taking mild recreational doses of opioids.
This has happened more severely with heroin #4 (insufflated) from
different sources, and less severely with pharmaceutical oxycodone IR
(oral).
All of the above was done with low
tolerance/experience. The heroin was 1 gram chipped over 7+ days,
and the oxycodone was 30-45mg oral doses each time.
I have no history of asthma or lung issues.
I still experience the typical positive effects from opioid abuse in addition to the negative respiratory effects.
Are
you aware of this as a relatively common reaction, or do you suspect
some form of allergic reaction or adverse predisposition toward opioids?
In searching I can only find the obvious link between opioids and cough suppression, but nothing that addresses my experience.
Thanks
-
Doc X,
Great thing your doing i salute u for this..
My question is , does Nubain the drug givinig in shot form really throw a everyday Opiate user into Withdrawl?
I
hear its like oxymorphone but it has an antagonists or something in it
thts i guess like subutex and will throw u into withdrawl..
True or no? Btw Im a 13 year opiate user so i do take daily..
-
Good stuff Hombre +1
I will absolutely be donating to you and urge others to do the same, thanks for your time Senor!
-
Newbottles:
Allergic-asmathic reactions to heroin are not a
common adverse effect, but they are possible, particularly using
inhalated route. There are some cases described in medical literature:
(CLEARNET)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1835195/pdf/bmj00315-0033.pdf
http://www.ncbi.nlm.nih.gov/pubmed/20857854
http://www.ncbi.nlm.nih.gov/pubmed/17639839
http://www.ncbi.nlm.nih.gov/pubmed/10631229
(CLEARNET)
Heroin,
morphine, oxycodone and hydrocodone contain a phenantrene molecule
structure, which can lead to cross-allergic reactions (that means, if
you are allergic or you are developing allergy to one of the molecules
of the family, you have more chance to be allergic to the rest). So is
theoretically possible to be allergic to both heroin and oxycodone.
Without
an exploration and allergic tests I can be sure that you are developing
an allergic reaction, but there are enough data to think it is
possible. The most prudent idea would be to avoid opiates. If you can´t
or you don´t want do this, in a risk reduction perspective you should be
very careful (don´t do it alone, do it in a place where you can search
for medical help quickly...) and get some adrenaline 1/10.000 for
subcutaneous administration in case of emergency
-
AnonymousAddict
Some opioids are agonists of opioid receptors
(morphine, codeine, heroin). Some other are antagonists (naloxone), and
other are mixed agonists-antagonists. Buprenophine and Nalbuphine
(Nubain) are among these substances and can precipitate withdrawal
symptoms in regular opiate users.
I don´t like to give moral
advices. But, in a clínical-objective point of view, the younger is a
drug user, the probability of problems with use increase. Opiates are
drugs difficult to handle and have severe adverse effects and can lead
to dependence. I think you should consider this, as you are 13 years
old.
Peace&love
-
Sending a BTC donation for your work now, I figure if I pay real doctors thousands to feed me bullshit.....
I can at least spare some change for one that gives out useful life saving advice!
Well done!
-
pkizenko98 and White Out
Thank you, and thank you also to all SR forum users for your warm-hearted welcome.
I
didn´t come here to become rich (if so, I would have tried as a
vendor ;D ;D ;D ;D) but it is true that to search, investigate and
answer your questions (and the PMs) take some time and effort and all
support will be welcome.
Thanks
-
Hey I think I already know the answers to this, but I might as well get another opinion.
Does
lets say daily crack use for about 3-6 months cause irreparable damage
to the body. Or can you fully recover eventually. Same question for
meth.
The purpose of the use would be a fun way to lose weight. I just want a straight answer, don't question the reason.
Thanks in advance
Chaos
-
Hey I think I already know the answers to this, but I might as well get another opinion.
Does
lets say daily crack use for about 3-6 months cause irreparable damage
to the body. Or can you fully recover eventually. Same question for
meth.
The purpose of the use would be a fun way to lose weight. I just want a straight answer, don't question the reason.
Thanks in advance
Chaos
I reckon it would be pretty harmful using daily for that amount of time. I worry about weekly amphetamine usage. Lol.
Crack is so rare in Australia... Thanks to Silk Road I can finally get good stuff at less than $250 / gram!
Ice
is t he easiest thing to get here. Even easier than weed. Most of it is
imported from the US, Canada or China because the drug lords know how
expensive the stuff is here and they can make a killing off it. It's
meth on the street in the US $80 - $140 / gram, depending on location?
it's $100 / 0.1gm here. $600+ for a gram.
-
Chaosforpeace
I think the most evident risk for daily use of
potent stimulants (meth or crack) would be the risk of dependence. This
is not technically "irreversible" but with such a pattern of use it
would be a likely consequence, and for most people dealing with
dependence of stimulants is hard. Stimulants produce pharmacological
tolerance (need to increase the dose to obtain the same effects over
time), and with a daily use tolerance will appear. Depending on dosage
and route of administration it is possible a variable degree of
cardiovascular harm (hypertension, enlargment of heart walls would be
the most common). Although is difficult to measure its seriousness and
reversibility the probability of these conditions seems medium-high.
There are some other possible problems (neurological, endocrine,
psychiatric...)that can be linked to daily use of stimulants .
There
are some clinical trials that have used methamphetamine for weight
lose. The magnitude of increased weight loss of drug-treated patients
over placebo-treated patients is only a fraction of a pound a week. The
rate of weight loss is greatest in the first weeks of therapy for both
drug and placebo subjects and tends to decrease in succeeding weeks. The
amount of weight loss associated with the use of an “anorectic” drug
varies from trial to trial, and the increased weight loss appears to be
related in part to variables other than the drug prescribed, such as the
physician-investigator, the population treated, and the diet
prescribed. The natural history of obesity is measured in years, whereas
the studies cited are restricted to a few weeks duration; thus, the
total impact of drug-induced weight loss over that of diet alone must be
considered clinically limited.
-
Chaosforpeace
I
think the most evident risk for daily use of potent stimulants (meth or
crack) would be the risk of dependence. This is not technically
"irreversible" but with such a pattern of use it would be a likely
consequence, and for most people dealing with dependence of stimulants
is hard. Stimulants produce pharmacological tolerance (need to increase
the dose to obtain the same effects over time), and with a daily use
tolerance will appear. Depending on dosage and route of administration
it is possible a variable degree of cardiovascular harm (hypertension,
enlargment of heart walls would be the most common). Although is
difficult to measure its seriousness and reversibility the probability
of these conditions seems medium-high. There are some other possible
problems (neurological, endocrine, psychiatric...)that can be linked to
daily use of stimulants .
There are some clinical trials that
have used methamphetamine for weight lose. The magnitude of increased
weight loss of drug-treated patients over placebo-treated patients is
only a fraction of a pound a week. The rate of weight loss is greatest
in the first weeks of therapy for both drug and placebo subjects and
tends to decrease in succeeding weeks. The amount of weight loss
associated with the use of an “anorectic” drug varies from trial to
trial, and the increased weight loss appears to be related in part to
variables other than the drug prescribed, such as the
physician-investigator, the population treated, and the diet prescribed.
The natural history of obesity is measured in years, whereas the
studies cited are restricted to a few weeks duration; thus, the total
impact of drug-induced weight loss over that of diet alone must be
considered clinically limited.
Would weekly or fortnightly use of amphetamine raise tolerance very quickly?
-
Wouldnt be the healthiest way of losing weight lol....
-
Dingo Ate My Drugs
No, weekly or fortnightly amphetamine use would not lead to significant pharmacological tolerance
-
You are saying in controlled studies weight loss doesn't really
occur. This is because they feed them a diet and so on and so forth. I
have lost ten pounds in a week on a binge of meth, multiple times. This
method of weight loss is clearly unhealthy, but it does work. The plan
is do the meth, then work out on the meth which becomes easier because
of the meth. I don't eat, so I lose weight, but because of the extreme
work outs I gain muscle mass as a replacement. Of coarse I force myself
to drink water through out this.
Chaos
-
Dingo Ate My Drugs
No, weekly or fortnightly amphetamine use would not lead to significant pharmacological tolerance
Thanks. Awesome! I didn't really want to have a tolerance and start having more negative side effects.
-
You
are saying in controlled studies weight loss doesn't really occur. This
is because they feed them a diet and so on and so forth. I have lost
ten pounds in a week on a binge of meth, multiple times. This method of
weight loss is clearly unhealthy, but it does work. The plan is do the
meth, then work out on the meth which becomes easier because of the
meth. I don't eat, so I lose weight, but because of the extreme work
outs I gain muscle mass as a replacement. Of coarse I force myself to
drink water through out this.
Chaos
Chaos...
As someone who was once quite large (6' 3", 290lbs) AND someone who has
experimented with many drugs (primarily uppers) for a good chunk of
time (~3 years) I can honestly tell you that the route you are
considering is a very poor choice. Let's start with the psychological
effects. My drug of choice for the longest time was ecstasy (with some
coke and meth mixed in every now and then). I would roll probably 2-3
times per week. I did that for about a year straight, and then I
continued to do it with less frequency (~ once every other week) for
another year. Doing those kinds of drugs with that frequency over that
amount of time was absolutely HORRIBLE for my head. After about 3 months
of use, I became a different person. I felt as if I lost some of the
wit I was known for. My mind just wasn't as sharp. Short term memory was
completely shot. Worst of all was that it made me depressed. I spent
most of my life a happy person. This turned me to thoughts that to this
day freak me out. I don't want to get into them, but you get where I'm
going with that. This alone is reason not to do drugs like the ones you
are talking about. Keep in mind, my drug of choice was ecstasy- a drug
with very little to no chemical dependence factor. I couldn't imagine
what would have come of me had I chosen meth to satisfy my urges.
This
drug use primarily occurred after my weight loss as a side note. With
regards to the weight. Sure.... you'll lose it and you'll probably lose a
lot. But I can guarantee you that as soon as you stop (if you can) you
will yoyo back to where you were before. You might even get bigger. Not
eating is TERRIBLE for weight loss because your body goes into survival
mode. Any calories consumed will be turned to fat at the first
opportunity. I lost 90 lbs doing nothing but jogging and eating
properly. I'm not talking about fad diets. I chose to go on a low carb
diet where my primary food intake was salad/vegetables and lean protein
like chicken breast/tuna/cottage cheese. Once a day I would let myself
have a sandwhich on WHOLE GRAIN bread along with a cup of non-processed
fruit juice. I avoided processed sugars like the plague (primarily
soda). When you say you will just "lift" and preserve the muscle mass,
you are completely wrong. Your body requires fuel, more specifically,
the PROPER fuel to gain muscle mass. There is a reason you will never
see a ripped/fit meth head. Because guess what? When you don't eat, you
don't have the energy to lift. Sure... you might be able to lift the
first few days of your binge, but go a couple weeks malnourished and see
where your motivation goes.
Now I could be completely wrong
here, but you sound very similar to how I thought when I had the extra
pounds on me. I would be willing to put you in your late teens or early
twenties-- male and angry at the females of the world for not giving you
attention for just being you. I'm not bagging on you man. I was the
SAME person. Anything that's going through your mind to make you
consider meth as a method for weightloss probably went through my mind
at one point. I'm also not going to play mommy and tell you that
everyone loves you and please reconsider. The world is a cold cruel
place and people outside your family, in general could give two shits
about me or you. What I would like to do is ask you to honestly think
about what you've said. Think about where it could lead you. If you've
got any questions about my story or advice I could give, I would be more
than happy to message you or answer them here. Always remember... the
human mind is more powerful than any substance. If the solution doesn't
come from your head, whatever you do is just going to be a bandaid for
whatever problem truly afflicts you.
Be safe,
Pink
-
Hello Doctor!
Thank you for the replies!
There's one
more question from me: when on psychedelics (LSD or NBOMe - much more on
NBOMe) people have unpleasant feelings in their body (usually in the
beginning of a trip). A feeling of cold, arms and legs are shaking, a
tension, etc.
Why does it happen? And is it harmful?
-
yellowmattercustard
I´m not sure what could be the cause of
this effect. What I know is that, undoubtedly, LSD is physically
harmless (at least for most people, or does not have significant organic
toxicity). LSD was first synthetized in 1938 and has been widely
studied in celular models, animals and humans. Even, there are enough
clinical trials in humans that show it doesn´t have organic toxicity on
any human organ or system (excluding psychiatric problems, but that is
other story...)
We can´t say the same things about all the NBOMe
family. They were discovered in 2003 and there are no data about their
effects and risks in humans. In this sense they are far more dangerous,
at least potentialy, and users are acting as guinea pigs.
At least in
Spain it is common that blotters with 25I-NBOMe or bromo-dragonfly are
being sold as LSD. One simple way to distinguish the two substances is
illumination with a UV Black Light. LSD has a fluorescent reaction that
does not have with other substances
-
Hi,
I'm currently taking 75mg effexor exel and 50mg amisulpride for depression and social anxiety after a drug related psychosis.
This combo has me feeling great and alot more secure so i'm concidering going back to school.
Ive
never been diagnosed with ADD, but studying and focusing was always
very hard for me despite having a very good memory. Ive done a few
online test for ADD which indicate a high possibility.
Im concidering using Rilatine for future exams and was wondering about possible interactions with my medication.
I
tried tapering off the antidepressants after my first upswing, but got
more and more depressed and anxious so i'm not sure i wanna try that
again for now.
grts,
sam
-
Hi there, great thread! I have a slightly odd question, but if you
have the time, would you mind reviewing my MDA harm reduction guide and
assessing any inaccuracies or oversights I may have incurred while
writing it? It would be very much appreciated. :)
It can be found here: http://dkn255hz262ypmii.onion/index.php?topic=147668
-
There's
one more question from me: when on psychedelics (LSD or NBOMe - much
more on NBOMe) people have unpleasant feelings in their body (usually in
the beginning of a trip). A feeling of cold, arms and legs are shaking,
a tension, etc.
yellowmattercustard
I´m not sure what could be the cause of this effect.
Anecdotal
reports indicate that people are using magnesium to combat tension
caused by psychedelics such as LSD with "success" (assuming it's not a
placebo effect). Neck and shoulder tension is something I experience on
almost every psychedelic and also in daily live to a lesser extend.
Considering that there are many variables in play I'm sure it's not only
caused by the drug ingested.
Could you perhaps elaborate on the
use of magnesium for reducing tension, if magnesium can indeed reduce
tension and if there are any dangers we should be aware of?
-
samuelkane
It is not likely that combination of venlafaxine
and/or amisulpiride have significative negative interactions with
methylphenidete.
But people with antecedent of toxic psychosis (in
doesn´t matter if caused by illegal drugs or prescription drugs) should
be very careful with substances that are able to trigger toxic
psychosis. This includes most psychedelics and stimulants, both illegal
(cocaine, amphetamines) and prescription drugs like methylphenidate. Its
tecnical sheet warns that it should be "administered cautiously in
patients with a history of psychosis or a predisposition to agitated
states"
-
I will continue in Saturday evening/Sunday...too much work in real world these following days ;))
-
There's
one more question from me: when on psychedelics (LSD or NBOMe - much
more on NBOMe) people have unpleasant feelings in their body (usually in
the beginning of a trip). A feeling of cold, arms and legs are shaking,
a tension, etc.
yellowmattercustard
I´m not sure what could be the cause of this effect.
Anecdotal
reports indicate that people are using magnesium to combat tension
caused by psychedelics such as LSD with "success" (assuming it's not a
placebo effect). Neck and shoulder tension is something I experience on
almost every psychedelic and also in daily live to a lesser extend.
Considering that there are many variables in play I'm sure it's not only
caused by the drug ingested.
Could you perhaps elaborate on the
use of magnesium for reducing tension, if magnesium can indeed reduce
tension and if there are any dangers we should be aware of?
I
can actually chime in on this. LSD induces a release of extracellular
glutamate in the hippocampus. Glutamate is the body's primary excitatory
neurotransmitter. It binds to NMDA receptor sites, along with glycine,
opening the ion channels and allowing calcium to enter the neuron. This
is how the brain sends cascading electrical signals. When the ion
channels open for too long or too frequently, calcium concentrations can
become too high in the neuron. This can lower the effectiveness of your
ion channels, or can even cause neuronal death. Magnesium is the
substance your body uses to block the channel in a voltage-dependent
manner. This means that the ion channel will not allow Ca2+ to pass,
even if glutamate and glycine are bound to their receptor sites.
However, once the neuronal membrane's electrical potential rises to an
excited state, the Mg molecule will clear the channel and allow for
normal operation. Most people are deficient in magnesium as it is.
Supplementing a highly bioavailable magnesium supplement such as
magnesium glycinate (avoid magnesium oxide!) will give your body the
substance it needs to naturally protect itself from excitotoxicity.
Suffice to say, I firmly believe these claims to be far from placebo and
I myself always take magnesium glycinate before any recreational drug
as it smooths the experience by quite a bit. Also, I have to be
redundant in saying that you need to be sure you are getting a
BIOAVAILABLE magnesium supplement such as magnesium glycinate, as
magnesium oxide has only a ~4% absorption rate compared to the ~80% of
glycinate.
Here are a few sources...
This diagram illustrates the release of glutamate by psychedelics (LSD included):
> http://www.nature.com/nrn/journal/v11/n9/fig_tab/nrn2884_F1.html
This study finds that LSD antagonized glutamate excitation of neurons:
> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702892/
This summation states that LSD modulated the NMDA receptor-mediated sensory, perceptual, affective and cognitive processes:
> http://www.nhtsa.gov/people/injury/research/job185drugs/lysergic.htm
These studies explain how magnesium plays a role in regulation:
> http://www.sciencedirect.com/science/article/pii/S1044576584710128
> http://www.ncbi.nlm.nih.gov/pubmed/1661812
-
Animus, you are the best. +1
Doctor, would it be safe to
combine desmopressin with cannabis? I'm thinking that I'd cannabis
disrupts ADH and therefore memory, could you prevent that with some
desmopressin? Thanks in advance, and thanks for this helpful thread.
-
AnimusVox
Congratulations for your guide!
In general I
think it is a very good work. I can only give you my personal opinion
(opinion based on scientific knowledge) about the issues of
neurotoxicity and heat stroke risk .
As I said in other topic, I
think the general perception about this risks is overestimated. I´m not
saying that neurotoxicity or heat stroke are not possible complications,
but media and scientific reports have created exaggerated alarm about
these things.
Doses, ways of administration and metabolism in animals
don´t permit to directly extrapolate data from investigation in animals
to humans. Data from animals show that MDA is more neurotoxic than
MDMA, and this is probably the same for humans. But experiments on rats
with 50 mg/kg intravenous MDA is not representative of a human 1-1.5 mg
oral route. In fact there are recent clinical trials on humans with MDA
that wouldn´t have been approved if neurotoxicity was so easy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996283/
It
happens the same thing with neuroprotective drugs. These experiments
are not to study potential neuroprotection in human, but understanding
molecular mechanisms of neurotoxicity, giving mega-doses of alpha
lipoic, vitamins or tryptophan. There is no evidence that these things
work in human.
In resume, moderate doses (80-100 mg) are not shown to
produce significant toxicity in humans. Supplements do not have
demonstrated protective effects. Probably high doses or
frequencies of MDA are neurotoxic (more than MDMA, probably) but there
is no evidence that supplements work there. So the only risk reduction
message should be be careful with dosage and timing,
In relation with
heat stroke, it is a possible MDA toxic consequence but really
uncommon. In Spain (warm country) we have 8-10 deaths/year associated to
MDMA, and 45-50 associated to heat stroke and physical exercise in
summer. Of course I agree that advice to get hydrated, not to do
exhausting dance and search for fresh environments are valid. But, in
practice, I think it is enough with applying common sense and don´t go
to a rave in August in the desert during the day
The rest of the guide seems superb, good work.
To better organize my time and my work i´m posting here, but feel free to copy-paste to your thread if you like
-
I
can actually chime in on this. LSD induces a release of extracellular
glutamate in the hippocampus. Glutamate is the body's primary excitatory
neurotransmitter.
...
Thank you for the detailed explanation and sources, I will definitely keep it in mind for the next trip :)
-
Doc, what are your thoughts on the use of GHB? Frequency, positive/negative effects, dosage, etc.
-
Hello Doc,
Sorry I didn't go through all the pages so apologies if my question was repeated.
I
do meth every once in a while. However, since I started doing it I
began grinding my teeth. I never did before. I believe it became a habit
now that I can't stop.
I want to know what causes it and how can I stop
Thanks in advance
-
What's your opinion on anti-depressant drugs?
-
smogmonster13
The evidence that desmopressin is useful in
improving memory is weak and based in old, low quality studies. There is
no evidence that desmopressin is useful in that way. Cannabis alters
short time memory by neuromodulation of cerebral CB receptors, not
related with antidiuretic hormone (ADH). And even if that effect of
desmopressine existed it should be of very limited magnitude. So I think
it is useless in that way
-
zipstyle
Pharmacologically, GHB is a drug very similar to
alcohol. It acts in a very similar way, effects are relatively similar,
it is depressant for Central Nervous System on overdose and has a
similar dependence potential. The difference is that, for alcohol, you
can difference if you are drinking beer or tequila by taste. But knowing
the dose of GHB is far more difficult. If you have a very reliable
source or you do it by yourself, GHB safe dosage is possible. If not, it
is very difficult.
I think there is enough good quality information
about GHB dosage and effects in sources as Erowid...if you can be more
concrete or have interest in discussing anything in particular...
-
Hey Doc,
I begin exams next week and I am considering taking
Adderall. What doses should I begin with? I have heard that you can only
remember the stuff you learn on Adderall when you take it again (so if
you stop using you forget what you've learned). Is this true? Do you
know of any evidence that shows it can help during exams?
I have 5 exams over 4 weeks. I would take doses almost daily, except for weekends. Thanks
-
go4green
Bruxism (grinding teeth) is a common amphetamine or
amphetamine derivative adverse effect. It can happen at recreational
doses with speed, meth, MDMA, MDA...Initially, it should only last
hours/days after use of these substances. But, for some people,
when they start having a bruxism problem, it is often unaffected by the
removal of the causal factor. Jaw movements are controlled by conscious
and subconscious process in the brain. for some people bruxism is more
important during the night (where subconscious processes are more
common).
It would be important to rule out other well-known causes of
bruxism (allergic reactions, prescription drugs, medical
conditions...). It is also known that stress can trigger bruxism in
susceptible persons. There are some effective treatments for bruxism
(Biofeedback, Botox...). Some dietary supplements may alleviate bruxism,
Magnesium is a well known supplement for this.
-
I'm wondering if the damaging affects of MDMA are decreased when you are older and your brain is properly formed?
For
example if an 18-22 year old abused mdma over a 3 year period how would
the permanent damage of the brain compare with someone aged 23-27
abusing it in the same way but didnt start till they were older?
-
LSDLucidity
Sorry, but I don´t understand well the question.
It is very difficult to have a general opinion on "antidepressants",
as I don´t have an opinion on antibiotics or anti hypertensives.
Antidepressants is a wide family of drugs, which include 4 or 5
sub-families of molecules, all of them with their indications, adverse
effects and toxicity problems. Some of them have been known and studies
during decades, other are too new to have all data about security. They
can be very useful for helping to treat several mental disorders if they
are used properly. When they are used in treatment of mental health
problems it is necessary to use also some kind of psychological or
psychoterapeutical help. They don´t "cure" mental health problems but
can help in some cases, as any other medications. They have their own
adverse effects and toxicity problems as many other psychoactives.
Over-prescription is a problem with this substances, but antidepressants
have their own pros and cons as any other drug
-
How long does benzodiazepine (Xanax) withdrawal last? Is it really more addictive than heroin?
I
have a buddy who's been taking 1 mg a night for sleep for the past 3 or
4 months. He stopped and got some sort of withdrawals. They weren't
severe but he had bad anxiety and he couldn't sleep and he was very
depressed and jittery. Today is day 3 (almost 84 hours) and he wants to
know when the worst of it will be over..
and when will it be all the way over.?
-
And how dangerous is GHB for insomnia (brand name Xyrem) taken by
itself and in accordance with the medication guide from the FDA ?
-
What drugs are relatively "safe" for someone with a psychotic
disorder? I know psychedelics carry a high risk, do dissociatives also
carry that risk?
Thank you, Doctor.
-
What
drugs are relatively "safe" for someone with a psychotic disorder? I
know psychedelics carry a high risk, do dissociatives also carry that
risk?
Thank you, Doctor.
When you say dissociatives are u talking about drugs like DXM or ketamine? I am interested in this question too...
-
sharonneedles
Amphetamines have been used during decades for
improving cognitive performance in study. But, in a objective point of
view, there are only a few scientific studies that have explored this,
and most of them have methodological problems. One of the most recent
and important is a study on 46 healthy volunteers taking Adderall 20 mg
in a single occasion. It examined effects in 13 measures of cognitive
ability (including episodic memory, working memory, inhibitory control,
convergent creativity, intelligence and scholastic achievement...). The
results did not reveal enhancement of any cognitive abilities by
amphetamines for participants in general. But, nevertheless,
participants believed their performance was more enhanced by the
active capsule than by placebo.
http://www.ncbi.nlm.nih.gov/pubmed/22884611
In
other studies, some authors they have found an effect of 10 mg of
amphetamine (single occasion) on acute administration of d-amphetamine
helping to bind different features of an item in memory, in turn leading
to an increased ability to recollect both the item and its context.
http://www.ncbi.nlm.nih.gov/pubmed/20521323
Doses
usually used for cognitive enhancement are between 5-20mg. You should
consider also the possibility of adverse effects (insomnia, nervousness,
anxiety, anorexia...) that may have influence in the exam results.
The
idea that "if you stop using you forget what you learnt" has not a
pharmacological explanation, I think it should be considered as a myth.
-
theupsman1
The question of MDMA neurotoxicity is one of the
most controversial and complex. First of all, we should define what we
understand for "neurotoxicity", because it is not clear that some of the
changes observed mean a real toxic effect. For example, we can exactly
measure the degree of liver toxicity caused by alcohol by blood tests,
ecography, even biopsy. These tests have diagnostic and pronostic value
and are universally admitted in this sense.
But, with MDMA, we still
don´t know if changes in density neurorreceptors and images on PET or
SPECT are indicative of neurotoxicity, and what are the clinical
implications. Some studies (but not all) have found differences in
memory in heavy MDMA users. Some studies (but not all) have shown that
these deficit recover after some months-years of abstinence. What it is
clear that these effects appear only in heavy-long term MDMA users and
it is very difficult to know the exact role of MDMA, as there are many
factors (lifestyle, use of other drugs...) that can mislead results.
There
are so many things unclear on MDMA neurotoxicity that it is almost
impossible to answer your concrete question. What is clear is that
moderate use of MDMA (in dose and frequency) has not been linked to
neurotoxic changes. The exact impact of age in heavy users is, as far as
I know, impossible to determinat
-
sofish89
Dependence to substances it is not only caused by
the drug itself, but also depends on factors of person and environment.
So it is not possible to know if benzos are more or less adictive than
heroin, but it is clear that both are drugs with high potential
addictive.
Exact duration of abstinence symptoms depend on
pharmacological characteristics of each benzodiacepine. But, in general,
the acute phase lasts two months, and some symptoms are manifested in
the 4-6 following months.
Abrupt supression of 1 mg alprazolam after
4-5 months of treatment will undoubtedly cause abstinence symptoms.
They can last weeks and give severe symptoms. In this case abrupt
supression is never recomemended. He should change to a
benzodiacepine with a long half life and less potent ( for
example, 10-20 mg diazepam or 15-30 mg clorazepate) and slow dose
reduction (2-5 mg/week) during 8 weeks. So, abstinence symptoms
will be minimum
-
Hey Doc,
thank you for your time!
A friend of mine
wants to try MDMA to work through some personal stuff concerning his
childhood. He is on 20mg Citalopram daily, does that interfere with
MDMA?
Also, do you have any experience in the therapeutic use of MDMA? Any literature hints? Any addresses in Europe?
Thank you :)
-
I have been using amphetamines/meth 1-2 times per week for the past 2
months. I'm now planning to use cocaine and mdma soon, both of which I
have used in the past.
Will my using of amp/meth have any impact
on the high of cocaine and/or mdma? And what is the recommended time to
wait inbetween use of cocaine and mdma? A little sidenote here; I
bought some 5-HTP 100mg pills, should I take these prior to rolling mdma
or after, whats your opinion on that?
My second question: Is it
harmful for my body to do cardio training close to/at comedown on
amp/meth, and is it hurting my cardio in any way just to do amp/meth
while not beeing physically active?
I'm currently trying to get
in shape for the upcoming season of football and I'm wondering if I have
to stop for good with the amp/meth or if I can do them both while still
staying as fit as possible?
-
Been on a bit of a drinking binge. Didn't think much of it cause,
whatever, I'm relatively young. But my liver started to hurt, only I
didn't really know it was my liver cause it's never hurt before and kind
of ignored it. Now I realize it's cause of my drinking and stuff. So
I'm definitely gonna stop that, but is there anything I can do to help
my liver out in the mean time? Any drugs I can take, vitamins, etc?
-
Sending a donation your way DoctorX. I would advise everyone to
thank this individual who is obviously an extremely competent,
knowledgeable physician for offering a unique resource to the Road.
-
What is your opinion on long term cannabis use? Admittedly, I have
been a daily heavy consumer for over 10 years. I am specifically
interested in decreasing cognition or other complications.
-
subbing
-
What
is your opinion on long term cannabis use? Admittedly, I have been a
daily heavy consumer for over 10 years. I am specifically interested in
decreasing cognition or other complications.
=
I recomend vinpocetive, phosphatidyl serine, acetyl-l-cartinine, ginkgo, phosphatidyl choline as supplements worth looking into.
I
almost def suffered neurotoxicity after accidentally Oding on M1 and
also abusing mdxx for a year or so. I smoked MJ heavily for years and
still do and i won't lie i am pretty spacey sometimes and I def think
that alzheimers/dementia risk are prob higher for me but it's hard to
say the effect MJ has had. I think MJ is mostly subtle.
Thanks
for the info; I am not too worried about my drug use. Regarding
cannabis, I have been vaporizing exclusively for about 3 years. I
typically consume about 1-1.5 grams per day at night.In the past, I
would smoke way more than that,especially during college. I have rolled
on MDxx many times. Fortunately I would space out my trips for the most
part, so I am not too worried about neurological damage.Although I did
binge out on MDxx on Ibiza for a week a few years ago...Ironically, I
had a really bad experience on what I think was M1...Basically felt like
I was going to die for a period of time ,with a very rapid cardiac rate
coupled with the feeling of my consciousnesses leaving my body.
Very weird experience, I never would have taken that shit ,but it was
sold to me as MDxx and I ate too much while intoxicated on
alcohol.
-
What actually happens to a drug(lets say heroin) when you IV it,
like where does it go how does it circulate in the body and does it
simply stay in the receptors of the brain or does it flow into any other
cells outside the brain
-
What
is your opinion on long term cannabis use? Admittedly, I have been a
daily heavy consumer for over 10 years. I am specifically interested in
decreasing cognition or other complications.
=
I recomend vinpocetive, phosphatidyl serine, acetyl-l-cartinine, ginkgo, phosphatidyl choline as supplements worth looking into.
I
almost def suffered neurotoxicity after accidentally Oding on M1 and
also abusing mdxx for a year or so. I smoked MJ heavily for years and
still do and i won't lie i am pretty spacey sometimes and I def think
that alzheimers/dementia risk are prob higher for me but it's hard to
say the effect MJ has had. I think MJ is mostly subtle.
If I remember correctly some studies show that the use of cannabis reduces the threat of alzheimers.
"
In 2007, Ohio State University researchers published a paper stating
that medications which can stimulate cannabinoid receptors in the brain
"may provide clinical benefits in age-related diseases that are
associated with brain inflammation, such as Alzheimer’s disease." In
2009, Italian and Israeli researchers found that cannabidiol (CBD),
marijuana’s primary non-psychoactive cannabinoid, may also block the
formation of the plaques in the brain believed to bring on Alzheimer’s."
I also have a question for the Doctor.
I
heard that LSD can cause schizophrenia for the people with a
disposition for it. Is that correct and how does one check if he has
this disposition? I am 28 yo and in good mental health, no history of
schizophrenia in the family. If I had this disposition would I already
be diagnosed with schizophrenia?
Thanks in advance. Respect what
you're doing here. I really enjoy reading your answers even to questions
I'm not too interested in. :)
-
sofish89
Xyrem (pharmaceutic name of GHB) is only approved by
FDA for treatment of excessive daytime sleepiness and cataplexy
associated to narcolepsy. Narcolepsy is a disturbed nocturnal sleep and
an abnormal daytime sleep pattern, associated with an abnormal pattern
of night sleep, but it is different to insomnia. The risks would be
similar to other sleep treatments: potential of dependence, abstinence
symptoms with abrupt discontinuation, risk of respiratory depression on
overdose in combination with other CNS depressors, morning hangover...
-
careb
As you say, psychedelic drugs are not good for people
who have suffered psychotic disorders, as it is can trigger a new
episode. The evidence is clear for drugs as LSD, psilocybin, mescaline,
cannabis or ayahuasca. For old dissociatives (phencyclidine) there are
enough data too. There are some data that contraindicate new
dissociatives (ketamine, DXM)in persons who have suffered psychotic
disorders:
http://www.primarypsychiatry.com/aspx/articledetail.aspx?articleid=953
http://www.ncbi.nlm.nih.gov/pubmed/9272481
In
my opinion, depressors (alcohol, GHB, opiates..) are the drugs less
risky in this sense. But I insist "in this sense" because each drug has
its own problems or particular risks.
-
Interesting thread :)
I sell MDMA caps, and I add caffeine
(~80mg) to each one in order to help make up the fill weight, and also
because I hoped that taking the drug along with caffeine might increase
the short-term bioavailability, in the same way that it does for OTC
"express" paracetamol and other such things that include caffeine to
speed up onset.
I'm not aware of any studies that have been done on
the subject, but does this seem like a reasonable thing to be doing in
your opinion?
-
Citalopram atenuates the effects (psychological, physical, cardiovascular) of MDMA, at least in acute administration.
http://www.ncbi.nlm.nih.gov/pubmed/10731626
http://www.ncbi.nlm.nih.gov/pubmed/11106307
It is possible that people who use citalopram regularly develop some degree of tolerance to this effect.
I
have not professionally used MDMA as and adyuvant to psychotherapy, but
I know some patients that have done, most with good results. Some
psychoterapeuts use MDMA in this way, although they would face serious
legal problems if they are discovered. The problem is the lack of
controlled clinical trials and the negative disposition of sanitary
authorities to authorize and promote these studies.
To know more about therapeutic use of MDMA, the best web is: http://www.maps.org
-
thanks a lot :)
-
DopeSneaky
Amphetamine, meth and MDMA are drugs with a very
similar chemical structure and the three of them can develop tolerance
with regular use. So it is reasonable to suppose that tolerance to one
of them will lead to develop cross-tolerance to others. In your case it
is probable that regular use of amphetamine/meth will decrease some MDMA
effects.Cocaine, at least on theory, would be unaffected. Note that
these are only suppositions based on pharmacology, and you have to
consider other factors (including setting, dose, expectatives...)
5-HTP is probably harmless but there are no scientific data to support its use before/after MDMA.
The
degree and probability of cardiovascular damage with amphetamines
depend on frequency, dose and personal susceptibility. You could control
your cardiac frequency and blood presure as indirect indicators on the
response of your body to amphetamines. In general, it would be better to
train without amphetamines (or some time after their effect is
finished). Regular use is more dangerous than occasional.
-
cerealbox
You should first consult your doctor. The liver
doesn´t have receptors for pain, that is, liver doesn´t hurt (except in
final stages of some severe hepatic diseases, that does not seem to be
your case). So it doesn´t seem likely that your problem is caused by an
hepatic problem related to alcohol. It may be other kind of problem
(gastritis, peptic or duodenal ulcer...) related to binge drinking or
not, but hepatic disease is not likely.
-
What
is your opinion on long term cannabis use? Admittedly, I have been a
daily heavy consumer for over 10 years. I am specifically interested in
decreasing cognition or other complications.
There
have been some scientific studies on long-term cannabis effects. The
best studies in science are meta-analysis. I can´t explain here with
details what a meta-analysis is because it is too complicated, but we
assume that is some kind of statistical remix of different scientific
studies, and it is considered in science the best proof. Meta-analysis
about cannabis and memory show that:
Short term memory is the
neurocognitive ability most affected in chronic cannabis users. Chronic
cannabis users forget more easily and learn less quickly concepts
related to short-term/operative memory
http://www.ncbi.nlm.nih.gov/pubmed/12901774
This
effect is not neurotoxic (irreversible) but neuroadaptative. One month
of abstinence (aproximately) is needed to revert these changes.
http://www.ncbi.nlm.nih.gov/pubmed/22731735
There
are no scientific data on vinpocetive, phosphatidyl serine,
acetyl-l-cartinine, ginkgo, phosphatidyl choline and cannabis. These
substances are probably harmless but don´t have proved efficiency
-
SuperHans68
When you use a drug IV the substance goes to the
right side of your heart through veins, passes to lungs, then back to
the left part of the heart and then is distributed to brain through
arteries. Most drugs act on different parts of the brain, the exact
mechanism depend on the substance. Some drugs act on specific cerebral
receptors (opiates, cannabis), other act on cerebral receptors used for
other tasks (cocaine, MDMA, LSD...). Neurons are physically
separated and, in the space between two neurons there are some compounds
called enzymes that degrade drugs. First the drug acts on the receptor
and then it is degraded by enzymes.
-
If I remember correctly some studies show that the use of cannabis reduces the threat of alzheimers.
I
heard that LSD can cause schizophrenia for the people with a
disposition for it. Is that correct and how does one check if he has
this disposition? I am 28 yo and in good mental health, no history of
schizophrenia in the family. If I had this disposition would I already
be diagnosed with schizophrenia?
Studies
of cannabis and alzheimer are based on celular and animal models.
Unfortunately there are no data on humans to recommend its use in
Alzheimer disease. Humans are far more complicated than animals (even
the closest primates) and data on animals can never be extrapolated.
One
question with schizophrenia susceptibility is that there are no 100%
sure tests to measure it. It is assumed that familiar antecedents and
story of mental health problems are risks factors. Schizophrenia usually
starts before 20-24 years, it is uncommon that it debuts after 25 year
old. If you had this disposition it is very likely that you were
diagnosed now. Psychedelic drugs can be a "triggering factor" for
schizophrenia but there exist many other conditions (parental divorce,
break-up with couple, military service...) that can do the same.
-
sofish89
Xyrem
(pharmaceutic name of GHB) is only approved by FDA for treatment of
excessive daytime sleepiness and cataplexy associated to narcolepsy.
Narcolepsy is a disturbed nocturnal sleep and an abnormal daytime sleep
pattern, associated with an abnormal pattern of night sleep, but it is
different to insomnia. The risks would be similar to other sleep
treatments: potential of dependence, abstinence symptoms with abrupt
discontinuation, risk of respiratory depression on overdose in
combination with other CNS depressors, morning hangover...
I
was asking about risks of overdoses and/or dying. Whenever I hear the
anti-drug propoganda talk about GHB, they say GHB is one of the most
harmful drugs in regards to accidental OD and deaths, However the same
government markets the drug under a trade name Xyrem and claims Xyrem is
one of the safest drugs when taken in accordance with the medication
guide. My question is that is there any truth to this "hype" and what
are the chances of someone dying or OD'ing on pharmaceutical grade GHB
powder taken by itself (no CNS depressents or alcohol) for insomnia ?
Is it really safer in this aspect(overdosing and death) than benzo's or barbiturates ?
-
Thanks for the reply!
-
What
is your opinion on long term cannabis use? Admittedly, I have been a
daily heavy consumer for over 10 years. I am specifically interested in
decreasing cognition or other complications.
There
have been some scientific studies on long-term cannabis effects. The
best studies in science are meta-analysis. I can´t explain here with
details what a meta-analysis is because it is too complicated, but we
assume that is some kind of statistical remix of different scientific
studies, and it is considered in science the best proof. Meta-analysis
about cannabis and memory show that:
Short term memory is the
neurocognitive ability most affected in chronic cannabis users. Chronic
cannabis users forget more easily and learn less quickly concepts
related to short-term/operative memory
http://www.ncbi.nlm.nih.gov/pubmed/12901774
This
effect is not neurotoxic (irreversible) but neuroadaptative. One month
of abstinence (aproximately) is needed to revert these changes.
http://www.ncbi.nlm.nih.gov/pubmed/22731735
There
are no scientific data on vinpocetive, phosphatidyl serine,
acetyl-l-cartinine, ginkgo, phosphatidyl choline and cannabis. These
substances are probably harmless but don´t have proved efficiency
Thank
you Dr. X, I have a science degree and am familiar with the concept
of meta analysis.Everything I have read leads me to conclude that
there isn't too much to worry about with cannabis, aside from the method
of ingestion.
-
By the way Thanks for all your advice, the next time I refill my bitcoins I will send some your way :)
(and i encourage anybody else who's been helped by DoctorX to do the same to show our appreciation)
-
By the way Thanks for all your advice, the next time I refill my bitcoins I will send some your way :)
(and i encourage anybody else who's been helped by DoctorX to do the same to show our appreciation)
Agreed;
in the States it is very challenging to have a frank discussion with a
physician because of our insurance system. There is company called the
Medical Insurance Bureau which is a "Non-profit" entity who's only
function is to accrue personal medical information of Americans to use
during the insurance underwriting process. Personal habits, genetic
disposition are all redeposited into a database and easily queried
by insurance companies. It is really fucked up because, it destroys the
notion of patient confidentiality and can cause your premiums to
increase, or to have certain medical issues completely omitted from a
policy.
-
Interesting thread :)
I
sell MDMA caps, and I add caffeine (~80mg) to each one in order to help
make up the fill weight, and also because I hoped that taking the drug
along with caffeine might increase the short-term bioavailability, in
the same way that it does for OTC "express" paracetamol and other such
things that include caffeine to speed up onset.
I'm not aware of any
studies that have been done on the subject, but does this seem like a
reasonable thing to be doing in your opinion?
Caffeine
increases absorption and bioavailability of some molecules: aspirin,
paracetamol and ergotamine. But it does not affect to many other
molecules. Amphetamines are structurally very different to these three
drugs and it is not logic to suppose a similar effect. I have searched
different pharmacological interactions databases and I haven´t found a
described interaction effect betweem amphetamine derivatives and
caffeine.
In addition, caffeine has psychoactive properties that some
people can find pleasant, but other will not. FDA allows a
maximum 72 mg caffeine for 12 oz/300ml beverages, so 80 mg should be
considered a high dose (or dose with cardiovascular and psychoactive
effects) that will be particularly noticed by people that don´t use
caffeine usually. An alternative is any pharmaceutical excipient or
additive non-active (like lactose or manitol)
-
Whenever I hear the anti-drug propoganda talk about GHB, they say GHB
is one of the most harmful drugs in regards to accidental OD and deaths,
However the same government markets the drug under a trade name Xyrem
and claims Xyrem is one of the safest drugs when taken in accordance
with the medication guide. My question is that is there any truth to
this "hype" and what are the chances of someone dying or OD'ing on
pharmaceutical grade GHB powder taken by itself (no CNS depressents or
alcohol) for insomnia ?
Is it really safer in this aspect(overdosing and death) than benzo's or barbiturates ?
I
agree with you with contradictions between GHB as drug and Xyrem. There
are things even more rare than you say: cost of GHB is ten thousand
less expensive than Xyrem, although production is extremely easy.
Barbiturates
are risky on overdose and death, benzos are much less risky on this
sense. And probably GHB (or Xyrem) is close to benzos in risks more than
to barbiturates (I mean, the risks of GHB are similar to benzos, and
both much lower than barbiturates).
Anyway, I think (and this is only
a personal opinion) that doses recommended for narcolepsy (4 g x2) are
objectvly high, at least for non-narcoleptic persons. And I´m not sure
if quality of sleep would be better on GHB or on benzos. I have no
enough information to give my opinion on this particular.
-
Thanks a lot for making this thread.
I couldn't find much
besides anecdotal evidence on forums, do postload/preload do anything?
(taking magnesium and vit c before MDMA, and htp5 after)
I myself
take magnesium and melatonin for MDMA (not usually vit. c since i
started to eat more vegetables and fruits), and from times to times when
taking amphetamines I tend to use a supplement for "memory" which is b1
b6 b12 and L-phenylanine. and melatonin as antioxidant.
What would you recommend for searching scientific papers on drug research?
So far most papers I found on google needed subscription to be read or I couldn't find much.
-
(...)
I
couldn't find much besides anecdotal evidence on forums, do
postload/preload do anything? (taking magnesium and vit c before MDMA,
and htp5 after)
I myself take magnesium and melatonin for MDMA (not
usually vit. c since i started to eat more vegetables and fruits), and
from times to times when taking amphetamines I tend to use a supplement
for "memory" which is b1 b6 b12 and L-phenylanine. and melatonin as
antioxidant.
What would you recommend for searching scientific papers on drug research?
(...)
The
evidence to reccomend supplements is extremely weak. Most regimes
are based on studies on animals. These studies are not designed to
search neuroprotective drugs applicable to humans. They pretend to
discover the molecular mechanisms behind MDMA neurotoxicity. The doses
used in these studies are far away to these used in humans. One rat
weights 0.1 kg; the dose in studies is 5-10 mg/kg/2 hours/4 times. That
means, that, extrapolating to humans, 4-5 gr of injected pure MDMA.
In
addition, there is a great inter-species different sensibility to MDMA
neurotoxicity in mammals (rabbits, rats, monkeys...) Even with the same
species, some strains of animals ( Sprague-Dawley or Dark Agouti rats)
show different sensibility to this effects. Many times rats must be
keeped in freezers during studies ;if not, they die because of the
massive MDMA doses. In summary, data from studies are no worthy to
humans. Most of these substances are innocuous, but there are no data
that suggest efficacy.
To search scientific papers I will tell you my ultra-secret-trick
1) You enter this web: http://www.sci-hub.org/
2) You enter in the box the title of the article you have searched previously on PubMed, for example
3) You obtain the pdf cracked version.
It doesn´t work always, but 50-70%
-
DoctorX,
are there any known problems mixing Warfarin (Anticoagulant) with LSD?
I
have Gandalf's and Hoffman's from two legit vendors and no matter how
much acid I drop I don't get any effect at all..... ? does
warfarin neutralize LSD??
-
DoctorX,
are there any known problems mixing Warfarin (Anticoagulant) with LSD?
I
have Gandalf's and Hoffman's from two legit vendors and no matter how
much acid I drop I don't get any effect at all..... ? does
warfarin neutralize LSD??
As
far as I know there are no described pharmacological interactions
between warfarin and LSD. In fact there are only a few described
interactions between LSD and other prescription drugs and most of them
are psychotropic prescription drugs. Warfarin does not interact with
other prescription drugs structurally similar to LSD, like ergotamine. I
don´t know what is the cause that LSD has no effect on you but I don´t
believe it is a pharmacologic interaction problem
-
thank you Doctor!! Well,that's rather strange,I really don't know
what to think.... how can LSD have no effect on me anymore,taken it
plenty of times in the past and it always worked.Maybe the product is
bunk?
-
Doctor, what is your point of view about methylone neurotoxicity?
Also, do you have a personal opinion about how often can be taken?
Thanks!
-
thank
you Doctor!! Well,that's rather strange,I really don't know what to
think.... how can LSD have no effect on me anymore,taken it plenty of
times in the past and it always worked.Maybe the product is bunk?
I
said "I don´t beleive that it is a pharmacological interaction
problem", but it is impossible to be 100% sure. I could´t find any data
about this interaction in the US National Library of Medicine. I don´t
think it is a predictable interaction based on the way of action of both
substances. Warfarin and LSD are well known drugs for decades and this
interaction has not been previously described as far as I know.
There are several articles about illegal/prescription drugs interactions and this is not mentioned:
http://www.erowid.org/psychoactives/health/health_article1.pdf
I
can´t say that is a problem of your LSD quality but you should rule out
this possibility first. If in your country there is no Drug Testing
Service available you can look your LSD under a ultraviolet-black light:
LSD has a fluorescent reaction under it.
If your LSD is right we
could consider the drug interaction possibility. It is true that not
all the possible interactions are described and, as LSD is an illegal
drug some kind of interaction should not be described yet in scientific
literature. But I don´t think it is the first option to explain the
problem
-
Doctor, what is your point of view about methylone neurotoxicity?
Also, do you have a personal opinion about how often can be taken?
Thanks!
There
are only a few relevant recent studies about mechanisms of action of
methylone. All of them are studies in rats. The first did not show
changes that suggest neurotoxicity in rat brains. The second suggests
that high doses of methylone or medium doses with methamphetamine can
cause neurotoxicity. The last shows shows little effect of methylone in
mice, and changes suggesting neurotoxicity in rats.
http://www.neurophys.wisc.edu/~cozz/Mephedrone%20and%20methylone%20transporters.%20Baumann.%20Neuropsychopharmacology,%20doi%2010.1038-np.2011.304%20%282011%29.pdf
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137202/
http://www.ncbi.nlm.nih.gov/pubmed/23099177
According
to its molecular structure and comparing with other similar drugs it is
possible that methylone can cause some neurotoxic changes. If which way
this is relevant to humans or not it is unknown in this moment.
I
can´t reccomend or suggest a safe use in terms of dose or frequency,
based on scientific research. And if you ask me for my "personal
opinion" I don´t think it is an interesting substance. Shulgin said:
"[Methylone] has almost the same potency of MDMA, but it does not
produce the same effects. It has an almost antidepressant action,
pleasant and positive, but not the unique magic of MDMA." And there have
been some deaths directly related to methylone, some of them with low
doses. Considering that it is not a drug as spread as others (LSD, MDMA,
meth, GHB...) and the relatively high number of deaths (in comparision
with its relative low use in general population) I think there are
substances less risky and more pleasurable. But this is only my personal
opinion.
http://www.ncbi.nlm.nih.gov/pubmed/22582221
http://www.ncbi.nlm.nih.gov/pubmed/22589523
http://www.ncbi.nlm.nih.gov/pubmed/22318528
-
Small donation sent Doc, keep up the good work :D
Glad to see good harm reduction advice being made.
-
How aware are you and others in your profession about the bladder
damaged caused by ketamine? I just wonder if it is filtering through or
if the medical profession is still playing catch up
-
Great thread, and kudos to you Doctor! Since there is much
contradicting information online, I have a few questions on 5-HTP with
its combined use with a)MDMA or b)Mescaline.
MDMA- Do you find
any overwhelming evidence that 5htp is beneficial to take before, during
or after taking MDMA? I have heard many things, that it is a good
preventative supplement, that it makes the roll better (thanks to a
greater availability of serotonin) and that it helps with the come down.
Do you find any of these true for any of the time frames
(before/during/after MDMA)
Mescaline- I have tried mescaline
once, and I took 5htp at the end of the trip. It seemed to immediately
bring back the trip almost to peak levels. Is it possible that 5htp can
have this affect (potentiate or prolong trips?)
Thank you again for all you have done!
-
How
aware are you and others in your profession about the bladder damaged
caused by ketamine? I just wonder if it is filtering through or if the
medical profession is still playing catch up
Ketamine
vesicopathy can be an illness difficult to recognize and treat. First,
it is relatively uncommon and new. Second, many professionals do not
know about its existence. Finally, sometimes patients are reluctant to
talk about their drug use with doctors because of moral
prejudices. I attended a young man with this problem last year but
it is not a common disease. Although some reports suggest that
approximately 20%-30% of ketamine users suffer from lower urinary tract
symptoms , my personal opinion is that it is overestimated.
There
are approximately 110 cases reported in the medical literature. In
general it is typical of people that use ketamine in a compulsive way
(several grams each day), although there are atypical cases in
episodic/occasional use. Symptoms are intense urgency, extreme
frequency, pain while urinating and , sometimes, blood in urine.
Treatment include antibiotics, nonsteroidal anti-inflammatory
drugs, steroids, anticholinergic drugs and cystodistension. Results of
treatment are, in general, no good. Some times when the person
abandons ketamine use, symptoms improve.
-
How
aware are you and others in your profession about the bladder damaged
caused by ketamine? I just wonder if it is filtering through or if the
medical profession is still playing catch up
Ketamine
vesicopathy can be an illness difficult to recognize and treat. First,
it is relatively uncommon and new. Second, many professionals do not
know about its existence. Finally, sometimes patients are reluctant to
talk about their drug use with doctors because of moral
prejudices. I attended a young man with this problem last year but
it is not a common disease. Although some reports suggest that
approximately 20%-30% of ketamine users suffer from lower urinary tract
symptoms , my personal opinion is that it is overestimated.
There
are approximately 110 cases reported in the medical literature. In
general it is typical of people that use ketamine in a compulsive way
(several grams each day), although there are atypical cases in
episodic/occasional use. Symptoms are intense urgency, extreme
frequency, pain while urinating and , sometimes, blood in urine.
Treatment include antibiotics, nonsteroidal anti-inflammatory
drugs, steroids, anticholinergic drugs and cystodistension. Results of
treatment are, in general, no good. Some times when the person
abandons ketamine use, symptoms improve.
That's
good to know that the medical profession are aware. I fear it could be
more common than you think, certainly in the UK. I have seen so many
people with bladder problems and a lot of people using K daily. People
are starting to feel the craps they get are just a normal part of their K
usage, very worrying. Hopefully the fact that its gone up in price over
the last few years will lower consumption.
-
Doctor,
A
friend of mine has Multiple Sclerosis and is considering taking LSD
with me. He is concerned that the LSD may cause damage to his already
compromised nervous system. Would there be any danger in doing so?
Thank you for taking the time to answer my question
The
mechanism of action of LSD is not related to mechanisms of Multiple
Sclerosis in any way. There are no preclinical or clinical data
suggesting that ocasional use of LSD could trigger an attack of MS. It
should be important to review all the medications this person is taking,
some of them (as interferon) can have psychological side effects. The
ideal moment to use LSD should be one free of medication (or at least
with few medications) and good health both physical and psychological.
Uhthoff's
phenomenon is the worsening of neurologic symptoms in multiple
sclerosis (MS) and other neurological, demyelinating conditions when the
body gets overheated from hot weather, exercise, fever, or saunas and
hot tubs. LSD should not raise body temperature but, in prevention, you
should take care about a fresh environment and drink fresh fluids.
-
just wanted to chime in and say thanks doc. don't have a question (i
know cocaine is bad for me. i'm not going to stop doing it because i
like it ;) ) but i'm glad the Road has someone like you giving straight
facts and not trying to scare the crap out of everyone.
+1 and a donation :)
-
Thanks Doc!
-
just
wanted to chime in and say thanks doc. don't have a question (i know
cocaine is bad for me. i'm not going to stop doing it because i like it
;) ) but i'm glad the Road has someone like you giving straight facts
and not trying to scare the crap out of everyone.
+1 and a donation :)
Agreed. Many props and much respect.
Chaos
-
I sent a very small donation with what I had left. I'll send
some more your way when I can. You're doing a great service for
the community.
-
Great
thread, and kudos to you Doctor! Since there is much contradicting
information online, I have a few questions on 5-HTP with its combined
use with a)MDMA or b)Mescaline.
MDMA- Do you find any
overwhelming evidence that 5htp is beneficial to take before, during or
after taking MDMA? I have heard many things, that it is a good
preventative supplement, that it makes the roll better (thanks to a
greater availability of serotonin) and that it helps with the come down.
Do you find any of these true for any of the time frames
(before/during/after MDMA)
Mescaline- I have tried mescaline
once, and I took 5htp at the end of the trip. It seemed to immediately
bring back the trip almost to peak levels. Is it possible that 5htp can
have this affect (potentiate or prolong trips?)
Thank you again for all you have done!
Most of the things previously said for neuroprotective agents are applicable to 5-HTP
http://dkn255hz262ypmii.onion/index.php?topic=147607.msg1088661#msg1088661
There
is no evidence that 5-HTP contained in supplements reaches
serotoninergic neurons in quantity and speed necessary. There is no
evidence of a clinical effect. We don´t know what should be the
necessary dose. There are only a few studies on human with MDMA and
tryptophan and are no worthy about this issue.
http://www.ncbi.nlm.nih.gov/pubmed/12759801
You
say " Is it possible that 5htp can have this effect (potentiate
or prolong trips?)?". It is possible. But it is not proven on studies or
clinical trials. And a significant part of the effect of any drug is
explained by placebo effect. Some of the most prescribed medications for
headache are 20-50% more potent than a placebo. Effects of
psychoactives like mescaline are particularly sensitive to placebo
effects. If you know the techniques and have ability, sometimes you
could cut a bad trip of LSD with an aspirin or whatever thing in pill.
It is possible the 5-HTP enhancing effect, but without proofs I am
sceptic . Unfortunately scientist only study negative effects of drugs
and not these things.
-
.
-
I
sent a very small donation with what I had left. I'll send some
more your way when I can. You're doing a great service for the
community.
Thanks you all for donations and support!!! It is a pleasure to share time an dknowledge with you all here
-
How on Earth is this thread not a sticky? He gives his actual
information, but I suppose anyone can do this on TOR. However, he
also links to actual studies, so the information is still viable.
That of which he has not linked, and I looked up seems to be legit as
well, even though I am not qualified to interpret some of the results as
much as he has.
Doc X:
I read above that marijuana is
actually not a good drug choice for those who study or do intellectual
work. I have to agree. My line of work is particularly
intellectual, and during my study in university, I found I had to
abstain from it in order to really get into my work.
My questions are:
1) Can even moderate (perhaps 2-3 times per week) usage cause memory and cognitive problems?
2)
Why is it that some seem to not have this blunting effect with
marijuana? Is it that they are so smart that being blunted has no effect
or does this just happen to some individuals more than others?
3) Would there be any difference in strains like indica/sativa and hybrids and cognitive problems?
4)
I have been on a benzodiazipine/klonopin for nearly 7 years. I
fear getting off of it now because I've read that after being on them
for so long, the brain almost automatically adjusts to them.
Should I attempt to come off of them with the assistance of a Dr? I do
have a neurotic disorder that I don't want to mention in public, but it
seems to help.
5) What do you think of SR?
6) Do you think you
would be under fire for assisting and offering drug users information in
any way if you were a US doctor? It seems if you were based in
the US, you would most likely be harassed and ridiculed by the news
(most likely fox news). Has this caused any problems in Spain or
is it more liberal there?
7) What percentage of doctors, chemists,
and biologists who study drugs do you think get into the field because
of their own drug habits?
8) What is your position on the
"right to die"? Do you think people with severe physical or
mental/emotional distress that consumes their lives and may always do so
to a large extent deserve that right?
Lastly, thank you very much for your contributions.
-
I got a question, mainly about research chemicals and their
long-term effects. I've dug up as much info as I can on it (online,
bought a $130 book on toxic pharmacology, etc.) but still have questions
about persistent symptoms I'm having. I used to use 4-MMC, methylone,
4-FA, 4-EMC, and MXE with my use spread out over a 2 year period
in small quantities. Apart from the 2-3 times I've gotten out of control
with 4MMC, I was pretty good about using everything carefully and only
tiny doses, only bought 8g total of any of this stuff, as I was broke
back then and RC's were cheap and plentiful.
Anyways, currently I
have permanent bruxism and problems with my vision. What made me quit
was when I started seeing floaters and swirls of light in my vision 24/7
after a night of methylone, whether my eyes are opened or closed, I
still see things. I tested 2 anti-psychotics out recently (seroquel and
lamictal), and they make the swirls away, so I think I've been
hallucinating for a long time now without realizing it :-\. I'd
like to know if I should be concerned about any brain damage or possible
mental health conditions down the road and how to mitigate any
potential risks. I longer mess with RC's or any dodgy/illegal stuff but I
do still drink beer from time to time. Thanks.
-
FA's are nasty as fuck, any user should read this very informative
thread: http://www.drugs-forum.com/forum/showthread.php?t=175262
-
Do you use recreational drugs?
-
How
on Earth is this thread not a sticky? He gives his actual information,
but I suppose anyone can do this on TOR. However, he also links to
actual studies, so the information is still viable. That of which
he has not linked, and I looked up seems to be legit as well, even
though I am not qualified to interpret some of the results as much as he
has.
Doc X:
I read above that marijuana is actually not a
good drug choice for those who study or do intellectual work. I
have to agree. My line of work is particularly intellectual, and
during my study in university, I found I had to abstain from it in order
to really get into my work.
My questions are:
1) Can even moderate (perhaps 2-3 times per week) usage cause memory and cognitive problems?
2)
Why is it that some seem to not have this blunting effect with
marijuana? Is it that they are so smart that being blunted has no effect
or does this just happen to some individuals more than others?
3) Would there be any difference in strains like indica/sativa and hybrids and cognitive problems?
4)
I have been on a benzodiazipine/klonopin for nearly 7 years. I
fear getting off of it now because I've read that after being on them
for so long, the brain almost automatically adjusts to them.
Should I attempt to come off of them with the assistance of a Dr? I do
have a neurotic disorder that I don't want to mention in public, but it
seems to help.
5) What do you think of SR?
6) Do you think you
would be under fire for assisting and offering drug users information in
any way if you were a US doctor? It seems if you were based in
the US, you would most likely be harassed and ridiculed by the news
(most likely fox news). Has this caused any problems in Spain or
is it more liberal there?
7) What percentage of doctors, chemists,
and biologists who study drugs do you think get into the field because
of their own drug habits?
8) What is your position on the
"right to die"? Do you think people with severe physical or
mental/emotional distress that consumes their lives and may always do so
to a large extent deserve that right?
Lastly, thank you very much for your contributions.
1)
Short time memory is the neurocognitive field more affected by cannabis
use. This effect is dose-dependent, although some people are more
sensitive to this effect. Probably a 2-3 joints a week pattern of use
does not have a significant effect in this way, at least for most
people. It also depends on the variety of cannabis used (% of THC)
http://whyprohibition.com/sites/default/files/Grant%20Neurocognitive%20Effects%20of%20Cannabis%20JINS%202003.pdf
2)
Adverse effects of any prescription or illegal drug depends on many
factors. Individual sensitivity is very important. Most people can use
aspirin without problems but some of them develop an ulcer. Here is the
same
3) Yes. Usually Cannabis sativa has higher levels of THC
than Cannabis indica. THC is the most relevant cannabinoid responsible
of psychoactive and neurocognitive effects. High levels of CBD diminsh
these effects.
4)In general, to diminish and quit benzodiacepines
is easier using a long-lasting action benzodiacepine as clorazepate,
clordiazepoxide or diazepam. But it is also possible to lower
doses of clonazepam. A doctor help can be useful to choose the right
option for you in your particular circumpstances.
5) I think SR
is an intelligent way to obtain illegal psychoactives avoiding or
diminishing most of the inconvenients and risks of black market. I think
the way opened by SR will have a significant impact on the stupid war
against drugs
6) Europe is slightly more developed in risk and
harm reduction politics on drugs. But only slightly. In Europe most of
the prevention is based on fear and repression (as in the States) but it
is true that things like Drug Testing Services are easier (but poorly
financed by public institutions). On the other hand, in the States are
based webs like Erowid or MAPS... People who work in risk reductions are
accused of "promote drug use" and these things, but we accept it as
part of the game. Aaaah...and it would be very funny for me to be on
FoxTV ;D ;D ;D ;D
7) I don´t know the answer. Some people
have a personal relation with drugs, for other this relation is only
professional. Anyway, you don´t need to be diabetic if you want to
become a doctor expert on diabetes. Although, if you are diabetic it
will give you a different perspective...
8) I think people should have the right to have a death with dignity
-
I
got a question, mainly about research chemicals and their long-term
effects. I've dug up as much info as I can on it (online, bought a $130
book on toxic pharmacology, etc.) but still have questions about
persistent symptoms I'm having. I used to use 4-MMC, methylone,
4-FA, 4-EMC, and MXE with my use spread out over a 2 year period
in small quantities. Apart from the 2-3 times I've gotten out of control
with 4MMC, I was pretty good about using everything carefully and only
tiny doses, only bought 8g total of any of this stuff, as I was broke
back then and RC's were cheap and plentiful.
Anyways, currently I
have permanent bruxism and problems with my vision. What made me quit
was when I started seeing floaters and swirls of light in my vision 24/7
after a night of methylone, whether my eyes are opened or closed, I
still see things. I tested 2 anti-psychotics out recently (seroquel and
lamictal), and they make the swirls away, so I think I've been
hallucinating for a long time now without realizing it :-\. I'd
like to know if I should be concerned about any brain damage or possible
mental health conditions down the road and how to mitigate any
potential risks. I longer mess with RC's or any dodgy/illegal stuff but I
do still drink beer from time to time. Thanks.
We
have discussed previously in this thread about the potential harms
related to RCs. There is little experience with substances like
4-MMC, methylone, 4-FA, 4-EMC, and MXE.It is not clear if 4-FA is
neurotoxic or not. MXE is clearly related with reversible cerebellar
toxicity and cathinone derivatives are known to cause problems, although
they are so new and experience is so small that it is impossible to
know what are "safe" doses.
http://www.ncbi.nlm.nih.gov/pubmed/22108839
http://www.ncbi.nlm.nih.gov/pubmed/22578175
If
your problems are persistent I think you should search for direct,
personal and professional attention. We can´t give advice through
Internet about if you need exams or treatment, but if symptoms persist
after weeks of abstinence I think it would be important to search for
help.
-
Do you use recreational drugs?
Well...I´m
not a pop star and this is not a reality show so I think my personal
use of drugs is irrelevant 8) 8) 8) ...anyway it has been
previously discussed in this thread
-
Do you use recreational drugs?
Well...I´m
not a pop star and this is not a reality show so I think my personal
use of drugs is irrelevant 8) 8) 8) ...anyway it has been
previously discussed in this thread
Fair point. Okay something I have always wanted to know...
Is
it dangerous to mix uppers and downers and if so why? Is it just a case
of overdosing on one of the drugs when the other one wares off or is it
by its very nature dangerous (stress on the heart?). I have seen so
many contradictory answers so this question thus I am asking you.
Thank you for
LP
-
Do you use recreational drugs?
Well...I´m
not a pop star and this is not a reality show so I think my personal
use of drugs is irrelevant 8) 8) 8) ...anyway it has been
previously discussed in this thread
Fair point. Okay something I have always wanted to know...
Is
it dangerous to mix uppers and downers and if so why? Is it just a case
of overdosing on one of the drugs when the other one wares off or is it
by its very nature dangerous (stress on the heart?). I have seen so
many contradictory answers so this question thus I am asking you.
Thank you for
LP
As
always, it depends on doses and contexts. In general is more dangerous
(and less pleasurable) to mix substances with similar properties
(stimulants: speed+meth, meth+coke..., depressors: GHB+alcohol,
alcohol+opiates). Moderate doses of downers after stimulants probably
don´t suppose dramatic risks if they are used properly, in a safe
environment and with reasonable doses. To use some cannabis at home
after partying with MDMA, for example, is not necessary terrible in
risks. But to drink huge amounts of alcohol, mixing with high doses of
cocaine to diminish the depressor effect is probably dangerous. That´s
why so important to know the properties of the substances you are
mixing. I think answers can be contradictory because "mixing uppers and
downers" can refer to many different situations involving different
risks
-
By the way, I will be out of office all next week and I don´t think I
will have a TOR connection. So I will continue discussing with you from
May 25th
DoctorX
-
Forgive me if you have covered this already. I know you have said
that the evidence of neurotoxicity of MDMA is thin. If I assume that
MDMA is neurotoxic, and am looking to reduce harm, would taking an SSRI
after MDMA use be a potential strategy? What about SAM-e?
-
Back to work!!! :o
-
DoctorX,
1. Can amphetamine use cause heart problems in
healthy individuals using low to moderate dosages of amphetamine, over a
long period of time?
2. Is it safe to combine, say, 30mg of
amphetamine (dexedrine) with 200ug of LSD. Both elevate heart
rate. Could my heart beat too fast and I die if I get a panic attack?
3. Can a drug-induced panic attack cause someone to get a heart attack or stroke?
-
Subbing. Haven't read any of it yet, but I imagine I will be grateful for this thread soon.
-
Forgive
me if you have covered this already. I know you have said that the
evidence of neurotoxicity of MDMA is thin. If I assume that MDMA is
neurotoxic, and am looking to reduce harm, would taking an SSRI after
MDMA use be a potential strategy? What about SAM-e?
What
I exactly say is that "there is no evidence that MDMA has long-lasting
neurotoxic effects in humans at common recreational doses and
occasional/intermitent use". I think all these details are important, if
not, the idea can be misunderstood.
In fact, I assume that MDMA
is neurotoxic too. If neurotoxic changes have been detected in all
animal species, in human there will be a dose that will cause neurotoxic
changes. But this dose (unknown) does not seem to be close to
recreational ones (120-150 mg with maybe 1-2 half boosters 2 hours
after).
People who use MDMA at higher doses or frequencies are
probably more exposed to these risks. Megadoses of some SSRIs have
showed some neuroprotective effects in animal models but,
interescalating species, you should use toxic doses of fluoxetine or
citalopram to imitate this effect. What concrete SSRI should you use?
After any dose of MDMA or only at high doses? What dose? Should you take
it after, during or before MDMA? What dose and frequency?...
There
is no way to know the exact answer to these questions. The theorical
bases of SSRI use as neuroprotectors in humans are so weak that, in my
opinion, are not enough to consider it as a potential harm
reduction strategy. In relation with MDMA and avoiding neurotoxic
effects, the safest and most effective strategy is not to use it
regularly (once a month or, preferabely, less) and moderate
dosification. It is also the best way to enjoy the effects and diminish
or avoid "loss of magic".
As far as I know, there are no human or
animal studies on SAM-e (S-adénosyl-methionina) and MDMA.
According to mechanisms of MDMA toxicity and SAM-e way of action I think
it would be useless, but it is only theoretical speculation.
-
hey nice to see this thread is still going!
I have a question. Have you heard any reports about drugs turning sweet?
I mean the original nasty chemical taste disappears and its sweet as sugar.
I could put it in my tea instead of it and I wouldn't notice the difference.
happens after heavy nasal use. i rub it in my gums and i love the taste.
It really freaks me out. so I usually stop use right away, cry a little then flush it.
a sweet taste could be a sign of heavy physical addiction? or is it mental?
it
only happened to me with amphetamine and methoxetamine. and i think
these are more.... mental addictive drugs. heavy physicals like xanax
never turned sweet. ..
any ideas?
thanks!!!!
-
DoctorX,
1.
Can amphetamine use cause heart problems in healthy individuals using
low to moderate dosages of amphetamine, over a long period of time?
2.
Is it safe to combine, say, 30mg of amphetamine (dexedrine) with 200ug
of LSD. Both elevate heart rate. Could my heart beat too fast and I
die if I get a panic attack?
3. Can a drug-induced panic attack cause someone to get a heart attack or stroke?
1.-
Evidence about heart problems in long time amphetamine use, even in a
classical therapeutic context, is inconclusive. Long time use produces
elevation in heart rate and blood pressure. It seems that long
time use causes more problems to adults than to adolescents and
children. Although it is not completly demostrated, I believe that
long time amphetamine use could be considered as a "risk factor" (as
tobacco, hypertension or dyslipemia) for cardiovascular disease. But in
the other hand it is clear that amphetamine sulphate has been used daily
over decades at doses 10-20 mg (even 40) without noticing a dramatic
raise in cardiovascular problems in general population. I think the risk
exists, but probably dose-dependent and reasonable in doses used in
therapy and oral route.
http://www.ncbi.nlm.nih.gov/pubmed/23160939
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405448/
2.- It can happen, but it should be a very uncommon effect
3.-
It could happen, and it depends on the properties of the drug. In
general, stimulants like cocaine or amphetamine could trigger this
problem more easily than other substances. "Bad trips" of LSD or other
psychedelics could also produce this, although, in practice, it is very
uncommon.
http://heart.bmj.com/content/83/6/627.long#ref-40
-
since i'm into mixing drugs i have experienced that when you snort cocaine during a lsd trip (also mdma-trip)
it suppresses the effects of lsd/mdma for a certain amount of time.
1. does that mean dopamine inhibits the effects of serotonin?
2.if so, would be a longer lasting dopamine active substance like mdpv be even more effective?
very interesting thread btw
cheers minchia
-
Hello DoctorX,
First I would like that I really appreciate what
you are doing for us guys here. It is often hard to get reliable
information about drugs. Anyways I got a question about combining
25c-NBOMe and MDMA. A friend of mine dropped 800mg of the 25c and 150mg
MDMA a 2 nights ago and still did not sleep yet. He is still dancing
around in the room to the music and does totally ignore that he should
sleep.
And another question, I am not sure if it was asked already,
but do you know something about the long time harms of weekly usage of
25c-NBOMe?
Thanks in advance.
-
hey nice to see this thread is still going!
I have a question. Have you heard any reports about drugs turning sweet?
I mean the original nasty chemical taste disappears and its sweet as sugar.
I could put it in my tea instead of it and I wouldn't notice the difference.
happens after heavy nasal use. i rub it in my gums and i love the taste.
It really freaks me out. so I usually stop use right away, cry a little then flush it.
a sweet taste could be a sign of heavy physical addiction? or is it mental?
it
only happened to me with amphetamine and methoxetamine. and i think
these are more.... mental addictive drugs. heavy physicals like xanax
never turned sweet. ..
any ideas?
thanks!!!!
I
had never heard about that kind of effect. If it happens olny after
heavy nasal use it could be related with changes of sensization of
nerves in nose cavity and throat. But this is only a personal
hypothesis, I have no idea what could be the explanation, and I don´t
think it is a physical effect derivated from properties of drugs
-
hey nice to see this thread is still going!
I have a question. Have you heard any reports about drugs turning sweet?
I mean the original nasty chemical taste disappears and its sweet as sugar.
I could put it in my tea instead of it and I wouldn't notice the difference.
happens after heavy nasal use. i rub it in my gums and i love the taste.
It really freaks me out. so I usually stop use right away, cry a little then flush it.
a sweet taste could be a sign of heavy physical addiction? or is it mental?
it
only happened to me with amphetamine and methoxetamine. and i think
these are more.... mental addictive drugs. heavy physicals like xanax
never turned sweet. ..
any ideas?
thanks!!!!
I
had never heard about that kind of effect. If it happens olny after
heavy nasal use it could be related with changes of sensization of
nerves in nose cavity and throat. But this is only a personal
hypothesis, I have no idea what could be the explanation, and I don´t
think it is a physical effect derivated from properties of drugs
Dude,
I know this exact effect. It's purely mental, imo...after a while (and
still do) think about meth crystals as if they were rock candy. And I
swear if I were to taste some meth right now, it'd probably taste like
sugar. It's just the brain's way of telling you that it doesn't care
about the taste, it LOVES whatever that stuff is!
Luckily I've
never really gone overboard with my use and I also ended up throwing
away my stash, but you aren't the only one brother.
-
since i'm into mixing drugs i have experienced that when you snort cocaine during a lsd trip (also mdma-trip)
it suppresses the effects of lsd/mdma for a certain amount of time.
1. does that mean dopamine inhibits the effects of serotonin?
2.if so, would be a longer lasting dopamine active substance like mdpv be even more effective?
very interesting thread btw
cheers minchia
This
effect is typical when you mix cocaine with psychedelics. The mechanism
it is not well studied, but probably involves dopamine release. In my
personal opinion it is a way to "ruin" psychedelic effects but this is
only a personal opinion.
The problem with MDPV is that it is not a well-known substance and it has a few studies on humans.
If
you are searching specifically for that effect, I think amphetamine
(speed) would be a better choice than MDPV. Anyway, I don´t reccomend
these kind of combinations in a risk reduction perspective. If you feel
LSD is too long, you could try short-acting well-studied psychedelics
like psilocibin, 2C-B or 4-Aco-DMT
-
This is really great work. Thanks a lot for this thread DoctorX.
I
made a thread about my friend having a seizure after taking LSD,
followed by a period of semi-consciousness and then an intense migraine
and vomiting. I now believe it was a panic attack set off by a bad trip,
but I know my friend would love to hear your opinion.
http://dkn255hz262ypmii.onion/index.php?topic=165311.0
-
does that mean dopamine inhibits the effects of serotonin?
This
effect is typical when you mix cocaine with psychedelics. The mechanism
it is not well studied, but probably involves dopamine release. In my
personal opinion it is a way to "ruin" psychedelic effects but this is
only a personal opinion.
The problem with MDPV is that it is not a well-known substance and it has a few studies on humans.
If
you are searching specifically for that effect, I think amphetamine
(speed) would be a better choice than MDPV. Anyway, I don´t reccomend
these kind of combinations in a risk reduction perspective. If you feel
LSD is too long, you could try short-acting well-studied psychedelics
like psilocibin, 2C-B or 4-Aco-DMT
well i was mainly just interested if dopamine inhibits the effects of serotonin.
since
i've read that mdpv is about 13x times stronger than ritalin i guessed
this would be the strongest dopamine active drug around.
im perfectly fine with the durance of lsd.. and if not, opium did always the trick for me :)
cheers minchia
-
hey nice to see this thread is still going!
I have a question. Have you heard any reports about drugs turning sweet?
I mean the original nasty chemical taste disappears and its sweet as sugar.
I could put it in my tea instead of it and I wouldn't notice the difference.
happens after heavy nasal use. i rub it in my gums and i love the taste.
It really freaks me out. so I usually stop use right away, cry a little then flush it.
a sweet taste could be a sign of heavy physical addiction? or is it mental?
it
only happened to me with amphetamine and methoxetamine. and i think
these are more.... mental addictive drugs. heavy physicals like xanax
never turned sweet. ..
any ideas?
thanks!!!!
I
had never heard about that kind of effect. If it happens olny after
heavy nasal use it could be related with changes of sensization of
nerves in nose cavity and throat. But this is only a personal
hypothesis, I have no idea what could be the explanation, and I don´t
think it is a physical effect derivated from properties of drugs
Dude,
I know this exact effect. It's purely mental, imo...after a while (and
still do) think about meth crystals as if they were rock candy. And I
swear if I were to taste some meth right now, it'd probably taste like
sugar. It's just the brain's way of telling you that it doesn't care
about the taste, it LOVES whatever that stuff is!
Luckily I've
never really gone overboard with my use and I also ended up throwing
away my stash, but you aren't the only one brother.
Thanks! good to read im not the only one!
got to be careful! with this game.
take care!
-
Hello DoctorX,
First
I would like that I really appreciate what you are doing for us guys
here. It is often hard to get reliable information about drugs. Anyways I
got a question about combining 25c-NBOMe and MDMA. A friend of mine
dropped 800mg of the 25c and 150mg MDMA a 2 nights ago and still did not
sleep yet. He is still dancing around in the room to the music and does
totally ignore that he should sleep.
And another question, I am not
sure if it was asked already, but do you know something about the long
time harms of weekly usage of 25c-NBOMe?
Thanks in advance.
2C-C-NBOMe
has no history of human use prior to 2010 when it first became
available online. In fact there is only one published studied about its
propreties and it is a investigation on pigs. There are no data about
its mechanism of action in humans, adverse effects, short or long time
toxicity. We can´t say anything about short or long term effects because
they are completely unknown. Compared with other substances (like MDMA,
for example, with more than 6.000 studies in the last 40 years) people
taking 25-NBOMe are behaving as guinea pigs.
I hope your friend has finished dancing :o
-
Hello DoctorX,
First
I would like that I really appreciate what you are doing for us guys
here. It is often hard to get reliable information about drugs. Anyways I
got a question about combining 25c-NBOMe and MDMA. A friend of mine
dropped 800mg of the 25c and 150mg MDMA a 2 nights ago and still did not
sleep yet. He is still dancing around in the room to the music and does
totally ignore that he should sleep.
And another question, I am not
sure if it was asked already, but do you know something about the long
time harms of weekly usage of 25c-NBOMe?
Thanks in advance.
2C-C-NBOMe
has no history of human use prior to 2010 when it first became
available online. In fact there is only one published studied about its
propreties and it is a investigation on pigs. There are no data about
its mechanism of action in humans, adverse effects, short or long time
toxicity. We can´t say anything about short or long term effects because
they are completely unknown. Compared with other substances (like MDMA,
for example, with more than 6.000 studies in the last 40 years) people
taking 25-NBOMe are behaving as guinea pigs.
I hope your friend has finished dancing :o
Yea
he did, he was around about 60 hours in total and is pretty fucked up
and exhausted now. Thanks for your replies, yet I got one more question
now. What did that study with the pigs return as results?
Thanks
-
Doctor X!
Question: How does one use cocaine without getting anxiety/panic attacks.
Xanax doesnt completely negate the effects of anxiety whilst on cocaine.
-
Doctor X!
Question: How does one use cocaine without getting anxiety/panic attacks.
Xanax doesnt completely negate the effects of anxiety whilst on cocaine.
do
you smoke pot? any type, hash or green? i get ultra paranoid if i smoke
even a week before or after i do coke - my body just can't handle both
in my system
-
nah i dont smoke anything
-
that's my theory out the window, i'll leave it to the expert then... ;)
-
Doctor X!
Question: How does one use cocaine without getting anxiety/panic attacks.
Xanax doesnt completely negate the effects of anxiety whilst on cocaine.
I only ever get anxiety attacks if I've had a lot of stimulants. I feel sorry sorry for people who are prone to them
-
This is really great work. Thanks a lot for this thread DoctorX.
I
made a thread about my friend having a seizure after taking LSD,
followed by a period of semi-consciousness and then an intense migraine
and vomiting. I now believe it was a panic attack set off by a bad trip,
but I know my friend would love to hear your opinion.
http://dkn255hz262ypmii.onion/index.php?topic=165311.0
It
is very difficult to know what can exactly have happened. It could be a
panic attack. But it is very uncommon that a panic attack causes a
complete lose of consciousness. The sequence ( short time of complete
lose of consciousness followed by a post critic state with symptoms)
could correspond to a seizure (epileptic-like). I can´t confirm it 100%
but it sounds possible to the story, as I have read in your thread. If
case she is taking LSD or stimulants, she should be careful with doses,
stay with someone else and consult to a doctor if something strange
happens
-
Does anyone know of any adverse reactions from taking 25i-nbome
while on an adderall prescription? I haven't taken it on a day I took my
medicine(stopped it a day before for good measure), but haven't found
anything about adverse reactions
-
Doctor X!
Question: How does one use cocaine without getting anxiety/panic attacks.
Xanax doesnt completely negate the effects of anxiety whilst on cocaine.
I only ever get anxiety attacks if I've had a lot of stimulants. I feel sorry sorry for people who are prone to them
Yeah I think i am the same, stimulants do it for me.
Even gym preworkouts can sometimes give me anxiety
-
Doctor,
I have been prescribed <20mg of Adderall for a couple
of years for ADHD. Recently I have decided to start exercising and
generally caring about my health. During some research I have seen
mention that Adderall's amphetamine mixture causes an increase in BP and
heart-rate more so than pure dextroamphetamine (Dexedrine). With my
limited knowledge Dexedrine seems like a potentially safer Adderall
alternative that may be worth a try. Any additional informational on
exercise and amphetamines or any related subject would be appreciated. I
understand long-term amphetamine use is a risk-factor but at this point
in time I will take my chances.
P.S. - Perhaps you could give me
a quick pointer on the best ways of finding applicable and reputable
literature/research online. I saw mention of PubMed and Sci-Hub so far.
Thank you very much for answering so many questions. ;D I have donated what I can, which wasn't much. :-\
-
Hello DoctorX,
First
I would like that I really appreciate what you are doing for us guys
here. It is often hard to get reliable information about drugs. Anyways I
got a question about combining 25c-NBOMe and MDMA. A friend of mine
dropped 800mg of the 25c and 150mg MDMA a 2 nights ago and still did not
sleep yet. He is still dancing around in the room to the music and does
totally ignore that he should sleep.
And another question, I am not
sure if it was asked already, but do you know something about the long
time harms of weekly usage of 25c-NBOMe?
Thanks in advance.
2C-C-NBOMe
has no history of human use prior to 2010 when it first became
available online. In fact there is only one published studied about its
propreties and it is a investigation on pigs. There are no data about
its mechanism of action in humans, adverse effects, short or long time
toxicity. We can´t say anything about short or long term effects because
they are completely unknown. Compared with other substances (like MDMA,
for example, with more than 6.000 studies in the last 40 years) people
taking 25-NBOMe are behaving as guinea pigs.
I hope your friend has finished dancing :o
Yea
he did, he was around about 60 hours in total and is pretty fucked up
and exhausted now. Thanks for your replies, yet I got one more question
now. What did that study with the pigs return as results?
Thanks
The
pig study was performed to know if 25c-NBOMe acts on 5HT2
serotoninergic effects. Pigs under anaesthesia were injected NBOMe and
then submitted to a Positron Emission Tomography, showing high affinity.
This is all we know. No data on animal toxicity, short or long term
effects in humans.
If you compare this with the decades on
investigation on MDMA or LSD, you can understand why I think NBOMe are
potentially dangerous substances
-
Looks like doctor X cant help :(
-
This is really great work. Thanks a lot for this thread DoctorX.
I
made a thread about my friend having a seizure after taking LSD,
followed by a period of semi-consciousness and then an intense migraine
and vomiting. I now believe it was a panic attack set off by a bad trip,
but I know my friend would love to hear your opinion.
http://dkn255hz262ypmii.onion/index.php?topic=165311.0
It
is very difficult to know what can exactly have happened. It could be a
panic attack. But it is very uncommon that a panic attack causes a
complete lose of consciousness. The sequence ( short time of complete
lose of consciousness followed by a post critic state with symptoms)
could correspond to a seizure (epileptic-like). I can´t confirm it 100%
but it sounds possible to the story, as I have read in your thread. If
case she is taking LSD or stimulants, she should be careful with doses,
stay with someone else and consult to a doctor if something strange
happens
Thanks
for taking the time to read my thread. My understanding of epilepsy is
that everyone has some sort of seizure threshold, and potentially can
have an epileptic fit. I know she was complaining of it all getting too
much, she said everything was just rushing at her eyes and there was way
too much to take in. This was when she said she couldn't see, and I
believe it was getting too much even when her eyes were shut.
Is
it possible then that the hallucinations she experienced were powerful
enough to set off an epileptic seizure in someone with no history of
epilepsy? If so, does this mean she will have a lower seizure threshold
in future? I know she's not going to jump back in on the same dose of
LSD straight away, but if she was to take a similar amount, is there a
good chance the hallcuinations would again become too overwhelming? I
know you won't be able to answer such questions with any certainty, but I
value your opinion.
My theory regarding her lack of
consciousness (if it was a panic attack), is that she had a panic attack
just as she experienced ego death, the experience of ego death
rendering her seemingly un/semi-conscious. She was in the fetal
position, and would move intermittently. She would make noise, and would
be able to communicate with me but could not muster up the effort to
say many actual words. There is no doubt she experienced ego death
during this period.
I am certainly not trying to challenge your
knowledge or opinion which is much more credible than my own, but is it
actually possible that fear could trigger an epileptic seizure? She fell
to the ground screaming, and this was preceded by a very definite
increase in stress and fear and panic. I have never seen someone have
their *first* epileptic seizure though... is it possible that someone
would get very scared as they began to experience the prelude to an
epileptic seizure?
On a side note, there were no flashing lights
and it was actually getting progressively darker at the time. If it was
epileptic, do you think her not being able to see (except
hallucinations) was an early symptom of the epileptic attack set off by
an unknown cause, or is it more likely to be the cause itself?
I've
probably repeated myself a bunch of times there, sorry. She is
perfectly fine and happy now and had a wonderful experience, but out of
my group of friends I'm "the one" who does the most research and who
gets to know all of this stuff etc. so I still feel a certain
responsibility about all of this, and I want to be able to offer sound
advice where possible. Thanks a lot DoctorX, awesome work you're doing
here!
-
Doctor X!
Question: How does one use cocaine without getting anxiety/panic attacks.
Xanax doesnt completely negate the effects of anxiety whilst on cocaine.
Sorry...but my time is limited and questions (here and private) are too much...
But
I agree, in this case I think there is little help. There are some
properties that are intrinsic to drugs. Aspirin can hurt the stomach and
cocaine (and stimulants in general) can trigger anxiety. Most people
can take aspirin without problems but for some people it is
contraindicated. By the same reason, cocaine is not good for everyone
and people susceptible to anxiety will suffer this effect. I can´t think
of another help. But there are many different drugs...
-
Hi Doctor,
I got some pure Diethyl Ether from a laboratory, and no matter how much vapors I inhaled- it had no effect.
I
am on the medication Duloxetine (for Dysthymia, though I don't really
think it does anything and I am not really depressed, I just struggle
with motivation and drive).
I am wondering if there is any basis to believing Duloxetine could have blocked the effects of Diethyl Ether?
I
believe Diethyl ether is an NMDA antagonist and I am wondering if
Ketamine will work while on Duloxetine because it is also the same?
Thank you
-
Hey Doc,
What you think about this?
http://silkroadvb5piz3r.onion/silkroad/user/2135facd39
"I believe a 35mg-50mg dose for 7 consecutive days could heighten one's understanding with oneself, friends, and family.
*For beginners - avoid physical labor during trial if you do not prefer a strong come-down. :)"
WTF?
Actually taking low dose mdma is not much different to taking an SSRI like Paxil or even prozac.
Look
at the chemical structure of 'paroxetine' as opposed to mdma ...
they are suprisingly 'similar' , snip off a functional group, methylate
in vivo ... who knows what happens but the effects of these two drugs
mdma and paroxetine are remarkably similar!
have a look https://en.wikipedia.org/wiki/Paroxetine
https://en.wikipedia.org/wiki/MDMA
hmmmm motek :o
-
Does
anyone know of any adverse reactions from taking 25i-nbome while on an
adderall prescription? I haven't taken it on a day I took my
medicine(stopped it a day before for good measure), but haven't found
anything about adverse reactions
Sorry
for being repetitive but the situation about 25-I is similar to 25-C
previously discussed. There are no scientific data about 25I-NBOME
pharmacological effects on human, so t must be considered as a dangerous
substance indeed. In general, combining different substances increases
risks. Some times this increment is no important but other times risks
can be very dangerous. In this case, it is virtually impossible to
assess if the risk is significative or not.
-
Sorry
for being repetitive but the situation about 25-I is similar to 25-C
previously discussed. There are no scientific data about 25I-NBOME
pharmacological effects on human, so t must be considered as a dangerous
substance indeed. In general, combining different substances increases
risks. Some times this increment is no important but other times risks
can be very dangerous. In this case, it is virtually impossible to
assess if the risk is significative or not.
Glad
I am on the same page as the doctor, I would NEVER take a research
chemical and would only take LSD from a very reputable vendor after
testing the stuff with EZ TEST. Even LSD is not something I would take
more than occasionally. The only thing I am totally comfortable with
taking on a regular basis is Marijuana- I have been using Marijuana for
22 years and I am very confident its not going to mess me up :) Well I
also binge on Benzodiazepines (they are the devil- you have to be
careful) and opiates (separately, not at the same time), but have been
doing so for many years and have not become addicted. Indeed in my case
Benzo's are the greater threat than Opiates. Benzo's make me want "more
more more", while I feel content and satiated when I take opiates. I
take everything orally, though I am willing to consider snorting some
substances or even perhaps IM injection, but only on the absolute
HIGHEST QUALITY merchandise. IV to me is yuck yuck yuck.
Doctor: I
*WILL* donate from time to time the dollars left over from my drug
transactions. I encourage other people to do the same. Help the Doctor
out if you can spare a few $$ people! He has been extremely patient with
all the babbling questions :)
-
Hi Dr.
I am a chronic pain management person with Systemic
Sclerosis (scleroderma), and as drug/pain doctor you may have run into
this rare autoimmune disorder. What drug, in your opinion offers
the best in pain management. Many people have been directing me to
cannabis but I'm currently on opiates. What's your experience
been with your patients, in particular with joint pain and general
Fibermyalgia pain?
-
Clinical trials don´t show that there is a significative increment
of blood presure and pulse under Adderall. So, in this sense, there is
no need to adjust or change if you are thinking about doing physical
exercise. There are some cases of cardiovascular disease in Adderall
use, but they are very rare and it doesn´t seem to be a significative
risk. Technical sheet from FDA doesn´t say anything about physical
exercise so the combination should be considered safe, at least for most
people.
http://www.ncbi.nlm.nih.gov/pubmed/16182674
I´m sorry I
have no time to explain how to search in PubMed. It takes some time (and
experience) to find things and to distinguish important issues from
non-important. Anyway you can have a look here:
http://www.ncbi.nlm.nih.gov/books/NBK3827/#pubmedhelp.PubMed_Quick_Start
Doctor,
I
have been prescribed <20mg of Adderall for a couple of years for
ADHD. Recently I have decided to start exercising and generally caring
about my health. During some research I have seen mention that
Adderall's amphetamine mixture causes an increase in BP and heart-rate
more so than pure dextroamphetamine (Dexedrine). With my limited
knowledge Dexedrine seems like a potentially safer Adderall alternative
that may be worth a try. Any additional informational on exercise and
amphetamines or any related subject would be appreciated. I understand
long-term amphetamine use is a risk-factor but at this point in time I
will take my chances.
P.S. - Perhaps you could give me a quick
pointer on the best ways of finding applicable and reputable
literature/research online. I saw mention of PubMed and Sci-Hub so far.
Thank you very much for answering so many questions. ;D I have donated what I can, which wasn't much. :-\
-
This is really great work. Thanks a lot for this thread DoctorX.
I
made a thread about my friend having a seizure after taking LSD,
followed by a period of semi-consciousness and then an intense migraine
and vomiting. I now believe it was a panic attack set off by a bad trip,
but I know my friend would love to hear your opinion.
http://dkn255hz262ypmii.onion/index.php?topic=165311.0
It
is very difficult to know what can exactly have happened. It could be a
panic attack. But it is very uncommon that a panic attack causes a
complete lose of consciousness. The sequence ( short time of complete
lose of consciousness followed by a post critic state with symptoms)
could correspond to a seizure (epileptic-like). I can´t confirm it 100%
but it sounds possible to the story, as I have read in your thread. If
case she is taking LSD or stimulants, she should be careful with doses,
stay with someone else and consult to a doctor if something strange
happens
Thanks
for taking the time to read my thread. My understanding of epilepsy is
that everyone has some sort of seizure threshold, and potentially can
have an epileptic fit. I know she was complaining of it all getting too
much, she said everything was just rushing at her eyes and there was way
too much to take in. This was when she said she couldn't see, and I
believe it was getting too much even when her eyes were shut.
Is
it possible then that the hallucinations she experienced were powerful
enough to set off an epileptic seizure in someone with no history of
epilepsy? If so, does this mean she will have a lower seizure threshold
in future? I know she's not going to jump back in on the same dose of
LSD straight away, but if she was to take a similar amount, is there a
good chance the hallcuinations would again become too overwhelming? I
know you won't be able to answer such questions with any certainty, but I
value your opinion.
My theory regarding her lack of
consciousness (if it was a panic attack), is that she had a panic attack
just as she experienced ego death, the experience of ego death
rendering her seemingly un/semi-conscious. She was in the fetal
position, and would move intermittently. She would make noise, and would
be able to communicate with me but could not muster up the effort to
say many actual words. There is no doubt she experienced ego death
during this period.
I am certainly not trying to challenge your
knowledge or opinion which is much more credible than my own, but is it
actually possible that fear could trigger an epileptic seizure? She fell
to the ground screaming, and this was preceded by a very definite
increase in stress and fear and panic. I have never seen someone have
their *first* epileptic seizure though... is it possible that someone
would get very scared as they began to experience the prelude to an
epileptic seizure?
On a side note, there were no flashing lights
and it was actually getting progressively darker at the time. If it was
epileptic, do you think her not being able to see (except
hallucinations) was an early symptom of the epileptic attack set off by
an unknown cause, or is it more likely to be the cause itself?
I've
probably repeated myself a bunch of times there, sorry. She is
perfectly fine and happy now and had a wonderful experience, but out of
my group of friends I'm "the one" who does the most research and who
gets to know all of this stuff etc. so I still feel a certain
responsibility about all of this, and I want to be able to offer sound
advice where possible. Thanks a lot DoctorX, awesome work you're doing
here!
In
general, panic attacks don´t trigger an epileptic seizure.In fact,
epileptic seizures are not a known complication of LSD use (at least in
healthy, non-epileptic persons) although LSD use is contraindicated in
epileptic persons.In medicine, it is sometimes very difficult to
distinguish between a panic attack and an epileptic seizure. I can´t be
sure about what has happened with your friend. The story resembles more
of seizure but it is not a sure diagnosis. In my professional
experience, when someone has suffered a very unpleasant experience on
LSD at his first experiences, there is more chances the bad experience
will repeat with subsequent uses of the same substance. It is not always
in 100% cases but I have seen it many times.
-
Hi Doctor,
I got some pure Diethyl Ether from a laboratory, and no matter how much vapors I inhaled- it had no effect.
I
am on the medication Duloxetine (for Dysthymia, though I don't really
think it does anything and I am not really depressed, I just struggle
with motivation and drive).
I am wondering if there is any basis to believing Duloxetine could have blocked the effects of Diethyl Ether?
I
believe Diethyl ether is an NMDA antagonist and I am wondering if
Ketamine will work while on Duloxetine because it is also the same?
Thank you
The only significative interaction with diethyl ether I have found is with alcohol:
http://www.ncbi.nlm.nih.gov/pubmed/3296835
I
have not found interactions with duloxetine and, according to it
mechanism of action, I don´t think this is the cause of your situation,
although I´m not able to offer an alternative explanation. The fact that
diethyl ether and ketamine are NMDA antagonists does not mean that it
won´t work, there are different degrees and types of antagonism
-
What are your thoughts on Cocaethylene, or combining cocaine and alcohol? Someone brought it up in this thread:
http://dkn255hz262ypmii.onion/index.php?topic=164746.0
I'm
relatively new to cocaine, and I've almost always drank alcohol with
it. Now I find it hard to do either cocaine or alcohol separately,
because when I drink I have strong cravings for coke, and when I do
coke, I usually want to drink. I use fairly small amounts of each (2-5
beers combined with a few bumps or small lines of coke - maybe a total
of 100 mg each time). Am I doing myself a lot of damage here, or is that
only in people who are much heavier drinkers/users? I'm quite healthy
otherwise.
-
Hey Doc,
What you think about this?
http://silkroadvb5piz3r.onion/silkroad/user/2135facd39
"I believe a 35mg-50mg dose for 7 consecutive days could heighten one's understanding with oneself, friends, and family.
*For beginners - avoid physical labor during trial if you do not prefer a strong come-down. :)"
WTF?
Actually taking low dose mdma is not much different to taking an SSRI like Paxil or even prozac.
Look
at the chemical structure of 'paroxetine' as opposed to mdma ...
they are suprisingly 'similar' , snip off a functional group, methylate
in vivo ... who knows what happens but the effects of these two drugs
mdma and paroxetine are remarkably similar!
have a look https://en.wikipedia.org/wiki/Paroxetine
https://en.wikipedia.org/wiki/MDMA
hmmmm motek :o
That
pattern of use is a nice way to waste MDMA, but it will be completely
useless. MDMA causes tolerance ( phenomenon whereby a drug user becomes
physically accustomed to a particular dose of a substance, and requires
increasing dosages in order to obtain the same effects). If someone
takes MDMA daily the desired effects will dissapear in 2-3 days and
there will be only undesired effects (tachycardia, jaw clenching...).
And using low doses will make the desired effects unnoticeable,
even in the first days.
Shulgin was the first who described this properties of MDMA in PIHKAL:
"In
one study, MDMA was consumed at 9:00 a.m. each day for almost a week
(120 milligrams the first day and 160 milligrams each subsequent day)
and by the fifth day there were no effects from the drug except for some
mydriasis. And even this appeared to be lost on the sixth day. (...) A
complete holiday from any drug for another 6 days led to the reversal of
this tolerance, in that 120 milligrams of MDMA had substantially the
full expected effects."
And this tolerance phenomenon has been
confirmed in many clinical trials. So, with no doubt, the pattern of use
proposed here is useless.
-
But SSRIs also do not give any noticable physiological effects, not
even mydriasis sometimes. But they do change behavior when being
consumed for 2 weeks or more. Is there a research that shows that
consuming MDMA in small doses daily does NOT change behavior?
-
But
SSRIs also do not give any noticable physiological effects, not even
mydriasis sometimes. But they do change behavior when being consumed for
2 weeks or more. Is there a research that shows that consuming MDMA in
small doses daily does NOT change behavior?
You
are right. Such a study does not exist. But your reasoning is out of
scientific rules. In science, demonstration and argumentation must be
positive. There is no study that show that consuming MDMA in small doses
daily does not change behaviour. There are no proofs that there aren´t
nazi spaceships on the moon. The fact that there aren´t proofs does not
mean that something is or can be true. (I hope you understand my idea
even though my English is limited ;) . And, in fact, there are
reasonable evidences of pharmacological tolerance to MDMA effects.
-
i fell lots of pain (mostly in my legs, feet) whenever i'm in Nbome or Marijuana. It feels like there is pressure there.
Is this because of vasoconstriction ? What can i do to make it better?
-
Hi Dr.
I
am a chronic pain management person with Systemic Sclerosis
(scleroderma), and as drug/pain doctor you may have run into this rare
autoimmune disorder. What drug, in your opinion offers the best in
pain management. Many people have been directing me to cannabis
but I'm currently on opiates. What's your experience been with
your patients, in particular with joint pain and general Fibermyalgia
pain?
I
am sorry but I can´t give you a concrete advice. Systemic sclerosis is a
very rare and complicated disease and advice must be personalized
depending on concrete clinical presentation of the patient. In general,
nonsteroidal anti-inflammatory drugs and corticoids are the best
options, but it depends on each concrete case. Each drug (legal or
illegal) can have contraindications in this situation and must be
prescribed in concrete cases.
-
just read through this thread, some top advice given by the doc
my first +1 to this guy for much appreciated harm reduction advice for the people
-
I agree. +1!
Question for the doctor: Is there anything you can give someone on SSRIs to help them roll on MDMA?
-
Hi DoctorX,
Thanks for your time!
My question is about
MDMA dosage. I saw one of your previous messages advised 70-100mg
for women or first time users, but is body weight a factor? I've
seen conflicting information about this some places say 1.5-2.0mg/kg,
others just recommend amounts without taking into account sex and
weight. Particularly the MAPS ptsd protocol below doses 125 mg
without considering sex and weight. Of course I could be
missing something I don't read clinical trial protocols for a
living :) I'm 150 lbs(68 kg) and find that ~125 mg is my
sweet spot so that's inline with both 1.5-2.0 mg/kg and the recommended
amounts.
Anyway some friends of mine will be trying MDMA for the
first time this summer and some are taller/wider than others and I want
to make sure they have a good time 8)
I currently plan on
giving 100-125mg based on their personalities. The more adventurous and
experienced with other drugs will receive the higher dose.
What are your thoughts? Many thanks!
http://www.maps.org/research/mdma/mdma_ptsd_u.s._study_veterans_of_war/
-
130lbs, is 13mg of 2cbs too much for a first timer? what are the bad effects of 2cbs? are they "safe"?
-
What are your thoughts on Cocaethylene, or combining cocaine and alcohol? Someone brought it up in this thread:
http://dkn255hz262ypmii.onion/index.php?topic=164746.0
I'm
relatively new to cocaine, and I've almost always drank alcohol with
it. Now I find it hard to do either cocaine or alcohol separately,
because when I drink I have strong cravings for coke, and when I do
coke, I usually want to drink. I use fairly small amounts of each (2-5
beers combined with a few bumps or small lines of coke - maybe a total
of 100 mg each time). Am I doing myself a lot of damage here, or is that
only in people who are much heavier drinkers/users? I'm quite healthy
otherwise.
Most
of the ideas discussed in this thread about MDMA neurotoxicity are
aplicable to cocaethylene. The combination of cocaine and alcohol
increases neurotoxicity and hepatotoxicity. But the basis for this is
animal model studies, where very heavy doses of both substances are
used. It is not clear in what extent these effects are
extrapolable to humans.
When a combination of drugs is clinically
relevant in toxicity terms, there are many data about it ( e.g.:
GHB+alcohol) There are no clinical studies showing that moderate doses
of cocaine and alcohol produce more harm than both substances
separately. It is very probable that, at the doses you are using in
healthy people, the risks are moderate. Risk in this sense is probably
dose and frequency dependent, and heavy users of this combination will
be the most exposed.
-
i fell lots of pain (mostly in my legs, feet) whenever i'm in Nbome or Marijuana. It feels like there is pressure there.
Is this because of vasoconstriction ? What can i do to make it better?
Cannabis
does not produce any arterial vasoconstriction. It can alter the
sensitivity of self-perception and pain (for most people is analgesic,
but not for all, and not for any kind of pain). Sometimes drugs can make
you feel with more intensity body sensations that are not usually
perceived.
Effects in humans on Nbome are not studied, so I can´t think of a theory about that.
With the little information and the limitations of Internet, I´m sorry I can´t offer advice in this case
-
I agree. +1!
Question for the doctor: Is there anything you can give someone on SSRIs to help them roll on MDMA?
In
general, SSRI diminish effects of MDMA, although probably tolerance is
developed over time. Increasing MDMA dose will increase also adverse
effects of this substance.
In this kind of situation it is important
to think beyond pharmacological aspects. What I mean is that, if someone
is on SSRI it is probably because of psychological or emotional
problems/stress. And the best way to enjoy MDMA effects is to be in
"good mental health". In general, I think it is more wise to wait until
SSRI treatment is finished.
-
Hi DoctorX,
Thanks for your time!
My
question is about MDMA dosage. I saw one of your previous
messages advised 70-100mg for women or first time users, but is body
weight a factor? I've seen conflicting information about this some
places say 1.5-2.0mg/kg, others just recommend amounts without taking
into account sex and weight. Particularly the MAPS ptsd protocol
below doses 125 mg without considering sex and weight. Of
course I could be missing something I don't read clinical trial
protocols for a living :) I'm 150 lbs(68 kg) and find that
~125 mg is my sweet spot so that's inline with both 1.5-2.0 mg/kg and
the recommended amounts.
Anyway some friends of mine will be
trying MDMA for the first time this summer and some are taller/wider
than others and I want to make sure they have a good time 8)
I
currently plan on giving 100-125mg based on their personalities. The
more adventurous and experienced with other drugs will receive the
higher dose.
What are your thoughts? Many thanks!
http://www.maps.org/research/mdma/mdma_ptsd_u.s._study_veterans_of_war/
Reccomended
doses of MDMA are expressed in both ways in clinical trials: mg of
substance or mg/kg. I think this data are orientative, and there
is also some interindividual variability: some peoples achieve great
effects with moderate doses, other few need high doses (sometimes over
200 mg) to feel the substance.
In general, mg of substance are the
easiest way to measure. And there are some important facts to be
considered when calculating a dose:
1) In general, novices need lower doses. It is better 80 mg + 40 mg (2 hours after if needed) than 120 mg for a novice.
2) Women need lower doses than men : they feel more psychological positive and adverse effects than men at the same dose
http://www.ncbi.nlm.nih.gov/pubmed/23112822
http://www.ncbi.nlm.nih.gov/pubmed/11314678
3)
Extremly thin or fat people can need adjusts, but doses below 40 mg do
not produce noticeable effects and doses over 150-180 mg can be
dangerous and have more adverse effects. In general the rank 1.5-2 mg/kg
is adequate
-
subbed this is excellent
-
Thanks Doc the next time I get some bitcoins I'll send a little your
way and I suggest anyone who finds this thread valuable to do the same.
-
I just saw this thread, and I have already read it all. ;D
Are
you on CannabisCafe/Energy Control/etc ? Is just that the Spanish scene
is not that big, and I thought that I should had read or known about
you before as you seen pretty active even with a topic here on SR.
Well,
my questions are mainly related to the use of nootropics and
supplements as a harm reduction mechanism when taking other drugs.
I
take in a daily basis creatine, acetyl-l-cartinine, alpha-gpc and
multivitamin pills, taking some rest of them as is recommended to each
particular substance. I also take like 3 or 4 days per week some
pramiracetam and two days per week a pill of modafinil if I feel like I
want to do something productive for some time without feeling sleepy.
I'm an almost 19 years old healthy individual.
For the first ones, I
know that the evidence about them doing any kind of neuroprotective or
intelligence enhance in healhy young humans is mostly incidental, but
all in all, and being the use of them probably not very rational, I feel
comfortable as the risk are (as far as I know) almost nonexistent if
you take them with a good timing and low doses. Also maybe the
neuroprotective effects can be seen if the stack is maintained long
enough, but I haven't seen studies about that, and my consumption is
mostly based in Kurzweil etc Faith probably.
Does make sense use
attack doses of some vitamins, or take some neuroprotective stuff like
Noopept, pramiracetam etc when a consumption of some drug is planned ?
Can
my nootropic stack cause some problems taking into account that I'm
planning to take it for years ? Or this substances are almost innocuous
if taken correctly ? I change this stack from time to time. Probably
more and more will be added permanently eventually.
Do you think
that there is a considerable possibility of some RCs causing dramatic
effects in the medium-long term even if they are taken a few times ? I'm
talking mostly about nbomes, mxe, methylone, amt, mdpv, 4-ho-met,
5-meo-dmt etc And by dramatic, I mean some kind of
neurodegenerative/etc disease being directly caused by the drug action,
and with a high prevalence of the disease in the people who tried it.
Also, in another topics:
I
would like to know if there is some kind of organization or individuals
who is doing some pressure in Spain from a professional and scientific
side about the drug laws and prohibitions, and in which grade the actual
laws are based in factual data instead of FUD and tradition/particular
and biased opinions. Do you think we are far from some regulation at
least reaching substances as MDMA, speed, LSD etc ?
Do you think
that in a good environment with drugs regulated and an scientific and
business world arousing would be possible the development of drugs with
almost not negative reactions even if consumed weekly, or even more,
daily ?
I would love to have a potent stim for almost every day use,
they make me productive as hell. In my weeks, great days are caffeine
and modafinil days, and It's nothing compared to good speed or mdpv.
The
best would be methylphenidate, even if I don't like it as much as
speed, I suppose. But is expensive as hell, and ethylphenidate I don't
think is really an alternative. Is there really also a chemistry
difference to make 1 gr of ethylphenidate cost nothing compared to a few
pills of methylphenidate ? It's probably some fucking patent. :-X
Thanks, and sorry but I'm a little stim today and I cannot help me with the verbosity lol.
-
130lbs, is 13mg of 2cbs too much for a first timer? what are the bad effects of 2cbs? are they "safe"?
Reccomended
dosage (Shulgin) of 2C-B is 12-24 mg. 2C-B was first syntethized in
1974. It has now almost 40 years of human use and there are only a few
reports of significant human toxicity:
http://www.ncbi.nlm.nih.gov/pubmed/20445431
http://www.ncbi.nlm.nih.gov/pubmed/21036198
So,
the physical risks of 2C-B seem to be very moderated; probably 2C-B
acts as a "classical" psychedelic in terms of physical toxicity, that is
very low for substances like LSD or psilocybin.
The only study I
know about effects of 2C-B in humans is the one that our team published
last year, there you can find data about adverse effects .Although the
sample is small, I think those are the most recent data about 2C-B
http://www.slideshare.net/fernandocaudevilla/2cb
-
hey i guess i want to know what the medical society (other doctors,
scientists, etc.) thinks of the drug DMT?? Does it amaze
you? Im very interested to see what different people think of this
drug, or if they are even informed on it because i have recently tried
it and it blew my mind!!!
-
Hey doc, are 2cb and mdma cross tolerant? And while I have you, how cross tolerant is mda and mdma?
-
Hi Doc',
I think it's great what you're doing here ;)
I've
read you are quite suspicious to NBOME compared to LSD,
because of all the studies that have been done about LSD over the past
decade.
I would like to know what do you think of DOM (STP) ?
Thx you very much !
-
Hey doc, are 2cb and mdma cross tolerant? And while I have you, how cross tolerant is mda and mdma?
Hi, I also would like that.
How you'd see doing 2cb and next day candy/hippy flip?
Hola, también me gustaría saberlo
Hasta que punto ves peligroso hacer un día 2cb y el dia siguiente candy/hippy flip? Y a nivel de tolerancias?
Un saludo.
Por
cierto, tienes alguna direccion btc para hacer donaciones? Es mi
primera consulta pero me han servido muchas otras que he visto en otros
sitios y aqui mismo... realmente haces un enorme trabajo..
Edito: vi tu direccion en tu signatura. En cuando vuelva a tener btc te mando una donacion
-
hey doctor, sorry if this is already been asked
But what can
you tell me about the negative physical effects of using cocaine? Other
than chemical dependency, I already know that.
I have been using
it once every two weeks for the past month, one weekend two nights in a
row. Each night I consumed probably .4-.5 grams spaced out over about
four hours
-
Hola Doc,
Just curious if you knew about any possible
interactions between LSD\alprazolam\anti-psychotics, in the context of
taking either or both coming down from, or to end an LSD trip
prematurely. I've read anti-psychotics work best for bringing you back
down to earth quickly, but it seems like a small dose of xanax to try to
help cope with it and then an anti-psychotic as a back-up if that
doesn't work would be ideal.
-
Thanks for the thread, doc. Anxiously awaiting your response to Obkkoa and modafinil.
-
I just saw this thread, and I have already read it all. ;D
Are
you on CannabisCafe/Energy Control/etc ? Is just that the Spanish scene
is not that big, and I thought that I should had read or known about
you before as you seen pretty active even with a topic here on SR.
Well,
my questions are mainly related to the use of nootropics and
supplements as a harm reduction mechanism when taking other drugs.
I
take in a daily basis creatine, acetyl-l-cartinine, alpha-gpc and
multivitamin pills, taking some rest of them as is recommended to each
particular substance. I also take like 3 or 4 days per week some
pramiracetam and two days per week a pill of modafinil if I feel like I
want to do something productive for some time without feeling sleepy.
I'm an almost 19 years old healthy individual.
For the first ones, I
know that the evidence about them doing any kind of neuroprotective or
intelligence enhance in healhy young humans is mostly incidental, but
all in all, and being the use of them probably not very rational, I feel
comfortable as the risk are (as far as I know) almost nonexistent if
you take them with a good timing and low doses. Also maybe the
neuroprotective effects can be seen if the stack is maintained long
enough, but I haven't seen studies about that, and my consumption is
mostly based in Kurzweil etc Faith probably.
Does make sense use
attack doses of some vitamins, or take some neuroprotective stuff like
Noopept, pramiracetam etc when a consumption of some drug is planned ?
Can
my nootropic stack cause some problems taking into account that I'm
planning to take it for years ? Or this substances are almost innocuous
if taken correctly ? I change this stack from time to time. Probably
more and more will be added permanently eventually.
Do you think
that there is a considerable possibility of some RCs causing dramatic
effects in the medium-long term even if they are taken a few times ? I'm
talking mostly about nbomes, mxe, methylone, amt, mdpv, 4-ho-met,
5-meo-dmt etc And by dramatic, I mean some kind of
neurodegenerative/etc disease being directly caused by the drug action,
and with a high prevalence of the disease in the people who tried it.
Also, in another topics:
I
would like to know if there is some kind of organization or individuals
who is doing some pressure in Spain from a professional and scientific
side about the drug laws and prohibitions, and in which grade the actual
laws are based in factual data instead of FUD and tradition/particular
and biased opinions. Do you think we are far from some regulation at
least reaching substances as MDMA, speed, LSD etc ?
Do you think
that in a good environment with drugs regulated and an scientific and
business world arousing would be possible the development of drugs with
almost not negative reactions even if consumed weekly, or even more,
daily ?
I would love to have a potent stim for almost every day use,
they make me productive as hell. In my weeks, great days are caffeine
and modafinil days, and It's nothing compared to good speed or mdpv.
The
best would be methylphenidate, even if I don't like it as much as
speed, I suppose. But is expensive as hell, and ethylphenidate I don't
think is really an alternative. Is there really also a chemistry
difference to make 1 gr of ethylphenidate cost nothing compared to a few
pills of methylphenidate ? It's probably some fucking patent. :-X
Thanks, and sorry but I'm a little stim today and I cannot help me with the verbosity lol.
Yes, I´m working in Energy Control since 2003 as Medical Consultant.
http://energycontrol.org/infodrogas/el-consultorio-de-dr-x.html
It
is probable that common doses of nootropics, vitamins and supplements
you mention don´t have a significant negative effects, even in long term
use, as most of them are nutrients for the body or substances related.
But
what is the sense of using "attack doses" of supplements when using
drugs? First of all most psychoactives are not neurotoxic ( basically
alcohol and some amphetamines can have neurotoxic effects in some
patterns of use ), but cocaine, cannabis, opiates and "classical"
psychedelics are not. So there can´t be a protective effect. On the
other hand, water-soluble vitamines are harmless (eliminated with urine)
but lipophillic vitamines can be toxic in overdose.
The question
of long-term effects of RCs depends on the substance. Some of the drugs
you cite (AMT, 5-MeO-DMT) have been known for decades and it is not
probable that cause long term problems. In fact, there are a few
substances that can cause "some kind of neurodegenerative/etc disease
being directly caused by the drug action, and with a high prevalence of
the disease in the people who tried it". MPTP
(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is the classical example.
But risks of RCs are basically unknown and potentially higher than
classical substances.
In Spain the most important change in drugs
is related to Cannabis Associations. Personal use of drugs is not a
criminal offense in Spain and it is technically possible to associate to
cultivate cannabis. It is an interesting way to unblock the prohibition
(at least on cannabis). I think there will be substantial changes in
following years although South America seems now to be on the first
line. But I´m not an expert on drug politics.
The idea of a
drug with only pleasurable effects and no adverse effects is an uthopy.
All prescription drugs in the world have adverse and toxic effects,
they are properties inherent to the substances.
The difference
between methyl and ethylphenidate is not only a patent. Methylphenidate
has been used for decades and widely studied. There are 6528 studies on
MedLine of this substance and only 16 of ethylphenidate (none of them in
humans). And sometimes a single atom of carbon can make a big
difference. Ethanol is the alcohol of beverages, methanol is a toxin for
human eye that can make you blind. I don´t mean that it happens the
same with methyl and ethyphenidate but the fact that two molecules are
similar does not necessarily mean that effects and risks are so.
-
Great Thread!
It is a credit to humanity that people with the
knowledge, spend their time to offer it to the people that need it;
Well done DoctorX! on-wards humanity!
I have some questions for
you! I would like to understand more about the endocrine system and how
it is activated when smoking marijuana...which alkaloids affect it; THC,
CBD etc? Can a form of marijuana, for example oil, by used locally as a
healing treatment (salve). I am also interested in the current
'medicalisation' of marijuana; I have heard of strange patented forms
such as inhalers etc...and would like to know, your opinion, about the
efficacy of natural forms of marijuana over synthetic, for use in
medicine!
All the best,
NaturalOils
-
What about mixing LSD with anti headache pills like dolormin
specially? I get headache quite a lot after acid and would really
love to take some dolormin then but im always quite scared for what can
happen. I know lsd will make the heart rate go up and dolormin will make
the blood thinner. I can imagine thats not a good combination.
Is it possibly dangerous?
Dolormin
has a component thats called Lysin, that is to make the pill hit faster
(in like 10-15 mins ur headache is all gone). Maybe this could interact
with the drug too? Maybe drugs can even be perfected using this
substance to make it hit faster?
Also i figured when i use
dolormin the headache is gone forever most of the times. Feels like it
has healing powers too! maybe that could even help avoid getting
something destroyed in the brain by the drug? At least it can maybe help
to heal the parts that got destroyed (or attacked) better?
Thanks for your time in advance and have a great day!
-
hey
i guess i want to know what the medical society (other doctors,
scientists, etc.) thinks of the drug DMT?? Does it amaze
you? Im very interested to see what different people think of this
drug, or if they are even informed on it because i have recently tried
it and it blew my mind!!!
I´m sorry I don´t have personal experience with DMT and I don´t have a personal opinion on it.
There are some interesting theories about why DMT is produced in human brain. There is a very interesting documentary on DMT
http://www.youtube.com/watch?v=c4FaDMak-TQ
I don´t agree with some of the theories exposed but I think it is very interesting anyway
-
Would taking drugs such as MDMA and 25i-nbome a few days prior to smoking DMT have any effects on the DMT?
-
First of all: Thank you for your feedback and the service you provide here, DoctorX.
As
a person with +14 years of experience with cocaine, without making it a
daily habbit (Yes, that demands allot of self control). I am curious,
as to what your experience with cocaine and cocaine users may be? I
don't have a particular question as such. I am merely queries about the
feedback we may be able to give each other.
For instance: My advice to users of cocaine, that have startet to realise that it is starting to be "too much".
1: Break the cocaine - sex, associations.
Hopefully I am not the only one here, that knows what I am talking about?
-
Hi Doc',
I think it's great what you're doing here ;)
I've
read you are quite suspicious to NBOME compared to LSD,
because of all the studies that have been done about LSD over the past
decade.
I would like to know what do you think of DOM (STP) ?
Thx you very much !
DOM
(dimethoyxamphetamine) is a prototype of psychedelic amphetamine.
Probably the differences between DOM and LSD depends basically on dose.
At low-medium doses the psychedelic effects are quite similar (although
each substance develops its own psychedelic experience). But at
higher doses, physical effects (sweatining, dizziness, tachycardia,
anxiety...) are more noticeable with DOM. Duration of effects is,
indeed, longer with DOM but this property increases at higher doses
(until 48-72 hours). And effects start later with DOM (2-3 hours)
than with LSD; it is very important to remember this in order to avoid
overdosing.
From a "historical" point of view, DOM was a "classic"
during the sixties and has been studied enough. In this sense it is
quite similar to LSD more than to NBOME.
-
How often can mephedrone be used safely?
hat dosages to start with and in one session are recommended?
I've read that it is not neurotoxic, but I know this still means it needs to be used in moderation.
-
A mid-forties female has been suffering recurrent anxiety episodes
that lead to respiratory distress with hyperventilation syndrome.
Following a particularly serious attack of this type, a medical
screening and detailed exam showed "no evidence of any type of acute
emergency process at this time." BP at the time was mildly
elevated -- enough to suggest ongoing treatment for hypertension.
The patient's subjective experience of the recent, particularly serious attack includes the following:
- A multitude of voices shouting in her head, mixed with an overwhelming clamour of noise in general
- "I felt like I was dying"
-
Extreme confusion about her physical location. At different times
during the episode, she clearly stated her location as two different
places that are separated by 100 miles or more.
The patient has a
history of "seizures" that have been recurring infrequently for more
than 20 years. Information about the exact nature of these
episodes is sparse, but some of the incidents did lead to ER visits and
medical exams. At no time did any medical exams produce a
diagnosis of any organic process causing these "seizures," and they have
always been attributed to general anxiety. For much of this
historical period she has been a very heavy smoker of cannabis.
Light drinker, 1/4 pack per day cigarette smoker, no other drugs of
abuse.
Physically the patient is very slender. Her measured
body temperature tends to be lower than normal, yet her skin feels warm
to the touch -- warmer than an average person. She states that
she has had "thyroid problems"in the past but we have no specific
information about those.
Two weeks prior to the most recent spate
of anxiety attacks, the patient used DMT for the first time. This
was her first genuine psychedelic experience of any kind. In the
immediate aftermath of the trip she reported the usual feelings of
wonder, awe, and amazement, expressing a desire to do it again as soon
as possible and try a higher dose to achieve "breakthrough."
However
in the two week period that followed, this already slender woman lost
10 lbs, became increasingly anxious and irritable, and finally began
having the acute anxiety attacks that culminated in something resembling
a psychotic break.
The patient believes that the DMT trip caused, or at least precipitated, her psychiatric symptoms.
Any thoughts?
-
Hey doc, are 2cb and mdma cross tolerant? And while I have you, how cross tolerant is mda and mdma?
Hi, I also would like that.
How you'd see doing 2cb and next day candy/hippy flip?
Hola, también me gustaría saberlo
Hasta que punto ves peligroso hacer un día 2cb y el dia siguiente candy/hippy flip? Y a nivel de tolerancias?
Un saludo.
Por
cierto, tienes alguna direccion btc para hacer donaciones? Es mi
primera consulta pero me han servido muchas otras que he visto en otros
sitios y aqui mismo... realmente haces un enorme trabajo..
Edito: vi tu direccion en tu signatura. En cuando vuelva a tener btc te mando una donacion
First
of all, the degree of risk depends on dosage. Doses below 20 mg of 2C-B
are probably physically and mentally harmless, at least for most
healthy people. Tolerance between 2C-B and other psychedelics has not
been studied but, in my opinion and according to pharmacological way of
action there might be some degree of cross-tolerance. Probably this
effect it is not very big (would notice more with higher 2C-B dose) but I
think psychedelic effects could be more subtle, and after effects
(hangover) higher
-
Hola Doc,
Just
curious if you knew about any possible interactions between
LSD\alprazolam\anti-psychotics, in the context of taking either or both
coming down from, or to end an LSD trip prematurely. I've read
anti-psychotics work best for bringing you back down to earth quickly,
but it seems like a small dose of xanax to try to help cope with it and
then an anti-psychotic as a back-up if that doesn't work would be ideal.
In
my opinion, if you are planning to stop a LSD trip because is too long,
one alternative is to choose another short-acting psychedelic instead
(4-AcO-DMT or even psilocybes). If the reason to stop is anxiety, first
of all I would follow the Haight-Asbury recomendations (Techniques for
Treating The Acute Panic Reaction)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1503525/pdf/califmed00024-0019.pdf
If
it doesn´t work, a benzodiacepine will lower anxiety but it is not so
specific as antipsychotics. Chlorpromazine is the most studied in this
sense, although adverse effects make that it should be used with caution
and only if specifically needed.
-
Hola Doc,
Just
curious if you knew about any possible interactions between
LSD\alprazolam\anti-psychotics, in the context of taking either or both
coming down from, or to end an LSD trip prematurely. I've read
anti-psychotics work best for bringing you back down to earth quickly,
but it seems like a small dose of xanax to try to help cope with it and
then an anti-psychotic as a back-up if that doesn't work would be ideal.
In
my opinion, if you are planning to stop a LSD trip because is too long,
one alternative is to choose another short-acting psychedelic instead
(4-AcO-DMT or even psilocybes). If the reason to stop is anxiety, first
of all I would follow the Haight-Asbury recomendations (Techniques for
Treating The Acute Panic Reaction)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1503525/pdf/califmed00024-0019.pdf
If
it doesn´t work, a benzodiacepine will lower anxiety but it is not so
specific as antipsychotics. Chlorpromazine is the most studied in this
sense, although adverse effects make that it should be used with caution
and only if specifically needed.
Thanks
a lot DoctorX, the reading I've done since is making me lean towards
having a benzo handy but I'm quite intrigued by those techniques I'll
give it a read :)
-
Hi Doc',
I think it's great what you're doing here ;)
I've
read you are quite suspicious to NBOME compared to LSD,
because of all the studies that have been done about LSD over the past
decade.
I would like to know what do you think of DOM (STP) ?
Thx you very much !
DOM
(dimethoyxamphetamine) is a prototype of psychedelic amphetamine.
Probably the differences between DOM and LSD depends basically on dose.
At low-medium doses the psychedelic effects are quite similar (although
each substance develops its own psychedelic experience). But at
higher doses, physical effects (sweatining, dizziness, tachycardia,
anxiety...) are more noticeable with DOM. Duration of effects is,
indeed, longer with DOM but this property increases at higher doses
(until 48-72 hours). And effects start later with DOM (2-3 hours)
than with LSD; it is very important to remember this in order to avoid
overdosing.
From a "historical" point of view, DOM was a "classic"
during the sixties and has been studied enough. In this sense it is
quite similar to LSD more than to NBOME.
I think I will give DOM a try but you gave me priceless information to avoid redrop, I have not see that before.
Thanks Doc, nice to give us so much time and informations.
-
Doc I had a really uncomfortable bodyload on TMA-6 (45mg) never
experienced it before (nbomes, mephed, amps, those are said to be hard
vasoconstrictors drugs that i've taken and felt no physical discomfort)
I
don't have more tma but I am planing on taking some DOC, am I prone to
experience same bodyload ? (cold hands, a little numbing on the little
finger and some hours into the trip lowerback pain)
If this is vasoconstriction, what can I take or do to avoid it, Should I dress up, get heat, exercise, none of those?
Thanks doc, also great articles in your website.
-
I know MDMA's neurotoxicity is somewhat of a controversial topic.
According to what I've read, which may be wrong, you can find almost
equal amounts of evidence on either side, as to it being neurotoxic or
not. So try and be as explanatory as you can, shatter my illusions, or
whatnot.
Will rolling on it now have a significant effect on me
later in life? People often say neurotoxic, but never state what this
implies. Will it be safer if I limit the usage to a few times a year, or
is this still not desirable? Would rolling every couple of weeks have a
significantly awful effect on me later in life, specifically?
Give
a conservative answer if you must, but a reasonable one. :) I love
MDMA, but may want to limit the usage in case of any of these things.
-
Any information on the health risks of JWH-018 Dr?
-
hey doctor, sorry if this is already been asked
But
what can you tell me about the negative physical effects of using
cocaine? Other than chemical dependency, I already know that.
I
have been using it once every two weeks for the past month, one weekend
two nights in a row. Each night I consumed probably .4-.5 grams spaced
out over about four hours
Negative
effects of cocaine depends on factors as frequency, dosage, route of
administration and personal characteristics. In high doses or
susceptible persons it can lead to agitation, hostility, hallucinations,
convulsions...Stroke or heart attack are relativelly uncommon, although
intensive users and people with latent congenital heart defects, high
blood pressure, or thyroid problems are more susceptible to these
effects. Infections on nose and septum are possible (if the product is
not properly insufflated). Some people can develop psychiatric problems.
-
Dear Dr.
Because of you I did my work and put my 50 reply's
in to tell you I think you are great. Your answers are amazingly
cogent, especially, since I suspect, English is not your first
language. Now my question:
Assuming a person likes the
feeling derived from smoking weed but feels they like it too much and
are not in control. Are there any medicines you would recommend to
help stop the habit or would you suggest talk therapy to get a handle
on things or something else entirely?
You classify weed as a
minor psychedelic and you also suggest limiting ones use of these
substances. Do you also suggest a non-binge pot use for those who
choose to do it? My problem is if I have it I want to use it until
I don't have it anymore. Like a food addict who can't control the
sweet tooth.
SR is an intelligent alternative to both extremes
in the drug world when someone like yourself comes out of the
blue. Take note all you LEO's stalking these pages, treatment is
the answer not punishment. Thanks a bunch DoctorX.
-
Great Thread!
It
is a credit to humanity that people with the knowledge, spend their
time to offer it to the people that need it; Well done DoctorX! on-wards
humanity!
I have some questions for you! I would like to
understand more about the endocrine system and how it is activated when
smoking marijuana...which alkaloids affect it; THC, CBD etc? Can a form
of marijuana, for example oil, by used locally as a healing treatment
(salve). I am also interested in the current 'medicalisation' of
marijuana; I have heard of strange patented forms such as inhalers
etc...and would like to know, your opinion, about the efficacy of
natural forms of marijuana over synthetic, for use in medicine!
All the best,
NaturalOils
Effects
of cannabis are basically focused on Central Nervous System (activation
of CB1 receptors) and immune system (CB2 receptors). These are
responsibles of the therapeutic effects of cannabinoids in some diseases
(nauseas in chemotherapy, multiple sclerosis, neuropatic pain,
wasting-HIV syndrome...). CNS response produces an activation of
endocrine system (sexual and thyroid hormons, growth hormone...)
although these changes are not significant to humans, considering
pattern of use. SOme experiments have shown infertility in animals who
receive high doses of cannabinoids, but these data are not extrapolable
to humans.
More on neuroendocrine effects of cannabis: http://www.ukcia.org/research/EndocrineEffects.pdf
There is no evidence that salves, creams or oints have effect on topic use. Cannabinoids do not trespass the skin.
As
a medical practicioner I prefer synthetic compounds to natural ones in
medicine. Prescription drugs allow isolate molecules and calculate the
exact dose. I don´t beleive that natural plants are better than
medicines only by the fact that the first are "natural". Of course I
beleive also that the plant of cannabis can have benefits on health if
properly used but, in a therapeutical perspective, I prefer prescription
drugs. There are some important points or details (for example, the
fact that the sublingual extract of cannabis Sativex costs more than
400$), but that is other story...
-
Have you ever saw this documentary
http://topdocumentaryfilms.com/making-a-killing-the-untold-story-of-psychotropic-drugging/
and what's your opinion on it?
-
What
about mixing LSD with anti headache pills like dolormin
specially? I get headache quite a lot after acid and would really
love to take some dolormin then but im always quite scared for what can
happen. I know lsd will make the heart rate go up and dolormin will make
the blood thinner. I can imagine thats not a good combination.
Is it possibly dangerous?
Dolormin
has a component thats called Lysin, that is to make the pill hit faster
(in like 10-15 mins ur headache is all gone). Maybe this could interact
with the drug too? Maybe drugs can even be perfected using this
substance to make it hit faster?
Also i figured when i use
dolormin the headache is gone forever most of the times. Feels like it
has healing powers too! maybe that could even help avoid getting
something destroyed in the brain by the drug? At least it can maybe help
to heal the parts that got destroyed (or attacked) better?
Thanks for your time in advance and have a great day!
There
are not known interactions between ibuprofen (and NSAID in general) and
LSD. Lysine helps to make ibuprofen more soluble, and so enhances
absorption. But this is no useful for LSD or any other drug solubility
and will not make the absoprtion of other drugs faster. It also has no
effect in avoiding neurotoxicity of any drug.
-
Would taking drugs such as MDMA and 25i-nbome a few days prior to smoking DMT have any effects on the DMT?
I
don´t know studies covering this topic. In general, psychedelics can
create some cross-tolerance. Probably MDMA will not have a noticeable
effect on this, but it is possible that 25I-NBOMe has. Depending on dose
of 25I-NBOME and time between this drug and DMT this effect will be
noticeable or not. But this is only theoretical speculation and no based
in scientific studies.
-
First of all: Thank you for your feedback and the service you provide here, DoctorX.
As
a person with +14 years of experience with cocaine, without making it a
daily habbit (Yes, that demands allot of self control). I am curious,
as to what your experience with cocaine and cocaine users may be? I
don't have a particular question as such. I am merely queries about the
feedback we may be able to give each other.
For instance: My advice to users of cocaine, that have startet to realise that it is starting to be "too much".
1: Break the cocaine - sex, associations.
Hopefully I am not the only one here, that knows what I am talking about?
Cocaine
is a drug that can be more difficult to control than others. It doesn´t
mean that everybody who tries it, even who use it regularly, will
have a dependence problem. But dependence and abuse are a
frequent complication compared with other drugs.
Beyond
neurochemical and pharmacological questions, I think the cause for this
is that cocaine is a drug very useful for cotidiane activities. I
explain. For most people it is difficult to work, study or do routine
activities on LSD, MDMA, cannabis or alcohol. But cocaine is a drug that
fits very well in this sense. Even, it is possible that, in short time,
one can work or study better using cocaine. So it is a drug that can
easily go beyond the frontier between recreative and cotidiane
activities. In general, recreational use of drugs is less risky than
instrumental, operative use. If one person starts using cocaine outside
recreative settings and use it for work in a daily pattern of use, it is
more probable that will have associated problems.
Cocaine users
must be conscious about their pattern of use. I don´t think control is
impossible, but, at least for some people, it can be more difficult than
for other drugs
-
How often can mephedrone be used safely?
hat dosages to start with and in one session are recommended?
I've read that it is not neurotoxic, but I know this still means it needs to be used in moderation.
There
are not clinical trials using mephedrone in humans. The only data come
from animal studies, mice in concrete, and these data are not
extrapolable to humans:
http://www.ncbi.nlm.nih.gov/pubmed/22922498
In
this case, in order to estimate dosage, I recommend Erowid data. Please
note that, as it says in the page, "Erowid's dosage information is a
summary of data gathered from users, research, and other resources. This
information is intended to describe the range of dosages people report
using. It should not be construed as a recommendation of any sort.
Individuals can respond very differently to the same dosage. What is
safe for one can be deadly for another. "
http://www.erowid.org/chemicals/4_methylmethcathinone/4_methylmethcathinone_dose.shtml
In
relation to frequence of use, it happens the same. There is a lack of
data. But we know that mephedrone causes tolerance, so a minimum 2-week
frequence should be a safe way to avoid this problem, at least in theory
-
A
mid-forties female has been suffering recurrent anxiety episodes that
lead to respiratory distress with hyperventilation syndrome.
Following a particularly serious attack of this type, a medical
screening and detailed exam showed "no evidence of any type of acute
emergency process at this time." BP at the time was mildly
elevated -- enough to suggest ongoing treatment for hypertension.
The patient's subjective experience of the recent, particularly serious attack includes the following:
- A multitude of voices shouting in her head, mixed with an overwhelming clamour of noise in general
- "I felt like I was dying"
-
Extreme confusion about her physical location. At different times
during the episode, she clearly stated her location as two different
places that are separated by 100 miles or more.
The patient has a
history of "seizures" that have been recurring infrequently for more
than 20 years. Information about the exact nature of these
episodes is sparse, but some of the incidents did lead to ER visits and
medical exams. At no time did any medical exams produce a
diagnosis of any organic process causing these "seizures," and they have
always been attributed to general anxiety. For much of this
historical period she has been a very heavy smoker of cannabis.
Light drinker, 1/4 pack per day cigarette smoker, no other drugs of
abuse.
Physically the patient is very slender. Her measured
body temperature tends to be lower than normal, yet her skin feels warm
to the touch -- warmer than an average person. She states that
she has had "thyroid problems"in the past but we have no specific
information about those.
Two weeks prior to the most recent spate
of anxiety attacks, the patient used DMT for the first time. This
was her first genuine psychedelic experience of any kind. In the
immediate aftermath of the trip she reported the usual feelings of
wonder, awe, and amazement, expressing a desire to do it again as soon
as possible and try a higher dose to achieve "breakthrough."
However
in the two week period that followed, this already slender woman lost
10 lbs, became increasingly anxious and irritable, and finally began
having the acute anxiety attacks that culminated in something resembling
a psychotic break.
The patient believes that the DMT trip caused, or at least precipitated, her psychiatric symptoms.
Any thoughts?
It
is important to consider that it is not possible to give concrete
diagnosis based on Internet information, although you have explained
very well and detailed the situation. There is only one thing that
sounds strange in the story. The fact that " a multitude of voices
shouting in her head, mixed with an overwhelming clamour of noise in
general" does not coincide with panic attacks. There are some rare
diseases (like temporal epilepsy) that can curse with symptoms like
that. I´m not stating that is the cause of the problem, I´m only
pointing one possibility and the idea that, in general, auditive
alucinations are not typical of panic or anxiety.
Of course DMT
can trigger a psychotic problem. It is an uncommon situation but, in my
experience this can happen more frequently with DMT than other drugs. In
general, these episodies occur in pre-morbid, predisposed
personalities. The symptoms you describe could indicate this (once more,
it is only a possibility, I can´t be 100% sure). Anyway, if she is
experiencing psychotic symptoms I think she should search for
professional help. DMT psychosis usually have an excelent response to
antipsychotics and 2-3 months are enough for most patients. It is
important also to avoid DMT and psychedelics in general.
-
Doc
I had a really uncomfortable bodyload on TMA-6 (45mg) never experienced
it before (nbomes, mephed, amps, those are said to be hard
vasoconstrictors drugs that i've taken and felt no physical discomfort)
I
don't have more tma but I am planing on taking some DOC, am I prone to
experience same bodyload ? (cold hands, a little numbing on the little
finger and some hours into the trip lowerback pain)
If this is vasoconstriction, what can I take or do to avoid it, Should I dress up, get heat, exercise, none of those?
Thanks doc, also great articles in your website.
I´m
not sure the symptoms you are saying can be caused by true
vasoconstriction. There is a difference between "uncomfortable bodyload"
(that can be attributed to psychedelics changes of self-perceptions)
and vasoconstriction (blue fingers, pain, extreme hypertension and
tachycardia). Vasoconstriction is an uncommon and potentially very
dangerous situation associated to some drugs. But in fact it is not a
problem with DOC, or at least there are no known data in humans with
this problem. In fact there is only a fatal case known
http://www.ncbi.nlm.nih.gov/pubmed/19078842
-
Hola Doc,
I am an occasional (2-3 a month) user of
stimulants (coke, amphetamines, modafinil, mephedrone, nicotine). I've
been running (jogging) outside 3-4 times a week for 3 months with no
problems whatsoever.
I've used mephedrone last week and
nicotine daily (electronic cigarette). Since then, whenever I go for a
jog, I have to stop after 3 minutes because there is a strong pain in my
heart. I don't feel breathless, I just have to stop because of the
pain. Once I stop running, the pain disappears.
1) do stimulants have a long-term negative effect on your heart ?
2) does this pain could be related to mephedrone use or nicotine ?
Muchas Gracias !
-
Cocaine is directly cardiotoxic. It literally kills your heart.
-
I
know MDMA's neurotoxicity is somewhat of a controversial topic.
According to what I've read, which may be wrong, you can find almost
equal amounts of evidence on either side, as to it being neurotoxic or
not. So try and be as explanatory as you can, shatter my illusions, or
whatnot.
Will rolling on it now have a significant effect on me
later in life? People often say neurotoxic, but never state what this
implies. Will it be safer if I limit the usage to a few times a year, or
is this still not desirable? Would rolling every couple of weeks have a
significantly awful effect on me later in life, specifically?
Give
a conservative answer if you must, but a reasonable one. :) I love
MDMA, but may want to limit the usage in case of any of these things.
There
is evidence that intravenous or intraperitoneal administration of high
doses of MDMA produces neurotoxic changes in all animal species studied.
But these results of animal studies are not directly extrapolable to
humans. The doses used in these studies are far away to these used in
humans. One rat weights 0.1 kg; the dose in studies is 5-10 mg/kg/2
hours/4 times. That means, that, extrapolating to humans, 4-5 gr of
injected pure MDMA.
In addition, there is a great inter-species
different sensibility to MDMA neurotoxicity in mammals (rabbits, rats,
monkeys...) Even with the same species, some strains of animals (
Sprague-Dawley or Dark Agouti rats) show different sensibility to this
effects. Many times rats must be keeped in freezers during studies ;if
not, they die because of the massive MDMA doses. In summary, data from
studies are no worthy to humans.
There is no evidence that
occasional moderate doses (lower than 120-150 mg oral) have any
neurotoxic effects in humans. In fact at least four investigation teams
have been administrating MDMA to healthy human volunteers in clinical
trials with the approval of sanitary authorities and ethical comitees of
clinical trials.
The question of MDMA neurotoxicity is one of the
most controversial and complex. First of all, we should define what we
understand for "neurotoxicity", because it is not clear that some of the
changes observed mean a real toxic effect. For example, we can exactly
measure the degree of liver toxicity caused by alcohol by blood tests,
ecography, even biopsy. These tests have diagnostic and pronostic value
and are universally admitted in this sense.
But, with MDMA, we still
don´t know if changes in density neurorreceptors and images on PET or
SPECT are indicative of neurotoxicity, and what are the clinical
implications. Some studies (but not all) have found differences in
memory in heavy MDMA users. Some studies (but not all) have shown that
these deficit recover after some months-years of abstinence. What it is
clear that these effects appear only in heavy-long term MDMA users and
it is very difficult to know the exact role of MDMA, as there are many
factors (lifestyle, use of other drugs...) that can mislead results.
What
is clear is that moderate use of MDMA (in dose and frequency) has not
been linked to neurotoxic changes. The exact impact in heavy users is,
as far as I know, impossible to determinate. Is there a safe frequency?
Unfortunately the scientific investigations are not oriented to analyze
this, but to scare people about MDMA use. There are no data of MDMA
neurotoxicity in human ocassional use. No use of MDMA means risk zero.
In my opinion, use of “a few times a year” in moderate doses and safe
environments means an acceptable risk.
-
Any information on the health risks of JWH-018 Dr?
There
are significant reports of toxicity of JWH-018 and many other synthetic
cannabinoids. These substances produce desired effects similar to
cannabis, but health risks are much more important than cannabis ones.
Cannabis is almost physically harmless, but synthtetic cannabinoids are
not.
http://www.ncbi.nlm.nih.gov/pubmed/19652769
http://www.ncbi.nlm.nih.gov/pubmed/20531137
http://www.ncbi.nlm.nih.gov/pubmed/21740143
http://www.ncbi.nlm.nih.gov/pubmed/21802885
http://www.ncbi.nlm.nih.gov/pubmed/21970775
http://www.ncbi.nlm.nih.gov/pubmed/22245279
http://www.ncbi.nlm.nih.gov/pubmed/22417829
-
Cocaine is directly cardiotoxic. It literally kills your heart.
A
few searches brought up the idea that cocaine is the most cardiotoxic
drug. Yet I have a feeling that mephedrone is no better.
-
Dear Dr.
Because
of you I did my work and put my 50 reply's in to tell you I think you
are great. Your answers are amazingly cogent, especially, since I
suspect, English is not your first language. Now my question:
Assuming
a person likes the feeling derived from smoking weed but feels they
like it too much and are not in control. Are there any medicines
you would recommend to help stop the habit or would you suggest talk
therapy to get a handle on things or something else entirely?
You
classify weed as a minor psychedelic and you also suggest limiting ones
use of these substances. Do you also suggest a non-binge pot use
for those who choose to do it? My problem is if I have it I want
to use it until I don't have it anymore. Like a food addict who
can't control the sweet tooth.
SR is an intelligent alternative
to both extremes in the drug world when someone like yourself comes out
of the blue. Take note all you LEO's stalking these pages,
treatment is the answer not punishment. Thanks a bunch DoctorX.
Thanks.
Yes, as you see English is not my first language and my expression and
comprehension are limited. In fact I´m not sure if I have understood
your question.
I thinks drugs have to be used for pleasure, it must
be the person who controls the substance and not the opposite. For some
people, in some situations, with some substances...sometimes this can be
difficult. It someone thinks that his pattern of use is inadequate, and
feels unable to stop it, maybe it is the moment to look for help.
It is not a question of the concrete substance (you are talking about
cannabis, but it is the same for any other drug), but also the person
and the way he/she uses the drug.
Depending on the concrete case,
sometimes is necessary pharmacological help. But it is not a question of
substitute an illegal drug for a prescription drug (with this, we
create another addiction), but to use it wisely during a limited time,
with agreement of the patient. The concrete drug depends on the concrete
situation
-
Have
you ever saw this documentary
http://topdocumentaryfilms.com/making-a-killing-the-untold-story-of-psychotropic-drugging/
and what's your opinion on it?
I´m
sorry I don´t have time to see a 1.30 hour documentary. I have read the
summary and have a quick look but the issue does not interest me. It
sounds to me like conspiracy theories. Of course I think that excessive
prescription of drugs is a problem but the way the data are presented in
a parcial, inexact, alarmist and biased way.
-
Hola Doc,
I
am an occasional (2-3 a month) user of stimulants (coke, amphetamines,
modafinil, mephedrone, nicotine). I've been running (jogging) outside
3-4 times a week for 3 months with no problems whatsoever.
I've
used mephedrone last week and nicotine daily (electronic cigarette).
Since then, whenever I go for a jog, I have to stop after 3 minutes
because there is a strong pain in my heart. I don't feel breathless, I
just have to stop because of the pain. Once I stop running, the pain
disappears.
1) do stimulants have a long-term negative effect on your heart ?
2) does this pain could be related to mephedrone use or nicotine ?
Muchas Gracias !
I
can´t say exactly what can be happening but data you provide are enough
to reccomend search medical assistance. It is not sure that you have a
problem, even I don´t know if this problem is or not related to drugs.
But there are several respiratory and cardiac conditions with symptoms
like yours. It should be important to have a RX and cardio-respiratory
stress test to rule out the possibility of serious problems. In the
meanwhile, I reccomend you to stop jogging and using stimulants.
-
doctorx i wanted to know if there was a drug that can reverse the effects of meth and/or speed?
i think there such a drug for heroin??
thanks
-
doctorx i wanted to know if there was a drug that can reverse the effects of meth and/or speed?
i think there such a drug for heroin??
thanks
Naloxone
reverts completelly the effects of heroin. Although it should be used
in a medical environment, in case of emergency it can be used
intranasally if a person is completely unconscious and breathless after
an overdose of heroin.
Benzodiacepines can revert some of the effects
of meth or speed, but are not specific antidotes. They can alleviate
some symptoms of anxiety but will not be enough in case of a severe
intoxication
-
How often can mephedrone be used safely?
hat dosages to start with and in one session are recommended?
I've read that it is not neurotoxic, but I know this still means it needs to be used in moderation.
There
are not clinical trials using mephedrone in humans. The only data come
from animal studies, mice in concrete, and these data are not
extrapolable to humans:
http://www.ncbi.nlm.nih.gov/pubmed/22922498
In
this case, in order to estimate dosage, I recommend Erowid data. Please
note that, as it says in the page, "Erowid's dosage information is a
summary of data gathered from users, research, and other resources. This
information is intended to describe the range of dosages people report
using. It should not be construed as a recommendation of any sort.
Individuals can respond very differently to the same dosage. What is
safe for one can be deadly for another. "
http://www.erowid.org/chemicals/4_methylmethcathinone/4_methylmethcathinone_dose.shtml
In
relation to frequence of use, it happens the same. There is a lack of
data. But we know that mephedrone causes tolerance, so a minimum 2-week
frequence should be a safe way to avoid this problem, at least in theory
Thanks for your time.
I will look it up on erowid.
I always research drugs before I use them, but thee isn't too much info on Mephedrone that I have found.
-
In fact there is little information available about mephedrone in humans, besides several recent toxicity reports
http://www.ncbi.nlm.nih.gov/pubmed/23749863
http://www.ncbi.nlm.nih.gov/pubmed/23436895
http://www.ncbi.nlm.nih.gov/pubmed/23134715
http://www.ncbi.nlm.nih.gov/pubmed/22524925
There are on-going clinical studies giving mephedrone to humans, so I expect soon we will have more accurate data
-
In fact there is little information available about mephedrone in humans, besides several recent toxicity reports
http://www.ncbi.nlm.nih.gov/pubmed/23749863
http://www.ncbi.nlm.nih.gov/pubmed/23436895
http://www.ncbi.nlm.nih.gov/pubmed/23134715
http://www.ncbi.nlm.nih.gov/pubmed/22524925
There are on-going clinical studies giving mephedrone to humans, so I expect soon we will have more accurate data
I
will test it out anyway. Done a bit of reading and it seems to not be
neurotoxic. Read some erowid reports and it seems like it's somewhere
between MDMA and speed. Should be a good experience when I try it.
thanks DoctorX.
-
not sure is the right thread to ask.
first of all, I know is addictive, like other drugs or more, but it's not what im worried about.
I was thinking to smoke meth regularly (just some months), not more than once or twice a week.
which
is a safe dose to recover and don't get permanent effects/side effects?
if there is any chances at all to not get permanent effects...
probably it's too strong to use without risks.
once a week, twice in same day 15 + 15 after ~3 hours? or just 10+10?
twice a week regularly maybe is too much, few days to rest.
any hint?
I didn't found much searching around.
Thanks
-
passng a drug test in 10 days . just smoked a lot today and heavy for the past week.
-
DoctorX,
Cannabis users in some locations can semi-legally
use everyday for many ailments physical and/or psychological. Some
doctors make a practice of doing a quick checkup and routinely providing
the patient with a prescription. Do you think this is a rational
health care policy? Would you ever recommend a patient take
cannabis on a daily basis?
Southpark's 22 minute episode
'Medicinal Fried Chicken' makes great fun of this legalization
trend.
http://www.southparkstudios.com/full-episodes/s14e03-medicinal-fried-chicken.
-
DoctorX,
Cannabis
users in some locations can semi-legally use everyday for many ailments
physical and/or psychological. Some doctors make a practice of doing a
quick checkup and routinely providing the patient with a
prescription. Do you think this is a rational health care
policy? Would you ever recommend a patient take cannabis on a
daily basis?
Southpark's 22 minute episode 'Medicinal Fried
Chicken' makes great fun of this legalization trend.
http://www.southparkstudios.com/full-episodes/s14e03-medicinal-fried-chicken.
Of
course smoking cannabis is not medically valid, it is just a sham to
get weed legalized. There are pharmaceuticals derived from cannabis that
serve the same function, and those are what any legitimate doctor would
prescribe.
-
Of
course smoking cannabis is not medically valid, it is just a sham to
get weed legalized. There are pharmaceuticals derived from cannabis that
serve the same function, and those are what any legitimate doctor would
prescribe.
The
sham is the federal government strongly opposing cannabis use for any
purpose because the pharmaceutical companies control the FDA. If you
look at the information on whitehouse dot gov, their page reads like a
sales ad for the pharmaceuticals you mention. Big pharma is afraid of
cannabis because it works and has few side effects. It's just they can't
make any money on it unless they bastardize it and make a patented
'drug' out of it. Next will be GMO cannabis, if it doesn't already
exist.
-
No legitimate doctor is going to prescribe that people smoke a
cancerous substance, or consume orally a drug with unknown dosage, when
they can instead take a pill that is accurately dosed, does the same
thing and doesn't cause cancer.
-
No
legitimate doctor is going to prescribe that people smoke a cancerous
substance, or consume orally a drug with unknown dosage, when they can
instead take a pill that is accurately dosed, does the same thing and
doesn't cause cancer.
True,
but many users cannot afford medical care and are only able to
self-medicate or experiment on their own with various substances.
By understanding the benefits and risks involved in self-medicating
perhaps users could have a better experience and healthier longer term
outcomes. Just because we love something doesn't mean it is good
for us.
-
not sure is the right thread to ask.
first of all, I know is addictive, like other drugs or more, but it's not what im worried about.
I was thinking to smoke meth regularly (just some months), not more than once or twice a week.
which
is a safe dose to recover and don't get permanent effects/side effects?
if there is any chances at all to not get permanent effects...
probably it's too strong to use without risks.
once a week, twice in same day 15 + 15 after ~3 hours? or just 10+10?
twice a week regularly maybe is too much, few days to rest.
any hint?
I didn't found much searching around.
Thanks
Hi,
your
question is very difficult to answer as there is a lack of data about
it. In your question, "permanent effects" and "risks" are not defined
(physical?, psychological?, social?, all of them?. People use to think
that risks of drugs depend only on the substance (meth in this case),
but risks depend also on individual who uses it (age, sex, state
of health, motivations for use, previous experience with drugs,
psychological and social stete...) and the context of use. To valorate
the specific risks of a drug we need always to consider this data, and
this valoration is aproximative and not an exact, mathematic law.
I
think that using a high addictive drug (meth) in a high addictive way
of use (smoked) will probably lead to tolerance in a few weeks. At least
I think this is the most obvious and probable consequence. I´m not
saying you will irremediably become an addict, but it seems the most
obvious risk. In a physical perspective, it is unlikely that occasional
use of meth will lead to severe health conditions, but if it happens,
consequences would be serious.
-
No
legitimate doctor is going to prescribe that people smoke a cancerous
substance, or consume orally a drug with unknown dosage, when they can
instead take a pill that is accurately dosed, does the same thing and
doesn't cause cancer.
I'd
recommend looking into the birthplace of THC research, Israel. Doctors
there prescribe concentrates and the like in very controlled dosages
like any medicine should be, it really makes the American medical
marijuana industry sound like a bit of a joke.
It's a bit
foolish to write off all THC or marijuana-related substances as
potentially beneficial and necessarily inferior to mass-produced pharms
in my opinion. There's a huge amount of research still to be done, but
each different strain of cannabis has unique effects of concentrations
of varying cannabinoids that really does make it a medicine that can be
tailored to the individuals needs.
And the cancer shit I think
we've all heard, post some evidence that supports the claim there's
cancer-causing effects from smoking cannabis other than the obvious
carcinogens of inhaling any plant material. Not arguing there it's
clearly unhealthy in that aspect, but that's just one of many routes of
administration.
-
Can you explain some basics of tolerance?
Is it the depletion of
neurotransmiters, or the body gets used to cleaning the body of that
drug, is the brain that gets used to the effects?
-
Can you explain some basics of tolerance?
Is
it the depletion of neurotransmiters, or the body gets used to cleaning
the body of that drug, is the brain that gets used to the effects?
Think of it this way:
Every
component in your body works together to maintain homeostasis (or at
least what those components think is homeostasis). Drugs actually shift
the balance, creating an imbalance. That imbalance is oftentimes what
people experience as the "high." The brain, in this case, recognizes
this and starts to lower sensitivity to this intruder chemical causing
an imbalance so that the body and the brain can function at "normal"
levels once again.
That was the short and easy explanation lol
-
Two things:
1) The higher the high the lower the low?
2) Should we all just stop our experimentation and join a club or something?
"I´m not saying you will irremediably become an addict, but it seems the most obvious risk."
I
' m curious what you mean by irremediably? Actually I'm a gonna
lookee up that there number. It just don't look right if you know
what I mean. "Irremediably" means cannot be fixed, broken without
hope of repair, like all PC laptops after three or four years.
Two more things:
1) Can people avoid addictions by doing something?
2)
Why is it that no drug causes addiction in 100% of its users?
This includes nicotine which I thought was the most addictive drug other
than speed perhaps.
Thanks to the wisdom of those
who have come before us, also know as, we stand on the shoulders of
those who have come before us as well as give me a place to put my lever
and I will move the earth.
-
passng a drug test in 10 days . just smoked a lot today and heavy for the past week.
Most
urine test for cannabis will be positive after 7-10 days for occasional
users and 30-90 days for regular users. These data are orientative,
depend on the exact test used and also in individual characteristics.
-
DoctorX,
Cannabis
users in some locations can semi-legally use everyday for many ailments
physical and/or psychological. Some doctors make a practice of doing a
quick checkup and routinely providing the patient with a
prescription. Do you think this is a rational health care
policy? Would you ever recommend a patient take cannabis on a
daily basis?
Southpark's 22 minute episode 'Medicinal Fried
Chicken' makes great fun of this legalization trend.
http://www.southparkstudios.com/full-episodes/s14e03-medicinal-fried-chicken.
Cannabinoids
can be useful for treatment of symptoms of several diseases. There are
enough scientific data to support use of cannabinoids (THC/CBD) in
conditions as nausea and vomiting associated to chemotherapy,
HIV-wasting syndrome, urinary symptoms of multiple sclerosis or
neuropathic pain. Scientific investigation are oriented to prescription
drugs containing THC or THC/CBD, but it is a base for people who decide
to automedicate themselves with cannabis plant.
So I don´t agree
with the phrase " Of course smoking cannabis is not medically valid, it
is just a sham to get weed legalize". It is true that smoking is not a
good way of administration, but these problems can be avoided using an
approved vaporizator. Cannabis is not a medicine for everyone, as it has
psychoactive effects that many persons can consider as negative .
It is not also a panacea, as sometimes is shown. But can releive some
symptoms in many patients.
-
Hello,
Three questions:
1) Did you watch the linked Southpark episode? 1a) is it viewable in your land? 1b) Was it funny for you?
2) Where in the world is Carmen Sandiego?
3) Cannabis research points to which recommendation for its pleasure seeking users:
1)
Avoid
2) OK
Thank you kindly,
Mr. Clean "Squeaky" Sober
-
I've been mixing around with a few different psychedelics, mainly
DXM, LSD and 25I-nbome over the past couple of weeks and it's got to the
point that last night when I took 2 150ug LSD tabs, I did not
experience a single notable visual or auditory change, but it did feel
nearly identical to a moderate dose of ecstasy.
I was wondering
how much of a break should be taken between trips to ensure that you're
getting the full effect of the drug? And is there anything I can do to
help this process go faster?
Also, how long should one stay off LSD/25I before a drug test? (blood + urine)
-
Can you explain some basics of tolerance?
Is
it the depletion of neurotransmiters, or the body gets used to cleaning
the body of that drug, is the brain that gets used to the effects?
A
basic, intuitive approach to tolerance means that the body adapts to
extern stimulli and searches for balance. If someone lifts a heavy
weight everyday, the body will adapt growing muscles, for example.
In pharmacology, both mechanisms you point are involved on tolerance, depending on specific drug:
"The
body gets usea to cleaning the drug" means that liver creates more
enzymes to break some drugs (for example this is the mechanism involved
in tolerance to alcohol).This is technically called "pharmacocynetic
tolerance".
"The brain gets used to effects" means that
neurorreceptors in brain are less expressed (diminish in number) or less
sensitive (the same stimulus causes less neurotransmissor release) when
drug use is more frequent. This is called "pharmacodynamic tolerance"
and is involved, for example, in amphetamines or opiates tolerance.
Usually, tolerance is a mix of both mechanisms in different proportions.
-
Two things:
1) The higher the high the lower the low?
2) Should we all just stop our experimentation and join a club or something?
"I´m not saying you will irremediably become an addict, but it seems the most obvious risk."
I
' m curious what you mean by irremediably? Actually I'm a gonna
lookee up that there number. It just don't look right if you know
what I mean. "Irremediably" means cannot be fixed, broken without
hope of repair, like all PC laptops after three or four years.
Two more things:
1) Can people avoid addictions by doing something?
2)
Why is it that no drug causes addiction in 100% of its users?
This includes nicotine which I thought was the most addictive drug other
than speed perhaps.
Thanks to the wisdom of those
who have come before us, also know as, we stand on the shoulders of
those who have come before us as well as give me a place to put my lever
and I will move the earth.
1)
In general yes, "the higher the high, the lower the low". Sometimes
there can be a big high without a significative low or vice versa, but
in general this is the way.
2) I think I have not expressed myself
correctly. "Irremediably" is probably a bad translation from Spanish. I
tried to say that, using meth the way you pretend addiction will not be
an automatic, direct or sure consequence, but the risk is significative.
3)Using
addictive substances wisely in doses and frequency lower the risk of
addiction. The more frequent or long is the pattern of use, the risk of
addiction is higher
4) Basically we all are different and there is an
interaction between the drug and personality. For some people
(genetical , educational or social characteristics) it is easier or more
difficult to develop addictive behaviours, even with substances like
nicotine
-
Hello,
Three questions:
1) Did you watch the linked Southpark episode? 1a) is it viewable in your land? 1b) Was it funny for you?
2) Where in the world is Carmen Sandiego?
3) Cannabis research points to which recommendation for its pleasure seeking users:
1)
Avoid
2) OK
Thank you kindly,
Mr. Clean "Squeaky" Sober
1)
Yes, I had a lot of fun with it. I think it contains very intesting
lessons about war on drugs and testicular cancer. I´m not an expert on
drugs politics but there are several ways of legalizing drugs, each one
of them with their own pros and cons. The "medical model" (as shown in
the episode) should have some problems as shown in the episode
2) I have no idea, but it must be exhausting running away all the time
3) I regret I didn´t understand the meaning of the question...could you express in other words?
-
not sure if you have background with knowledge about anabolics, but here goes nothin.
what
is your opinion on adequate levels of testosterone in a healthy male in
his early 20s? I have had a few tests done by my GP and by an
endocrinologist. My total test is virtually 0 mg/dL during the day, and
around 350 mg/dL when being tested around 8 in the morning. Ive been
working out for over 3 years and cant get any bigger with a solid diet.
Im not sure if i should just start cycling juice to get bigger or if I
should actually be seeking testosterone replacement therapy from a
different doctor. But I have read a lot stating that TRT will cause
impotency, and cycling usually does not cause impotency BUT has the
potential to cause it. So I guess what I am asking is whether or
not you think I should consider seeking out a different doctor for TRT
or if I would be better off just cycling test and other juice. And also I
am curious to just hear your opinion in regards to health in general
about cycling anabolics, progesterones, DHTs, other performance
enhancers, etc.
also:
+100 to a doctor that isnt a douchebag.
plz respond.
-
Hey doctor, sorry to bother if so, i didnt read all the pages so
sorry if this as been asked before. Ive made another topic where ive
been asking for "natural" remedies for cancer, ive got a friend who has
been thrugh a surgery of colo-rectal cancer, then he went to chimio and
now after 1 month cancer came back. I was about to give him ganoderma
lucidum (reishi, lingh zhi), DCA, and rick's oil made from myself, what
do u think about this? And i guess most important, he's doing some
alcalyne diet, no sugar, no acids, something else to help? I'll
apreciate your point of view on this subject.
-
Abstract: Writer wondering if he can smoke weed with the good
Doctor's permission. Looking for loopholes in the health care
system.
Yes, it must be exhausting for Carmen to run
all the time, exactly how I felt about football fifty years ago.
How could anyone run so dynamically for those long durations and not be
superhuman? Now I understand how, with proper training, nearly
anyone can enjoy the game. One reported danger for the
advanced footballer is the concussive effect of headers. Many
sports pose a potential danger to the developing brain. Brain
research always seems to focus on youth players and not how the brain
reacts to trauma after it is fully developed.
Along these
lines, what is your view of persons under 25 using cannabis?
For years I preached to my two, youngest 19, kids to avoid pot
until they reached the age of 25 or later. My readings indicate
the brain is developing and continues to do so until 25, by using
cannabis we may compromise this stage. There was a recent
long-term longitudinal study concluding there are significant IQ
reductions with certain patterns of use. A similar sort of study
indicated potential trauma for young people overindulging in alcohol as I
recall. My question then is, do you think younger people should
be more cautious than older folks need to be when deciding how to
pleasure themselves (pun intended, masturbate) using pot or
alcohol? Do you think the older brain has a built-in protection
against the potential damage simply because the older brain is less
active may have both a physical and psychological immunity built up by
having years and years of plain vanilla consciousness?
-
not sure if you have background with knowledge about anabolics, but here goes nothin.
what
is your opinion on adequate levels of testosterone in a healthy male in
his early 20s? I have had a few tests done by my GP and by an
endocrinologist. My total test is virtually 0 mg/dL during the day, and
around 350 mg/dL when being tested around 8 in the morning. Ive been
working out for over 3 years and cant get any bigger with a solid diet.
Im not sure if i should just start cycling juice to get bigger or if I
should actually be seeking testosterone replacement therapy from a
different doctor. But I have read a lot stating that TRT will cause
impotency, and cycling usually does not cause impotency BUT has the
potential to cause it. So I guess what I am asking is whether or
not you think I should consider seeking out a different doctor for TRT
or if I would be better off just cycling test and other juice. And also I
am curious to just hear your opinion in regards to health in general
about cycling anabolics, progesterones, DHTs, other performance
enhancers, etc.
also:
+100 to a doctor that isnt a douchebag.
plz respond.
I
can´t find an explanation to your variations in testosterone levels.
First of all you should get an accurate diagnostic (to find if there is
some physical problem and what it is the cause) and then see if you need
a treatment and what are the options.
"TRT will cause impotency,
and cycling usually does not cause impotency " is a very big
simplification, in my opinion. It all depends on causes, persons,
dosages and patterns of use. Some regimes (of both TRT and cycling) can
cause little or many problems, depending on dose and exact
characteristics of the person.
In my opinion, the approach of
steroids cycling should be similar to any other drugs. There are
patterns of use reasonabily safe and others more dangerous. The problem
is that, with recreative use of drugs it is easy to find valid
information focused on risk reduction and responsible use. But with
steroids there is a lack of this information. You will find some people
saying that any use of steroids will cause gynaecomastia, loss of hair,
cancer and impotence. But you will find also people talking about cycles
with megadoses of different products that can have a significant impact
on health. It is difficult to find reasonable information. In general I
do not reccomend steroids use under 25 years aprox. I have an article
about it in my web page, although it is in Spanish and I don´t know if
automatic translators will help
http://www.doctorcaudevilla.com/index.php/las-sustancias/92-uso-responsable-de-esteroides-anabolizantes
-
My doctor told me opiates can cause problems with testosterone.
-
Hey
doctor, sorry to bother if so, i didnt read all the pages so sorry if
this as been asked before. Ive made another topic where ive been asking
for "natural" remedies for cancer, ive got a friend who has been thrugh a
surgery of colo-rectal cancer, then he went to chimio and now after 1
month cancer came back. I was about to give him ganoderma lucidum
(reishi, lingh zhi), DCA, and rick's oil made from myself, what do u
think about this? And i guess most important, he's doing some alcalyne
diet, no sugar, no acids, something else to help? I'll apreciate your
point of view on this subject.
When
I express my professional opinion of any subject I try to always use
the same the same criteria: evidence provided by scientific research.
This is valid when we talk about adverse effects and risks of
recreational drugs and also for cancer treatment.
In my point of
view, if there are not enough valid scientific investigations about one
treatment, it should be considered as useless. Unfortunately this
is the case for Ganoderma lucidum or alkaline diet and so many other
"natural" treatments. Data from Ganoderma lucidom come from in vitro
test in laboratory conditions and the effects on human treatment of
cancer are not proved. And there are no data in humans showing efficace
of alkaline diet.
I don´t think these treatments should be
dismissed, if they are used as complementary treatments and the patient
continues to use conventional options. It is very important to be
careful and sensitive offering hope to people suffering from incurable
or difficult to cure diseases. If someone feels better using non-toxic
alternative therapies while continuing to use standard treatments, the
complementary therapy can't hurt and may give hope to the patient.
Rick
Simpson´s oil is particularly annoying for me (right, this is more a
personal than professional point of view). It is a mixture of
conspirative theories, data out of context, pharmacological
incongruences suggesting a global conspiration aganist cannabis
therapeutic use. He says that cannabis cures cancer, suggesting that
conventional treatments are toxic. There is absolutly no data to suspect
that it will work.
Of course we still can be critical with
conventional medicine and its often times over-technical and dehumanized
approach.. And pharmaceutical industry is not an innocent one. But that
does not mean that there is a global conspiracy about cannabis and, I
repeat, there is nothing to think that his method can work. As I work
offering advice to people who use therapeutic cannabis (for nausea in
chemotherapy, neurological diseases or neuropathic pain) I feel myself
authorized that all the story is a fraud.
-
Rick
Simpson´s oil is particularly annoying for me (right, this is more a
personal than professional point of view). It is a mixture of
conspirative theories, data out of context, pharmacological
incongruences suggesting a global conspiration aganist cannabis
therapeutic use. He says that cannabis cures cancer, suggesting that
conventional treatments are toxic. There is absolutly no data to suspect
that it will work.
DoctorX,
I'm curious if you have ever heard of or have an opinion on the
supposed therapeutic benefits of 'juicing' with cannabis. My curiosity
was piqued from the short video (12 minutes) that I'll post below, I
apologize I don't have an article handy with the same information but it
seems most claims are being substantiated by dietary physicians. They
have some pretty 'out there' ideas, but if you had the time I'd love to
hear your thoughts on it.
Video link: http://www.youtube.com/watch?v=DE4pK0U4NJo
"Cannabis is the most importable vegetable on the planet"
-
Hello doctor!
Do you know any safe way of reducing vasoconstrictive effect of LSD/NBOMe?
-
Thank u so much for your answer, i will consider your opinion and in fact, its pretty reasonable.
-
I am curious about drug testing and ways to naturally pass a urine
analysis dont in a lab that will be detailed and looking for specific
usage. Obviously, being clean is the best option.
However,
lets say a person takes the test in the morning one day and last used
the night before that. For example, test is Monday and person last
took some pain pills on Saturday night and was using daily but not
excessively before that.
The lab will be testing for flush kits
and the like. So, is there a way to flush out the metabolites and
other markers for the use of opiates in that short of a time
frame? I already drink a lot of water, take a Vitamin B Complex
daily, as well as creatine.
Any suggestions you have would be great?
-
Abstract:
Writer wondering if he can smoke weed with the good Doctor's
permission. Looking for loopholes in the health care system.
Yes,
it must be exhausting for Carmen to run all the time, exactly how I
felt about football fifty years ago. How could anyone run so
dynamically for those long durations and not be superhuman? Now I
understand how, with proper training, nearly anyone can enjoy the
game. One reported danger for the advanced footballer is the
concussive effect of headers. Many sports pose a potential danger
to the developing brain. Brain research always seems to focus on
youth players and not how the brain reacts to trauma after it is fully
developed.
Along these lines, what is your view of persons
under 25 using cannabis? For years I preached to my two,
youngest 19, kids to avoid pot until they reached the age of 25 or
later. My readings indicate the brain is developing and continues
to do so until 25, by using cannabis we may compromise this stage.
There was a recent long-term longitudinal study concluding there are
significant IQ reductions with certain patterns of use. A similar
sort of study indicated potential trauma for young people overindulging
in alcohol as I recall. My question then is, do you think younger
people should be more cautious than older folks need to be when deciding
how to pleasure themselves (pun intended, masturbate) using pot or
alcohol? Do you think the older brain has a built-in protection
against the potential damage simply because the older brain is less
active may have both a physical and psychological immunity built up by
having years and years of plain vanilla consciousness?
The
idea that use of drugs by young people is more risky because of
developing brain is very frequent. Strangely, some psychiatrists who
defend this don´t use the same criteria when prescribing antidepressants
, new anticonvulsives or amphetamine derivatives for illnesses of
uncertain diagnostic in adolescents.
In general, I agree with
this idea. Among professional who treat drug problems, there is a
general agreement about this. People who start using drugs (both legal
and illegal) at younger ages are more prone to develop problems related
with their use. But it is very difficult to prove in scientific studies
that a specific neurocognitive, neurological or psychological problem it
is caused by the use of one specific drug and not by other factors. And
it is not clear what should be the exact age that would lower the risk.
I
prefer to think about this in a wider, general point of view. It is not
only the neurological question, but also personal, psychological and
social factors. In general, people at thirties are more mature than at
twenties or teenagers, simply because experience of life. As many other
things in life, experience makes that (in general) an adult can use
drugs in a better way than adolescents.
But it is important a
social context that aids adolescents the right way of using drugs. In
mediterranean culture adolescents learn to use alcohol in family. There
is a "social control" about it that works reasonabilly right. But the
actual context with the rest of drugs does not make this easy. Anti
drugs laws are supposed to "protect the children" but paradoxically it
is easier for a teenager to find pot than for an adult.
If an
adolescent or a young adult is "well-educated" (that can mean a wide
range of factors: self esteem, responsability, ability to make
decissions, reflexivity...) it is unlikely that ocasional use of drugs
will cause many problems. Of course some patterns of use of
psychoactives in teenagers are inadequate. But I think it is not a
question of "all or nothing", but the mix of different factors.
-
Omg this is so cool. I appreciate the fact that the board has this.
What
do we know for sure about bath salts? Why do people call it
poison? Are they neuro toxic? If so to what degree? What are some
of the most common problems and ways to avoid them while on the drug?
-
Abstract:
Writer wondering if he can smoke weed with the good Doctor's
permission. Looking for loopholes in the health care system.
Yes,
it must be exhausting for Carmen to run all the time, exactly how I
felt about football fifty years ago. How could anyone run so
dynamically for those long durations and not be superhuman? Now I
understand how, with proper training, nearly anyone can enjoy the
game. One reported danger for the advanced footballer is the
concussive effect of headers. Many sports pose a potential danger
to the developing brain. Brain research always seems to focus on
youth players and not how the brain reacts to trauma after it is fully
developed.
Along these lines, what is your view of persons
under 25 using cannabis? For years I preached to my two,
youngest 19, kids to avoid pot until they reached the age of 25 or
later. My readings indicate the brain is developing and continues
to do so until 25, by using cannabis we may compromise this stage.
There was a recent long-term longitudinal study concluding there are
significant IQ reductions with certain patterns of use. A similar
sort of study indicated potential trauma for young people overindulging
in alcohol as I recall. My question then is, do you think younger
people should be more cautious than older folks need to be when deciding
how to pleasure themselves (pun intended, masturbate) using pot or
alcohol? Do you think the older brain has a built-in protection
against the potential damage simply because the older brain is less
active may have both a physical and psychological immunity built up by
having years and years of plain vanilla consciousness?
The
idea that use of drugs by young people is more risky because of
developing brain is very frequent. Strangely, some psychiatrists who
defend this don´t use the same criteria when prescribing antidepressants
, new anticonvulsives or amphetamine derivatives for illnesses of
uncertain diagnostic in adolescents.
In general, I agree with
this idea. Among professional who treat drug problems, there is a
general agreement about this. People who start using drugs (both legal
and illegal) at younger ages are more prone to develop problems related
with their use. But it is very difficult to prove in scientific studies
that a specific neurocognitive, neurological or psychological problem it
is caused by the use of one specific drug and not by other factors. And
it is not clear what should be the exact age that would lower the risk.
I
prefer to think about this in a wider, general point of view. It is not
only the neurological question, but also personal, psychological and
social factors. In general, people at thirties are more mature than at
twenties or teenagers, simply because experience of life. As many other
things in life, experience makes that (in general) an adult can use
drugs in a better way than adolescents.
But it is important a
social context that aids adolescents the right way of using drugs. In
mediterranean culture adolescents learn to use alcohol in family. There
is a "social control" about it that works reasonabilly right. But the
actual context with the rest of drugs does not make this easy. Anti
drugs laws are supposed to "protect the children" but paradoxically it
is easier for a teenager to find pot than for an adult.
If an
adolescent or a young adult is "well-educated" (that can mean a wide
range of factors: self esteem, responsability, ability to make
decissions, reflexivity...) it is unlikely that ocasional use of drugs
will cause many problems. Of course some patterns of use of
psychoactives in teenagers are inadequate. But I think it is not a
question of "all or nothing", but the mix of different factors.
Thanks
for this, Doc. I am loathe to sound like I'm recommending drug use to
adolescents. I'm not. But I think your point about responsible (I would
add conscious and safe) use of not just alcohol by adolescents also
appears with sacred uses of plant-based drugs as well.
-
My guess is many younger users find it problematic to avoid bad drug
use habits. This holds true for all forms of altered
thinking. What I wonder is if being drunk was our normal mental
state would drugs that mimicked sobriety be illegal? My guess is
that they would be. One of my yoga teachers told his
students to forget about learning to stand on our head, what we need to
do is to learn to stand on our feet first. Anyone who has
attempted to slackline can appreciate this.
-
That would be something if everyone was drunk all the time unless they were on a drug. What a fascinating question though??
-
The
idea that use of drugs by young people is more risky because of
developing brain is very frequent. Strangely, some psychiatrists who
defend this don´t use the same criteria when prescribing antidepressants
, new anticonvulsives or amphetamine derivatives for illnesses of
uncertain diagnostic in adolescents.
In general, I agree with
this idea. Among professional who treat drug problems, there is a
general agreement about this. People who start using drugs (both legal
and illegal) at younger ages are more prone to develop problems related
with their use. But it is very difficult to prove in scientific studies
that a specific neurocognitive, neurological or psychological problem it
is caused by the use of one specific drug and not by other factors. And
it is not clear what should be the exact age that would lower the risk.
I
prefer to think about this in a wider, general point of view. It is not
only the neurological question, but also personal, psychological and
social factors. In general, people at thirties are more mature than at
twenties or teenagers, simply because experience of life. As many other
things in life, experience makes that (in general) an adult can use
drugs in a better way than adolescents.
But it is important a
social context that aids adolescents the right way of using drugs. In
mediterranean culture adolescents learn to use alcohol in family. There
is a "social control" about it that works reasonabilly right. But the
actual context with the rest of drugs does not make this easy. Anti
drugs laws are supposed to "protect the children" but paradoxically it
is easier for a teenager to find pot than for an adult.
If an
adolescent or a young adult is "well-educated" (that can mean a wide
range of factors: self esteem, responsability, ability to make
decissions, reflexivity...) it is unlikely that ocasional use of drugs
will cause many problems. Of course some patterns of use of
psychoactives in teenagers are inadequate. But I think it is not a
question of "all or nothing", but the mix of different factors.
So
how would you recommend parents to discussion drug use with Children?
What the best way for us parents (I know some of most likely are) to
discuss drugs with our offspring. I don't want to promote all drug all,
but I certainly wouldn't want them missing out on positive use of some
psychedelics .
-
My doctor told me opiates can cause problems with testosterone.
It
is true that there is a relation between some opiates and testosterone
levels. Long term use of prescription opiates or opiates used in
treatment of opioid dependence (buprenorphine, naltrexone...) are the
most studied.
http://www.ncbi.nlm.nih.gov/pubmed/14622741
http://www.ncbi.nlm.nih.gov/pubmed/18093096
It
all depends on specific opiate and pattern of use. One aspect with
opium or heroin is a loss of sexual interest during its effects (at
least for most people).
-
This thread is a good read. Third year med student here with way too much knowledge about pharmacokinetics.
I'll try to answer what I can when I can.
-
So
how would you recommend parents to discussion drug use with Children?
What the best way for us parents (I know some of most likely are) to
discuss drugs with our offspring. I don't want to promote all drug all,
but I certainly wouldn't want them missing out on positive use of some
psychedelics .
I'm
no parent so take this with a grain a salt because the subjectivity of
this is off the charts. Personally I believe, depending on the age of
the child of course, that honesty works great. I was a very intuitive
child and knew my parents were smoking pot or whatever. Would even go
pick the plants for my relatives when the time came lol.
If you
feel your kids have a good grasp on right and wrong, then there is no
reason you shouldn't explain to your children what you do and to educate
them on the potentially negative aspects of it. Parents always told me
that you're going to experiment in high school and college, just use
your brain and do not be afraid to call us if something bad happens.
From my experience, the parents that sheltered their kids from it always
had the children most likely to try out this forbidden thing they
weren't even supposed to know about.
Again, it's all subjective but if the children are level headed, they will understand.
-
Although prices are better on Atlantis, a community like this one is
way more work to maintain and develop than merely offering low prices.
To
the 3rd year med stud "stayawake", would you say you are the exception
to the norm among fellow students? My guess would be it would take
too much energy away from bio chem and the rest of it, consequently few
med studs would be here investigating like you are?
DoctorX,
Does
the health care system in Spain reward you financially as much as say a
plastic surgeon in the States? My reading of the literature
indicates that the Spanish economy is in some sort of trouble. Do
you agree with this assessment and if so how does this crisis affect the
health care system? Also, do you think you could train a
competent janitor to talk like a doctor in a few weeks? If so I
will travel to Madrid if you are willing to both teach me Spanish (may
take longer than three weeks, more like three years, I think) as well as
how to be a Doctor. Yes I'm joking but all kidding aside what do
you think of Nuvigil as an legal alertness drug? Thanks.
Have a nice day,
Mr. Clean, Esq.
my web site: short form: http://bit.ly/1beuN1L
or for the PGP group, this is the full link:
http://www.mrclean.com/en_US/home.do?utm_source=google&utm_medium=cpc&utm_term=mr%20clean&utm_campaign=Mr.+Clean_Search_Desktop_Brand+Awareness&utm_content=syMeoh9EH_15185172069_p_mr%20clean
-
To
the 3rd year med stud "stayawake", would you say you are the exception
to the norm among fellow students? My guess would be it would take
too much energy away from bio chem and the rest of it, consequently few
med studs would be here investigating like you are?
I
would say that I'm an anomaly with regards to openly discussing/reading
about illegal narcotics on a site like this. Ironically enough, a
fellow med student actually turned me on to SR. To answer your question
though, I don't expend a lot of energy here or "researching" anything,
I've just always been fascinated with drugs and how they work in the
body all the way to the molecular level.
This probably isn't
surprising to everyone but many people would be shocked at the amount of
med students/residents that abuse
amphetamines/modafinil/methylphenidate. If I wasn't a statistic myself, I
would go as far as saying its an epidemic. ;)
-
How repairable are veins? Does the scar tissue and damage stay done
or for how long would it need to really repair itself. This would be
with an injection 3-4 times a week with rotating sites
-
Very subjective answer.
It all depends on the extent of the
damage to the veins themselves as well as the location of the tracks.
Healing depends on tons of different factors from how often the site
reused, the type of dope or cut that was in the product, and even stuff
like basic genetics.
I would think a dermatologist could give you at least some options despite the embarrassment.
-
stayawake,
Thanks for the new word, pharmacokinetic. I
thought it meant something about lsd but I see it has to do with how the
body deals all drugs not just psychoactive ones. My instant expert
thinking makes me think most folks on SR are more concerned with
pharmacodynamics, would you agree? In my post I meant to say I
would be surprised to hear if med students could afford to lose 4-12
hours tripping given the work load required to get the coveted MD title.
smogmonster13,
When
you say "sacred uses of plant-based drugs" do you include synthesized
drugs under the sacred heading or only naturally occurring ones?
We westerners seem to have abandoned or never developed rituals
for sacred anything especially all things related to drugs, this unless
you consider "happy hour" a sacred ritual.
-
I would like to know just exactly how caustic/damaging the
insufflation of adderall/amphetamine is (no cocaine, methamp, opiates,
etc.).
Clearly it's terrible and should not be used to put drugs
into your body, but unfortunately I have discovered & chase the
euphoria associated with it.
Specifically I am wondering what
exactly is this 'caustic' action that takes place with continued use.
Does one's nasal cavity start to literally disintegrate or deteriorate?
Are there any breathing problems as a result (excluding the obvious
effect on sense of smell)? At what point (like any physical signs)
should you know you need to be done for good?
Also: random myth I
would like debunked because I hope you have experience with
adderall/stims being an MD :) Is it true that the powder from crushed
adderall pills (either IR or XR) has some wax that clogs one's nose
making in ineffective? Based on personal experience I don't feel like it
does, but my friend swears by it
-
Rick
Simpson´s oil is particularly annoying for me (right, this is more a
personal than professional point of view). It is a mixture of
conspirative theories, data out of context, pharmacological
incongruences suggesting a global conspiration aganist cannabis
therapeutic use. He says that cannabis cures cancer, suggesting that
conventional treatments are toxic. There is absolutly no data to suspect
that it will work.
DoctorX,
I'm curious if you have ever heard of or have an opinion on the
supposed therapeutic benefits of 'juicing' with cannabis. My curiosity
was piqued from the short video (12 minutes) that I'll post below, I
apologize I don't have an article handy with the same information but it
seems most claims are being substantiated by dietary physicians. They
have some pretty 'out there' ideas, but if you had the time I'd love to
hear your thoughts on it.
Video link: http://www.youtube.com/watch?v=DE4pK0U4NJo
"Cannabis is the most importable vegetable on the planet"
In
comparision with other documentals about therapeutical cannabis, the
one you showed seems reasonable. There are some different ways to
extract the cannabinoids from the plant, and tjat "juicing" method
sounds reasonable, although I´m not an expert on botanical and plants.
The
important thing is that, as any other medicinal plant in the world,
applications of cannabis are limited. Nausea from chemotherapy,
neuropathic pain, symptoms of multiple sclerosis and wasting syndrome of
HIV are the most important applications for cannabinoids. And, as any
other drug, they can have interactions, contraindications and not be
adequate for everyone. Sometimes therapeutic cannabis is shown as a
panacea for all diseases, I don´t think that is true.
-
Hello doctor!
Do you know any safe way of reducing vasoconstrictive effect of LSD/NBOMe?
LSD
has not vasoconstrictive effects. The molecule of LSD is related to
some vasoconstrictors but LSD itself does not have this risk. In fact
LSD is physically harmless and has been widely studied for over 80
years.
On the other hand, there is little information about
NBOMe. It is a very new molecule, first detected in 2010 and without
pharmacological or toxicity data. It has not been studied, so we don´t
know how frequent is vasoconstriction, what are the mechanisms and
possible ways to avoid it.
If I had to choose between one of the two substances, I would undoubtedly use LSD. Using NBOMe is behaving like guinea pigs.
-
DoctorX: Thanks so much for offering your time and knowledge here.
I am currently rather concerned after an experience I have had and hoping maybe you could offer some insight:
Last
tuesday and wednesday I did some pretty pure coke I bought from here on
SR. Only 1 gram total for both days. I also had on hand, about 70-80
mgs of valium to help with the comedown and increased
heartrate/nervousness. Besides having the valium on hand, having to do
with history before taking the coke, I have also been taking 10 mg
lexapro as well as 250mg Rhodiola Rosea 2x day for 2 years. Lexapro is
an SSRI and rhodiola seems to be a dopamine/serotonin reuptake inhibitor
as well (also read it could be a slight MAOI). But overall rhodiola has
a very safe track record.
So on the 2 days I did the 1 gram
coke, I had taken my regular dosages of 10 mg lexapro and 500 mg
rhodiola. Alongside those, I also ended up taking all of my valium
(maybe 80-90mgs) as I hate the jitteryness of coke (do it for the
euphoria) and I hate the comedown.
The following days, starting
thursday, up until now, I just feel so very very down, unable to feel
back to my normal self and really unable to feel any sort of happiness.
Just an overall feeling of shit basically. Like there was some overload
of dopamine or serotonin maybe and some possible damage to synapses in
my brain that are just not regenerating. I understand 1-2 days of rehab
time is normal, but it is going on 4 days now and I still feel like
shit. I have never felt like this after doing coke before in my life
(but had not been on the lexapro/rhodiola combo) and I am feeling very
very concerned that some kind of permanent damage might have taken
place? Something to do with dopamine/serotonin reuptake inhibitors being
maxed or damaged? OR could it just be I am still detoxing from all that
valium? (4 days doesnt make sense though...)
Do you think my
brain could regenerate from this? Any ideas on what is going on? Should I
stop taking the lexapro and rhodiola for a couple days to try and
initiate a reset of my brain chemistry?
Any feedback is massively appreciated.
-
bodizzle,
Cocaine, as far as I know doesn't act very strongly
on seratonin like it does dopamine. The feelings you're describing
sound fairly standard from a weekend of some amphetamines and partying
or what not. Now I don't know a whole lot about Rhodiola but I've read
it has shown to help fatigue and have similar mechanism as MAOIs. Not
only that but MAOIs react with virtually EVERYTHING, especially
amphetamines.
I would personally drop the herbal shit you take
just for a week or two but it sounds to me that your body is just
extremely drained from a good amphetamine run.
The feeling of
worthlessness, guilt and general down feeling after a weekend partying
with good coke or meth is normal. I've felt like shit up to a week
before after a good party hard weekend. Your brain is just taxed right
now with depleted dopamine.
Stick with the valium to keep your
anxiety down and help you sleep just ease up on the amount. Only take
enough to relieve your anxiety. Drink tons of water and eat some good
meals. You'll feel better in a couple days.
I did some MDMA
while on celexa a few years ago and had panic attacks and extreme
anxiety for a couple days. Finally I went to the ER thinking that I may
have Seratonin Syndrome. He laughed and said, "stop reading your medical
books unless you have a exam, you're only scaring yourself worse." Fed
me some valium and I was fine after that.
-
I
am curious about drug testing and ways to naturally pass a urine
analysis dont in a lab that will be detailed and looking for specific
usage. Obviously, being clean is the best option.
However,
lets say a person takes the test in the morning one day and last used
the night before that. For example, test is Monday and person last
took some pain pills on Saturday night and was using daily but not
excessively before that.
The lab will be testing for flush kits
and the like. So, is there a way to flush out the metabolites and
other markers for the use of opiates in that short of a time
frame? I already drink a lot of water, take a Vitamin B Complex
daily, as well as creatine.
Any suggestions you have would be great?
It
all depends on the exact kind of test. There are available test for
some drugs (opiates, benzodiacepines, amphetamines, LSD, cannabis,
cocaine...) but other drugs (GHB, ketamine, some legal highs...) are
very difficult to detect in routine lab tests.
Each test has his own
specificity and sensibility, characteristics that indicate the accuracy
of the test to detect a specific drug during a period of time. Most
routine test detect drugs between 1 hour after last use until 3-4 days,
depending on the drug and the own test. A notable exception is cannabis:
most test detect 1 week after ocasional use and 1-3 months in regular
users.
The body has its own speed to eliminate drugs. This process
does not affect by taking water, sweating, making exercise or taking
supplements. All these measures are useless. It is not a good idea to
dilute or adulterate the urine, the tests are designed to detect this
too.
-
Omg this is so cool. I appreciate the fact that the board has this.
What
do we know for sure about bath salts? Why do people call it
poison? Are they neuro toxic? If so to what degree? What are some
of the most common problems and ways to avoid them while on the drug?
"Bath
salts" is a generic name, used in press, for a wide family of
stimulants that can be purchased by Internet. Obviously, they are not
sold as "drugs".They are offered as bath salts, aromas or fertilizers to
avoid legal problems, but users know that they have psychoactive
properties.
Originally, MDPV (3,4-methylenedioxypyrovalerone) was
the first psychoactive detected. The fact that MDPV is still legal in
some countries does not mean that it is safe or better than other
illegal drugs. MDPV is an uncommon stimulant with a short history of
human use. It is known for its tendency to cause compulsive redosing and
some users report sexual arousal as an effect.
Anyway, in
laboratory analysis of "bath salts" it is common to find a mixture of
different psychoactives. Other cathinone derivatives, ephedrine,
naphthylpyrovalerones... are commonly found in different samples. Even
the same commercial name has different components during time.
So,
it is very difficult to know the possible health problems of these
substances, as there is a lack of investigation data in human for most
of them. From a risk reduction perspective, "classical" drugs are much
less risky than these substances, or at least risks can be predicted
more easily
-
Hello Doctor X. Was just wondering if you might have any insight on my above earlier post?
Thanks so much.
-
Hello Doctor X. Was just wondering if you might have any insight on my above earlier post?
Thanks so much.
Hi,
Sorry
for delay, but I have too much work (here in SR and outside) and I have
little time to answer all your questions in general forum and in PM. I
usually answer questions one by one, but I understand you have some
urgency. I have read your story. It is difficult to give advice only by
Internet, without personal communication. But, in your case, I suspect
what is happening can be a "normal" effect after high doses of cocaine. I
don´t know if you are a frequent user or if you have tolerance to the
substance, but a gram of cocaine can cause your symptoms. Depressive
episodes are common after a binge of coke. They are related to monoamine
deplection, but they are normally reversible along time.
I would not
reccomend to abandomn Lexapro, as it can help to mitigate symptoms. I
have doubts on Rhodolia, as there is little information available about
its mechanism of action. But, probably, symptoms will improve in
following days. It is important that you sleep well (as long as you
need) during these days and try not to be stressed or make important
decissions. I think you will improve during following days, if it is not
the case I reccomend for proffesional evaluation
-
DoctorX,
Your measured response to bodizzle raises a question
for me in general. At what point do you look for medical,
psychological or other forms of help? Seems to me the last person
to figure out they have a problem is the person themselves.
How
people can ask a question without editing is a puzzle to me. All
my questions are in need of correcting and changing once I think for a
while about what I'm asking. Even with editing and re-writing I
never feel like I get the real question asked, part way not
completely.
Mr. bodizzle uses lexapro for depression, at
least this is my understanding of the pharmacodynamics of this
drug. Would you say that the drug lexapro is prescribed with less
than strict guidelines by some physicians? We all have heard
stories of drugs like that causing suicidal thoughts, I think we have
anyway. Would it be wise for Bo to go and get a second opinion and
do you consider general practice physicians qualified to prescribe it
anyway?
Stay thirsty ...
-
Thank you doctorx.
Yeah, what concerns me is that in the past (4-5 years ago) I had done coke while on lexapro and didnt get these effects...
The
difference with this time is that the coke was most defnitely more pure
and I am taking rhodiola as well.. The reason I mentioned getting off
the lexapro temporarily is I read a wiki answers topic on this, and the
guy said he tried coke w/ lexapro once (did more coke than me though)
but said the following days when he continued with his lexapro dosage he
experienced a reverse effect where he felt the lexapro was now doing
opposite of what its intention was. Like the coke had distorted its
mechanism of action somehow and it was further throwing things off
chemically. He mentioned he felt a suicidal depression for a week after
and had to stop the lexapro. This was the reason for my
concern. BUT, everyone is different, he did do more coke than I did, and
maybe his body chemistry was just different. This is what gets me
confused on whether or not to stop the lexapro for a "body reset" or
not.
Uhg, decisions decisions. I should probably stay on the
lexapro as the experience I read of was only one person's but I square
yesterday I was definitely feeling a massive deep, dark, and very bleek
depression..
-
Thank you doctorx.
Yeah, what concerns me is that in the past (4-5 years ago) I had done coke while on lexapro and didnt get these effects...
The
difference with this time is that the coke was most defnitely more pure
and I am taking rhodiola as well.. The reason I mentioned getting off
the lexapro temporarily is I read a wiki answers topic on this, and the
guy said he tried coke w/ lexapro once (did more coke than me though)
but said the following days when he continued with his lexapro dosage he
experienced a reverse effect where he felt the lexapro was now doing
opposite of what its intention was. Like the coke had distorted its
mechanism of action somehow and it was further throwing things off
chemically. He mentioned he felt a suicidal depression for a week after
and had to stop the lexapro. This was the reason for my
concern. BUT, everyone is different, he did do more coke than I did, and
maybe his body chemistry was just different. This is what gets me
confused on whether or not to stop the lexapro for a "body reset" or
not.
Uhg, decisions decisions. I should probably stay on the
lexapro as the experience I read of was only one person's but I square
yesterday I was definitely feeling a massive deep, dark, and very bleek
depression..
Don´t
trust everything you can read in Internet. Escitalopram is a well known
and studied antidepressive, there are not interactions described with
cocaine as you have read. The "body reset" theory does not have any
logic. I insist in resting, maybe take a benzo if you can´t sleep and
seek for proffesional help if you feel very dark
-
So
how would you recommend parents to discussion drug use with Children?
What the best way for us parents (I know some of most likely are) to
discuss drugs with our offspring. I don't want to promote all drug all,
but I certainly wouldn't want them missing out on positive use of some
psychedelics .
I'm
no parent so take this with a grain a salt because the subjectivity of
this is off the charts. Personally I believe, depending on the age of
the child of course, that honesty works great. I was a very intuitive
child and knew my parents were smoking pot or whatever. Would even go
pick the plants for my relatives when the time came lol.
If you
feel your kids have a good grasp on right and wrong, then there is no
reason you shouldn't explain to your children what you do and to educate
them on the potentially negative aspects of it. Parents always told me
that you're going to experiment in high school and college, just use
your brain and do not be afraid to call us if something bad happens.
From my experience, the parents that sheltered their kids from it always
had the children most likely to try out this forbidden thing they
weren't even supposed to know about.
Again, it's all subjective but if the children are level headed, they will understand.
There
are some commentaries before on this subject. I´m not an expert on
education or drugs politics, so I think my opinion in this is
irrelevant. But I think some of the moral prejudices with sex that
existed in society some decades ago have changed to drugs. Drugs and
drug users are scapegoats of all society problems. This prejudices can
only be manteined through ignorance. There is a big ignorance and
prejudices against drugs even between doctors and scientist. If we don´t
educate people (and that includes young and adolescents) with reliable
information there will always be more problems.
-
Although
prices are better on Atlantis, a community like this one is way more
work to maintain and develop than merely offering low prices.
To
the 3rd year med stud "stayawake", would you say you are the exception
to the norm among fellow students? My guess would be it would take
too much energy away from bio chem and the rest of it, consequently few
med studs would be here investigating like you are?
DoctorX,
Does
the health care system in Spain reward you financially as much as say a
plastic surgeon in the States? My reading of the literature
indicates that the Spanish economy is in some sort of trouble. Do
you agree with this assessment and if so how does this crisis affect the
health care system? Also, do you think you could train a
competent janitor to talk like a doctor in a few weeks? If so I
will travel to Madrid if you are willing to both teach me Spanish (may
take longer than three weeks, more like three years, I think) as well as
how to be a Doctor. Yes I'm joking but all kidding aside what do
you think of Nuvigil as an legal alertness drug? Thanks.
Have a nice day,
Mr. Clean, Esq.
my web site: short form: http://bit.ly/1beuN1L
or for the PGP group, this is the full link:
http://www.mrclean.com/en_US/home.do?utm_source=google&utm_medium=cpc&utm_term=mr%20clean&utm_campaign=Mr.+Clean_Search_Desktop_Brand+Awareness&utm_content=syMeoh9EH_15185172069_p_mr%20clean
Armodafinil
(Nuvigil) is a stimulant-like drug , it is an enantiopure drug
consisting of just the active enantiomer of the racemic drug modafinil
(Provigil). So it is, theoretically, an "enhanced" version of modafinil,
and it has been studied with the same indications than this drug: sleep
disorders, depression, schizophrenia and jet-lag. Only in sleep
disorderes clinically diagnosed has shown efficacy, studies on
schizophrenia have been dismissed and it didn´t get the FDA
authorization for jet lag
http://www.ncbi.nlm.nih.gov/pubmed/20957846
http://www.ncbi.nlm.nih.gov/pubmed/20530317
http://www.ncbi.nlm.nih.gov/pubmed/19880686
Anyway,
it can have the same problems related to all stimulant drugs:
tachycardia, restlessness, headache, and even psychotic problems
at high doses
http://www.ncbi.nlm.nih.gov/pubmed/23775049
My
personal opinion on most of this enantiomer drugs is that they are an
easy way to get a new drug far much expensive than the original one,
and, in most cases, there are not significant differences from the
original. There are exceptions (escitalopram is different from
citalopram, for example), but in most cases they are an easy way to
improve pharmacological industry benefits.
I think the rest of your
questions are out of the thread, but yes, I think I earn less money than
a plastic surgeon in the US. I chose bad my speciality
-
How
repairable are veins? Does the scar tissue and damage stay done or for
how long would it need to really repair itself. This would be with an
injection 3-4 times a week with rotating sites
The
degree of damage to veins depend, in a great way, on the way you do
injection technique. Think that intravenous therapy is used in hospitals
with little problems. Of course illegal drugs have not sanitary
controls and this is a problem and, depending on the drug purity and
specific drug, there can be much or less problems. But washing hands,
cleaning the site with alcohol after and before injection, using steril
and proper material (clean needles and syringes, gloves...) and taking
care of possible wounds with specific ointments or creams are the best
way to avoid problems. This subject is very wide. I strongly recommend
to have a look to this guide:
http://issuu.com/harmreduction/docs/getting_off_right/21?e=3225910/2673970
-
I have started a thread for those interested in meth and health...
I'd love to see an actual doctor on that... I don't care about other
drugs, just meth... I'm fine sticking to just that and using it
healthily.\
http://dkn255hz262ypmii.onion/index.php?topic=182590.0
-
Dear Doctor,
Please tell us that regular use of MXE/PCP won't cause harm to your body.
Gracias!
-
So at a music festival a couple of weeks ago. I ended up eating
about 1.5g of MDMA, 1400ug of LSD and ended the night with loads of
Ketamine. Now when I use drugs I want to compete with that night and
anything else is just shit. Any suggestions?
-
So
at a music festival a couple of weeks ago. I ended up eating about 1.5g
of MDMA, 1400ug of LSD and ended the night with loads of Ketamine. Now
when I use drugs I want to compete with that night and anything else is
just shit. Any suggestions?
in one night? must have been one hell of a night :o
I
don't need to be a doctor to tell you that you're dicing with death
with that kinda MDMA dose,and insanity with that kind of LSD dose -
don't try this at home kids.
Even if it was over the whole weekend it's still well excessive. +1 to you for surviving though
-
So
at a music festival a couple of weeks ago. I ended up eating about 1.5g
of MDMA, 1400ug of LSD and ended the night with loads of Ketamine. Now
when I use drugs I want to compete with that night and anything else is
just shit. Any suggestions?
in one night? must have been one hell of a night :o
I
don't need to be a doctor to tell you that you're dicing with death
with that kinda MDMA dose,and insanity with that kind of LSD dose -
don't try this at home kids.
Even if it was over the whole weekend it's still well excessive. +1 to you for surviving though
Im
a big guy and have a very high tolerance to what seems every drug. Even
at the dentist about a year ago when my wisdom was pulled. The doctor
gave me 3 shots to try and sedate me and said if you arent out after
this one I cannot give you anymore. I was awake through the whole
procedure.
This was all in one night.
-
So
at a music festival a couple of weeks ago. I ended up eating about 1.5g
of MDMA, 1400ug of LSD and ended the night with loads of Ketamine. Now
when I use drugs I want to compete with that night and anything else is
just shit. Any suggestions?
in one night? must have been one hell of a night :o
I
don't need to be a doctor to tell you that you're dicing with death
with that kinda MDMA dose,and insanity with that kind of LSD dose -
don't try this at home kids.
Even if it was over the whole weekend it's still well excessive. +1 to you for surviving though
Im
a big guy and have a very high tolerance to what seems every drug. Even
at the dentist about a year ago when my wisdom was pulled. The doctor
gave me 3 shots to try and sedate me and said if you arent out after
this one I cannot give you anymore. I was awake through the whole
procedure.
This was all in one night.
be careful goliath cause david is around the corner watching you.
:-*
-
So
at a music festival a couple of weeks ago. I ended up eating about 1.5g
of MDMA, 1400ug of LSD and ended the night with loads of Ketamine. Now
when I use drugs I want to compete with that night and anything else is
just shit. Any suggestions?
in one night? must have been one hell of a night :o
I
don't need to be a doctor to tell you that you're dicing with death
with that kinda MDMA dose,and insanity with that kind of LSD dose -
don't try this at home kids.
Even if it was over the whole weekend it's still well excessive. +1 to you for surviving though
Im
a big guy and have a very high tolerance to what seems every drug. Even
at the dentist about a year ago when my wisdom was pulled. The doctor
gave me 3 shots to try and sedate me and said if you arent out after
this one I cannot give you anymore. I was awake through the whole
procedure.
This was all in one night.
If you took 1400 ug of acid I can't see how you'd be in a fit state to take anything else tbh, but whatever you say!
-
I
would like to know just exactly how caustic/damaging the insufflation
of adderall/amphetamine is (no cocaine, methamp, opiates, etc.).
Clearly
it's terrible and should not be used to put drugs into your body, but
unfortunately I have discovered & chase the euphoria associated with
it.
Specifically I am wondering what exactly is this 'caustic'
action that takes place with continued use. Does one's nasal cavity
start to literally disintegrate or deteriorate? Are there any breathing
problems as a result (excluding the obvious effect on sense of smell)?
At what point (like any physical signs) should you know you need to be
done for good?
Also: random myth I would like debunked because I
hope you have experience with adderall/stims being an MD :) Is it true
that the powder from crushed adderall pills (either IR or XR) has some
wax that clogs one's nose making in ineffective? Based on personal
experience I don't feel like it does, but my friend swears by it
Intranasal
use of most drugs can cause local problems. The degree is between
little imperceptible wounds to massive destruction of bones and
structure of nasal cavity. There are different factors to this:
characteristics of the substance, purity, technique and frecuency of
use... The presence of continuous nasals congestion, bad odour or green
mucus or bleeding can indicate that there is a problem and use should be
stopped or diminished.
There are some tips to reduce this risks or avoid it:
1) To crush very well the substance before using it
2) Using a clean surface
3) To use both nostrils to snort, alternating
4)
Using clean material. Don´t use a bill to snort, use better a drinking
snort or a clean paper. Several studies have shown a higher rate of
Hepatitis C Virus in intranasal cocaine users.
http://www.ncbi.nlm.nih.gov/pubmed/15132748
http://www.ncbi.nlm.nih.gov/pubmed/22740714
http://www.ncbi.nlm.nih.gov/pubmed/17052278
It
is unclear if sharing material to snort (straws) can be a route of
infection, but you should use personal material to introduce in your
nose and not sharing it, by general hygiene reasons.
Most prescription drugs susceptible to be abused are formulated in a way to avoid intranasal or intravenous use
-
For those interested in meth / ice I've re-started this thread.
http://dkn255hz262ypmii.onion/index.php?topic=22378.0 Safe Methamphetamine Dosage/Usage. Read this if you do Ice!
DoctorX
- would be great to see you over there sometime but I know you have
VERY limited time and it's just good to see a doctor here at all...
better than nothing, whatever you can do.
-
DoctorX : Reply #312
I´m not an expert on education or drugs politics, so I think my opinion
in this is irrelevant. But I think some of the moral prejudices with
sex that existed in society some decades ago have changed to drugs.
Drugs and drug users are scapegoats of all society problems. This
prejudices can only be maintained through ignorance. There is a big
ignorance and prejudices against drugs even between doctors and
scientist. If we don´t educate people (and that includes young and
adolescents) with reliable information there will always be more
problems.
DoctorX: Reply #286
Anti
drugs laws are supposed to "protect the children" but paradoxically it
is easier for a teenager to find pot than for an adult.
If an
adolescent or a young adult is "well-educated" (that can mean a wide
range of factors: self esteem, responsibility, ability to make
decisions, reflexivity...) it is unlikely that occasional use of drugs
will cause many problems. Of course some patterns of use of
psychoactives in teenagers are inadequate. But I think it is not a
question of "all or nothing", but the mix of different factors.
Those two quotes provoke enough questions for me to finally
finish that PhD in sociology that I never started. There does
seems to be two poles to the discussion here. On the one hand,
"just say no" and the other hand we hear, at least on this site, much
more openness to drug use. The notion that education is the
solution to sensible drug use runs counter to the fact that schools
provide fertile breeding grounds for over-use or poor drug use choices,
both legal and illegal.
Our
governments try to help stem our human weaknesses, when it comes to
substances they deem cause compulsive auto-use and harm to the family
unit and social structure, by making these drugs harder to get.
The pleasure derived from these substances move us to make choices about
their use which can move us to one side or the other. Many
branches of the Christian faith like the Catholic Church seem to ignore
all drugs and only talk about them when they want to do good deeds and
help the poor folks who feel addicted to one thing or the other.
Some well know religions ban all forms of consciousness altering
products outright. The other extreme are Hindu sects and various
groups who talk about sacred plants. This includes the Irish and
our well know and often joked about affinity for alcohol.
Slupper: Reply #325
Thanks to Slupper for giving me something to hang this comment on, you say:I
am going to college this fall and probably going to be drinking and
smoking weed at least most weekends. I am interested in trying MDMA.
Is there anything I should be worried/wary about?
Clearly you are talking about the physical health risks
associated with your heart and not questioning whether or not you should
take drugs, you seem very confident you will be taking them. When
I went to college many years ago I took up the practice of
Transcendental Meditation which recommends limited or no drugs. My
entire college years, all six of them, had only one or two weed smoking
occurrences. For many years after college with the outside
authority of many yoga type sanctions against drugs I seldom drank to
excess and never used drugs. When I meet my then wife to be,
and she had a small bag of pot stashed away for years in a drawer I
opened up and reentered the habit of smoking weed having spent most of
high school either high or trying to get high.
Fast forward to today with the drums of legalization beating and a
president who is known to have enjoyed his dank but now says taking
drugs was his biggest moral failing and what we have is the need for a
solid internal authority to guide us in this minefield of potential bad
choices. You sound like someone who has his head on straight now,
but the question I have is what is sensible when it comes to drug
use? While many on SR pay lip-service to this important question
the vast majority appear to be just shopping and have no conflict at
all, or at least have given up trying to wrestle with it.
Like Goldilocks, too hot, too cold, and just right, what is just
right when it comes to drugs? For each person the answer will be
different but our authority figures all seem to be either too hot or too
cold, few are willing to look at it from the scientific position like
DoctorX does. For me the abstinence route did not work, for others
it does. Many adults who are out of the drug loop have no
auto-medicate compulsion, but might have if it were more
available. So for them, in this case government sanctions are
working to protect its population from themselves. I see the whole
thing as a huge statistical game where we roll the dice and the numbers
that come up are random, we can hope for 7's but as the wise man said,
"it is what it is". No Doctor, no Guru, and no software program
can be given our numbers and come up with our 100% accurate risk rating
for bad things to happen with our patterns of drug use.
One thing I will say with no reservations is that college
alcohol use is a complete disaster. Perhaps it will take MOOCs and
China to send the cold winds of change into the college drinking/drug
free for all. In case someone has failed to notice this today's
economy and job prospects are much changed from what it was even 10
years ago but education usually takes decades to make significant
change.
Do I know the answers, hell
no, I'm just trying to decide if I should buy some weed or not, and if
it weren't for my fear of prison, would have already. When you say
you, "probably will be smoking weed and drinking at least most
weekends" that sounds like the acceptance by you of a fatally and
fundamentally flawed system. We all must learn to walk on our own
two feet but colleges have had a tough time addressing these long time
patterns of abuse. Re-read or read DoctorX's replies 286 and 312;
he is wise beyond his young years.
No more preaching since the coffee is gone, see you in church.
Mr Sober Esq.
-
As a baby I had an ASD repair ("hole in the heart" in layman's
terms), it was repaired and now I am on no restrictions; doc says I'm
able to do everything anybody else could do. I have a slight heart
murmur.
I am going to college this fall and probably going to be
drinking and smoking weed at least most weekends. I am interested in
trying MDMA.
Is there anything I should be worried/wary about?
EDIT:
Also, do you think it would be worthwhile (if you think there's any
risk involved) to get one of those 24-hour heart monitors, smoke some
weed or even do it with the MDMA, and see if anything bad pops up? I
have very good health insurance so it shouldn't cost me much, if
anything.
-
I think you just answered your own question... probably wouldn't
hurt to get a general health check up too - get a doc to look at your
blood tests, pressure, heart etc... Should do it as a habit
anyway.
And don't be an idiot and load up and get all hot and dehydrated... Use some common sense.. Less is more.
And
don't turn in to a weed smoking college loser either... there's plenty
of those already with degrees and check out jobs.. Stay focussed
on your goals and approach drugs with respect, very deep respect.
Also
probably wouldn't hurt to get some 'non using' friends, at least one,
to watch out for any changes, even if that's turning in to a loser
bum. You kinda want to catch it early. From what I hear, loser
bums aren't doing too well in America for jobs right now.
-
I
think you just answered your own question... probably wouldn't hurt to
get a general health check up too - get a doc to look at your blood
tests, pressure, heart etc... Should do it as a habit anyway.
And don't be an idiot and load up and get all hot and dehydrated... Use some common sense.. Less is more.
And
don't turn in to a weed smoking college loser either... there's plenty
of those already with degrees and check out jobs.. Stay focussed
on your goals and approach drugs with respect, very deep respect.
Also
probably wouldn't hurt to get some 'non using' friends, at least one,
to watch out for any changes, even if that's turning in to a loser
bum. You kinda want to catch it early. From what I hear, loser
bums aren't doing too well in America for jobs right now.
I
have no intent of smoking up every day or anything like some stories
I've read. Finishing with a 3.5 or higher is much more important to me
than drugs. The jobs I'm striving for require at minimum that. I like
the idea of telling a 'non-using' friend, though. +1
But I didn't
really answer my question. I read about some guy doing the 24-hour
thing stating "It worked for me, but YMMV" and so that's where that came
about. When it comes to the murmur, I'm seeing varying answers from
non-medical folk on the interwebs. If I can get a more 'official'
answer, I'll take it. When my doc said "You can do anything of anybody
else," I'm sure he wasn't thinking I'd be rolling.
-
As
a baby I had an ASD repair ("hole in the heart" in layman's terms), it
was repaired and now I am on no restrictions; doc says I'm able to do
everything anybody else could do. I have a slight heart murmur.
I
am going to college this fall and probably going to be drinking and
smoking weed at least most weekends. I am interested in trying MDMA.
Is there anything I should be worried/wary about?
make sure you have healthy habits, such as walking, running, no smoking, good diet, etc.
try MXE.
-
DoctorX,
There seems to be an agreement that roughly
10% persons who try cannabis become dependent. Based on what I
read here on SR and my own observations elsewhere it seems that regular
users have a much higher rate of dependency than 10%. Would you
agree with this and if so what percentage of more frequent male users do
you think may have dependency problems? Male patterns of abuse
seem much more frequent
Some studies of wine
drinkers point to some health benefits from drinking a few glasses a day
but we are told the risk of becoming dependent on alcohol outweighs
these benefits. Do you see pot in the same way? There are
some feel-good benefits but would you say, for most people, especially
risk taking youngsters, but also so called adults, the risk of
dependency outweighs these potential health gains?
Sorry, must end this now, my supplier is knocking at my door, really.
Thanks
-
DoctorX,
Your
measured response to bodizzle raises a question for me in
general. At what point do you look for medical, psychological or
other forms of help? Seems to me the last person to figure out
they have a problem is the person themselves.
How people
can ask a question without editing is a puzzle to me. All my
questions are in need of correcting and changing once I think for a
while about what I'm asking. Even with editing and re-writing I
never feel like I get the real question asked, part way not
completely.
Mr. bodizzle uses lexapro for depression, at
least this is my understanding of the pharmacodynamics of this
drug. Would you say that the drug lexapro is prescribed with less
than strict guidelines by some physicians? We all have heard
stories of drugs like that causing suicidal thoughts, I think we have
anyway. Would it be wise for Bo to go and get a second opinion and
do you consider general practice physicians qualified to prescribe it
anyway?
Stay thirsty ...
I
think that is a very difficult question to answer. In general, if you
feel you can´t handle a situation by yourself it is time to search for
specialized help. It is true that, in relation to drugs, most physicians
are more based in moral than in science. But I think sometimes
professional help is important. I beleive that prescription psychotropic
drugs can be useful if properly used, and as a complement for
psychological help ot treatment.
-
Dear Doctor,
Please tell us that regular use of MXE/PCP won't cause harm to your body.
Gracias!
I´m sorry I can´t say that.
In
fact I don´t know. They are two different substances and risks are
probably different. To explain well the question I will start talking
about ketamine. Ketamine is a well known drug, widely used in therapy
during 50 years. Recreative use of ketamine has, more or less, 15-20
years. In the last 5 years there have been a lot of scientific reports
talking about bladder and urinary problems in ketamine users. It was an
unknown problem until 2005 (more or less), and has been detected after
15-20 years of recreative, intranasal use. In general, it only affects
to intensive users.
http://www.ncbi.nlm.nih.gov/pubmed/21155941
PCP
was used in medicine from 1920 to 1950 and it was finished then because
of its adverse side effects, such as hallucinations, mania, delirium,
and disorientation. In fact ketamine has its substitute, because it has
less adverse effects. PCP has been linked to neurotoxicity in animals,
but it is not probably extrapolable to humans.
Methoxetamine is a
very new substance. We don´t know anything about its pharmacological
properties and toxicity in humans, although there are reports of
problems linked to its use:
http://www.ncbi.nlm.nih.gov/pubmed/23111916
http://www.ncbi.nlm.nih.gov/pubmed/22578175
http://www.ncbi.nlm.nih.gov/pubmed/22205276
http://www.ncbi.nlm.nih.gov/pubmed/23349353
Considering
overall risks and benefits, probably ketamine is the safest, most
pleasurable and less risky of all dissociatives, although it has it own
problems associated indeed.
-
How can this thread not be sticky? Who awards sticky status to a thread anyway?
Also what is karma and how can I get some, good preferably?
thanks
-
smogmonster13,
When you say "sacred uses of plant-based
drugs" do you include synthesized drugs under the sacred heading or only
naturally occurring ones? We westerners seem to have
abandoned or never developed rituals for sacred anything especially all
things related to drugs, this unless you consider "happy hour" a sacred
ritual.
[/quote]
Clean:
I was not including synthesized
drugs, not because a case for sacred use can't be made for them, but
rather because sacred plants (peyote, ayuhausca, and the like) have
generations of ceremonial use by young people with no reported harm.
-
So
at a music festival a couple of weeks ago. I ended up eating about 1.5g
of MDMA, 1400ug of LSD and ended the night with loads of Ketamine. Now
when I use drugs I want to compete with that night and anything else is
just shit. Any suggestions?
It
is no worthy to "try to compete" with a previous experience. In your
case, it also seems dangerous, because of the high doses used. LSD is
not physically dangerous, but doses over 500 micrograms will have no
more desired effects and are a waste of substance. Doses over 250-300 mg
of MDMA increase adverse effects and risks of toxicity. The fact you
have some tolerance does not mean that there are less risks: tolerance
to pleasurable effects is generally faster to tolerance to, for example,
cardiovascular effects. It happens the same witk K.
The only way I
know is to wait several weeks and use lower doses of substances. I think
this is not too much for advice, but it is the only thing I can
suggest.
-
As
a baby I had an ASD repair ("hole in the heart" in layman's terms), it
was repaired and now I am on no restrictions; doc says I'm able to do
everything anybody else could do. I have a slight heart murmur.
I
am going to college this fall and probably going to be drinking and
smoking weed at least most weekends. I am interested in trying MDMA.
Is there anything I should be worried/wary about?
EDIT:
Also, do you think it would be worthwhile (if you think there's any
risk involved) to get one of those 24-hour heart monitors, smoke some
weed or even do it with the MDMA, and see if anything bad pops up? I
have very good health insurance so it shouldn't cost me much, if
anything.
If
the Atrial Sept Defect was repaired when you were a baby, you have a
good health, you are using no medication because of this and you don´t
have any limitations in your life (you can do physical exercise in
normal conditions, for example) I think your risks would be similar to
the rest of the population. You should take the same preventive measures
(knowing information about the substance, adequate set, setting, doses,
substance analysis if it is available in your country...) but anything
else. I don´t think a heart monitor is neccesary.
-
LSD
is not physically dangerous, but doses over 500 micrograms will have no
more desired effects and are a waste of substance. Doses over 250-300
mg of MDMA increase adverse effects and risks of toxicity.
How cool, the good Doctor is against overdosing since it is a waste of product. How often does this happen?
-
Jumping in on this thread!
Probably the only person with no minus karma at all and rightly so! Thank you for such a free knowledgeable service!!! :)
-
Thank you loneKarma man!
HitTheRoad,
How rare is no negative Karma from your experience?
Thanks for posting, nice to see others are interested in having fun but staying safe too.
Clean
-
Thank you loneKarma man!
HitTheRoad,
How rare is no negative Karma from your experience?
Thanks for posting nice to see others are interested in having fun but staying safe too.
Clean
I
don't like the whole karma feature and don't bother dishing them out at
all for any reason but find it amusing to see my positive and negative
fluctuate after a night of coke fueled bullshitting on here! :)
If
you have a bad experience with a seller and give out about them on the
forum then the negative brigade who love that seller or feel they have a
tie to the seller will lash you out of it!
While here Doc, I'm
sure it's been covered already but I'd have to scroll back a lot of
pages and am wondering the best treatment for the liver after doing coke
and drinking alcohol at the same time? Is milk thistle the best or do
you know of a better way other than not doing it? Thanks!
-
DoctorX,
There
seems to be an agreement that roughly 10% persons who try cannabis
become dependent. Based on what I read here on SR and my own
observations elsewhere it seems that regular users have a much higher
rate of dependency than 10%. Would you agree with this and if so
what percentage of more frequent male users do you think may have
dependency problems? Male patterns of abuse seem much more
frequent
Some studies of wine drinkers point to
some health benefits from drinking a few glasses a day but we are told
the risk of becoming dependent on alcohol outweighs these
benefits. Do you see pot in the same way? There are some
feel-good benefits but would you say, for most people, especially risk
taking youngsters, but also so called adults, the risk of dependency
outweighs these potential health gains?
Sorry, must end this now, my supplier is knocking at my door, really.
Thanks
The
risk of becoming dependence for many psychoactives, not only cannabis,
is around 10%. Even some studies on cocaine (that is a highly addictive
drug) suggest that around 10-15% of persons who have tried once in their
lives will have a dependence problem.
Strictly, a drug dependence
problem must fit some criteria. There are some desadaptative patterns of
use that can´t be classified as "dependence", although this is a
technical detail that maybe is not important. It is true that male have
more abuse/dependence problem than women, although for some substances
(prescription benzodiacepines for example) rates are inverse.
http://www.uscourts.gov/uscourts/federalcourts/pps/fedprob/2006-09/accountability_table1.html
The
important thing, in my opinion, is that this "10% risk" is not a
lottery. It depends on many factors: substance, route of administration,
pattern of use and, very important, social, personal and psychological
factors difficult to measure.What I mean is that the person behavior and
his relation with the substance (motivations, objectives, pattern of
use...) will make easier or more difficult that a dependence problem
appears.
The cardiovascular benefits of low doses of alcohol are well stablished.
http://www.bmj.com/content/342/bmj.d671
Only
red wine has shown this benefit, but in my opinion it is not a reason
for start drinking. As I said, dependence is caused by many factors, I
think the main motivation for drink low doses of wine should be
pleasure, not a cardiovascular protective effect. I don´t think this
effect should promote dependence, although it should be well explained
and sometimes is not.
And I don´t see cannabis in the same way. There
are no clear benefits for health of using low doses of cannabis daily .
Cannabis can be useful for some diseases but has not health benefits
for general population. OK... for some people it is relaxant, improves
creativity or simply, they like or enjoy it: this is health too. But I
don´t think it can be compared to the alcohol issue.
-
Hi DoctorX
I was guided to ask my question from you:
I have one post in newbie section where i tell about myself and my health condition(ptsd).
However
im asking here is there any drug that doesn't interfere with my memory
and emotions much except it would soothe fear and anxiety(euphoria type
feeling could of course push me at bit better forward)? This is for
therapeutic purposes.
I took MDMA only little while ago(couple
days ago) and felt bit that high cortisol production(i suspect) kinda
interfered any kind of remembering and feeling. I only felt like i want
to rest and were really unable to think anything. It weren't bad, but it
weren't something that i looked for either.
So do you know anything that could help?
Regards,
blackroses
-
Findingcure:
Hope you don't mind I'm posting one of your
earlier comments as I think it adds important details needed to
understand your situation. Be thankful you live where you do, the
Finnish system is the envy of many, if you do in fact live there.
findingcure:
It
seems that i cant post any other topic other than this even though this
doesn't belong to here. Maybe i still give it to go and hope
some more experienced could give me advise. Unlike most, i'm looking for medical-type help.
I've
just recently got Ptsd(nervous breakdown in very critical point of
life). Now after 2 months i'm unable to reach my positive
emotions
properly(mildly i can since before breakdown i managed to detach myself
aka i have very positive feelings from time before bd but they are shut
inside me) since there is fear barrier between me and my emotions.
My
life is practically frozen because of this. Doctors have suggested me
to talk to psychologist, without even understanding my condition. Other
have suggested me ssri, but after looking what it may cause, i just
couldn't. After making research i find out about marijuana use in Ptsd
as well as the MDMA. Since i do feel my situation is a bit unusual
because of mild presence on positive feelings and yet i feel i need some
med to help me and my brain to recover i experience that numbing
medication is wrong(cant really tell is it good for anyone). Naturally
drugs like marijuana and MDMA are illegal
in my country and doctors are unable to prescript either as well, so after searching i end up here.
First
of all i would like to hear opinions about my situation and suggestions
what i should do. How should i use these drugs? Can i use both "same
time"(Maybe use marijuana couple days a week and MDMA once later on
week)? I need to know how much i can take without getting addiction and
then again without damaging my brain more. I would be also happy to hear
from other people who had/ have Ptsd or mental illness have they gotten
help from any drug(these or other). Most important thing for me would
be that that huge fear/anxiety barrier would low down and i would be
able to get contact to my other feelings so that i can relax and process
my break down properly with them.
I dont hope to become regular user
:P ,but my situation needs action and i want to help myself(since
doctors are unable). I hope to get quick answers
because i want to
get "my medication" on before i loose my reach to those positive
feelings and maybe fall into depression. Thanks for anyone who can help.
-
Thank you cleansober. Very kind of you for thinking of posting that :)
I do yes live in Finland. I can only hope that country's system can keep me up. Thanks :)
-
smogmonster13,
When
you say "sacred uses of plant-based drugs" do you include synthesized
drugs under the sacred heading or only naturally occurring ones?
We westerners seem to have abandoned or never developed rituals
for sacred anything especially all things related to drugs, this unless
you consider "happy hour" a sacred ritual.
Clean:
I
was not including synthesized drugs, not because a case for sacred use
can't be made for them, but rather because sacred plants (peyote,
ayuhausca, and the like) have generations of ceremonial use by young
people with no reported harm.
[/quote]
I think things are a
bit more complicated than that. I agree with you that "happy hour" does
not seem a sacred ritual but I believe there are many elements in techno
and rave culture that could be easily related to rituals.
You say
that some plants have"generations of ceremonial use by young people with
no reported harm". That is true, but only for their own culture.
Ayahuasca use is not related to psychotic episodes in Amazonic cultures,
but this can happen in other cultural settings. I have looked after
several psychotic episodes after ayahuasca intake. This transcultural
perspective is important, because ways of use, motivations, social
meanings and negative effects are not neccesary the same.
I think if
you give MDMA, for example, to a Yanomami in a european rave, effects
will be different. And it is very possible that he does not understand
anything ;)
-
Hi DoctorX,
Is Milk Thistle good to clean ones liver or is there a better product?
It's something I want to do after nights of using cocaine in combination with alcohol.
-
You
say that some plants have"generations of ceremonial use by young people
with no reported harm". That is true, but only for their own culture.
I
doubt even that could be assumed to be true - after all, has anyone
actually kept track of any harm over all those generations?
And
if it is something used in a rite of passage or similar, i'd assume all
tribe members actually use it so there would not be a control group left
to compare the results against.
-
Ben has a point in his post above when he says
I
doubt even that could be assumed to be true - after all, has anyone
actually kept track of any harm over all those generations?
Who knows if some so-called sacred medicine has
hindered cultural/technological/scientific advances in native
cultures. Perhaps we would be wearing loin cloths if these
societies had avoided these mind bending practices? Yet another
area for study; cross-cultural effects of drug use. For me,
whenever I try to justify my drug use by saying, "look, this or that
extinct or nearly vanished group does it or did it", I feel I'm
stretching to rationalize an activity frowned on by the majority
culture. Is Silk Road akin to the enlightenment with it's radical
ideas of freedom? It seems more like a whole bunch of people
violating postal regulations with a lot of success.
I'm crushed to get a negative karma, what have I done to
deserve this shameful tag? Nothing a dose of this or that won't
cure. ha ha. On the other hand too much good Karma could be a
bad thing?
kind of, Clean
-
First of all - ignore karma. I get plenty of negative karma just
because i tell people things they do no want to hear, regardless if they
are true (they mostly are). If you believe in karma, it is not measured
by whatever +/- numbers appear under your user name ;)
As far as
excusing drug use based on some group that did so in the past, or even
does today, that fact in itself says nothing about safety of the drug.
With
such logic you could reason that smoking tobacco must not be dangerous
because everyone in the western world was doing it in the 50s, 60s, 70s
and 80s. Westerners certainly did not go extinct because of this habit,
but in retrospect scientific analysis does prove that it actually is
detrimental to health.
As a smoker myself i don't even fall for
that line of reasoning: surely the majority of people that lit up in the
70s are not dead because of that, but a significant number of them are
facing death due to their use back in the day.
I suppose being
honest with yourself about these things is the best thing: i am very
well aware that smoking could kill me at some point, sooner or later,
but i -choose- to accept that risk because i feel the short term
benefits outweigh it. Scientifically this makes no sense at all, but
that is often the problem with addiction to any drug.
-
First
of all - ignore karma. I get plenty of negative karma just because i
tell people things they do no want to hear, regardless if they are true
(they mostly are). If you believe in karma, it is not measured by
whatever +/- numbers appear under your user name ;)
As far as
excusing drug use based on some group that did so in the past, or even
does today, that fact in itself says nothing about safety of the drug.
With
such logic you could reason that smoking tobacco must not be dangerous
because everyone in the western world was doing it in the 50s, 60s, 70s
and 80s. Westerners certainly did not go extinct because of this habit,
but in retrospect scientific analysis does prove that it actually is
detrimental to health.
As a smoker myself i don't even fall for
that line of reasoning: surely the majority of people that lit up in the
70s are not dead because of that, but a significant number of them are
facing death due to their use back in the day.
I suppose being
honest with yourself about these things is the best thing: i am very
well aware that smoking could kill me at some point, sooner or later,
but i -choose- to accept that risk because i feel the short term
benefits outweigh it. Scientifically this makes no sense at all, but
that is often the problem with addiction to any drug.
That
is true. I'd like to think I contribute positively to the forums
frequently, but I find I often get -1 karma when you tell people
something they don't want to hear... Such as they come on here and
complain about being scammed and then you tell them they shouldn't FE
and they get defensive because they feel like an idiot and don't want to
be told anything.
Also I find that if you mention on the forums
about how people have reveled too much personal info, they get angry
because they think it is acceptable. Also people on comedowns aren't
pleasant to deal with. Lol
-
Thank you loneKarma man!
HitTheRoad,
How rare is no negative Karma from your experience?
Thanks for posting nice to see others are interested in having fun but staying safe too.
Clean
I
don't like the whole karma feature and don't bother dishing them out at
all for any reason but find it amusing to see my positive and negative
fluctuate after a night of coke fueled bullshitting on here! :)
If
you have a bad experience with a seller and give out about them on the
forum then the negative brigade who love that seller or feel they have a
tie to the seller will lash you out of it!
While here Doc, I'm
sure it's been covered already but I'd have to scroll back a lot of
pages and am wondering the best treatment for the liver after doing coke
and drinking alcohol at the same time? Is milk thistle the best or do
you know of a better way other than not doing it? Thanks!
Both
cocaine and alcohol can produce hepatic damage. This effect is, in
general, dose-dependent and reversible at low-medium doses. It is
hypothesized that combination of both substances (cocaine and alcohol)
creates a metabolite (cocaethylene) that is more toxic for liver and
heart than just one substance at a time. But, really, evidence from
cocaetyhlene comes from cellular and animal studies and its real impact
on human health is not clearly demostrated.
In my opinion risks of
cocaethylene have been exaggerated to create fear. I won´t say
that the toxic effect is not real, but I think it is exaggerated.
There
is no evidence yet that low-medium doses or frequencies of
cocaine and alcohol have long-lasting, important toxic effects on liver
function. In alcohol this has been well studied (even, there are studies
that shows cardiovascular benefits of low doses of wine, we talked
about this before). The fact that alcohol is a legal , socially accepted
drug, facilitates this kind of investigation.
Of course, high doses
and/or frequencies of cocaine and alcohol can damage the liver. And by
mixing both substances this risk will more than likely increase. The
molecular mechanisms that produce this damage can´t be avoided using
antidotes, treatments, plants or milk. These measures have no known
health benefits other than the possible placebo effect. Moderation on
doses and frequencies (and abstinence in the case of liver diseases as
viral, autoinmune or drug-induced hepatitis) are the most important and
effective ways to avoid or minimize harm.
-
Are you there DoctorX? It's me, Margaret.
I have a problem with a needle. Well, it wouldn't be a problem if I was better at using it.
I
am overweight, have trouble finding veins, and I know it's an issue of
skill and practice since some of my old-timer junkie friends find them
(with a little trouble) but no misses. I end up with dozens of
bruises and the occasional infection (the most recent was very serious).
I'd
like to say I'll quit, but I don't lie to my doctors. If you have
any advice (and yes, I know the weight lifting and hot water tricks)
please, it would be greatly appreciated.
Yours truly,
Margaret
-
Hi Doctor,
On the subject of cocaine binges -- using .75grams
of decent cocaine (presumably no active cuts) 5 out of 7 days a week
for a couple months straight, usually over the course of 6 hours or
so. Healthy diet -- lots of fruits and veggies, immunity &
respiratory supplements (various mushroom extracts, active), 100-200 ue
Vitamin E daily, along with ending each session with 7-10mg diazepam and
a good saline wash. Daily GABA Calm supplements (Magnesium 5
mg, gamma-aminobutyric acid 125 mg, Glycine 50 mg, N-Acetyl L-Tyrosine
25 mg, Taurine 20 mg). Also exercising 45-60 minutes in the mornings 4
days a week. Male age between 26-32, generally healthy otherwise,
don't smoke or drink.
I don't feel amazing but I definitely don't
feel like a wreck either. Though my eyes have looked better
-- I am definitely getting some bruising near & below my eyes next
to the top of my nose. Anything I can do to help with that?
And am I in serious trouble (aside from getting an addiction under
control)? I have heard stories of people using cocaine for
years. I know not everyone is different, just trying to get an
honest assessment of how dangerous this might be. Be honest please
:) Many blessings to you.
-
Not a doctor here, but cocaine it's very dangerous for your nose on the long run.
-
BEN:
« Reply #348 on: July 21, 2013, 01:10 am »
First
of all - ignore karma. I get plenty of negative karma just because i
tell people things they do no want to hear, regardless if they are true
(they mostly are). If you believe in karma, it is not measured by
whatever +/- numbers appear under your user name ;)
As far as
excusing drug use based on some group that did so in the past, or even
does today, that fact in itself says nothing about safety of the drug.
With
such logic you could reason that smoking tobacco must not be dangerous
because everyone in the western world was doing it in the 50s, 60s, 70s
and 80s. Westerners certainly did not go extinct because of this habit,
but in retrospect scientific analysis does prove that it actually is
detrimental to health.
As a smoker myself i don't even fall for
that line of reasoning: surely the majority of people that lit up in the
70s are not dead because of that, but a significant number of them are
facing death due to their use back in the day.
I suppose being
honest with yourself about these things is the best thing: i am very
well aware that smoking could kill me at some point, sooner or later,
but i -choose- to accept that risk because i feel the short term
benefits outweigh it. Scientifically this makes no sense at all, but
that is often the problem with addiction to any drug.
The
whole tobacco thing makes me think about my own addiction to nicotine,
given up more or less 30 years ago. In those 30 years maybe 10-15
smokes in three or fours year give or take a few, years and
smokes. Still today I would love to smoke a nice cigarette and did
a few months ago. Bad move, it screwed up my body for several
weeks. Some sort of cold, or cold sore, or some such thing.
Now when I smoke weed I'm fantasizing about tobacco. I wonder what
% of cigarette smokers are addicted? It must be more than 75% of
regular day to day smokers who are addicts. Talk about a gateway
drug, tobacco is it.
Some of the folks around here make a whole
lot more sense than straight folks do. Ben is still under
probation but he seems to be one of those people.
-
Hi DoctorX
I was guided to ask my question from you:
I have one post in newbie section where i tell about myself and my health condition(ptsd).
However
im asking here is there any drug that doesn't interfere with my memory
and emotions much except it would soothe fear and anxiety(euphoria type
feeling could of course push me at bit better forward)? This is for
therapeutic purposes.
I took MDMA only little while ago(couple
days ago) and felt bit that high cortisol production(i suspect) kinda
interfered any kind of remembering and feeling. I only felt like i want
to rest and were really unable to think anything. It weren't bad, but it
weren't something that i looked for either.
So do you know anything that could help?
Regards,
blackroses
Hi,
there are several studies showing improvements in treatment of PSTD with MDMA assisted psychotherapy.
https://www.ncbi.nlm.nih.gov/pubmed/20643699
https://www.ncbi.nlm.nih.gov/pubmed/23118021
https://www.ncbi.nlm.nih.gov/pubmed/23172889
Results
are preliminar but, due to the unique characteristics of MDMA
experience there is enough data to think that it may be useful, at least
in some patients. One important point to consider is that we are
talking about "assisted psychotherapy". To be useful, MDMA should be
administered in a clinical setting; in general after several interviews
with therapist, one or two sessions of psychotherapy are performed under
MDMA effects, exploring psychological barriers that are difficult to
handle in a normal state of consciousness. In theory, the patient
"learns" to manage with the repressed psychological material causing
stress.
But it is very difficult (I would say almost impossible) that
one can do that by oneself without a good professional psychologist or
psychiatrist specifically trained and with personal experience of
MDMA. MDMA is administered in 1-2 occasions during treatment. MDMA
wouldn´t cure as conventional drugs, but offering a unique experience
useful for the patient.
There are several studies and scientific
teams working with MDMA and PTSD. MAPS page
(http://www.maps.org/research/mdma/) offers the best information
available on this treatment approach.
There are several studies and
scientific teams working with MDMA and PTSD. MAPS page
(http://www.maps.org/research/mdma/) offers the best information
available on this particular.
-
Re: What is the best drug for social anxiety?
« Reply #85 on: January 20, 2013, 07:14 am »
Well,
I have a bit of experience with these issues. I had beed diagnosed by
both a neurologist and a pychiatrist (however that's properly spelled)
with Generalized Anxiety Disorder and Social Anxiety Disorder with
Disphoria (a low to mid level) depression. I was prescribed a few SSRI's
(not simultaneously, we worked on several 'til We found one that worked
well. Celexa, Effexor and finally Lexapro were the SSRI's, with Lexapro
working quite well with no side effects at all (for me). I also
suffered from panic attacks (severe ones) for which I was prescribed
Xanax. These all worked extremely well for me (note: as someone stated a
few pp up everyone is different - Zoloft was absolutely horrible for
me, for example). I took these (legitimately under a doctor's care) for
approx 6-9 years with excellent results - I'm rather shy, but after a
few years I was entertaining the idea of joining a nudist resort - I
didn't, but gave considerable thought to it.
It
should be noted that Xanax is, as previously stated, bext for short term
anxiety issues (panic attacks, for which it works very, very well), but
is is very addictive and the withdraws (if not tapered down gradually)
can (and did with me) cause Grand Mal siezures - very bad while driving
or the like, obviously. Also, the SSRI's, if that is the route you would
take, are a multi-year therapy, perhaps permanently - this it best
decided by a medical doctor.
There is help
available for this, very effective help, so don't fret too much nor fall
into depression - lots of people have these issues, and the
pharamsuticals (sp) are getting quite sophisticated. Do avoid meth, I'm
sorry, that seems like a very bad idea (unless a real doc prescribes an
amphetamine-based med. Hang in there, this is a far from hopeless
situation.
The
above quoted reply taken from the thread "What is the best drug for
social anxiety?" seems to be the norm when it comes to treating anxiety
or depression. It seems to be the same treatment plan many long
time cigarette smokers are given also, at least those who have trouble
giving it up on their own. Not exactly, but similar maybe from a
non-expert (me) perspective. While this may be not DoctorX's specialty I
wonder if he could comment on treating nicotine addiction as
such. Whatever that means, {as such}, I mean.
One
reason not to take anti-depressants is to avoid going about sans
clothes. Since occasionally I would like to go to a nudist colony,
I'm afraid if I take those new fangled drugs I will find the impulse to
disrobe so powerful and extraordinary that I would find it impossible
to keep my clothes buttoned up.
But
it is very difficult (I would say almost impossible) that one can do
that by oneself without a good professional psychologist or psychiatrist
specifically trained and personally experienced on MDMA. MDMA is
administered in 1-2 occasions during treatment. MDMA wouldn´t cure as
conventional drugs, but offering a unique experience useful for the
patient.
DoctorX,
So
you are saying to do this sort of therapy you must have taken the MDMA
yourself? Do you think it could also be used for behavior
modification as well as PTSD?
Thanks to all and X.
-
Hi DoctorX,
Is Milk Thistle good to clean ones liver or is there a better product?
It's something I want to do after nights of using cocaine in combination with alcohol.
Both
cocaine and alcohol can produce hepatic damage. This effect is, in
general, dose-dependent and reversible at low-medium doses. It is
hypothesized that combination of both substances (cocaine and alcohol)
creates a metabolite (cocaethylene) that is more toxic for liver and
heart than just one substance at a time. But, really, evidence from
cocaetyhlene comes from cellular and animal studies and its real impact
on human health is not clearly demostrated.
In my opinion risks of
cocaethylene have been exaggerated to create fear. I won´t say
that the toxic effect is not real, but I think it is exaggerated.
There
is no evidence yet that low-medium doses or frequencies of
cocaine and alcohol have long-lasting, important toxic effects on liver
function. In alcohol this has been well studied (even, there are studies
that shows cardiovascular benefits of low doses of wine, we talked
about this before). The fact that alcohol is a legal , socially accepted
drug, facilitates this kind of investigation.
Of course, high doses
and/or frequencies of cocaine and alcohol can damage the liver. And by
mixing both substances this risk will more than likely increase. The
molecular mechanisms that produce this damage can´t be avoided using
antidotes, treatments, plants or milk. These measures have no known
health benefits other than the possible placebo effect. Moderation on
doses and frequencies (and abstinence in the case of liver diseases as
viral, autoinmune or drug-induced hepatitis) are the most important and
effective ways to avoid or minimize harm.
-
Any evidence of meth use in low dosages (20-60mgs per day) over long
periods? Any studies on people 60 years or more after a life of
drug use? Not hard, but more 'recreational' type drug use.
MDMA too.
-
Are you there DoctorX? It's me, Margaret.
I have a problem with a needle. Well, it wouldn't be a problem if I was better at using it.
I
am overweight, have trouble finding veins, and I know it's an issue of
skill and practice since some of my old-timer junkie friends find them
(with a little trouble) but no misses. I end up with dozens of
bruises and the occasional infection (the most recent was very serious).
I'd
like to say I'll quit, but I don't lie to my doctors. If you have
any advice (and yes, I know the weight lifting and hot water tricks)
please, it would be greatly appreciated.
Yours truly,
Margaret
I have found an interesting thread on safer injection, there you will find reliable information about how to find veins:
http://www.drugs-forum.com/forum/showthread.php?t=28116
Using
a tourniquet is reccomended, but it also has some risks. Here is
additional information on this. Remember: never use it more than 1
minute and always quit it before injecting
http://injectingadvice.com/articles/basics/147-tourniquet30nov
-
Posted by: b999
« on: Today at 12:42 pm »
Any
evidence of meth use in low dosages (20-60mgs per day) over long
periods? Any studies on people 60 years or more after a life of
drug use? Not hard, but more 'recreational' type drug use.
MDMA too.
If
I might piggyback on b999's question here. Is there a difference
in ability to get work done on meth compared with say ritilan/adderal
and cocaine? From my memory Freud and others had substantial coke
habits back in their day. We all know of the opium dens that the
Chinese had in California when they worked on the railroads in late
1800's and early 1900's.
-
But
it is very difficult (I would say almost impossible) that one can do
that by oneself without a good professional psychologist or psychiatrist
specifically trained and personally experienced on MDMA. MDMA is
administered in 1-2 occasions during treatment. MDMA wouldn´t cure as
conventional drugs, but offering a unique experience useful for the
patient.
DoctorX,
So
you are saying to do this sort of therapy you must have taken the MDMA
yourself? Do you think it could also be used for behavior
modification as well as PTSD?
Thanks to all and X.
Thats
rather interesting idea - behavioral modification i mean. Any way, to
return my own topic, it would be quite a miracle to find "professional"
psychologist, who have used mdma and who really knows how to guide
me(person who is not "academic", but really can guide me by my
individual personality - thats rare. Finding similar temperament as you)
and has needed information/experience. In a small country. Even though
im willing to try mdma, is there any other drug that would me allow
think(no memory interrupting) and feel(especially cry; haven't been able
to do that in a while) without fear present? Question is for all. Out
of curiosity. :)
-
You will never find a drug that replaces the human spirit. Cry
with fear, that's what it's all about. Just cry full stop.
Laughing also activates the same neural pathways too so seriously, a
good hearty laugh helps too, with friends especially.
Meth has
helped me for the dopamine reward combined with exercise, boy it sure
helps 'behavioural modification'. I'm not sure about MDMA as I
don't think I need any more seratonin. I'm actually cautious about
boosting seratonin and think dopamine is the key and then use indirect /
other methods to boost seratonin - like lifestyle overall and a healthy
social life.
Dopamine helps focus, and in small modest amounts
meth seems to work really well despite all concerns and suggestions I
should try something else, not that I have much if any experience with
anything else so I wouldn't really know.
I just need to dive in
and do stuff, not run around hugging people. An active social /
community / physical lifestyle seems to take care of that bit. Was
once depressed.. Community involvement and making lots of friends
cured that pretty quickly.
Be careful of replacing the basic human need for ongoing social connection in a 'village' with drugs.
That's
why (ironically) I think I prefer meth. It just helps me improve
my lifestyle, lose weight, focus etc but leaves the rest of the
'personal development' to me.
Unorthodox I know, perhaps. But... who knows.
-
Anyone got some advice for the kid with the pointy things?
:o
-
Margaret,
Just curious did you look at the links X posted for you? What did you think?
I have found an interesting thread on safer injection, there you will find reliable information about how to find veins:
http://www.drugs-forum.com/forum/showthread.php?t=28116
Using
a tourniquet is reccomended, but it also has some risks. Here is
additional information on this. Remember: never use it more than 1
minute and always quit it before injecting
http://injectingadvice.com/articles/basics/147-tourniquet30nov
-
Hi Doctor,
On
the subject of cocaine binges -- using .75grams of decent cocaine
(presumably no active cuts) 5 out of 7 days a week for a couple months
straight, usually over the course of 6 hours or so. Healthy diet
-- lots of fruits and veggies, immunity & respiratory supplements
(various mushroom extracts, active), 100-200 ue Vitamin E daily, along
with ending each session with 7-10mg diazepam and a good saline
wash. Daily GABA Calm supplements (Magnesium 5 mg,
gamma-aminobutyric acid 125 mg, Glycine 50 mg, N-Acetyl L-Tyrosine 25
mg, Taurine 20 mg). Also exercising 45-60 minutes in the mornings 4 days
a week. Male age between 26-32, generally healthy otherwise,
don't smoke or drink.
I don't feel amazing but I definitely don't
feel like a wreck either. Though my eyes have looked better
-- I am definitely getting some bruising near & below my eyes next
to the top of my nose. Anything I can do to help with that?
And am I in serious trouble (aside from getting an addiction under
control)? I have heard stories of people using cocaine for
years. I know not everyone is different, just trying to get an
honest assessment of how dangerous this might be. Be honest please
:) Many blessings to you.
With
some drugs it is easy to calculate or estimate the risks of a concrete
pattern of usage. There are epidemiological studies about safe dosage of
alcohol, for example. Other drugs (like GHB or methamphetamine) have
been used as prescription drug and so we know adverse effects or
toxicity. But, as far as I know, there are no studies about risks of
daily or very frequent intranasal dosage cocaine and its relation with
dosage.
So, my "honest" (as you request) opinion is not based in
scientific studies, but in my experience and general knowledge. In
general, frequent use of drugs is more risky than ocassional, recreative
use. This is obvious, but I think this rise of risks is greater for
stimulants than for other drugs like, for example cannabis.
I
think daily or almost daily use of such a dose of cocaine may be harmful
at medium or long term. Cocaine has robust cardiovascular effects
and frequent use can cause problems such as hypertension.
Psychologically there can be also some problems: frequent users of
cocaine are prone to anxiety, depressive or paranoid reactions.
Sometimes these conditions are not serious but there are subtle
personality alterations. The risk of dependence also exists and may be
increased if you are using another addictive drug at the same time
(diazepam). This mixture (benzos after cocaine) can be useful used
occasionally but I don´t think it is a good idea an an habit. It is
important that you consider yourself ( I don´t know if this expression
is correct in English..."consider yourself", "think about...") about the
motivations, objectives and feel of self-contol of your cocaine use.
We talked about safe intranasal drug use some days ago:
http://dkn255hz262ypmii.onion/index.php?topic=147607.msg1328056#msg1328056
-
Margaret,
Just curious did you look at the links X posted for you? What did you think?
I have found an interesting thread on safer injection, there you will find reliable information about how to find veins:
http://www.drugs-forum.com/forum/showthread.php?t=28116
Using
a tourniquet is reccomended, but it also has some risks. Here is
additional information on this. Remember: never use it more than 1
minute and always quit it before injecting
http://injectingadvice.com/articles/basics/147-tourniquet30nov
I thought I had scoured this thread for a reply :o
Thanks cleansober! And thanks, DocX!
-
I thought I had scoured this thread for a reply
I'm
not sure whether you scoured this current thread or you scoured the IV
thread. Sounds like you have similar problem to small children and
babies when medical professionals need to locate good veins.
While I would like to say good luck on the hunt, I'm scared of pointy
things, especially needles.
Clean
-
I thought I had scoured this thread for a reply
I'm
not sure whether you scoured this current thread or you scoured the IV
thread. Sounds like you have similar problem to small children and
babies when medical professionals need to locate good veins.
While I would like to say good luck on the hunt, I'm scared of pointy
things, especially needles.
Clean
I
have the problem fat people have when finding a vein... Recently
got a nifty medical tourniquet that won't snap on my excessively
corpulent arms, and found that it solved most of the problem I was
having before. Two shots went off perfectly whereas before, I
would be digging around forever trying to get one even partial hit.
And
that's probably good. I think it's important for every drug user
to KNOW how to inject. Even if you don't every anticipate doing
it, it could come in handy for many reasons. But I'm more addicted
to the needle than any drug I have ever done. I'm not hooked on
H, haven't done more than a line or two of coke since I was a teenager,
and Meth's usually a no-no for me seeing as my family has a history of
speed abuse.
But even if I'm not fiending for something in
particular, I find myself wanting to take a poke. Fill it with
something that gives me a rush, see that blood enter...
Kids, I'm
not your mommy, and I won't tell you what to do, but take it from
someone who seems to only lie to their loved one about this one
thing-- DON'T pick that needle up unless you've already
started. At this point, I'm mostly resigned to it, trying not to
regret what's already done, and trying to do it correctly so I can
minimize harm.
Much love, my beautiful druggarts,
~Ali
-
Re: What is the best drug for social anxiety?
« Reply #85 on: January 20, 2013, 07:14 am »
Well,
I have a bit of experience with these issues. I had beed diagnosed by
both a neurologist and a pychiatrist (however that's properly spelled)
with Generalized Anxiety Disorder and Social Anxiety Disorder with
Disphoria (a low to mid level) depression. I was prescribed a few SSRI's
(not simultaneously, we worked on several 'til We found one that worked
well. Celexa, Effexor and finally Lexapro were the SSRI's, with Lexapro
working quite well with no side effects at all (for me). I also
suffered from panic attacks (severe ones) for which I was prescribed
Xanax. These all worked extremely well for me (note: as someone stated a
few pp up everyone is different - Zoloft was absolutely horrible for
me, for example). I took these (legitimately under a doctor's care) for
approx 6-9 years with excellent results - I'm rather shy, but after a
few years I was entertaining the idea of joining a nudist resort - I
didn't, but gave considerable thought to it.
It
should be noted that Xanax is, as previously stated, bext for short term
anxiety issues (panic attacks, for which it works very, very well), but
is is very addictive and the withdraws (if not tapered down gradually)
can (and did with me) cause Grand Mal siezures - very bad while driving
or the like, obviously. Also, the SSRI's, if that is the route you would
take, are a multi-year therapy, perhaps permanently - this it best
decided by a medical doctor.
There is help
available for this, very effective help, so don't fret too much nor fall
into depression - lots of people have these issues, and the
pharamsuticals (sp) are getting quite sophisticated. Do avoid meth, I'm
sorry, that seems like a very bad idea (unless a real doc prescribes an
amphetamine-based med. Hang in there, this is a far from hopeless
situation.
The
above quoted reply taken from the thread "What is the best drug for
social anxiety?" seems to be the norm when it comes to treating anxiety
or depression. It seems to be the same treatment plan many long
time cigarette smokers are given also, at least those who have trouble
giving it up on their own. Not exactly, but similar maybe from a
non-expert (me) perspective. While this may be not DoctorX's specialty I
wonder if he could comment on treating nicotine addiction as
such. Whatever that means, {as such}, I mean.
One
reason not to take anti-depressants is to avoid going about sans
clothes. Since occasionally I would like to go to a nudist colony,
I'm afraid if I take those new fangled drugs I will find the impulse to
disrobe so powerful and extraordinary that I would find it impossible
to keep my clothes buttoned up.
But
it is very difficult (I would say almost impossible) that one can do
that by oneself without a good professional psychologist or psychiatrist
specifically trained and personally experienced on MDMA. MDMA is
administered in 1-2 occasions during treatment. MDMA wouldn´t cure as
conventional drugs, but offering a unique experience useful for the
patient.
DoctorX,
So
you are saying to do this sort of therapy you must have taken the MDMA
yourself? Do you think it could also be used for behavior
modification as well as PTSD?
Thanks to all and X.
There
are three main pharmacological treatments for nicotine addiction.
Nicotine replacement therapy imitates the heroin/methadone model,
changing the way of administration of nicotine from a high-addictive one
(smoked) to a less adictive one: chewing gums, patchs, bucal or
intranasal sprays. The other two approved prescrition drugs for this
purpose are bupropion (a dopamine/noradrenaline reuptake inhibitor) and
varenicline (a nicotinic receptor partial agonist). Each one of these
drugs have their own benefits and disadvantages and are more o less
suitable depending on the situation.
Regarding MDMA therapy it is
very importat that the therapist has some experience with the drug.
This is one of the particular characteristics of therapeutic use of
psychedelics. You don´t need to have cancer or diabetes to be a good
doctor in cancer or diabetes. But this practical knowledge is essential
for psychedelic therapy.I think the unique characteristics of MDMA
experience can be useful for PTSD, but I don´t think the same for
behaviour modification. In this case I don´t think MDMA could work
-
sub
-
Any
evidence of meth use in low dosages (20-60mgs per day) over long
periods? Any studies on people 60 years or more after a life of
drug use? Not hard, but more 'recreational' type drug use.
MDMA too.
Methamphetamine
is a FDA-approved drug under the name of Desoxyn. There are clinical
trials and dosages studied are in the rank 5-25 mg, administered by oral
route. So, at these dosages and way of administration there is no risk
of neurotoxicity. Technical sheet of the product inform about known
adverse and toxic effects of stimulants (cardiac, psychiatric, risk of
dependence...)- In concrete case of meth, there are not studies on
people over 65 years.
There are studies of long-term effects of
almost every drug. But, in general, these studies give hypothesis or
orientations. The fact that one person takes a certain drug doesn´t mean
that the drug is the cause of a problem. For example, there are many
studies on MDMA users showing some memory deficit in very frequent
users. But it is unclear if MDMA is the cause or there can be other
factors (use of other drugs, adulteration, lifestyle...) that can be in
relation with the effect shown.
-
DocX,
What would you say are the proper precautions to take to avoid taking PMA in what you think is MDMA?
Sober,
-
How much is too much cocaine to ingest via insulffation in one
sitting? I have went through 3-4 grams in one sitting.I generally only
snort the purest cocaine.
-
How
much is too much cocaine to ingest via insulffation in one sitting? I
have went through 3-4 grams in one sitting.I generally only snort the
purest cocaine.
holy mackerel that's a lot of blow lol
-
I don´t agree with the idea that it should be very difficult to find
a therapist with practical experience with MDMA. The history of MDMA is
closely vinculated to psychiatry.MDMA first use was therapeutic, and
during the 70s-early 80s, at least in United States, thousands of
professional ( medicine, psychology, psychiatry) learnt and experimented
with patients.
" When Shulgin had him try MDMA in 1977, Zeff was
so impressed that he came out of retirement to proselytize for it. Ann
Shulgin remembers a speaker at Zeff's memorial service saying that Zeff
had introduced the drug to ''about 4,000'' therapists. "
http://www.nytimes.com/2005/01/30/magazine/30ECSTASY.html
Most
of these professional remain "in the closet" as nobody wants to be
related with a forbidden drug. There are a few professional that
administer MDMA to patients in therapeutic settings, but they remain
underground and information is only available by personal , selected
contacts because of the severe legal problems thwy would have to face if
their activity is illegal.
I think this personal experience is
fundamental. Nobody can learn to drive or skiing without a professor who
knows the subject. With psychedelics it is possible that oneself
experiments "illuminative" or trascendental experiences that mean deep
changes without other persons. But these experiences can´t be provoked
or searched, they just happen sometimes. Therapeutic use of psychedelics
imply some kind of guide or help by a person with enough knowledge,
both theoretical and practical
But
it is very difficult (I would say almost impossible) that one can do
that by oneself without a good professional psychologist or psychiatrist
specifically trained and personally experienced on MDMA. MDMA is
administered in 1-2 occasions during treatment. MDMA wouldn´t cure as
conventional drugs, but offering a unique experience useful for the
patient.
DoctorX,
So
you are saying to do this sort of therapy you must have taken the MDMA
yourself? Do you think it could also be used for behavior
modification as well as PTSD?
Thanks to all and X.
Thats
rather interesting idea - behavioral modification i mean. Any way, to
return my own topic, it would be quite a miracle to find "professional"
psychologist, who have used mdma and who really knows how to guide
me(person who is not "academic", but really can guide me by my
individual personality - thats rare. Finding similar temperament as you)
and has needed information/experience. In a small country. Even though
im willing to try mdma, is there any other drug that would me allow
think(no memory interrupting) and feel(especially cry; haven't been able
to do that in a while) without fear present? Question is for all. Out
of curiosity. :)
-
A Drug Testing Service is the best (and only) way to avoid PMA and
other adulterants. The simplest techniques use reactives (Marquis,
Mecke, Mandelin, Robadope...) to detect the presence or absence of a
determinated substance or family of substances. They have limitations.
For example, a sample with pure MDMA and other sample with MDMA+other
substances will test both positives. They don´t difference similar
substances (MDA and MDMA have the same reaction). There can be some
false positives ( some opiates give a positive reaction to Marquis
test). They only offer aproximate qualitative information, never
quantitative). On the other hand, they are easy to use and can be easily
purchased through Internet.
A Thin Layer Cromatography has a
medium difficulty (it needs an equipment and training), but it separates
different substances in a sample and gives more information about its
composition. Other techniques more sofisticated (Gas chromatography–mass
spectrometry, gas chromatography-ultraviolet) give accurate information
about the exact composition of almost every drug, but they are
expensive and need using complex equipment.
There are a few
countries in the world that allow Drug Testing Service as preventive
measures related with drugs. My country, Spain, is one of them although
these services are poorly financed and bad considered by many politics
and drug experts. You know, the kind of people that say that Drug
Testing Services promote the use of drugs, that are the same who thinks
that using condoms causes sexual promiscuity, or that fire extinguishers
promote fire. This kind of persons that are more concerned about their
moral prejudices than Public Health.
I am actually involved in a
project to create an International Drug Testing Service. In this moment
is a embryonic idea limited by funding problems. If anyone knows a rich
philanthropist SR vendor or some kind of patron, please tell them.
Anyway I will inform if the project is started-up
DocX,
What would you say are the proper precautions to take to avoid taking PMA in what you think is MDMA?
Sober,
-
Thanks :) +1
-
doc x,
what is your take on m1 in terms of it being more or less nuro-toxic than mdma?
Thank you,
-
How
much is too much cocaine to ingest via insulffation in one sitting? I
have went through 3-4 grams in one sitting.I generally only snort the
purest cocaine.
holy mackerel that's a lot of blow lol
Hahah
yeah I have snorted an 8ball in one sitting more than I would like to
admit. I don't get down as much as I use to. But when I do I go pretty
nuts.
-
I
think this personal experience is fundamental. Nobody can learn to
drive or skiing without a professor who knows the subject. With
psychedelics it is possible that oneself experiments "illuminative" or
trascendental experiences that mean deep changes without other persons.
But these experiences can´t be provoked or searched, they just happen
sometimes. Therapeutic use of psychedelics imply some kind of guide or
help by a person with enough knowledge, both theoretical and practical
DoctorX,
It
seems most of the time having a professional dedicated to helping you
learn anything is easier than trying to go it on your own. The old
saying when the student is ready the teacher will appear, seems apt
here. Maybe not, but I want to use the word apt so bear with me here.
Taking on the novice role is something I seem to have never gotten
beyond and part of the fascination weed has for me is it allows me to
forget about my perpetual novice status and move into a pleasant plane
where I'm no longer just a beginner but rather feel part of
something. I'm sure if there was an expert available who would say
more than "just say no" and guide me in proper integration of pot into
my life I would be better off. This assumes there is an answer to
the dilemma should I do it at all and how to avoid unhealthy patterns of
usage if I decide to continue. Do I really have free will when it
comes to making these choices or am I a bundle of biochemical and
neurological givens reacting to my environment? Its easy to say no
when you have no supply, more difficult if it is freely
available. Just thinkin'.
And furthermore why can't I
figure out that PGP stuff, makes me feel dumb. Everyone around
hear has keys and I'm keyless because of my ineptitude. My thought
is it don't matter anyway but others have good reason to disagree with
that.
Other people have what they need;
I alone possess nothing.
I alone drift about,
like someone without a home.
I am like an idiot, my mind is so empty.
Other people are bright;
I alone am dark.
Other people are sharper;
I alone am dull.
Other people have a purpose;
I alone don't know.
I drift like a wave on the ocean,
I blow as aimless as the wind.
Tao Te Ching
Much more to the Tao but this idea resonates for me every time I re-read it.
-
DoctorX,
I have a question about MDMA and lactation. A couple
I know had a child early this march. Both parents want to take MDMA to
open their harts about how beautiful their child is and that kind of
things, but the mother is pretty concerned about how this could affect
lactation. She can't take pharmaceuticals like ibuprofen so she wants to
know if MDMA would affect her breast milk. So I thought of asking the
good doctor for them and tell them if they could or couldn't do it. Do
you know something about this particular issue?
Thanks a lot, this threat is one of those things that justify the existence of Silk Road.
-
How
much is too much cocaine to ingest via insulffation in one sitting? I
have went through 3-4 grams in one sitting.I generally only snort the
purest cocaine.
This
question is very difficult to answer. Think about the question "How
much is too much alcohol to ingest in one setting? ". For some people
2-3 drinks of whisky should be too much, other people would think that
one bottle, there are even people that think that any quantity of
alcohol is too much. Factors like age, sex, speed of administration,
adulteration and personal factors are very important. Tolerance
makes that people who use regularly a drug, can take doses that would be
toxic for a non-regular user.
It is also important to consider what
do you mean with "too much"...Too much for having mild adverse effects?
To have an overdose? To die?.
In the particular case of cocaine, in
general it is considered that a normal dose in a line should be
30-100mg, and it also depends is on the intensity of effects
sought. Some people take just one dose and other will take more than 20
in a unique occasion.
We have exact ranks of dosage for prescription
drugs but not for recreative drugs. In pharmacology, there is a
parameter called "LD50" used to measure the toxicity of a drug. LD50
means the medium dose necessary to kill 50% of a group of
experimentation animals. Knowing the LD50 for different species (rats,
dogs, monkeys) and using mathematical models, it is possible to
calculate the human LD50, although it is only an estimation.
In the
case of LD50 for cocaine there are different data. Grinspoon and
Bakalar say in their book "Cocaine: A Drug and It’s Social Evolution"
that it is 20 mg/kg orally in dogs or 10 mg/kg
subcutaneously/intravenously. LD50 for humans is calculated in the rank
1.5-2.5 grams of pure cocaine, although I insist that this parameter in
only a theoretical estimation. Some people would have serious problems
using less cocaine in one occasion and other (people with tolerance)
could use higher doses.
In any case, I think 3-4 grams in one
occasion is a very high dosage and can lead to problems. You should also
consider that nasal surface of absorption is small, capacity of
absorption is saturated and the vasoconstrictor effect of cocaine makes
that, when you reach certain dosage, the rest is not absorbed and
wasted.
-
Doctor,
I am doing a very low carb diet. I get between 10 and 15 "net carbs" a day. I am overweight but am nearing my goal.
My
question is that a friend and I were planning on having a quiet party
with 25 mg of 2C-B each. Should I bring myself out of Ketosis for this
party and bring my blood sugar up? Is that something that you would
recommend or should I continue dieting through the 2C-B?
-
How
much is too much cocaine to ingest via insulffation in one sitting? I
have went through 3-4 grams in one sitting.I generally only snort the
purest cocaine.
holy mackerel that's a lot of blow lol
Hahah
yeah I have snorted an 8ball in one sitting more than I would like to
admit. I don't get down as much as I use to. But when I do I go pretty
nuts.
Would really have to know the purity. probably 30% cocaine?
-
"If you leave cocaine, MDMA, meth or 4-AcO-DMT on a table, they won´t try to assault you, rape you or hit your balls. "
This is axiomatic yet inexplicably overlooked by the mainstream.
And of course your turn of phrase is brilliant. Props, doc.
-
doctor x, i have a question sorry i did not read 29 pages, i am too lazy now
Cocaine.
Is snorting it the safest (less damage) way to use, instead of
smoking, or IV (considering its pure with no cuts/adulterants)?
Weed. smoking pure weed in joints, or in bongs.. is it safer for the lungs instead of smoking in a joint mixed with tobacco?
Thank you a lot in advance for any answer.
-
the best idea ever done, concerning drugs. All the best for you doctor :)
-
Wow doctor, thanks for taking the time out and replying to everyone's questions.Respect.
I
have a question for you regarding drug interactions. I am
currently taking abilify,an anti-psychotic medication. I have recently
thought about doing MDMA on a social basis. How will that drug interact
with that particular anti-psychotic? I've heard it reduces the
effects of MDMA at best,at worst it can make you really sick with
serotonin syndrome. How likely is SS?
Also, if you have the time
to explain how abilify interacts with other drugs such as; mephedrone,
ketamine and LSD, this information would be of most help.
Thank you.
-
top44 says in Reply 386:
doctor x, i have a question sorry i did not read 29 pages, i am too lazy now
Cocaine.
Is snorting it the safest (less damage) way to use, instead of
smoking, or IV (considering its pure with no cuts/adulterants)?
Weed. smoking pure weed in joints, or in bongs.. is it safer for the lungs instead of smoking in a joint mixed with tobacco?
Would
it be fair to say different ways of drug administration, ie. pill,
smoke, IV, etc all have a different risk of dependance/addiction?
One logical reason few teens become regular alcohol users is it takes a
good deal of work and money to drink on a daily basis while smoking
cannabis is a relatively quick and easy thing to do. Not to
mention it is probably easier to finance a pot den than alcohol parlor.
Also
this thread is a mere 26 pages but you might just look at just
DoctorX's posts to cut down the noise factor. Click his name and
"show posts" to get the straight dope.
CS
-
How
much is too much cocaine to ingest via insulffation in one sitting? I
have went through 3-4 grams in one sitting.I generally only snort the
purest cocaine.
holy mackerel that's a lot of blow lol
Hahah
yeah I have snorted an 8ball in one sitting more than I would like to
admit. I don't get down as much as I use to. But when I do I go pretty
nuts.
Would really have to know the purity. probably 30% cocaine?
Way
higher than that.A good friend of mine who is in Federal Prison was
pretty big in the game. I used to get stuff literally right off of the
block. I think the more pure the example, the more of a challenge to
stop.Thank Dr. for your response,I sent a small donation for your time. I
am aware of the concept of an LD. My concern with "too much" was ODing
specifically. I have passed out before from snorting cocaine. Not really
sure what happened to be honest. I was snorting rails all night with a
friend then he leaves and I obviously continue. I must have had about a
gram before I purchased an 8ball. I just remember waking up on my bed,
then having a very intense urge to vomit. Which I preceded to do for
about 10 minutes then I was left with massive diarrhea. My body temp
skyrocketed and I felt very faint. No idea how I came to end up on my
bed.For some reason I completely blacked out. I had fallen and hit my
head leaving a cut. The glass picture frame I was using to crank lines
off of was broken on the floor with my blow every where. I am guessing
that I overdosed..
-
How
much is too much cocaine to ingest via insulffation in one sitting? I
have went through 3-4 grams in one sitting.I generally only snort the
purest cocaine.
This
question is very difficult to answer. Think about the question "How
much is too much alcohol to ingest in one setting? ". For some people
2-3 drinks of whisky should be too much, other people would think that
one bottle, there are even people that think that any quantity of
alcohol is too much. Factors like age, sex, speed of administration,
adulteration and personal factors are very important. Tolerance
makes that people who use regularly a drug, can take doses that would be
toxic for a non-regular user.
It is also important to consider what
do you mean with "too much"...Too much for having mild adverse effects?
To have an overdose? To die?.
In the particular case of cocaine, in
general it is considered that a normal dose in a line should be
30-100mg, and it also depends is on the intensity of effects
sought. Some people take just one dose and other will take more than 20
in a unique occasion.
We have exact ranks of dosage for prescription
drugs but not for recreative drugs. In pharmacology, there is a
parameter called "LD50" used to measure the toxicity of a drug. LD50
means the medium dose necessary to kill 50% of a group of
experimentation animals. Knowing the LD50 for different species (rats,
dogs, monkeys) and using mathematical models, it is possible to
calculate the human LD50, although it is only an estimation.
In the
case of LD50 for cocaine there are different data. Grinspoon and
Bakalar say in their book "Cocaine: A Drug and It’s Social Evolution"
that it is 20 mg/kg orally in dogs or 10 mg/kg
subcutaneously/intravenously. LD50 for humans is calculated in the rank
1.5-2.5 grams of pure cocaine, although I insist that this parameter in
only a theoretical estimation. Some people would have serious problems
using less cocaine in one occasion and other (people with tolerance)
could use higher doses.
In any case, I think 3-4 grams in one
occasion is a very high dosage and can lead to problems. You should also
consider that nasal surface of absorption is small, capacity of
absorption is saturated and the vasoconstrictor effect of cocaine makes
that, when you reach certain dosage, the rest is not absorbed and
wasted.
I've
heard of people snorting one gram of pure cocaine .Also in the
movie Blow starring Johnny Depp he snorts ten grams in ten minutes..
Alcohol amplifies cocaines effect..the liver creates a toxic by product
which can kill.
Personally I think stuff that has been cut with
nasties such as Levisamole make the product much much more dangerous..
IV use with Coke is very high risk.I've snorted half a gram lines
of pure with no ill effect well over 3 grams on plenty of occasions.
It is true though a 100mg line is considered maximum for most people and 1gram is a huge night out.
-
doc x,
what is your take on m1 in terms of it being more or less nuro-toxic than mdma?
Thank you,
We talked about this subject some weeks ago:
http://dkn255hz262ypmii.onion/index.php?topic=147607.msg1096017#msg1096017
-
Hey Doctor,
Do you know anything about a correlation between regularly smoking marijuana and developing schizophrenia later in life?
Thanks for any info
-
The relation between MDMA and lactation is not clear. As far as I
know, there are no published studies on this particular issue. Available
data on amphetamine show that "In dosages prescribed for medical
indications, some evidence indicates that amphetamine might not affect
nursing infants adversely.". On the other hand, data from
methamphetamine show that meth is secreted to breast milk and it should
be avoided.
http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~LJwPas:1
http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~LJwPas:2
In
my opinion, it is basic to avoid use that can be harmful to third
persons. So there would be three options: 1) Wait to finish lactation
and then use MDMA 2) Interrupt natural lactation (use artificial
milk) and use MDMA 3) Collect enough milk for 3-4 days (using a
breast-pump), keep it in the fridge and use it during the following days
to MDMA use
DoctorX,
I
have a question about MDMA and lactation. A couple I know had a child
early this march. Both parents want to take MDMA to open their harts
about how beautiful their child is and that kind of things, but the
mother is pretty concerned about how this could affect lactation. She
can't take pharmaceuticals like ibuprofen so she wants to know if MDMA
would affect her breast milk. So I thought of asking the good doctor for
them and tell them if they could or couldn't do it. Do you know
something about this particular issue?
Thanks a lot, this threat is one of those things that justify the existence of Silk Road.
-
Although 2C-B is a drug first syntethized in 1974 and has more than 3
decades of recreative use, there are only a few studies about its
metabolism and biological effects in humans. In theory, it shouldn´t
alter glucose level, but it is only my opinion and there are no data
about it. So I think it should be prudent to take some sugar or
carbohidrates, at least a few hours before the experience.
Doctor,
I am doing a very low carb diet. I get between 10 and 15 "net carbs" a day. I am overweight but am nearing my goal.
My
question is that a friend and I were planning on having a quiet party
with 25 mg of 2C-B each. Should I bring myself out of Ketosis for this
party and bring my blood sugar up? Is that something that you would
recommend or should I continue dieting through the 2C-B?
-
Hello DoctorX, I am a nursing student, and i have become interested
in disassociates, mxe in particular. I started with DXM, and thru my
research i have discovered that many believe it to be worse than mxe,
because of its"dirty-ness". I have been using it and it seems to help
with physical motivation, I was wondering what your opinion on the
chemical is. I know it is a new chem, but if i am to continue using
disassociates, is it better to stick with occasional dxm, or mxe usage?
I was curious if you are under the impression that is as neurotoxic as pcp, or dxm?
Also, i was wondering if you could go over some of the effects disassociates have on organs and organ systems?
I enjoy psychedelics, but i find mxe helps with my seasonal depression
While cannabis does help my depression it also leaves me anti social, and feeling less intelegent
mxe on the other hand, makes me feel social, functional, and on small doses lets me "think outside of the box"
I feel ketamine has a more addictive craving quality due to its shorter duration
I was wondering if believed the negative effects of mxe, and disassociates in general are greater than what they allow me to be
-
REPLY #239
Dear Dr.
Because
of you I did my work and put my 50 reply's in to tell you I think you
are great. Your answers are amazingly cogent, especially, since I
suspect, English is not your first language. Now my question:
Assuming
a person likes the feeling derived from smoking weed but feels they
like it too much and are not in control. Are there any medicines
you would recommend to help stop the habit or would you suggest talk
therapy to get a handle on things or something else entirely?
You
classify weed as a minor psychedelic and you also suggest limiting ones
use of these substances. Do you also suggest a non-binge pot use
for those who choose to do it? My problem is if I have it I want
to use it until I don't have it anymore. Like a food addict who
can't control the sweet tooth.
SR is an intelligent alternative
to both extremes in the drug world when someone like yourself comes out
of the blue. Take note all you LEO's stalking these pages,
treatment is the answer not punishment. Thanks a bunch DoctorX.
Thanks.
Yes, as you see English is not my first language and my expression and
comprehension are limited. In fact I´m not sure if I have understood
your question.
I thinks drugs have to be used for pleasure, it must
be the person who controls the substance and not the opposite. For some
people, in some situations, with some substances...sometimes this can be
difficult. It someone thinks that his pattern of use is inadequate, and
feels unable to stop it, maybe it is the moment to look for help.
It is not a question of the concrete substance (you are talking about
cannabis, but it is the same for any other drug), but also the person
and the way he/she uses the drug.
Depending on the concrete case,
sometimes is necessary pharmacological help. But it is not a question of
substitute an illegal drug for a prescription drug (with this, we
create another addiction), but to use it wisely during a limited time,
with agreement of the patient. The concrete drug depends on the concrete
situation
DoctorX,
Sorry for repeatedly asking you what seems to be the same question but...
What
is your opinion of regular use of cannabis as a feel good medicine. If a
person takes a non-prescription pain relief drug several times a day we
don't call them a drug fiend or consider them morally bankrupt for
doing so. If someone does the same thing with cannabis they are
considered weak-willed sad sacks. Do you see any justification for
auto-medicating with cannabis? Or said differently what would you
say to a patient who tells you he wants to use weed on a daily basis
for no reason other than he likes how he feels after doing it?
In
a previous response, which I can't find now, you provided a link to the
DSM which detailed the two categories of addiction and
dependance. Persons who regularly use pain medicine might be
classified as dependent, as would many regular healthy compulsive
cannabis users. The main difference is the cannabis user is
reducing pain they didn't even know they have while the former has known
pain symptoms. The comparison is between a healthy cannabis user
and someone who needs pain medicine for a physical problem.
In other words do you think it is unhealthy to use until the bag
is gone? By many accounts I'm a much nicer person when I do so, if
maybe a little out of touch with the here and now.
When out with
friends at a restaurant or bar and drinking alcohol I'm always thinking
I'd rather be smoking than be here. It is both too expensive and
seems less satisfying in comparison with the illegal alternative. I
wonder if it were legal this auto-use compulsion would still exist for
me? Perhaps I need to move to Uruguay to find out. You
describe the paradoxical nature of drug access being easier for young
people to find than adults. Some of my youthful suppliers might
benefit from your wisdom on this subject too.
CS
-
Hello,
Is MDA neurotoxic? And what does that mean? Permanent
lower levels of serotonin? Lower number of serotonin receptors? Neuronal
death?
Also, I've read some people questioning that studies done on
rats are not applicable to humans because a greater response to the drug
in rats, any clue if this is true?
Thanks
-
In general snorting is the most safe of the three ways you indicate
to use cocaine. The risk of dependence depends on many factors, one of
them is way of administration. The fastest the substance reaches brain,
dependence potential is higher. In case of highly-addictive substances
like cocaine, heroin or meth, intranasal use reduces this potential,
although it exist indeed. In relation with other physical and
psychological problems, intranasal use is better also.
Combustion
of vegetals produce toxic substances for the lungs. This is valid for
every vegetal (tobacco or cannabis). It is unclear if products of
combustion from tobacco are more toxic than that from cannabis. But
there is a way to avoid this problem. Using a vaporizer eliminates
completely this problem. There are some models used in clinical trials
that have proved to vaporize cannabis without toxic components
http://www.ncbi.nlm.nih.gov/pubmed/16637053
http://www.ncbi.nlm.nih.gov/pubmed/17437626
http://www.ncbi.nlm.nih.gov/pubmed/17429350
doctor x, i have a question sorry i did not read 29 pages, i am too lazy now
Cocaine.
Is snorting it the safest (less damage) way to use, instead of
smoking, or IV (considering its pure with no cuts/adulterants)?
Weed. smoking pure weed in joints, or in bongs.. is it safer for the lungs instead of smoking in a joint mixed with tobacco?
Thank you a lot in advance for any answer.
-
Wow doctor, thanks for taking the time out and replying to everyone's questions.Respect.
I
have a question for you regarding drug interactions. I am
currently taking abilify,an anti-psychotic medication. I have recently
thought about doing MDMA on a social basis. How will that drug interact
with that particular anti-psychotic? I've heard it reduces the
effects of MDMA at best,at worst it can make you really sick with
serotonin syndrome. How likely is SS?
Also, if you have the time
to explain how abilify interacts with other drugs such as; mephedrone,
ketamine and LSD, this information would be of most help.
Thank you.
As
far as I know, there are no clinical trials or studies of drug
interactions between aripiprazol (Abilify) and MDMA, mephedrone,
ketamine or LSD. It will probably decrease some of the effects of these
substances, particularlly the psychedelic/hallucinogen, but this is only
theoretical speculation. In this case, it is not so important the
pharmacological interaction but the person using it. If you are having a
psychological problem (anxiety or whatever) maybe the use of drugs can
worsen your symptoms, not because a pharmacological problem but because
of the effects of the drug in your mind. Maybe it is more prudent to
wait until you stop your medication, and then enjoy the effects of drugs
-
Hey Doctor,
Do you know anything about a correlation between regularly smoking marijuana and developing schizophrenia later in life?
Thanks for any info
That´s
one of the most controversial things about marijuana. There are some
studies linking use of cannabis and after development of schizophrenia,
particularly in teenagers.
One important point in this subject is
that, the fact that two things are correlated or linked does not mind
that one is the cause of the other. I will try to explain with an
example. I read some time ago a study saying that "people who read the
composition of the food have less problems of obesity".
Probably, who read labels and get information about what they are
eating, are more concerned about their health and have better dietary
habits. But the fact of reading a label won´t keep you thinner ;)
This
is a very important idea,and it is forgotten many times talking about
drugs. In the model we explain schizophrenia actually, there is a
susceptible or pre-morbid personality and there are "stressing factors"
that trigger the disease. Known factors developing schizophrenia are
divorce of parents, military service or sentimental break-up. Use of
psychedelics can also trigger an schizophrenia, but only in susceptible,
pre-morbid personalities. Think that use of cannabis has grown all over
the world in the last 20 years and incidence of schizophrenia remains
stable, around 1%.
-
If LSD down-regulates serotonin receptors, then why isn't it considered as harmful as MDMA in this regard?
-
Wow doctor, thanks for taking the time out and replying to everyone's questions.Respect.
I
have a question for you regarding drug interactions. I am
currently taking abilify,an anti-psychotic medication. I have recently
thought about doing MDMA on a social basis. How will that drug interact
with that particular anti-psychotic? I've heard it reduces the
effects of MDMA at best,at worst it can make you really sick with
serotonin syndrome. How likely is SS?
Also, if you have the time
to explain how abilify interacts with other drugs such as; mephedrone,
ketamine and LSD, this information would be of most help.
Thank you.
As
far as I know, there are no clinical trials or studies of drug
interactions between aripiprazol (Abilify) and MDMA, mephedrone,
ketamine or LSD. It will probably decrease some of the effects of these
substances, particularlly the psychedelic/hallucinogen, but this is only
theoretical speculation. In this case, it is not so important the
pharmacological interaction but the person using it. If you are having a
psychological problem (anxiety or whatever) maybe the use of drugs can
worsen your symptoms, not because a pharmacological problem but because
of the effects of the drug in your mind. Maybe it is more prudent to
wait until you stop your medication, and then enjoy the effects of drugs
Thanks
Doc, your advice has helped me. I will restrain from taking any drugs
until im off the meds,which is only another 4/5 weeks down the line
anyway.Think i'll have a 'rest period' of 1 to 2 weeks before hitting my
stash!
-
Hey Doc. I would like to say that what you're doing is very cool. You're doing a great service here.
I
have been thinking about using etilozam to help me while I get off of
heroin. I have used valium for this in the past and it really
helped. Would you advise against this? How dangerous are [in
particular] benzo "research chemicals?"
Any advice for getting off the needle?
Thank
you for your service. I will look back through the thread to see
if this has been answered already and change my question if so.
It's just that I didn't want to read 20+ pages before getting a change
to ask you...
-
Doctor, thank you so much for volunteering your time and energy to
the users on this site. It is quite a bonus to have access to a doctor
for our questions.
I actually quit using opiates by doing a
flood dose of Iboga under clinical conditions in Mexico (where it is
legal). It immediately halted my physical addiction (130mg of oxy daily)
and withdrawals from it. I mean it when I say immediately. There were
zero w/d symptoms after taking it, though the experience of having Iboga
in my system required a lot of help for a day. It causes major ataxia
and can cause vomiting, though I did not experience that. To me, it is
an amazing option for those who really want to quit.
Do you know about Iboga/Ibogaine?
-
hi doc,
i am an old, longtime coke user.
in the
beginning i was injecting it for many many years, had good qualities
back then, was in peru and bolivia, and, as usual in cases like this, in
the end came paranoia.
it came slow, first a little, then getting harder, after 16 years it was so extreme that i had to stop injecting.
i
did base and crack a while, which, after some years, as well developed
paranoia that can be compared to the para i have when injecting.
today i can only snort.
then the para, which comes in times a little bit, can be controlled mostly.
but
when i injected now (after a break of 15 yerars i did it once shortly
ago) it has not gotten better even after a 15 years beak injecting and
over 10 years break in doing coke at all.
it is all there, as if there was no break.,
anyway, today i am just in the mode for some more coke.
when i did this one injection shortly, it brought me to hell.
as
the kick arrives, i feel like being thrown in a world or situation like
in the movie alien 2, when they are on that planet in that building and
all of a sudden the aliens start moving all around them (and they
realize they are surrounded by these deadly hostile aliens and will not
get out anymore).
all i do is rush back to the wall, down on my knees or lying down on bed, and try to not move.
behind
me (though there is no space behind me) i know and feel THEM who are
attacking me any second now by stabbing knifes into my throat, into my
eyes and whatever. they will do things i wont describe, they are
horrible.
if someone i know is there with me, and i usually trust her/him, i dont trust them anymore in this moment.
this person may assure me : there is noone, we are all alone !
i
dont believe it, i rather believe that person works now together with
the attackers, whom I FEEL AND KNOW are on the jump and located hidden
all around me.
depending in the amount i start trembling but not in a normal tremble way, but more in an epileptic way.
i dont want top describe further, the horrors are much worse than i can describe here.
as good as it was in the beginnign, as bad it is now.
my question to you :
I WANT TO GET RID OF THIS PARANOIA !
i want to inject again and have those divine cocaine kicks i used to have in the early times.
there MUST be some biochemical way to remove or block this paranoia !
there must be some chemical stuff that stops it, makes it not appear.
what do you think could be done ?
what is the reason for this paranoia ?
where is it located in the brain, what happens there when this extreme paranioia comes ?
and why it hasnt turned less after many years of not doing coke.
i know, you probably want to tell me :
stop it - its not worth it, you kill yourself etc. etc pp.
this is completely useless as i wont.
i am a convinced coke user, i may say it is more like a religion to me.
i have it pretty much under control when snorting.
but earlier i called snorting "kindergarten".
it doesnt give a tenth of what an injection can give you.
as it is now, i wont inject anymore, it is simply horrible and nothing else anymore.
but i wish i could !
i'd love to.
if i am to die from coke - so be it.
but what can be done to remove that nerv killing paranoia and be able again to enjoy the "injecting coke kicks" ?
even if it wouldnt be as good as in the beginning, but without that paranoia it would be still good.
so :
what is the reason for this paranoia ?
has anyone ever tried to find out moire about this ?
where is it located ?
what can be done against it ?
i dont need hints like "use diazepam, use lorazepam etc.
i do.
but it only lowers the paranoia, it cannot remove it. not at all.
could you think of any way and anything i could try to get rid of this paranoia and
enjoy the blessing of cocaine injections again ?
thanks.
-
doctor, i am so amazed as well , that you answer to each individual question with such professionalism!
MDMA: How is tolerance built? in a month i have tried 6 months, and every time i can feel it.
LSD:
When tripping i have an appetite for cocaine. I say my self "hmmm i
would easily snort a line if i had now". This is more psychological
issue for me, but my question is,
is LSD in combination with cocaine bad, in a way that even death could be caused???
Thank you very much in advance!
-
Brilliant work doc :) One very simple short question: Is nightly use
of GHB to aid sleep going to be causing physiological damage? Just I
notice that people with narcolepsy can be prescribed it (xyrem) with two
4.5g doses a night to help them sleep at night and stay awake in the
day. So it can't be that damaging, if at all, right?
-
Prescription Self Deliverance AKA Suicide
I am planning on taking
a gram of cyanide as my suicide method but I gotta be honest , I've
considered a great many different options and what it comes down to is :
I'm not a doctor. I dont have the necessary knowledge to determine what
is most painless and certain (and affordable , perhaps). but here you
are. You can't get away from this issue doc; people on silk road will
keep coming looking for answers about methods and you have a
professional obligation to correctly inform them in order to avoid more
painful demises or permanent damage from misinformation or improper
technique. Step away from the social taboo of it , fuck the scorn of the
ignorant parrot propagandist who will repeat slogans they put no
thought into about situations they have no way to critically evaluate ,
and just do the right thing by being a doctor; a caregiver; the provider
of health knowledge towards the ends of aleviating pain. because your
contribution on this matter could mean a great deal to those who reach
out for you and failure to offer your assistance very well may cause
more pain , the opposite of your purpose.
so please, help me , and them, out and tell me the fastest most painless way available currently from the silk road.
sincerely -teddy
-
subbed
-
Prescription Self Deliverance AKA Suicide
I
am planning on taking a gram of cyanide as my suicide method but I
gotta be honest , I've considered a great many different options and
what it comes down to is : I'm not a doctor. I dont have the necessary
knowledge to determine what is most painless and certain (and affordable
, perhaps). but here you are. You can't get away from this issue doc;
people on silk road will keep coming looking for answers about methods
and you have a professional obligation to correctly inform them in order
to avoid more painful demises or permanent damage from misinformation
or improper technique. Step away from the social taboo of it , fuck the
scorn of the ignorant parrot propagandist who will repeat slogans they
put no thought into about situations they have no way to critically
evaluate , and just do the right thing by being a doctor; a caregiver;
the provider of health knowledge towards the ends of aleviating pain.
because your contribution on this matter could mean a great deal to
those who reach out for you and failure to offer your assistance very
well may cause more pain , the opposite of your purpose.
so please, help me , and them, out and tell me the fastest most painless way available currently from the silk road.
sincerely -teddy
Teddy,
have you considered making it look like an accident? It's actually
easier on your loved ones and Life insurance will still pay out. Just a
thought.
-
I dont know that I have life insurance. I only have welfare medical insurance.
-
Ted,
You have the most powerful shit I have read during my
summer internship here at SR. Doc will kill you good, I'm
sure.
I just don't care. never let me tell you otherwise, never swallow my bullshit.
What
does that quote mean Mr.Goodfellow? Did you notice the straight
dope reference in my post above a few pages ago? We are like
prison bunk mates or whatever they are called.
DPR and I were
college roommates back in the day. Great guy and a whiz at
computer programming. Mostly open source complicated stuff.
Beyond my PGP special need status.
What does :p
mean anyway?
CleanSober
-
Hi Doctor,
I have a question about tolerance regarding Diazepam.
My doctor told me that the effects are cumulative, meaning that the
effect is greater each day. I always thought that the more you take a
drug the less it affects you. What is your opinion?
-
Hi Doctor,
I
have a question about tolerance regarding Diazepam. My doctor told me
that the effects are cumulative, meaning that the effect is greater each
day. I always thought that the more you take a drug the less it affects
you. What is your opinion?
I
don't know why, but I'm on a benzo and notice this. At first, it
has more of a body load, causing more lethargy than anti-anxiety. If I
don't take it for awhile, it pretty much becomes a sleep aid. Yet
if I take it consistently, I just get a power anti-anxiety effect.
I guess it's a tolerance to the body load and an increase in desired medicinal effect?
-
GOT A QUESTION DOC...I CAN TAKE 5 MG OF XANAX AT ONCE AND NOT EVEN PASS THE FUCK OUT...AND ONLY USE THEM ON OCCASIONS...WTF?
-
Hi Doctor,
I
have a question about tolerance regarding Diazepam. My doctor told me
that the effects are cumulative, meaning that the effect is greater each
day. I always thought that the more you take a drug the less it affects
you. What is your opinion?
I
don't know why, but I'm on a benzo and notice this. At first, it
has more of a body load, causing more lethargy than anti-anxiety. If I
don't take it for awhile, it pretty much becomes a sleep aid. Yet
if I take it consistently, I just get a power anti-anxiety effect.
I guess it's a tolerance to the body load and an increase in desired medicinal effect?
It is because is has a long half-life and the effects are still being felt when you take another dose.
Tolerance does rise though.
If
you take a break for 2 weeks you will notice the effects of the benzo
diminish. When you start taking it again, they will gradually build up
as you take each dose.
So by the time you take y our next dose,
you are still being affected by the previous dose, so they sort of
combine and the feeling is strengthened, even though tolerance will be
raised.
-
Ted,
You have the most powerful shit I have read during my summer internship here at SR. Doc will kill you good, I'm sure.
Cleansober
I
hope so man. hey, I didn't know you could intern on SR. that sounds
dope! :p get it? but yeah, i'm just some stupid fucking child who lacks
empathy and will play act this shit out for attention right up till I
actually fool myself into it. at least thats the most cynical view of it
. I've done some really wrong things in my life and regaurdless of why
people tell me I'm so intelligent I just dont have any ambition or
skills- I don't function in the real world so w/e. I'm ready to go. I
deserve it .
-
Shnelles
I'm no doctor but it's clear to me that you should gain control of your
life and do something else than coke to feel good.
I say this not to
state the obvious but because I fell in your situation with another
substance and maybe you can appreciate my 2 cents.
I felt the craving
for the substance, had it, and then realized I didn't feel so good as
the first times, or those particular occasions.
I also had friends
who got similar syndromes after years of use of coke, you never knew how
to deal with them (everyone around them becomes an enemy).
I hope
there are methods to "clean" your synapses or whatever and have a
cocaine kick again, but in a matter of time you'll be at the starting
point no?
-
hi doc,
i am an old, longtime coke user.
in
the beginning i was injecting it for many many years, had good
qualities back then, was in peru and bolivia, and, as usual in cases
like this, in the end came paranoia.
it came slow, first a little, then getting harder, after 16 years it was so extreme that i had to stop injecting.
i
did base and crack a while, which, after some years, as well developed
paranoia that can be compared to the para i have when injecting.
today i can only snort.
then the para, which comes in times a little bit, can be controlled mostly.
but
when i injected now (after a break of 15 yerars i did it once shortly
ago) it has not gotten better even after a 15 years beak injecting and
over 10 years break in doing coke at all.
it is all there, as if there was no break.,
anyway, today i am just in the mode for some more coke.
when i did this one injection shortly, it brought me to hell.
as
the kick arrives, i feel like being thrown in a world or situation like
in the movie alien 2, when they are on that planet in that building and
all of a sudden the aliens start moving all around them (and they
realize they are surrounded by these deadly hostile aliens and will not
get out anymore).
all i do is rush back to the wall, down on my knees or lying down on bed, and try to not move.
behind
me (though there is no space behind me) i know and feel THEM who are
attacking me any second now by stabbing knifes into my throat, into my
eyes and whatever. they will do things i wont describe, they are
horrible.
if someone i know is there with me, and i usually trust her/him, i dont trust them anymore in this moment.
this person may assure me : there is noone, we are all alone !
i
dont believe it, i rather believe that person works now together with
the attackers, whom I FEEL AND KNOW are on the jump and located hidden
all around me.
depending in the amount i start trembling but not in a normal tremble way, but more in an epileptic way.
i dont want top describe further, the horrors are much worse than i can describe here.
as good as it was in the beginnign, as bad it is now.
my question to you :
I WANT TO GET RID OF THIS PARANOIA !
i want to inject again and have those divine cocaine kicks i used to have in the early times.
there MUST be some biochemical way to remove or block this paranoia !
there must be some chemical stuff that stops it, makes it not appear.
what do you think could be done ?
what is the reason for this paranoia ?
where is it located in the brain, what happens there when this extreme paranioia comes ?
and why it hasnt turned less after many years of not doing coke.
i know, you probably want to tell me :
stop it - its not worth it, you kill yourself etc. etc pp.
this is completely useless as i wont.
i am a convinced coke user, i may say it is more like a religion to me.
i have it pretty much under control when snorting.
but earlier i called snorting "kindergarten".
it doesnt give a tenth of what an injection can give you.
as it is now, i wont inject anymore, it is simply horrible and nothing else anymore.
but i wish i could !
i'd love to.
if i am to die from coke - so be it.
but what can be done to remove that nerv killing paranoia and be able again to enjoy the "injecting coke kicks" ?
even if it wouldnt be as good as in the beginning, but without that paranoia it would be still good.
so :
what is the reason for this paranoia ?
has anyone ever tried to find out moire about this ?
where is it located ?
what can be done against it ?
i dont need hints like "use diazepam, use lorazepam etc.
i do.
but it only lowers the paranoia, it cannot remove it. not at all.
could you think of any way and anything i could try to get rid of this paranoia and
enjoy the blessing of cocaine injections again ?
thanks.
definetly
look into an ibogaine session. its pretty expensive like ($70 a
dose)but its potentially life saving for drug addicts. a single trip on
ibogaine can potentially release your physical addictions. interested to
see what the doc has to say tho. Love what your doin by the way doc,
learned a lot from this page
-
bump because major update to my REPLY 413
-
Firstly DoctorX I'd just like to thank you for taking the time to offer this service.
I was just wondering if you could help me with his issue: http://dkn255hz262ypmii.onion/index.php?topic=145708.0
Summery:
My gf is no longer able to drink due to suffering from a bout of acute
pancreatitis and I would like to know if GHB would be a safe alternative
for her.
-
Hello docter im new to opiates. I just tried heroin recently
and have only used about 160 mgs total in the two times. im getting some
more soon.
I really dont want to do heroin very much but am
loving the buzz from hydros and ocycodone. i only have hydro 5/500
hydro 10/367 and ocycodone 5/325
i love snorting and parachuting them like snorting an oxy 5 and parachuting a hydro 5 then snorting a hydro 10, 30 mins later.
My questions is is this to much acetaminophen? am i really hurting my liver if i do this two or three days in a row?
-
@doctorx
why is it when i consume 2cb its so fucking hard to sleep?
it isnt a stimulant isnt it?
-
Hi Doctor,
I
have a question about tolerance regarding Diazepam. My doctor told me
that the effects are cumulative, meaning that the effect is greater each
day. I always thought that the more you take a drug the less it affects
you. What is your opinion?
I
don't know why, but I'm on a benzo and notice this. At first, it
has more of a body load, causing more lethargy than anti-anxiety. If I
don't take it for awhile, it pretty much becomes a sleep aid. Yet
if I take it consistently, I just get a power anti-anxiety effect.
I guess it's a tolerance to the body load and an increase in desired medicinal effect?
It is because is has a long half-life and the effects are still being felt when you take another dose.
Tolerance does rise though.
If
you take a break for 2 weeks you will notice the effects of the benzo
diminish. When you start taking it again, they will gradually build up
as you take each dose.
So by the time you take y our next dose,
you are still being affected by the previous dose, so they sort of
combine and the feeling is strengthened, even though tolerance will be
raised.
Yep, Diazepam has a half-life of 50-200 hours...one dose lasts me two or three days.
-
Hello
DoctorX, I am a nursing student, and i have become interested in
disassociates, mxe in particular. I started with DXM, and thru my
research i have discovered that many believe it to be worse than mxe,
because of its"dirty-ness". I have been using it and it seems to help
with physical motivation, I was wondering what your opinion on the
chemical is. I know it is a new chem, but if i am to continue using
disassociates, is it better to stick with occasional dxm, or mxe usage?
I was curious if you are under the impression that is as neurotoxic as pcp, or dxm?
Also, i was wondering if you could go over some of the effects disassociates have on organs and organ systems?
I enjoy psychedelics, but i find mxe helps with my seasonal depression
While cannabis does help my depression it also leaves me anti social, and feeling less intelegent
mxe on the other hand, makes me feel social, functional, and on small doses lets me "think outside of the box"
I feel ketamine has a more addictive craving quality due to its shorter duration
I was wondering if believed the negative effects of mxe, and disassociates in general are greater than what they allow me to be
Each
drug has its own pros and cons. Experience with DXM is considered by
many persons as "dirty" although is possibly the safest and best known
dissociative. Effects of ketamine are pleasurable and interesting for
many people but it has its own problems :abuse and dependence potential
or urinary bladder problems in frequent users. This last problem has
been recognized only in the last 5 years, when use of ketamine has
spread and grown and, consequently, some problems are more frequent in
general population.
So, the after-effects or long time effects of MXE
are, in this moment, unknown. It will be necessary some temporal
perspective to know if it is more or less risky than K. MXE was marketed
by some "legal high" vendors as "bladder friendly", although there are
no data to be sure of this. Anyway, the best way to avoid problems with
dissociatives is using them occasionaly.
-
NOTICE: I´m having too much work in SR. I have 5-10 PM every day and
messages here. I will answer all your questions one by one but, as a
free voluntary service I can´t offer much more of my time.
-
Hey doc, I know you have expressed your concern of research
chemicals, but would you still recommend against using 25I-NBOMe only
once or twice a month? I research things before I put them into my body,
and I haven't seen anything suggesting normal doses at such a frequency
to be particularly harmful (albeit the chemical is fairly new). The
doses I plan on doing will be around .5-2mg on 1mg blotters. I have used
the substance once before, I took 1mg and very much enjoyed the
experience. No lasting side effects at all. Thoughts?
And thanks for using your limited time to answer our questions. It's appreciated.
-
I think it would be fair from now on if the people asking the doc
questions also send some coin his way. Specialist medical consultation
doesn't come cheap, and I'm sure s/he had to work damn hard for a long
time to acquire the knowledge s/he has and is willing to share. Even if
it's only $10 or so, it's the right thing to do.
-
Hi DoctorX
I have a question concerning Tramadol and Ecstasy
use which seems to cause a lot of confusion online. As we know, Tramadol
is a complex multi-action painkiller which effects serotonin-levels in
the brain, similar to how SSRI drugs work.
Note: For the sake of
this question, let's assume that "Ecstasy" is pure and has been verified
as such (I know the risks involved with Ecstasy pills being laced with
other substances, but let's assume for this question, this is pure
tested crystal/powder form Ecstasy, and not pills).
Questions:
1) Is it at all dangerous to take both Tramadol and Ecstasy together? i.e. 50mg Tramadol, then 8 hours later, 130mg Ecstasy?
2)
Assuming it's not safe to take these two drugs together, what would be a
reasonable "wash-out" period to abstain from Tramadol before using
Ecstasy? (I've seen people suggest wide ranging time periods, from 24
hours, to weeks, but generally 3 days is the recommend wash-out time
period).
3) If you did take both drugs together (by accident) and
had some adverse reaction, would taking a short-acting benzo (i.e.
Xanax) help in that situation and prevent or lessen the risk of seizure
and/or serotonin syndrome?
4) Is the risk higher on the Tramadol
side or Ecstasy side if taken together, in terms of dosing? i.e. It's
far more dangerous to take 250-400mg of Tramadol with 130mg Ecstasy,
than it is to take 3x130mg Ecstasy (spread out over several hours) with a
single dose of 50mg Tramadol in your system?
Thanks for your answers, I'm sure this will help clear up a lot of confusion and keep people safer out there!
-
Hi i have a quastions:
Does Lyrica(pregabalin) has cross-tolerance with benzo?
Im
planig to use benzo 1-2 times a week and Lyrica 1-2 times a week, if i
sudenly cold turkey it all, will i suffer from some wds?
-
Hi DoctorX! It's so refreshing to see someone doing something
like this! Thank you so much for taking the time out of your busy
schedule to help the members of the Silk Road community. My internet was
crapping out so I was unable to read the whole thread and I apologize
if someone else has already asked my questions.
I'm a type one
diabetic and so I'm always worried about long term effects drugs might
have on me. I try to do everything in my power to minimize risks
and maximize fun with any drug experiences I have but I have heard some
things recently that make me a bit concerned. I've heard from
multiple sources of pancreatic damage due to drugs, and everything I
have read has been so vague as too just say drug use. I've also
heard that users of Black Tar Heroin will have their veins harder and
become smaller. To me these both sound like very dramatic
reactions to long term addiction where daily use was involved but I
can't find anything thing to back this up. What are the risks (if
any) of recreational/social use of Black Tar Heroin and how difficult is
it to receive pancreatic damage from social use of drugs in general?
I
would also like some more information about Pipe Dreams or dreaming
while awake on Opiates and Opioids, and how and why it works. Also
if there is anywhere online to read up on this subject I would
appreciate a link.
Thank you for your time Doctor. I can't wait to hear what you have too say. :D
-
Ibogaine is the active chemical found in the African Tabernanthe
iboga root and other plant species. It is a strong psychedelic used
traditionally in rituals of passage but also known for its modern use in
treating opiate addiction. Ibogaine and noribogaine have action in many
different cerebral systems (dopamine, GABA, serotonin,
noradrenaline...). In relation with drug depencence, its mechanism of
action does not work as a substitutive for narcotics or stimulants and
has been defined as a "chemical dependence interrupter" that would have
the ability of "resetting" some parts of cerebral circuits responsible
on manteining drug-seeking behaviours.
There are enough scientific
communications to assert that ibogaine can be useful in opiate
dependence, at least for some patients.
http://www.ncbi.nlm.nih.gov/pubmed/15064541
http://www.ncbi.nlm.nih.gov/pubmed/10506904
http://www.ncbi.nlm.nih.gov/pubmed/10911935
But,
until now, there are no good clinical trials on it. The cause is
probably that ibogaine itself is a scheduled drug in many countries, and
the fact that pharmaceutic industry does not have a particular interest
on it. Ibogaine does have its own adverse effects and toxicity and it
should be prescribed or used by professionals with enough knowledge on
it. Finally, there is no magic drug to quit opiate dependence in
everybody. Some people are more sensible to a particular treatment,
Iboga may be useful for some people, for other it would be better
traditional options.
Doctor,
thank you so much for volunteering your time and energy to the users on
this site. It is quite a bonus to have access to a doctor for our
questions.
I actually quit using opiates by doing a flood dose
of Iboga under clinical conditions in Mexico (where it is legal). It
immediately halted my physical addiction (130mg of oxy daily) and
withdrawals from it. I mean it when I say immediately. There were zero
w/d symptoms after taking it, though the experience of having Iboga in
my system required a lot of help for a day. It causes major ataxia and
can cause vomiting, though I did not experience that. To me, it is an
amazing option for those who really want to quit.
Do you know about Iboga/Ibogaine?
-
I fucking love you doc, we need more people like you in order to prevent injuries related to drugs in general.
este hilo hizo mi día, mucha info interesante y útil SIIIII SEÑOR!!!
-
if one is taking dmt for the first time, and is taking it on his own
(one person), is there anything that should be taken into
consideration? Besides the usual like moderate food consumption before,
mood, etc. Experience with other drugs are okay but not extensive.
is ritalin known to interact bad with any common drug? like DMT, LSD, 2c-x ?
Thank you
-
Hi Doctor, i know you must be very busy but i have a quick question
related to my previous post (P.s I will make a donation to your wallet
as soon as i have BTC myself!)
My question is; How long does
abilify(aripiprazole) stay in one's system once one has stopped taking
it? I know the half-life is up to 75-94 hours(correct me if i'm
wrong)--so is then when the drug will completely leave my body?
Many Thanks.
-
My quibble is with statistical substantiation of behavior deemed
safe. Everyone starts out safe with usually one dose of X but
after a given time interval seek out more X. What is the
addiction/dependance rate among cigarette smokers who smoke a pack a
day? It must be near 100% given the nature of nicotine
addiction. Looking forward to hearing other opinions here
including Doctor X if he has time to address this one.
Soberman
-
Hi
Doctor, i know you must be very busy but i have a quick question
related to my previous post (P.s I will make a donation to your wallet
as soon as i have BTC myself!)
My question is; How long does
abilify(aripiprazole) stay in one's system once one has stopped taking
it? I know the half-life is up to 75-94 hours(correct me if i'm
wrong)--so is then when the drug will completely leave my body?
Many Thanks.
A
half-life is the time it takes for half of the substance to decay, so
say you take 10mg of the substance (I'm sure this is more complicated
with daily dosing). After 75-94 hours, there will be 5mg left in your
body. After another 75-94 hours there will be 2.5mg, ad infinitum.
-
I´m sorry I have no specific answer for your question. Your
explanation is very careful and detailed. I can´t say many things. Only
that substances have their own risks and characteristics,and paranoia is
one of the main characteristics of long-term, high-dose of cocaine, as
yours. It is related to the biochemical circuits activated by cocaine,
related to regulation of function like fear and alertness that are
directly affected by use of cocaine. There is no way to avoid it, at
least as far as I know. It is simply an adverse effect of cocaine,
typical of intensive use of some ways of administration (iv, smoked...)
and there is no way to avoid it. Suppose that you like the taste of
chilli but don´t like how it burns.
hi doc,
i am an old, longtime coke user.
in
the beginning i was injecting it for many many years, had good
qualities back then, was in peru and bolivia, and, as usual in cases
like this, in the end came paranoia.
it came slow, first a little, then getting harder, after 16 years it was so extreme that i had to stop injecting.
i
did base and crack a while, which, after some years, as well developed
paranoia that can be compared to the para i have when injecting.
today i can only snort.
then the para, which comes in times a little bit, can be controlled mostly.
but
when i injected now (after a break of 15 yerars i did it once shortly
ago) it has not gotten better even after a 15 years beak injecting and
over 10 years break in doing coke at all.
it is all there, as if there was no break.,
anyway, today i am just in the mode for some more coke.
when i did this one injection shortly, it brought me to hell.
as
the kick arrives, i feel like being thrown in a world or situation like
in the movie alien 2, when they are on that planet in that building and
all of a sudden the aliens start moving all around them (and they
realize they are surrounded by these deadly hostile aliens and will not
get out anymore).
all i do is rush back to the wall, down on my knees or lying down on bed, and try to not move.
behind
me (though there is no space behind me) i know and feel THEM who are
attacking me any second now by stabbing knifes into my throat, into my
eyes and whatever. they will do things i wont describe, they are
horrible.
if someone i know is there with me, and i usually trust her/him, i dont trust them anymore in this moment.
this person may assure me : there is noone, we are all alone !
i
dont believe it, i rather believe that person works now together with
the attackers, whom I FEEL AND KNOW are on the jump and located hidden
all around me.
depending in the amount i start trembling but not in a normal tremble way, but more in an epileptic way.
i dont want top describe further, the horrors are much worse than i can describe here.
as good as it was in the beginnign, as bad it is now.
my question to you :
I WANT TO GET RID OF THIS PARANOIA !
i want to inject again and have those divine cocaine kicks i used to have in the early times.
there MUST be some biochemical way to remove or block this paranoia !
there must be some chemical stuff that stops it, makes it not appear.
what do you think could be done ?
what is the reason for this paranoia ?
where is it located in the brain, what happens there when this extreme paranioia comes ?
and why it hasnt turned less after many years of not doing coke.
i know, you probably want to tell me :
stop it - its not worth it, you kill yourself etc. etc pp.
this is completely useless as i wont.
i am a convinced coke user, i may say it is more like a religion to me.
i have it pretty much under control when snorting.
but earlier i called snorting "kindergarten".
it doesnt give a tenth of what an injection can give you.
as it is now, i wont inject anymore, it is simply horrible and nothing else anymore.
but i wish i could !
i'd love to.
if i am to die from coke - so be it.
but what can be done to remove that nerv killing paranoia and be able again to enjoy the "injecting coke kicks" ?
even if it wouldnt be as good as in the beginning, but without that paranoia it would be still good.
so :
what is the reason for this paranoia ?
has anyone ever tried to find out moire about this ?
where is it located ?
what can be done against it ?
i dont need hints like "use diazepam, use lorazepam etc.
i do.
but it only lowers the paranoia, it cannot remove it. not at all.
could you think of any way and anything i could try to get rid of this paranoia and
enjoy the blessing of cocaine injections again ?
thanks.
-
In general most users of MDMA notice that effect diminish if using
more than once a week. It is not a mathematical rule, but a general
impression. For some people the appearance of this effect is quicker,
for some is slower. But sooner or later it always appear for everyone.
It
is unlikely that a line of cocaine has negative adverse effects or
significant toxicity during a LSD experience. But most people think that
stimulants can ruin a LSD (or psychedelic) experience. It is not a good
combination because it diminish psychedelic effects and increases
adverse psychological effects from stimulants. Again, this is not a
rule, but a common opinion on this combination
doctor, i am so amazed as well , that you answer to each individual question with such professionalism!
MDMA: How is tolerance built? in a month i have tried 6 months, and every time i can feel it.
LSD:
When tripping i have an appetite for cocaine. I say my self "hmmm i
would easily snort a line if i had now". This is more psychological
issue for me, but my question is,
is LSD in combination with cocaine bad, in a way that even death could be caused???
Thank you very much in advance!
-
From a physiological point of view, GHB is a safe drug. It does not
cause toxicity to liver, stomach, brain or other systems of the body. A
high potential of addiction and problems with overdosing and mixing with
other deppresors are the main problems of GHB. But, in a strictly
physic sense is a very low toxic substance.
Brilliant
work doc :) One very simple short question: Is nightly use of GHB to
aid sleep going to be causing physiological damage? Just I notice that
people with narcolepsy can be prescribed it (xyrem) with two 4.5g doses a
night to help them sleep at night and stay awake in the day. So it
can't be that damaging, if at all, right?
-
Prescription Self Deliverance AKA Suicide
I
am planning on taking a gram of cyanide as my suicide method but I
gotta be honest , I've considered a great many different options and
what it comes down to is : I'm not a doctor. I dont have the necessary
knowledge to determine what is most painless and certain (and affordable
, perhaps). but here you are. You can't get away from this issue doc;
people on silk road will keep coming looking for answers about methods
and you have a professional obligation to correctly inform them in order
to avoid more painful demises or permanent damage from misinformation
or improper technique. Step away from the social taboo of it , fuck the
scorn of the ignorant parrot propagandist who will repeat slogans they
put no thought into about situations they have no way to critically
evaluate , and just do the right thing by being a doctor; a caregiver;
the provider of health knowledge towards the ends of aleviating pain.
because your contribution on this matter could mean a great deal to
those who reach out for you and failure to offer your assistance very
well may cause more pain , the opposite of your purpose.
so please, help me , and them, out and tell me the fastest most painless way available currently from the silk road.
sincerely -teddy
You
propose a very interesting question. But I regret I´m not sure that
that this question fits into this thread. Advice in this way should
always be personal and personalized. I don´t think it should be useful
to give general rules using a general forum.
-
Hi Doctor,
I
have a question about tolerance regarding Diazepam. My doctor told me
that the effects are cumulative, meaning that the effect is greater each
day. I always thought that the more you take a drug the less it affects
you. What is your opinion?
As
someone said before, it is related to the half-life of substance. In
the short term there is a cumulative effect in the following days,
because diazepam is a drug with a long half-live. But, in some
weeks-months using the same dose you could feel a diminishing of some
effects because of tolerance. So, with benzos, the two things can
happen.
-
Doctor, around tapering off Diazepam, is it important to be really strict about the mgs?
Specifically,
let's say I've taken roughly 7.5mg daily for 3 months. Do I need
to start tapering down to .70 for a week, then .65 for a week, etc.. or
can I fairly safely taper down in larger amounts initially? i.e.
is there more concern in tapering slowly from 2.5mg to zero than from
7.5mg to 5mg?
the reason I ask is because I have read some
pretty stringent tapering suggestions online, and quite frankly I
eyeball the 7.5mg anyway (I just break the 10mg in half and half of it
in half) so the idea of tapering down by like .05mg per month seems a
bit extraneous.
Tip coming your way! THANK YOU
-
Doctor, around tapering off Diazepam, is it important to be really strict about the mgs?
I've been trying to slowly taper off benzos forever now.
It's a long and arduous process.
Right now I'm also tapering with Diazepam, but coming from 40mg per day roughly.
Working my way down the tapering chart at a very brisk pace, which I have linked below.
It can be difficult.
Mainly because it's hard to follow the routine exactly.
Because life can be crazy as we all know.
Plus the interactions and the possibility of so many other receptors getting hit at the same time.
It can be confusing, but try and stick with your schedule and drop your dosage based on being comfortable.
Tapering correctly will blunt the majority of the awful side effects.
You just have to approach with caution and see what works best for you.
Here is the tapering schedule I've been using.
*clearnet warning* - http://www.benzo.org.uk/manual/bzsched.htm#s2
Lots of other valuable information on that website as well.
Hope this helps and best of luck.
Vanquish
-
Thanks Vanquish! That is a useful resource, and I think it answers my question.
It
seems like without a proper scale, it could be difficult to precisely
measure out 1mg or .5mg decrements from 10mg pills. If
anyone has a suggestion on how to do it without a scale let me
know. I assume I could crush and dissolve the pills into a
measurable amount of water or other liquid, but I'm not sure how long
the Diazepam can stay good for like that.
-
It
seems like without a proper scale, it could be difficult to precisely
measure out 1mg or .5mg decrements from 10mg pills. If
anyone has a suggestion on how to do it without a scale let me
know. I assume I could crush and dissolve the pills into a
measurable amount of water or other liquid, but I'm not sure how long
the Diazepam can stay good for like that.
They come in 2mg, 5mg, and 10mg tablets.
That might come in handy for your taper, talk to your Psychiatrist or SR.
You would definitely need a very accurate scale otherwise.
-
Firstly DoctorX I'd just like to thank you for taking the time to offer this service.
I was just wondering if you could help me with his issue: http://dkn255hz262ypmii.onion/index.php?topic=145708.0
Summery:
My gf is no longer able to drink due to suffering from a bout of acute
pancreatitis and I would like to know if GHB would be a safe alternative
for her.
Alcohol
can be a direct cause of acute pancreatitis. As far as I know, there
are no known cases of pancreatitis associated to GHB and,
according to its mechanisms of action, it seems quite unlikely.
-
Hello
docter im new to opiates. I just tried heroin recently and have
only used about 160 mgs total in the two times. im getting some more
soon.
I really dont want to do heroin very much but am loving the
buzz from hydros and ocycodone. i only have hydro 5/500 hydro
10/367 and ocycodone 5/325
i love snorting and parachuting them like snorting an oxy 5 and parachuting a hydro 5 then snorting a hydro 10, 30 mins later.
My questions is is this to much acetaminophen? am i really hurting my liver if i do this two or three days in a row?
Liver
toxicity from acetaminophen is one of its main problems. Daily doses
over 4 gr/day are likely to cause this problems. In people drinking
daily amounts of alcohol this daily dose can be even lower. If you are
taking more than 3.2 gr/daily it is possible to have significative
harms.
http://www.fda.gov/Drugs/DrugSafety/ucm239821.htm
-
Bluedev, if you're particularly concerned about exact dosages when
it comes to tapering, you have one of two options to make your doses
accurate:
- if you're obtaining your Valium legally (ie. with a
prescription) you can go to a compounding pharmacy and they will
formulate a preparation with whatever dose you want.
- if you're
getting your Valium from SR or you don't have a compounding pharmacy
near you, titrating Valium in milk is very easy. Let's say you want to
take a 1mg dose. Drop a 5mg tab into 100ml of milk, leave it for a bit,
shake. The pill will dissolve readily and the mixture will be
homogenised. Put it in the fridge. When you want your dose, shake the
preparation, measure out 20ml, and drink. The milk will go bad before
the meds stop working; don't worry about that. Of course, it's easy to
adjust your dosage. If you are micro-tapering, just use less Valium in
more milk to make tiny cuts.
-
Hey doc, you mentioned you know about steroids. Here is my
question. Will using ghrp 6 or cjc 1295 for ~2 months inhibt your
natural hgh levels?
-
Liver
toxicity from acetaminophen is one of its main problems. Daily doses
over 4 gr/day are likely to cause this problems. In people drinking
daily amounts of alcohol this daily dose can be even lower. If you are
taking more than 3.2 gr/daily it is possible to have significative
harms.
http://www.fda.gov/Drugs/DrugSafety/ucm239821.htm
Absolutely agree with this.
From
what I can remember sometime in 2011 the FDA/Makers of Tylenol actually
dropped the maximum daily limit down to 3gr's from 4gr's.
Personally, anything over 2gr can feel extremely hepatoxic.
-
if
one is taking dmt for the first time, and is taking it on his own (one
person), is there anything that should be taken into consideration?
Besides the usual like moderate food consumption before, mood, etc.
Experience with other drugs are okay but not extensive.
is ritalin known to interact bad with any common drug? like DMT, LSD, 2c-x ?
Thank you
Hey Doc,
can you answer my Qs too?
Thank you!
-
@doctorx
why is it when i consume 2cb its so fucking hard to sleep?
it isnt a stimulant isnt it?
Well...2C-B
has indeed stimulant properties. They are not so noticeable as
amphetamines or cocaine but it gives some degree of stimulation to
Central Nervous System. Our team performed an study on 2C-B some years
ago and psychometric properties of 2C-B are mainly psychedelic, but with
some degree of stimulation
http://www.slideshare.net/fernandocaudevilla/2cb
-
Hey
doc, I know you have expressed your concern of research chemicals, but
would you still recommend against using 25I-NBOMe only once or twice a
month? I research things before I put them into my body, and I haven't
seen anything suggesting normal doses at such a frequency to be
particularly harmful (albeit the chemical is fairly new). The doses I
plan on doing will be around .5-2mg on 1mg blotters. I have used the
substance once before, I took 1mg and very much enjoyed the experience.
No lasting side effects at all. Thoughts?
And thanks for using your limited time to answer our questions. It's appreciated.
I
think this is all a question of personal attitude and decission. You
will find a little information about 25I-NBOMe because it does not
exist. There is not enough temporal perspective to know about long time
or adverse effects. Maybe these negative effects are little or maybe
not. I would not personally take the risk, having enough well-known
psychedelics. But this is my personal opinion, and everyone should take
the risk if he wants...but knowing what is the truth about this
substances.
There are significative reports of toxicity of 25I-NBOMe, in 3 years of recreative use
http://www.ncbi.nlm.nih.gov/pubmed/23731373
http://www.ncbi.nlm.nih.gov/pubmed/23473462
You won´t find reports like this for LSD or psilocibine in 100 years.
-
There are significant reports of toxicity of 25I-NBOMe, in 3 years of recreational use
http://www.ncbi.nlm.nih.gov/pubmed/23731373
http://www.ncbi.nlm.nih.gov/pubmed/23473462
You won´t find reports like this for LSD or psilocibin 100 years.
I would be extremely careful with the stuff. The safety profile is beyond sketchy.
Even though a large percentage of people can "safely" use this substance.
There is also an equally important percentage of people that will suffer grave side effects.
25I-NBOMe is easily the most toxic thing I've ever ingested.
Had the absolute worst trip of my life because of it.
500ug's
of blotter and had some type of reaction, overdosed, tripped harder
than anything I've ever experienced, then completely lost consciousness.
What was soon followed by a series of grand mal seizures, landing me in the hospital.
For some reason my body just plain rejects it. It's like vile poison coursing thorough my veins.
I believe to my body it's strongly hepatoxic, as well as cardiotoxic.
It's nasty, nasty stuff.
The entire experience and side effects were some of the worst I've experienced.
Almost too many to list.
Plus it was 50 cents that ended up almost costing me both my life and $3k in medical bills.
The risk to reward ratio is screwed up here.
It's also the one and only psychedelic or drug in general to ever give me a seizure, and I have done plenty.
That alone says something.
Thought that I would never recover from something like this.
But it was possible because of SR and it's been a triumphant return to glory.
*Rise and Return of Vanquish*
http://dkn255hz262ypmii.onion/index.php?topic=45270.msg1395142#msg1395142
Please, be extremely careful with this stuff.
For harm reduction sake this is some of the worst stuff you can touch.
You play with fire, and you get burnt.
This substance takes it to the next level.
Even if this keeps one person from having to go through what I experienced it will be well worth posting this.
Best Regards,
Vanquish
-
Brilliant work doc :) One very simple short question: Is nightly use
of GHB to aid sleep going to be causing physiological damage? Just I
notice that people with narcolepsy can be prescribed it (xyrem) with two
4.5g doses a night to help them sleep at night and stay awake in the
day. So it can't be that damaging, if at all, right?
-
One very simple short question:
Kōans
aside, who knows what is simple and what is complex? To the
observer it may appear both simple and complex simultaneously while to
the person doing the answering it may be complex to acquire the
requisite knowledge while simple to answer once said knowledge is
acquired.
Soberman
-
There are significant reports of toxicity of 25I-NBOMe, in 3 years of recreational use
http://www.ncbi.nlm.nih.gov/pubmed/23731373
http://www.ncbi.nlm.nih.gov/pubmed/23473462
You won´t find reports like this for LSD or psilocibin 100 years.
I would be extremely careful with the stuff. The safety profile is beyond sketchy.
Even though a large percentage of people can "safely" use this substance.
There is also an equally important percentage of people that will suffer grave side effects.
25I-NBOMe is easily the most toxic thing I've ever ingested.
Had the absolute worst trip of my life because of it.
500ug's
of blotter and had some type of reaction, overdosed, tripped harder
than anything I've ever experienced, then completely lost consciousness.
What was soon followed by a series of grand mal seizures, landing me in the hospital.
For some reason my body just plain rejects it. It's like vile poison coursing thorough my veins.
I believe to my body it's strongly hepatoxic, as well as cardiotoxic.
It's nasty, nasty stuff.
The entire experience and side effects were some of the worst I've experienced.
Almost too many to list.
Plus it was 50 cents that ended up almost costing me both my life and $3k in medical bills.
The risk to reward ratio is screwed up here.
It's also the one and only psychedelic or drug in general to ever give me a seizure, and I have done plenty.
That alone says something.
Thought that I would never recover from something like this.
But it was possible because of SR and it's been a triumphant return to glory.
*Rise and Return of Vanquish*
http://dkn255hz262ypmii.onion/index.php?topic=45270.msg1395142#msg1395142
Please, be extremely careful with this stuff.
For harm reduction sake this is some of the worst stuff you can touch.
You play with fire, and you get burnt.
This substance takes it to the next level.
Even if this keeps one person from having to go through what I experienced it will be well worth posting this.
Best Regards,
Vanquish
I'm
sorry you had that experience, but personal anecdotes of bad trips
won't sway me, I'll take the risk. I took 1mg on a blotter and I had one
of the best experiences of my entire life. I'll figure it out. Thanks
for the input though, both DoctorX and Vanquish.
-
Doctor, I have decided that i have smoked enough in my life. I have
decided to quit smoking, i know it is hard, i have tried with temporary
success in the past, and i know it is a thing that can be done. The key
is "forever". I cant promise it to my self though..
I want to be
like that member, i was reading when i was noob, that was telling us
that he uses only illegal drugs!!! but was free from alcohol and tobacco
and coffee!!!!! I am SO jealous of him :D
So, i am really into going
for a (portable) vaporizer, but since i am not rich, I dont know what
to buy. i dont want to spend more than 150-200 euros. Do all
vaporizers need replacement parts over time?
Actually doctor, i
wonder if it is the toxicity of the smoke in lungs that gets me "high"
rather than the THC itself. Will i get high with vaporizer?
And also,
if i vaporize tobbaco, do i get the nicotine in my blood? or only the
taste??? Is it nicotine that causes cancer, or the whole toxic mixture
of smoking a cigarette.
And now that i spoke of cancer, i want
your opinion, this is only that counts, on this question: Is the Hash
oil (rick simpson's recipe) the cure for cancer????
I mean, there is
scientific evidence that THC kills cancer cells, isn't there? but Rick
Simpson says only the oil does.. not buds or so.
What do you think
doctor? Tell me a reason that someone would promote this as the cure of
cancer, since it is illegal to obtain. I do believe it is.
I do
drugs, cause i want to feel different the real world. With cigarettes
all i see is myself raping my lungs, and yet no change in perception of
things / world.
Really these bastards have put all their effort to
make you addicted to smoking for life... People prefer to die over
quitting smoking, even after doctor's final recommendation.
I would really like your to see your answer Doctor. Have a nice day and thank you in advance. This shall be my last cigarette.
I
am very bad psychologically, with all this social hypocrisy on the
matter of drugs. Smokers see themselves as no junkies, i feel it
is...funny, i dont know the word, it is frustrating!!!
I now
will smoke the last cigarette. Tomorrow i will not buy, neither the day
after tomorrow. I really do know the first days are the difficult. I
prefer isolated and clean from smokers around, rather than social and
with the temptation around. And until i buy the vaporizer, i would use
my bong.
-
Hey DoctorX, what are your opinions on Dextroamphetamine?
I like
to use it recreationally sometimes. I'll take 65-70mg and then 6-8 hours
later take another 65-75mg. I'll generally be up all night and sleep
the following day. I once binged on 420mg Dextroamphetamine during a 48
hour period. I've only done this once, but I was curious as to what type
of damage I was doing. I always end my night with a high dose (3-4mg)
of Alprazolam for the comedown, sometimes taking another 2-4mg 5-6 hours
later as it's quite short acting.
I always space my highs out
14-21 days apart as I get a prescription every 3 weeks. Do you think I'm
causing any permanent damage considering how long I wait in between
doses? I also stay hydrated during my highs.
-
Hi DoctorX
I
have a question concerning Tramadol and Ecstasy use which seems to
cause a lot of confusion online. As we know, Tramadol is a complex
multi-action painkiller which effects serotonin-levels in the brain,
similar to how SSRI drugs work.
Note: For the sake of this
question, let's assume that "Ecstasy" is pure and has been verified as
such (I know the risks involved with Ecstasy pills being laced with
other substances, but let's assume for this question, this is pure
tested crystal/powder form Ecstasy, and not pills).
Questions:
1) Is it at all dangerous to take both Tramadol and Ecstasy together? i.e. 50mg Tramadol, then 8 hours later, 130mg Ecstasy?
2)
Assuming it's not safe to take these two drugs together, what would be a
reasonable "wash-out" period to abstain from Tramadol before using
Ecstasy? (I've seen people suggest wide ranging time periods, from 24
hours, to weeks, but generally 3 days is the recommend wash-out time
period).
3) If you did take both drugs together (by accident) and
had some adverse reaction, would taking a short-acting benzo (i.e.
Xanax) help in that situation and prevent or lessen the risk of seizure
and/or serotonin syndrome?
4) Is the risk higher on the Tramadol
side or Ecstasy side if taken together, in terms of dosing? i.e. It's
far more dangerous to take 250-400mg of Tramadol with 130mg Ecstasy,
than it is to take 3x130mg Ecstasy (spread out over several hours) with a
single dose of 50mg Tramadol in your system?
Thanks for your answers, I'm sure this will help clear up a lot of confusion and keep people safer out there!
1)
In more than 40 years of recreative use of MDMA there are no known
cases of significant toxicity by combination of tramadol and MDMA. It
does not mean that the combination is sure or safe, but is probable that
it does not mean severe risks.
2) Half life of tramadol is 6-9 hours, so a 24 hour wash-off would be enough to be 100% sure
3)
I don´t think that the combination will produce seizures or serotonin
syndrome. If there were a serotonin syndrome it shouls de managed in
hospital. A benzo will diminish the effects of the drugs, basically
MDMA.
4) The theorical risk would be lesser with small doses of tramadol
-
Hi i have a quastions:
Does Lyrica(pregabalin) has cross-tolerance with benzo?
Im
planig to use benzo 1-2 times a week and Lyrica 1-2 times a week, if i
sudenly cold turkey it all, will i suffer from some wds?
As far as I know, there is no cross tolerance known between pregabalin and benzodiacepines
-
Bluedev,
if you're particularly concerned about exact dosages when it comes to
tapering, you have one of two options to make your doses accurate:
-
if you're obtaining your Valium legally (ie. with a prescription) you
can go to a compounding pharmacy and they will formulate a preparation
with whatever dose you want.
- if you're getting your Valium from
SR or you don't have a compounding pharmacy near you, titrating Valium
in milk is very easy. Let's say you want to take a 1mg dose. Drop a 5mg
tab into 100ml of milk, leave it for a bit, shake. The pill will
dissolve readily and the mixture will be homogenised. Put it in the
fridge. When you want your dose, shake the preparation, measure out
20ml, and drink. The milk will go bad before the meds stop working;
don't worry about that. Of course, it's easy to adjust your dosage. If
you are micro-tapering, just use less Valium in more milk to make tiny
cuts.
thank you thank you thank you
-
Hi
DoctorX! It's so refreshing to see someone doing something like
this! Thank you so much for taking the time out of your busy
schedule to help the members of the Silk Road community. My internet was
crapping out so I was unable to read the whole thread and I apologize
if someone else has already asked my questions.
I'm a type one
diabetic and so I'm always worried about long term effects drugs might
have on me. I try to do everything in my power to minimize risks
and maximize fun with any drug experiences I have but I have heard some
things recently that make me a bit concerned. I've heard from
multiple sources of pancreatic damage due to drugs, and everything I
have read has been so vague as too just say drug use. I've also
heard that users of Black Tar Heroin will have their veins harder and
become smaller. To me these both sound like very dramatic
reactions to long term addiction where daily use was involved but I
can't find anything thing to back this up. What are the risks (if
any) of recreational/social use of Black Tar Heroin and how difficult is
it to receive pancreatic damage from social use of drugs in general?
I
would also like some more information about Pipe Dreams or dreaming
while awake on Opiates and Opioids, and how and why it works. Also
if there is anywhere online to read up on this subject I would
appreciate a link.
Thank you for your time Doctor. I can't wait to hear what you have too say. :D
Use
of drugs in diabetics is one of the most complicated things in this
thread. It depends in many factors (age, degree of control of the
disease, habits, patterns of use...) In general is important to know the
properties of the substances and adapt it to your disease. I mean, some
substances will make feel no hunger (MDMA, stimulants), other stimule
apetite (cannabis), some of them can make feel your body different
(ketamine) and you should be careful not to hurt you or have wounds in
your feet, for example...
Drugs that affect circulation system
(arteries and veins) should be used with caution. Tobacco is the most
important and should be avoided by diabetics. Probably, intranasal use
of heroin will not affect too much your disease (although you should be
concerned about all the problems of opioids) Other ways of use of heroin
(smoked and iv) are much harmful in your case. Pancreatic damage
depends on the substance and way of use also, alcohol is the most
harmful drug in this sense.
This matter is so extense and complicate...if you have a more particular or specific question I can try to assess...
-
if
one is taking dmt for the first time, and is taking it on his own (one
person), is there anything that should be taken into consideration?
Besides the usual like moderate food consumption before, mood, etc.
Experience with other drugs are okay but not extensive.
is ritalin known to interact bad with any common drug? like DMT, LSD, 2c-x ?
Thank you
When
using psychedelics for the first time it is important to have all the
information available about the specific substance. It´s like planning a
trip. If you do it well, risk of problems is much lesser. I always
reccomend this document:
http://www.erowid.org/psychoactives/faqs/psychedelic_experience_faq.shtml
And in your case, specific information about DMT:
http://www.erowid.org/chemicals/dmt/dmt_basics.shtml
Although
DMT is a short acting psychedelic, it is always reccomendable not to do
it alone, to be with someone else that does not use the substance at
the same time. So he/she can help if something goes wrong.
Metylphenidate
is a CNS stimulant. It will reinforce stimulant properties of other
drugs used at the same time. Probably effects on psychedelics will not
be noticeable (depending on dose), combination with stimulants (speed,
meth, cocaine, caffeine) will make adverse effects more noticeable.
-
Hi
Doctor, i know you must be very busy but i have a quick question
related to my previous post (P.s I will make a donation to your wallet
as soon as i have BTC myself!)
My question is; How long does
abilify(aripiprazole) stay in one's system once one has stopped taking
it? I know the half-life is up to 75-94 hours(correct me if i'm
wrong)--so is then when the drug will completely leave my body?
Many Thanks.
Half
life means the time in which concentration of a substance reduces 50%.
So, a single dose of aripiprazol will take 75-94 hours to reach 50% and
another 75-94 h to reach 25%. Things are far more complex in repeated
administrations, but in 7-10 days, in general, concentrations will be
unnoticeable
-
My
quibble is with statistical substantiation of behavior deemed
safe. Everyone starts out safe with usually one dose of X but
after a given time interval seek out more X. What is the
addiction/dependance rate among cigarette smokers who smoke a pack a
day? It must be near 100% given the nature of nicotine
addiction. Looking forward to hearing other opinions here
including Doctor X if he has time to address this one.
Soberman
In
this moment I only remember Spanish statistics, that I suppose are
extrapolable to the rest of the world. 10-15% of people who try
cannabis, MDMA, cocaine or heroine become regular users. 80-90% of
people who try tobacco become addicted.
-
Hey doc, I take 10mg Melatonin at night and 100mg 5htp in the
morrning, by doing this long term will it have effects on my brain?
-
Hi
Doctor, i know you must be very busy but i have a quick question
related to my previous post (P.s I will make a donation to your wallet
as soon as i have BTC myself!)
My question is; How long does
abilify(aripiprazole) stay in one's system once one has stopped taking
it? I know the half-life is up to 75-94 hours(correct me if i'm
wrong)--so is then when the drug will completely leave my body?
Many Thanks.
Half
life means the time in which concentration of a substance reduces 50%.
So, a single dose of aripiprazol will take 75-94 hours to reach 50% and
another 75-94 h to reach 25%. Things are far more complex in repeated
administrations, but in 7-10 days, in general, concentrations will be
unnoticeable
Thanks doc
-
Hi DoctorX
I
have a question concerning Tramadol and Ecstasy use which seems to
cause a lot of confusion online. As we know, Tramadol is a complex
multi-action painkiller which effects serotonin-levels in the brain,
similar to how SSRI drugs work.
Note: For the sake of this
question, let's assume that "Ecstasy" is pure and has been verified as
such (I know the risks involved with Ecstasy pills being laced with
other substances, but let's assume for this question, this is pure
tested crystal/powder form Ecstasy, and not pills).
Questions:
1) Is it at all dangerous to take both Tramadol and Ecstasy together? i.e. 50mg Tramadol, then 8 hours later, 130mg Ecstasy?
2)
Assuming it's not safe to take these two drugs together, what would be a
reasonable "wash-out" period to abstain from Tramadol before using
Ecstasy? (I've seen people suggest wide ranging time periods, from 24
hours, to weeks, but generally 3 days is the recommend wash-out time
period).
3) If you did take both drugs together (by accident) and
had some adverse reaction, would taking a short-acting benzo (i.e.
Xanax) help in that situation and prevent or lessen the risk of seizure
and/or serotonin syndrome?
4) Is the risk higher on the Tramadol
side or Ecstasy side if taken together, in terms of dosing? i.e. It's
far more dangerous to take 250-400mg of Tramadol with 130mg Ecstasy,
than it is to take 3x130mg Ecstasy (spread out over several hours) with a
single dose of 50mg Tramadol in your system?
Thanks for your answers, I'm sure this will help clear up a lot of confusion and keep people safer out there!
1)
In more than 40 years of recreative use of MDMA there are no known
cases of significant toxicity by combination of tramadol and MDMA. It
does not mean that the combination is sure or safe, but is probable that
it does not mean severe risks.
2) Half life of tramadol is 6-9 hours, so a 24 hour wash-off would be enough to be 100% sure
3)
I don´t think that the combination will produce seizures or serotonin
syndrome. If there were a serotonin syndrome it shouls de managed in
hospital. A benzo will diminish the effects of the drugs, basically
MDMA.
4) The theorical risk would be lesser with small doses of tramadol
Many
thanks Doc for clearing this up, and now we have a reference to show
people on other forums who are confused about the risks.
I thank you for your time replying, and have sent BC.
NOTE:
Everyone who asks the Doc a question which keeps them and others safe,
please consider sending a few bucks (whatever you can afford to spare,
why not donate any loose change BC on your account - see his signature
for his BC address). The Doc is making his time available and it's clear
this is taking up a lot of his time now. He needs payment for that
time, just as anyone else would. This is extremely valuable have a
medically trained doctor on hand and it would be a shame if the Doc
felt he was being taken for granted and stopped answering questions.
-
Doctor, around tapering off Diazepam, is it important to be really strict about the mgs?
Specifically,
let's say I've taken roughly 7.5mg daily for 3 months. Do I need
to start tapering down to .70 for a week, then .65 for a week, etc.. or
can I fairly safely taper down in larger amounts initially? i.e.
is there more concern in tapering slowly from 2.5mg to zero than from
7.5mg to 5mg?
the reason I ask is because I have read some
pretty stringent tapering suggestions online, and quite frankly I
eyeball the 7.5mg anyway (I just break the 10mg in half and half of it
in half) so the idea of tapering down by like .05mg per month seems a
bit extraneous.
Tip coming your way! THANK YOU
Tappering
off benzos depend on many factors: potency of the benzo, half-life,
initial dose , time you have been using it and reason of use. It is not
the same diminish alprazolam (active at 0.25 mg) than clorazepate
(active at 2.5 mg). For diazepam you can diminish 1 mg /week, ot even
1mg/3 days without problems.It shouldn´t give you any noticeable
problem, in the case, you could switch for a low-dose long-lasting
product like bromazepam or clorazepate
-
Hey doc, I have a question regarding the use of MDMA..
I'm not a
heavy MDMA user in the meaning of doing it much in a year. I only do
MDMA on festivals and I only do around 3 a year in summer holiday. But
on those festival I tend to take A LOT of MDMA, 600-800mg in around 6
hours, just because I love to roll that hard :D. Before and after I
roll, I take exra vitamine supplements and also take tryptophan
supplements after i have rolled.
I'm 19 years old and weight 58kg.. for the rest, I never touch drugs except weed, 2C-B and alcohol sometimes.
Will
this heavy MDMA use 3 times a year will affect my body a lot in the
long term? i'm still in High School and don't want to destroy my body.
greets
-
hey doc,
if i have the wrong person with me during a DMT trip, might be worst than having no one. I think.
I have people I trust around me, but nobody I trust concerning drugs.
Is it a good way to start out just to roll 15 mg in a joint? Id use very weak grass, as i don't smoke weed.
BTW... id suggest you put some kind of disclaimer in your signature to avoid legal trouble. just an idea.
-
Hello doc,
I just want to say I've read this thread through a
couple of times before. Even if a lot of the problems people talk about
here don't apply to me, I still find them very interesting.
My
question is this: Is there any cross-tolerance between
psilocin/psilocybin and DMT. If so how long should I go between a DMT
trip and a shroom trip (DMT trip first)?
Thanks.
-
Hi doctorX,
I have a couple benzo related questions. I'm not sure if this was asked before.
Anyway,
this first question is about xanx. I was wondering how tolerance quick a
tolerance develops and lasts. Specifically, if I take 1 mg a day for 3
days would the effects decrease each day? Then let's say I take a 1.5-2
week break would my tolerance be back to zero by then? I haven't used
benzos regularly for a while now for some background. Though, I did take
1 mg a week before.
Accordingly, I have a question about
post acute withdrawal for benzos specifically clonazepam. A little
background here, as adolescent I was prescribed clonazapam for anxiety. I
don't remember what my initial dosage was but I was taking 1 mg three
times a day for a while. Well, after doing that about ~10 years the docs
decided to pull me off because they are addictive. I've been off benzos
for nearly a year (except for just recently) and I am not sure if this
is a withdrawal, but for a long time I've been feeling constant anxiety.
The anxiety makes life so much more difficult because I tend to avoid
social interaction and makes falling asleep difficult; haven't had a
good sleep in about a year now. In addition its affecting my
concentration.
My question is this normal to have affects so
long after discontinuing benzos and if so how long could this take? If
this is not normal could it be because I began taking them at such a
young age which complicates the matter?
The only reason I took
the xanx is to help get through a stressful situation and to come down
from a psychedelic trip this week and another in 2 weeks.
Also,
do you have any suggestions as to my anxiety? I've tried SSRIs in the
past and they all cause suicidal thoughts. Should I just begin taking
benzos again? I would rather ask for your opinion because my current
doctor is completely against benzos under any circumstance so I would
prefer a more objective answer.
Thanks a lot for spending your
time helping people. Its a shame most doctors aren't like you. Here in
the US if you start asking questions about drugs they can put a note on
your medical info; this piece of info is then available to other
doctors. Basically, you will be treated like a junkie. I know many
people who refuse to go to the ER because of this.
Glad to see a doctor who cares more about safety then being indoctrinated to preach don't do drugs.
-
Anyway,
this first question is about Xanax. I was wondering how tolerance quick
a tolerance develops and lasts. Specifically, if I take 1 mg a day for 3
days would the effects decrease each day? Then let's say I take a 1.5-2
week break would my tolerance be back to zero by then? I haven't used
benzos regularly for a while now for some background. Though, I did take
1 mg a week before.
Tolerance
builds but not at an extreme pace, it's constantly hitting your GABAa
receptors and over time this can lead to heavy tolerance issues.
Short
term usage of them is rather safe. But you need to be super
careful. It can turn into an addiction before you even know what
happened.
Long term usage they become a bit more controversial.
Physical dependence, tolerance, adverse physical and psychological
effects, and are by far one of the hardest class of drugs to withdrawal
from.
Without knowing exactly what you are using them for, I can't really say anything else.
Some people like myself are dependent on them, because they are highly effective to begin with and that diminishes over time.
At the moment I'm tapering by following the Ashton Manual Valium taper, it's a long and seemingly endless process.
*clearnet warning* http://www.benzo.org.uk/manual/bzsched.htm#s2
You begin to see nasty side effects with long term usage. I wouldn't wish benzo withdrawals on my worst enemy.
If you are absolutely positive that you won't get hooked on them, then feel free to use them every once in a while.
They
are highly addictive and depending on what else is in your system, can
be dangerous or diminish other drug experiences (like psychedelics).
Approach
with caution and willpower don't let them consume your life, and other
than that I'll let DoctorX take over for more thorough answers.
Vanquish
-
doctor, i am very sorry that you did not answer my queries. i will try again though.
1.
does THC kill Cancer cells? if so, why rick simpson says that only the
oil extracted from high quality buds, is capable of curing the cancer.
You have any experience on this?
2. Does the toxicity of smoking cannabis make me high, or the THC? if i use the vaporizer i will see difference in the effects?
3. What is the lethal dose for first time heroin user?
Thank you in advance
-
doctor, i am very sorry that you did not answer my queries. i will try again though.
1.
does THC kill Cancer cells? if so, why rick simpson says that only the
oil extracted from high quality buds, is capable of curing the cancer.
You have any experience on this?
2. Does the toxicity of smoking cannabis make me high, or the THC? if i use the vaporizer i will see difference in the effects?
3. What is the lethal dose for first time heroin user?
Thank you in advance
doctor, i am very sorry that you did not answer my queries. i will try again though.
1.
does THC kill Cancer cells? if so, why rick simpson says that only the
oil extracted from high quality buds, is capable of curing the cancer.
You have any experience on this?
2. Does the toxicity of smoking cannabis make me high, or the THC? if i use the vaporizer i will see difference in the effects?
3. What is the lethal dose for first time heroin user?
Thank you in advance
1. CBD is what kills cancer cells, along with a host of other medical benefits.
*clearnet warning* http://www.projectcbd.org/home-2/439/ (Cancer)
*clearnet warning* http://projectcbd.org/ (All Other Conditions)
2.
THC. Marijuana is one of the safest and most researched drugs in the
world. Plus it's medicinal benefits are enormous and increase
every day.
THC and CBD content are rising at the fastest rate of all
time, and keep climbing. We may eventually see constant and life
changing breakthroughs because of it.
Vaporizing your weed will essentially make the smoke less harsh on your lungs in the simplest of explanations. Google it.
3.
To someone with absolutely no opiate tolerance the amount wouldn't be
much - no way to actually know the exact amount. Start small, and
practice harm reduction.
No reason to dive in and overdose.
Please be careful, and check out this dosage chart. Should give
you a decent starting point.
*clearnet warning* http://www.erowid.org/chemicals/heroin/heroin_dose.shtml
Hope it helps, and I'm sure Doc will give his input as well.
Vanquish
-
Hey
doc, you mentioned you know about steroids. Here is my
question. Will using ghrp 6 or cjc 1295 for ~2 months inhibt your
natural hgh levels?
The
effects of these substances are difficult to preview. In my opinion,
substances like Growth hormone releasing hexapeptide (GHRP6) or the
growth hormone releasing hormone analog CJC1295 are equivalent to "legal
highs" or "research chemicals" in recreative drugs. I must confess that
I`m not a expert in this particular kind of substances, but I have been
searching about them and most I have found are preclinical data. They
are no so developed to be sure about their real effects and risks. In my
opinion, is much better, safe and even cheap to use human growth
hormone. At least it has been a prescription drug used about 70 years
and all its properties, problems and risks are well studied
-
if
one is taking dmt for the first time, and is taking it on his own (one
person), is there anything that should be taken into consideration?
Besides the usual like moderate food consumption before, mood, etc.
Experience with other drugs are okay but not extensive.
is ritalin known to interact bad with any common drug? like DMT, LSD, 2c-x ?
Thank you
This question was answered before...I try to answer questions by order...
Hey Doc,
can you answer my Qs too?
Thank you!
-
Brilliant
work doc :) One very simple short question: Is nightly use of GHB to
aid sleep going to be causing physiological damage? Just I notice that
people with narcolepsy can be prescribed it (xyrem) with two 4.5g doses a
night to help them sleep at night and stay awake in the day. So it
can't be that damaging, if at all, right?
GHB
seems to be useful in narcolepsy. Narcolepsy is a disease and not a
normal condition. GHB is a prescription drug in narcolepsy with its own
adverse, negative effects, as any other drug. In this case the dangers
are similar to all sleeping aids: potential of addiction, risk of
overdosage, amnesia. Every drug in the world has positive, desired
effects and negative ones
-
Every drug in the world has positive, desired effects and negative ones.
Quoted for truth.
Plus those effects can differ so vastly in between individuals and dosages.
It's all about minimizing the risk and doing everything you can to prevent damage to your mind and body.
-
Doctor,
I have decided that i have smoked enough in my life. I have decided to
quit smoking, i know it is hard, i have tried with temporary success in
the past, and i know it is a thing that can be done. The key is
"forever". I cant promise it to my self though..
I want to be like
that member, i was reading when i was noob, that was telling us that he
uses only illegal drugs!!! but was free from alcohol and tobacco and
coffee!!!!! I am SO jealous of him :D
So, i am really into going for a
(portable) vaporizer, but since i am not rich, I dont know what to buy.
i dont want to spend more than 150-200 euros. Do all vaporizers
need replacement parts over time?
Actually doctor, i wonder if it
is the toxicity of the smoke in lungs that gets me "high" rather than
the THC itself. Will i get high with vaporizer?
And also, if i
vaporize tobbaco, do i get the nicotine in my blood? or only the
taste??? Is it nicotine that causes cancer, or the whole toxic mixture
of smoking a cigarette.
And now that i spoke of cancer, i want
your opinion, this is only that counts, on this question: Is the Hash
oil (rick simpson's recipe) the cure for cancer????
I mean, there is
scientific evidence that THC kills cancer cells, isn't there? but Rick
Simpson says only the oil does.. not buds or so.
What do you think
doctor? Tell me a reason that someone would promote this as the cure of
cancer, since it is illegal to obtain. I do believe it is.
I do
drugs, cause i want to feel different the real world. With cigarettes
all i see is myself raping my lungs, and yet no change in perception of
things / world.
Really these bastards have put all their effort to
make you addicted to smoking for life... People prefer to die over
quitting smoking, even after doctor's final recommendation.
I would really like your to see your answer Doctor. Have a nice day and thank you in advance. This shall be my last cigarette.
I
am very bad psychologically, with all this social hypocrisy on the
matter of drugs. Smokers see themselves as no junkies, i feel it
is...funny, i dont know the word, it is frustrating!!!
I now
will smoke the last cigarette. Tomorrow i will not buy, neither the day
after tomorrow. I really do know the first days are the difficult. I
prefer isolated and clean from smokers around, rather than social and
with the temptation around. And until i buy the vaporizer, i would use
my bong.
About
vaporizers, my recommendation is usually the Volcano model. I have no
relation with its company and I´m not trying to give free advertising,
but it is the only model that has proven in clinical trials efficacy in
delivering cannabinoids to lungs without any other toxic or carcinogenic
particles.
http://www.ncbi.nlm.nih.gov/pubmed/20118579
http://www.ncbi.nlm.nih.gov/pubmed/19852551
http://www.ncbi.nlm.nih.gov/pubmed/18515447
I
suppose there are other similar devices, cheaper, with similar
properties but Volcano has the best guarantee in this moment. If you
vaporize tobacco you will have nicotine, but not the rest of toxic
particles.
My opinion on Rick Simpson´s Oil is a big scam. There are
no real, clinical data about its efficacy and all the story sounds
incredible. He talks about "investigation" (not showing how,when and
what...), he does not consider the variety of the plant, dosages are
unknown ("a bit") and, in medicine, there is no single drug that can
cure almost any disease of humanity. I think this story is giving false
hopes to ill people, and I think it is not fair. Therapeutic use of
cannabinoids is one of my fields of work, I am a strong deffensor of it;
for this same reason I reject all this story
-
thanks Vanquish and DoctorX for your replies.
So, nicotine
alone is carcinogenic??? If i decide to stay addicted to nicotine,
without smoking it, will i have the same chances for cancer?
I as simple as i can to my query, is smoking that kills, or nicotine kills as well......????
And,
since i am on the road, i want to try DMT for first time in my life. I
only have a bong though... How could i not waste the DMT, what is a
secure way to smoke it and have the psychedelic effect?
Thanks a lot in advance.
Sorry for these simple questions, i just don't feel safe using google or any other search machine
-
Anyway,
this first question is about Xanax. I was wondering how tolerance quick
a tolerance develops and lasts. Specifically, if I take 1 mg a day for 3
days would the effects decrease each day? Then let's say I take a 1.5-2
week break would my tolerance be back to zero by then? I haven't used
benzos regularly for a while now for some background. Though, I did take
1 mg a week before.
Tolerance
builds but not at an extreme pace, it's constantly hitting your GABAa
receptors and over time this can lead to heavy tolerance issues.
Short
term usage of them is rather safe. But you need to be super
careful. It can turn into an addiction before you even know what
happened.
Long term usage they become a bit more controversial.
Physical dependence, tolerance, adverse physical and psychological
effects, and are by far one of the hardest class of drugs to withdrawal
from.
Without knowing exactly what you are using them for, I can't really say anything else.
Some people like myself are dependent on them, because they are highly effective to begin with and that diminishes over time.
At the moment I'm tapering by following the Ashton Manual Valium taper, it's a long and seemingly endless process.
*clearnet warning* http://www.benzo.org.uk/manual/bzsched.htm#s2
You begin to see nasty side effects with long term usage. I wouldn't wish benzo withdrawals on my worst enemy.
If you are absolutely positive that you won't get hooked on them, then feel free to use them every once in a while.
They
are highly addictive and depending on what else is in your system, can
be dangerous or diminish other drug experiences (like psychedelics).
Approach
with caution and willpower don't let them consume your life, and other
than that I'll let DoctorX take over for more thorough answers.
Vanquish
I
just began using them to sleep after psychedelic trip and for sessions
with my p doc. The sessions are a great deal more conductive because it
makes it easier to bring up repressed thoughts. These are the only
situations that I will be using xanax for.
I am well aware of
benzo addiction. Read the second half of my post. I was on clonazpam for
10 years and I still have issues a year later after quitting.
-
Is it possible to train your heart by taking cocaine occasionally instead of physically working out?
-
Posted by: Mr Lucy
« on: Today at 08:03 pm »
Is it possible to train your heart by taking cocaine occasionally instead of physically working out?
What about one of those high altitude tents in
combination with cocaine or some other drug? Is it possible to get
in better physical condition without all the annoying and at times
inconvenient physical exertion? My guess is that unless your
oxygen levels go up there is more risk of tissue damage than
conditioning going on from stimulant use. The high blood
pressure might be contraindicated in terms of getting fit.
Cannabis reportedly increases heart rate so if one were to combine deep
yoga breathing with mota consumption could this reduce the potential
negative effects, if there are some, of a faster beating heart?
-
Can you be super sensitive to weed because I can full on trip on weed with just 0.05g of weed?
-
Hey DoctorX, what are your opinions on Dextroamphetamine?
I
like to use it recreationally sometimes. I'll take 65-70mg and then 6-8
hours later take another 65-75mg. I'll generally be up all night and
sleep the following day. I once binged on 420mg Dextroamphetamine during
a 48 hour period. I've only done this once, but I was curious as to
what type of damage I was doing. I always end my night with a high dose
(3-4mg) of Alprazolam for the comedown, sometimes taking another 2-4mg
5-6 hours later as it's quite short acting.
I always space my
highs out 14-21 days apart as I get a prescription every 3 weeks. Do you
think I'm causing any permanent damage considering how long I wait in
between doses? I also stay hydrated during my highs.
Reccomended
dosage of prescritpion dextroamphetamine is a maximum 60 mg day. This
limit can work as an orientation, but it is difficult to say what and
how probable are the risks. In general, the higher is the difference
between your recreative dosage and the prescription dosage, the
risks increase. But some people can have negative or adverse effects at
therapeutic dosages, and other seem to be almost immune to overdose. It
is not only a question of permanent damage (neurological, for example,
although the risks of occasional overdoses are probably low) but also of
an acute problem caused by a high dose (blood presure, cardiovascular
or cerebrovascular events). In young healthy people these events are
uncommon, but possible
-
Hey doctorx
I have some questions regarding high blood pleasure, do you mind if I pm you
-
Hey doctorx
I have some questions regarding high blood pleasure, do you mind if I pm you
I
will keep it in the thread in case its of use to anyone else. My buddy
has High blood pressure and it has caused some complications as it was
so high. doctors are trying to control it but not doing to well.
They have prescribed 10mg of rampril and 5mg of amlodpine every day.
they started on much smaller doses and worked their way up in an effort
to bring the pressure down. now he has always been partial to a few
lines of coke but since the dose of rampril has gone up he has
noticed that after a few lines he gets palpitations. Is this a direct
result of mixing coke with these blood pressure pills or could it be
coincidence. I read on a thread a few days ago that a girl
quite often got palpitations when her heart rate went up and she used
beta blokers to bring down the rate. Is that a solution ? She also said
that her doctor had said the the palpitations were normal for some
people and nothing to worry about.
I know the answer is obvious. Stop sniffing coke but sometimes life aint that simple.
Thanks in advance
-
Can you be super sensitive to weed because I can full on trip on weed with just 0.05g of weed?
Kid, please do drugs when you become an adult. You don't "trip" on weed, ...., it is not a hallucinogenic drug...
-
Hey
doc, I take 10mg Melatonin at night and 100mg 5htp in the morrning, by
doing this long term will it have effects on my brain?
Melatonin
is a hormone found in most living beings. In animals, levels of
melatonin vary in a daily cycle, thereby allowing the entrainment of the
circadian rhythms of several biological functions. Melatonin has been
studied in a range of diseases: diabetes, enhancer of immnue system,
some headaches, mood disorders. It seems to be particularly useful for
jet-lag and some sleep disorders. Adverse effects seem to be little, if
any. Its efficacy is proved in some of these diseases but it is unclear
what are the benefits in healthy people. For some authors it improves
attention, memory and some cognitive functions.
http://www.ncbi.nlm.nih.gov/pubmed/23240152
http://www.ncbi.nlm.nih.gov/pubmed/23005039
http://www.ncbi.nlm.nih.gov/pubmed/22334085
http://www.ncbi.nlm.nih.gov/pubmed/23479460
http://www.ncbi.nlm.nih.gov/pubmed/21340475
5-HTP
is a precursor for serotonin, a basic cerebral neurotransmisor that
regules functions as sleep or mood. In theory, it should act as a mild
antideppresive and sleep regulator. Evidence of its efficacy is much
weaker than the case of melatonin
http://www.ncbi.nlm.nih.gov/pubmed/11869656
-
Hey doc, I have a question regarding the use of MDMA..
I'm
not a heavy MDMA user in the meaning of doing it much in a year. I only
do MDMA on festivals and I only do around 3 a year in summer holiday.
But on those festival I tend to take A LOT of MDMA, 600-800mg in around 6
hours, just because I love to roll that hard :D. Before and after I
roll, I take exra vitamine supplements and also take tryptophan
supplements after i have rolled.
I'm 19 years old and weight 58kg.. for the rest, I never touch drugs except weed, 2C-B and alcohol sometimes.
Will
this heavy MDMA use 3 times a year will affect my body a lot in the
long term? i'm still in High School and don't want to destroy my body.
greets
In
clinical settings, the highest doses MDMA has been studied are in the
rank 150-175 mg. So 600 mg seems a dosage too high. In general, I don´t
reccomend to exceed 250-300 mg (in experienced people): 125-130 mg at
first dose, one or two "boosters" of half a dosage each 2 hours. But,
for most people exceeding this gives more adverse effects and
possibilities of toxicity. From a risk reduction perspective, it would
be probably safer reducing that dosage that seems too much.
-
DoctorX,
What are your thoughts on combining dexedrine with benzos (clonazepam, valium) to counter-act the negative effects of dexedrine?
is this likely to cause any bad interactions?
-
DoctorX,
in regards to our recent debate about Hash oil being
the cure of cancer, i have two links that i would like you to visit.
You and everyone that believes that cannabis is the most medicinal plant
on earth.
this (clearnet) http://abcnews.go.com/Health/toddler-cancer-takes-cannabis-oil/story?id=15981324
and this (clearnet) http://www.ibtimes.com/tommy-chong-credits-marijuana-cancer-cure-i-kicked-cancers-ass-hash-oil-1264243
I
want a real reason on why you think R.S is a scam. from your post i
understand that you are kind of frustrated about rick simpson, and your
explanations are only restricted to "he does not refer a dosage, he
gives hopeless people hope." Clearly you imply that all this is a lie,
and the people that talk on this documentary are all well paid
actors. You support cannabis as medicine, yet, have you tried it
in oil form? have you tried in cancer cases?
I really do
appreciate your contribution to this community doc. You inform people on
how to use drugs safely, and i feel more than proud of being able to
ask you any drug-using related question.
But on the other hand
doctor, if it was as simple as taking this oil, and it worked, why
wouldn't you get well paid to hide that truth....?
No offense
doctor, you have your doubts about R.S , i have my doubts about you, and
doctors, generally. I have not taken any medicines for many years.
This
is world is simply full of conspiracies brothers and sisters of Silk
Road. :( They want to kill us all, but before that give all our money to
the so called "medical system"
If you, DPR, or any other admin,
thinks that what i am talking about here is completely irrelevant to
this thread, i would understand it, so go ahead and delete this. All i
wanted is an open discussion on the matter
Thanks
-
I know the answer is obvious. Stop sniffing coke but sometimes life aint that simple.
Thanks in advance
My blood pressure is normal after I lost 50 lbs. If your friend is overweight -he may benefit from diet and exercise.
-
Typical dosages of DMT are 10-50 mg, depending also on personal
sensitivity. Smoking in a joint or cigarrete will destroy most of the
active DMT. It is much better to use a glass pipe (or even aluminium
foil). Full psychedelic effects of DMT are of short duration but very
strong. This is the reason why is recommendable to have someone who can
take care in that moments. DMT effects start very quickly and there have
been people with problems because of not having time to put the fire
off or other kind of accidents.
hey doc,
if i have the wrong person with me during a DMT trip, might be worst than having no one. I think.
I have people I trust around me, but nobody I trust concerning drugs.
Is it a good way to start out just to roll 15 mg in a joint? Id use very weak grass, as i don't smoke weed.
BTW... id suggest you put some kind of disclaimer in your signature to avoid legal trouble. just an idea.
-
As far as I know, this subject has not been studied. But DMT and
psilocin/psilocybin (4-0H-DMT) are quite similar substances, act in same
receptors and are metabolyzed in a similar way. So is reasonable to
think that there might be some cross-tolerance. 5-7 days should be
enough to dissapear this effect
Hello doc,
I
just want to say I've read this thread through a couple of times
before. Even if a lot of the problems people talk about here don't apply
to me, I still find them very interesting.
My question is this:
Is there any cross-tolerance between psilocin/psilocybin and DMT. If so
how long should I go between a DMT trip and a shroom trip (DMT trip
first)?
Thanks.
-
Nicotine has only been proved carcinogenic properties at very high
doses in celular and animal models. There is no evidence that it can
cause cancer in humans (although it increases blood pressure and heart
rate in humans and enhances cardiovascular risk). Carcinogenic
properties of tobacco are mostly related to substances generated during
combustion.
thanks Vanquish and DoctorX for your replies.
So,
nicotine alone is carcinogenic??? If i decide to stay addicted to
nicotine, without smoking it, will i have the same chances for cancer?
I as simple as i can to my query, is smoking that kills, or nicotine kills as well......????
And,
since i am on the road, i want to try DMT for first time in my life. I
only have a bong though... How could i not waste the DMT, what is a
secure way to smoke it and have the psychedelic effect?
Thanks a lot in advance.
Sorry for these simple questions, i just don't feel safe using google or any other search machine
-
What is your opinion on using 30 - 40 mg ritalin 5 times per week for years and years?
Is that likely to cause long term problems? If so, what kind? Can anything be done to decrease those?
-
Hi Doctor X i just logged in to give you simple suggestions since
you seemed someone who should receive all that is good in the life.
-First
i suggest that you translate your webpage more international and
accessible, translate it to several languages just by investing a bit in
cloud workers to do that for you.
-Start accepting more cryptocurrencies if you want.
-Add your website into the wiki https://en.bitcoin.it/wiki/Trade#Health_Care, it brings a lot of bitcoiners directly to you.
-Keep
all the website simple and stupid, by providing more information to the
question that most people usually ask so that when people do ask you,
they will come with bigger and better questions.
This was just some ideas nothing mandatory to do.
Much Respect
Anon
-
Hi doctorX,
I have a couple benzo related questions. I'm not sure if this was asked before.
Anyway,
this first question is about xanx. I was wondering how tolerance quick a
tolerance develops and lasts. Specifically, if I take 1 mg a day for 3
days would the effects decrease each day? Then let's say I take a 1.5-2
week break would my tolerance be back to zero by then? I haven't used
benzos regularly for a while now for some background. Though, I did take
1 mg a week before.
Accordingly, I have a question about
post acute withdrawal for benzos specifically clonazepam. A little
background here, as adolescent I was prescribed clonazapam for anxiety. I
don't remember what my initial dosage was but I was taking 1 mg three
times a day for a while. Well, after doing that about ~10 years the docs
decided to pull me off because they are addictive. I've been off benzos
for nearly a year (except for just recently) and I am not sure if this
is a withdrawal, but for a long time I've been feeling constant anxiety.
The anxiety makes life so much more difficult because I tend to avoid
social interaction and makes falling asleep difficult; haven't had a
good sleep in about a year now. In addition its affecting my
concentration.
My question is this normal to have affects so
long after discontinuing benzos and if so how long could this take? If
this is not normal could it be because I began taking them at such a
young age which complicates the matter?
The only reason I took
the xanx is to help get through a stressful situation and to come down
from a psychedelic trip this week and another in 2 weeks.
Also,
do you have any suggestions as to my anxiety? I've tried SSRIs in the
past and they all cause suicidal thoughts. Should I just begin taking
benzos again? I would rather ask for your opinion because my current
doctor is completely against benzos under any circumstance so I would
prefer a more objective answer.
Thanks a lot for spending your
time helping people. Its a shame most doctors aren't like you. Here in
the US if you start asking questions about drugs they can put a note on
your medical info; this piece of info is then available to other
doctors. Basically, you will be treated like a junkie. I know many
people who refuse to go to the ER because of this.
Glad to see a doctor who cares more about safety then being indoctrinated to preach don't do drugs.
Hi,
Tolerance
to benzodiacepines develops in weeks. Not everybody develops the same
degree of tolerance and tolerance to each effect of benzodiacepines
(sedation, anticonvulsive, ansiolitic, muscle relaxant) develops at
different speed. But it is neccesary to wait 2-3 weeks to appear
tolerance.
Anxiety can be a symptom of benzodiacepine withdrawal. In
general, symptoms of withdrawal persist during weeks or one/two months
depending on the pharmacological characteristics of the specific benzo.
One year seems too much to think benzos are the cause of your
anxiety.The fact that you started at young age should not be important.
In
general, benzos are not reccomendated for long-time control of anxiety
because of dependence potencial and rebound effect. Escitalopram,
venlafaxine, duloxetine and paroxetine are, in general, the best
options. Some patients also get benefits with lamotrigine or
gabapentine. Of course, it is neccesary some psychological support. The
best option/s needs to be discussed face-to-face with a professional.
-
Is it possible to train your heart by taking cocaine occasionally instead of physically working out?
No,
I think that is impossible. Cardiovascular training through physical
exercise produces, among other effects, vasodilation ( widening of blood
vessels ) of coronary arteries that give blood to the heart.Physical
exercise has effects on the rests of the muscles and apparatus of the
body . But using cocaine produces the contrary effect (vasoconstriction)
and electrical and biochemical changes to the muscle of heart. So
using it for "cardiovascular training" is useless and dangerous.
-
Can you be super sensitive to weed because I can full on trip on weed with just 0.05g of weed?
Some
people are particularly sensible to the effects of cannabis. 0.05 gr
seems quite a little quantity, but there are marijuana plants with very
high concentration of cannabinoids, so I think it is possible. Another
possibility is that your weed was mixed with some synthetic
cannabinoids. If you have shared your weed with other people and you are
the only one having effects with such a little dosage, that would mean
that you are very sensitive. If other people have the same effects with
so little quantity or if the effects have some differences with other
weeds synthetic cannabinoids adulteration should be ruled out.
-
Hey doctorx
I have some questions regarding high blood pleasure, do you mind if I pm you
I
will keep it in the thread in case its of use to anyone else. My buddy
has High blood pressure and it has caused some complications as it was
so high. doctors are trying to control it but not doing to well.
They have prescribed 10mg of rampril and 5mg of amlodpine every day.
they started on much smaller doses and worked their way up in an effort
to bring the pressure down. now he has always been partial to a few
lines of coke but since the dose of rampril has gone up he has
noticed that after a few lines he gets palpitations. Is this a direct
result of mixing coke with these blood pressure pills or could it be
coincidence. I read on a thread a few days ago that a girl
quite often got palpitations when her heart rate went up and she used
beta blokers to bring down the rate. Is that a solution ? She also said
that her doctor had said the the palpitations were normal for some
people and nothing to worry about.
I know the answer is obvious. Stop sniffing coke but sometimes life aint that simple.
Thanks in advance
Yes,
I understand life is sometimes complicated. In fact, I don´t think I
can help too much with your question, because it is impossible to give
an advice without knowing exactly the case. Sometimes Internet is good
for giving advice but in this case it should be neccesary a personal
evaluation. Cocaine can trigger palpitations in sensible persons.
As far as I know, ramipril or amlodipine in combination with cocaine
should not give additional problems.
But there is a important thing
you should know. Mixture of cocaine and beta-blockers is not a good
idea. It can trigger hypertensive or cardiac diseases. There is still
some controversy in medicine on this topic, but there are enough data to
strongly advise against this combination.
http://www.ncbi.nlm.nih.gov/pubmed/16627850
http://www.ncbi.nlm.nih.gov/pubmed/18072171
http://www.ncbi.nlm.nih.gov/pubmed/20206876
http://www.ncbi.nlm.nih.gov/pubmed/21059982
-
DoctorX,
What are your thoughts on combining dexedrine with benzos (clonazepam, valium) to counter-act the negative effects of dexedrine?
is this likely to cause any bad interactions?
Diazepam
and clonazepam increases and dextroamphetamine decreases sedation.
Effect of interaction is not clear, will probably depend on the dosage
and timing of both substances. There are no other pharmacological
interactions described between these substances
-
DoctorX,
in
regards to our recent debate about Hash oil being the cure of cancer, i
have two links that i would like you to visit. You and everyone that
believes that cannabis is the most medicinal plant on earth.
this (clearnet) http://abcnews.go.com/Health/toddler-cancer-takes-cannabis-oil/story?id=15981324
and this (clearnet) http://www.ibtimes.com/tommy-chong-credits-marijuana-cancer-cure-i-kicked-cancers-ass-hash-oil-1264243
I
want a real reason on why you think R.S is a scam. from your post i
understand that you are kind of frustrated about rick simpson, and your
explanations are only restricted to "he does not refer a dosage, he
gives hopeless people hope." Clearly you imply that all this is a lie,
and the people that talk on this documentary are all well paid
actors. You support cannabis as medicine, yet, have you tried it
in oil form? have you tried in cancer cases?
I really do
appreciate your contribution to this community doc. You inform people on
how to use drugs safely, and i feel more than proud of being able to
ask you any drug-using related question.
But on the other hand
doctor, if it was as simple as taking this oil, and it worked, why
wouldn't you get well paid to hide that truth....?
No offense
doctor, you have your doubts about R.S , i have my doubts about you, and
doctors, generally. I have not taken any medicines for many years.
This
is world is simply full of conspiracies brothers and sisters of Silk
Road. :( They want to kill us all, but before that give all our money to
the so called "medical system"
If you, DPR, or any other admin,
thinks that what i am talking about here is completely irrelevant to
this thread, i would understand it, so go ahead and delete this. All i
wanted is an open discussion on the matter
Thanks
There
is no reason for deleting your message. The only limits should be lack
of respect or bad manners and this is not your case.
It is
possible that "scam" is a too strong word. You should excuse that my
English is limited and expressing complex ideas is sometimes difficult
to me. What I mean is that there are no proofs of its efficacy. I can´t
say that people in that video are actors, they probably beleive what
they are saying and, probably, some part of the story is true (Simpson
and friends began distributing cannabis oil, and Health and Law Canadian
Authorities got very angry because of that). But, in science,
demonstrations must be positive. It is them who should demonstrate with
irrefutable evidences that their story is true. Things work like this.
The fact that a story appears on Internet or reaches popularity does not
mean that it is true. If you look in YouTube or Google for "Queen
Elizabeth lizard" you would discover that the Queen is really a
reptilian. Arguments are similar to those of RS story.
I will try to summarize some of the points that make this story incredible.
1)
RS oil is supposed to cure cancer. "Cancer" is a generic word for more
than 140 different diseases, each one of them with their mechanisms of
productions (genetical, enviromental, toxic, metabolic, infectious...),
and different prognosis and treatments. It is impossible to "cure
cancer" as, a lymphoma treatment is different to lung cancer or cervix
cancer.
2) RS oil is also supossed to cure not also "cancer" but
many other diseases (he mentions asthma, high blood presure, "wounds",
Alzheimer, Parkinson...) . In medicine, each disease has its own
mechanism of production and there is no medication that is useful for
almost everything. In fact, when a drug is promoted as panacea it should
considered a fraud.
3) RS video says that "they have
investigated properties of cannabis oil". In science, methods of
investigation must be clearly explained in order that other scientist
can repeat, critic or refuse them. There is not a single word about this
"method of investigation". In the documentary they quote some
investigation data about cannabis in a false, biased way (as works of
Dr. Manuel Guzmán on cannabis and one specific type of cancer,
multiphorm glyoblastoma).
4) In medicine, every drug is active at
a specific dosage rank. Every drug in the world has adverse effects,
contraindications and toxicity. Nothing of this happens with RS oil.
There are weed plants that only have THC, THC/CBD or CBD in very
different concentrations. Nothing of this is important to RS oil, which
is active at a dose of "one or two drops or a grain of rice" (not very
precise pharmacologically)
5) RS oil story has all the elements
of conspirative theories. I´m not saying that pharmaceutical industry is
a innocent one (as many other enterprises). But such a
political-economical-pharmaceutical-judicial conspiration to hide
curative properties of cannabis oil is incredible. The best argument I
can offer is the fact that cannabis has been a medicine widely used in
the last 6000 years by different cultures. Surprisingly, Rick Simpson
was the first person in the History of Humanity who discovered that
cannabis oil cures everything. This fact had been unobserved by doctors
of all the cultures ( Ancient Chinese Empire, Classical Greece, Hindi,
Latin, Shamanic Eastern Cultures...) that have been using cannabis as a
therapeutic drug during milleniums. Or maybe they were all
included in the conspiration.
You ask me if I have tried to treat
my cancer patients with RS oil. I have never done that. But I have the
experience of three different cancer patients who have left all
their treatments, changing it for RS oil. The three of them died in
months. OK...maybe this make me to be a bit combative in this subject.
You
say you have your doubts about me and doctors. To be critic and a bit
sceptic is, in general, a healthy attitude. As long as we use reasoning
and logic arguments I´m open to continue discussing this subject
-
I have been diagnosed with Bipolar type 1. I've been hospitalized
several times but its been two years since I've taken any of the
prescribed medication for it. I have successfully been managing my
anxiety with cannabis and believe as long as I keep my stress levels
down it could be a very long time before I have another manic episode.
My
question is this: are the any drugs that I should absolutely avoid or
I'm risking a relapse (i.e. Meth)? And are than any (illegal) drugs I
should look into that could be beneficial specifically for my case (i.e.
Ketamine)?
-
Doctor X. I wondered if I could ask you about 4FA.
Ive been
using this 'research chemical' for a while in a range of doses as a
party drug (100mg) and as a study/work aid (around 20mg).
I
recently read an article on the website 'drugs-forum.com' [warning -
clearnet link]
(http://www.drugs-forum.com/forum/showthread.php?t=175262)
Where a
guy claims that 4FA in particular, as well as other 'halogenated
amphetamines', are terribly neural toxic. He says 4FA is closely related
to a compund called para-chloroamphetamine (4-CA) which is used in
research labs to selectively kill neurons.
So I am wondering if you know anything about this Doctor X?
I have stopped using 4FA after reading that article. But I am wondering to what extent I have given myself brain damage :(
Thanks
-
Hey doctorx
I have some questions regarding high blood pleasure, do you mind if I pm you
I
will keep it in the thread in case its of use to anyone else. My buddy
has High blood pressure and it has caused some complications as it was
so high. doctors are trying to control it but not doing to well.
They have prescribed 10mg of rampril and 5mg of amlodpine every day.
they started on much smaller doses and worked their way up in an effort
to bring the pressure down. now he has always been partial to a few
lines of coke but since the dose of rampril has gone up he has
noticed that after a few lines he gets palpitations. Is this a direct
result of mixing coke with these blood pressure pills or could it be
coincidence. I read on a thread a few days ago that a girl
quite often got palpitations when her heart rate went up and she used
beta blokers to bring down the rate. Is that a solution ? She also said
that her doctor had said the the palpitations were normal for some
people and nothing to worry about.
I know the answer is obvious. Stop sniffing coke but sometimes life aint that simple.
Thanks in advance
Drx Please answer above.
-
What is your opinion on using 30 - 40 mg ritalin 5 times per week for years and years?
Is that likely to cause long term problems? If so, what kind? Can anything be done to decrease those?
Maximum
daily dosage of methylphenidate dosage as a therapeutic drug is 30 mg.
Methyphenidate has common adverse and long-time effects as any other
psychostimulant: cardiovascular effects (high blood pressure,
alterations in cardiac rhythm...), psychiatric effects (trigger
psychotic symptoms or aggresive behaviour), dependence, tolerance...The
fact that methylphenidate is a legal stimulant does not mean that it is
safe. Factors as context of use, purposes, motivations...are also as
important as pharmacological properties of the substance in order to
estimate the risk.
-
I
have been diagnosed with Bipolar type 1. I've been hospitalized several
times but its been two years since I've taken any of the prescribed
medication for it. I have successfully been managing my anxiety with
cannabis and believe as long as I keep my stress levels down it could be
a very long time before I have another manic episode.
My
question is this: are the any drugs that I should absolutely avoid or
I'm risking a relapse (i.e. Meth)? And are than any (illegal) drugs I
should look into that could be beneficial specifically for my case (i.e.
Ketamine)?
Bipolar
disease can stand long time asymptomatic, but in order to avoid
relapses it is important to use properly prescribed medication, as long
as keeping stress levels down as you say. It is unclear if cannabis is
helpful or negative in bipolar disorders. Many (but not all) studies
state that cannabis has a negative impact on this disease.
http://www.ncbi.nlm.nih.gov/pubmed/20674039
http://www.ncbi.nlm.nih.gov/pubmed/19155808
http://www.ncbi.nlm.nih.gov/pubmed/9692379
Antidepressant
properties of ketamine are recently described but are not enough to
reccomend it, even less in a bipolar disorder. Ketamine is addictive and
has strong psychedelic effects. In general, in bipolar disorder
psychedelic and stimulant drugs (cocaine, amphetamines...for some people
even caffeine) should be avoided
-
I have been tested and diagnosed with ADHD. I cannot afford
medication. Would getting high quality Amphetamine sulphate on SR to
medicate everyday, be an ok alternative to filling a prescription for
concerta or adderall or something, or would that be a bad idea? Sorry I
didn't bother to read all 35 pages of the entire thread, sorry if this
has been asked before.
-
I
have been tested and diagnosed with ADHD. I cannot afford medication.
Would getting high quality Amphetamine sulphate on SR to medicate
everyday, be an ok alternative to filling a prescription for adderall or
something, or would that be a bad idea?
Absolutely.
-
Not sure if it is too late to ask questions here, but the New York
Times is taking questions now on addiction. Judging from the
questions and comments so far, when they are answered, it will be more
of the "just say no" approach but who knows. No disrespect here, just an
observation that the NYT must be monitoring these pages too.
http://www.nytimes.com/2013/08/14/booming/advice-on-addiction-in-boomers.html
-
Doctor X. I wondered if I could ask you about 4FA.
Ive
been using this 'research chemical' for a while in a range of doses as a
party drug (100mg) and as a study/work aid (around 20mg).
I
recently read an article on the website 'drugs-forum.com' [warning -
clearnet link]
(http://www.drugs-forum.com/forum/showthread.php?t=175262)
Where a
guy claims that 4FA in particular, as well as other 'halogenated
amphetamines', are terribly neural toxic. He says 4FA is closely related
to a compund called para-chloroamphetamine (4-CA) which is used in
research labs to selectively kill neurons.
So I am wondering if you know anything about this Doctor X?
I have stopped using 4FA after reading that article. But I am wondering to what extent I have given myself brain damage :(
Thanks
It
is true that "halogenated amphetamines" seem drugs more risky than
other amphetamines. I agree with some of the arguments in the link of
drugs-forum. In human pharmacology there are chemical elements common
and other that, in general,are more toxic. Some fluorine and chlorine
compounds are highly neurotoxic and structure of 4-FA resembles some of
these drugs.
But in animal experimentation there is no evidence that 4-FA is neurotoxic:
http://www.ncbi.nlm.nih.gov/pubmed/8749023
http://www.ncbi.nlm.nih.gov/pubmed/1196472
With
this, I don´t mean that 4-FA is sure. Animal data do not suggest that
neurotoxicity is an important problems but there is a lack of
investigation on 4-FA as it is a drug made popular in the last 3-5
years. In fact there are recent reports about deaths caused by 2-FA,3-FA
and 4-FA.
http://www.ncbi.nlm.nih.gov/pubmed/22286570
I think
advice against its use is valid but, probably, there are no data to be
extremely worried about neurotoxicity. Classical amphetamines have been
used during decades and their risks are perfectly known. This is not the
case of 4-FA and, in my opinion,this is enough to advise against its
use.
-
I
have been tested and diagnosed with ADHD. I cannot afford medication.
Would getting high quality Amphetamine sulphate on SR to medicate
everyday, be an ok alternative to filling a prescription for concerta or
adderall or something, or would that be a bad idea? Sorry I didn't
bother to read all 35 pages of the entire thread, sorry if this has been
asked before.
There
is no medical consensus about the best treatment for ADHD. Stimulants
are widely used for this condition, although there are important
differences in diagnosis criteria and neccesity of drug therapy. For
example, clinical guidelines in UK only reccomend stimulants in very
severe cases, and in United States this kind of treatment is more easily
prescribed.
I don´t want to expand on this issue, because I don´t
want to create more doubts in you, but I don´t think auto-medication
with amphetamine is a good strategy. In general, available amphetamine
is an unpurified mixture of amphetamine salts (with high amount of
caffeine and other adulterants, in many cases), and only
dextroamphetamine is the approved treatment for ADHD. And even
dextroamphetamine (and other medications as methylphenidate) should be
used with caution in ADHD (from a medical point of view)
-
doc you never answered my question : what is your
recommendation for suicide? besides don't do it. if some one is going to
do it and you can spare them unecesary pain then you should. so shoot:
how would you do it?
-
DoctorX.
First i want to say thanks for a great work in this thread and its very learning and intresting!
My
question is (and i do ask for forgiveness in case its already been
asked). Ive been usin cocain for about 8 months now on and of. The
latest 8 months maybe a gram in month give or take a little. How
damaging is this for the heart? Besides that i try to take care of
myself i train 4-6 times a week and try to eat healthy. My father
resently had a heart attack so there is a risk of bad genetics in this
case. I really love to put some luxury on the everyday life like this
but how bad is it for me? =) Regards Rambo ;)
-
The latest 8 months maybe a gram in month give or take a little. How damaging is this for the heart?
Rambo, do you consume alcohol at the same time? Cocaethylene increases cardiotoxicity greatly.
-
Yes alcohol is consumed at the same time, sometimes together with a benzo
-
doc
you never answered my question : what is your recommendation for
suicide? besides don't do it. if some one is going to do it and you can
spare them unecesary pain then you should. so shoot: how would you do
it?
Yes...I answered your question
https://dkn255hz262ypmii.onion.to/index.php?topic=147607.msg1441472;topicseen#msg1441472
My
thread is about risk and harm reduction in drug use, not about suicide.
I can understand your arguments, but my service here is providing
information about health and drugs. I would not have problems in
discussing this subject in a face-to-face, personal interview but not in
through Internet.
-
How bad is drug consumption while a teen? The news always says that its huge... Want to hear that from a doctor.
-
Hi doc!
Can you tell me more about health concerns regarding
aMT and 2C-E, I am especially worried about possible neurotoxicity? I
know both substances are quite rare/unknown/new and I have come to
believe scientific studies of these drugs are rather limited. I have
read that antioxidants eliminate some of the free radicals associated
with aMT ingestion.
Please enlighten me :)
-
« Reply #525 on: Today at 06:01 pm »
Quote
How bad is drug consumption while a teen? The news always says that its huge...
Along
these lines is there much or any evidence that alcohol binges can be
neurotoxic in young brains or for that matter mature brains?
Dementia is reportedly a symptom of alcoholism but would the level or
type of damage be different at younger ages?
You have
talked about the dependency issues being more common in younger, regular
drug users. It reminds me of second language learners who avoid
major accents if they learn to speak a second language before 17 or
so. Would it ever be healthy for a normal young person under 20,
to use cannabis every day, or three or four days in each week, for
several years? Given many student's experiences in school with
boredom, anxiety and most of all, dislike of school in general, this
pattern of use seems common.
Regarding a tangential matter,
do you think there is anything to the Rosetta Stoned phenomenon where
people think they know more than they do? This is more a footnote
to your observations as I'm thinking you are more based in
pharmacological solutions than environmental. Do you believe mota
consumption leads to significant learning problems or does it act as an
enhancer which I could use by the way. Clearly.
Pretty clean but not
Soberman
or
Sodaman
or
Superman
-
What is the best drug for Anxiety?
-
Hi Doc,
Great job, just sent some spare coins your way, I
strongly encourage encourage everybody else to do the same (BTW Erowid
also has a fundraiser at the moment, please also consider sending some
coins their way).
I have some questions that I hope answers to which other users will also find valuable:
1.
What kind of drugs for emergency would you recommend to have at hand -
let's say you are in a remote place and would like to have something
when things go south with experiments. (Of course I'm not treating them
as the replacement for proper medical treatment in cases of really
dangerous side effects/ODing, just in super mild ones).
So far I tried to have with me:
- diazepam for bad-trips emergencies with psychedelic drugs
-
prednisone and some antihistamines for every new drug in case of being
allergic for any cutting agent or active substance (also doing allergy
test with very small dose with each new substance/batch)
- some drinkable electrolytes supplements from pharmacy for dehydration (for MDMA and stimulants)
- mild stims (ephedrine) if me or friend shall feel that new depressant shall go to strong (GHB, opioids etc.)
-
proton pump inhibitors when taking things that maybe harsh on a stomach
(like bigger amounts of plants ;) also always before drinking)
-
modafinil in case of drugs that tends to induce partial amnesia or
downers that make sleepy (it works PERFECTLY for this -- you loose less
from the experience and from what I researched is very safe drug)
-
sphygmomanometer (for blood pressure measuring for those unfamiliar
with the name) and glucose meter for checking if everything is okay in
some cases
I would also love to know what's your opinion on the
last one, as I know that mixing uppers and downers is wrong because it
may interact or promote dose abuse, but I'm talking only about
"emergency" use
I also do electrolytes and vitamin supplements prophylactically before and after testing most substances.
So, what would you add to these/would you modify that?
2.
Friend has elevated blood pressure and is significantly overweight --
is there any blood pressure lowering drug that could be taken
temporarily to counteract the heightening effect of some stimulants
(coke in different forms, amphetamine analogue family, some
psychedelics)? I'm not talking about constant treatment, I'm just
talking about 2-3 times a month at most experiments, each time with
something different. In my country getting something prescribed for this
reason is impossible due to legal issues with drugs (use and possession
is illegal).
Alternatively, is there any fast acting drug that
could be taken once pressure would go too high that could be added to
the kit I'm asking about in first question? (Also, as I said we have
pretty decent electronic sphygmomanometer at hand during experiments so
we can control it - so any advice about when such drug/s shall be taken
can also be of value).
Also, if they are types of lowering blood
pressure drugs that may have dangerous interactions with any of drugs
from mentioned categories I would appreciate heads-up (I try to research
such things but of course I can get sometimes drowned within amount of
medical, specialized info).
Many thanks in advance and take care.
-
doc
you never answered my question : what is your recommendation for
suicide? besides don't do it. if some one is going to do it and you can
spare them unecesary pain then you should. so shoot: how would you do
it?
Yes...I answered your question
https://dkn255hz262ypmii.onion.to/index.php?topic=147607.msg1441472;topicseen#msg1441472
My
thread is about risk and harm reduction in drug use, not about suicide.
I can understand your arguments, but my service here is providing
information about health and drugs.I would be happy to discuss this
subject in a face-to-face interview but a drug health and safety forum
is the wrong place to address this subject.
-
DoctorX.
First i want to say thanks for a great work in this thread and its very learning and intresting!
My
question is (and i do ask for forgiveness in case its already been
asked). Ive been usin cocain for about 8 months now on and of. The
latest 8 months maybe a gram in month give or take a little. How
damaging is this for the heart? Besides that i try to take care of
myself i train 4-6 times a week and try to eat healthy. My father
resently had a heart attack so there is a risk of bad genetics in this
case. I really love to put some luxury on the everyday life like this
but how bad is it for me? =) Regards Rambo ;)
It
is very difficult to estimate individual risks with illegal drugs. It
wolud be neccesary to have big epidemiological studies with accurate
information about patterns of use. There are some studies on tobacco and
alcohol that are useful for these substances. But for the rest of
substances it is far more difficult.
Cardiovascular risks depend on
many factors: genetic factors, age, sex, blood pressure, cholesterol,
diet, obesity, diabetes...it is very difficult to estimate the weight of
cocaine use in an individual among these factors. The fact of familiar
antecedents of cardiovascular disease should be considered as an
additional risk factor, but not as an irreversible indicator.
The way
of use of cocaine is also important. You say "one gram a month more or
less" but, obviously, it is not the same to use one gram one night (once
a month) than four times 250 mg. According to medium doses of cocaine
use, one gram a month does not seem a tremendous excesive quantity,
although I don´t mean with this that it is absolutely sure.
In your
case, as a risk reduction measure, it would be important to control
other possible cardiovascular factor risks (weight, blood pressure,
tobacco use...) I don´t reccomend to use at the same benzodiacepines and
alcohol as "downers" (as you say in the following message). The mixture
of these two substances can increase adverse and toxic effects from
benzos. Leaving cocaine use only for special situations, and not
integrating it as an habit or usual activity will also help.
-
How bad is drug consumption while a teen? The news always says that its huge... Want to hear that from a doctor.
Well...general
questions mean general answers. So, in general, I agree with that idea.
That is one of the clear ideas of drug epidemiology. The younger onset
of drug use, the higher possibilities of harms related to drugs. This is
valid both for legal (tobacco and alcohol, widely used by teenagers)
and illegal drugs (in general, cannabis is the most used drug by teens).
It
does not mean that any pattern of use of teenagers will destroy its
life. Many teenagers use drugs in a occasional way or a limited time in
their lifes without relevant negative consequences. But a young use is a
risk factor for problems. Physical, psychological and social factors
are related to this, as maturity on life makes easier to manage drugs
(as many other dangerous things in life).
http://www.ncbi.nlm.nih.gov/pubmed/19630711
http://psycnet.apa.org/psycinfo/1988-98105-000
-
Hi doc!
Can
you tell me more about health concerns regarding aMT and 2C-E, I am
especially worried about possible neurotoxicity? I know both substances
are quite rare/unknown/new and I have come to believe scientific studies
of these drugs are rather limited. I have read that antioxidants
eliminate some of the free radicals associated with aMT ingestion.
Please enlighten me :)
Well....i´m sorry enlightening is not one of my abilities :D
AMT
was discovered in the sixties of last century. There was some
investigation in animals during 70s and 80s and, as far as I know, there
are no evidences of neurotoxicity in animals. Its analog
alpha-ethyl-tryptamine seems to have neurotoxic potential at very high
doses in animals. There are also some reports on human toxicity and
deaths related to this substance
http://www.ncbi.nlm.nih.gov/pubmed/1722753
http://www.ncbi.nlm.nih.gov/pubmed/16105268
Data
on 2C-E are even more scarce. There is a lack of animal or experimental
data. In my personal opinion and according to its molecular structure
and prevalence of use, it is unlikely that neurotoxicicy is one of its
problems. On the other hand there is a recent report on cerebral
toxicity in humans. I think (I insist, this is only my personal
opinion) that this case has to be considered as a rarity and not as a
frequent risk
http://www.ncbi.nlm.nih.gov/pubmed/23077393
Role of
antioxidants is only theoretical speculation. If it is not clear the
existence or toxic dosage of this substance, even less an hypothetical
protective role of antioxidants.
-
What is the best drug for Anxiety?
"Anxiety"
is a symptom that can be present in many different diseases; anxiety
can appear as "crisis" (acute episodies) or as a "state". Each one of
these conditions has its own therapeutical management. Benxodiacepines
are used in acute crisis and ISRS (paroxetine, sertraline, citalopram)
or other antidepressives are more useful and safer for anxiety manteined
on time. Evaluation of anxiety and the best way to treat it should
always be personalized. I think this is too complex to give advice
through Internet.
-
Quote from: Flyerz1934 on August 22, 2013, 06:01 pm
How bad is drug consumption while a teen? The news always says that its huge... Want to hear that from a doctor.
Well...general
questions mean general answers. So, in general, I agree with that idea.
That is one of the clearest ideas derived from drug epidemiology
research. The earlier the onset of drug use, the higher the
possibilities of problems related to drug use will be. This is valid
both for legal (tobacco and alcohol which are widely used by teenagers)
and illegal drugs (in general, cannabis is the drug of choice for
teens).
It does not mean that all patterns of use by teenagers
will ultimately destroy their lives. Many teenagers use drugs in a
occasional way or for limited time in their lives without relevant
negative consequences. But early use is a risk factor for later
problems. Physical, psychological and social factors are related to
this, as maturity is gained by a longer time on the planet makes it
easier to manage drugs along with many other dangerous things.
DoctorX,
Do
you think teens are able to make a clear judgement about their drug use
being out of control or having a potential large negative for their
future lives? Seems many adults are unable to control their own
compulsions, dependencies, and addictions, so it may be unreasonable to
expect teens to do any better? No? Which recovery program seems to
have the best success with alcohol and pot troubles? What about
when there are multiple drugs involved in the person's recovery
program? I'm thinking I want the Lindsay Lohan type where you stay
for a few months on the ocean front with great chairs, fancy meals, and
professional coaches. Table tennis, shuffle board and checkers
matches to while (sic, and no, I am not clear why I'm using this word,
"sic" I mean) away the day. Swimming, resting, and reading provide more
engaged moments.
Physical therapy would be nice too
since a few old football injuries need attention. Sorry to
write a book but there is a lot to think about here. Lindsay
cancelled her vacation to Europe because she had planned to hang out
with DocX. Oprah convinced her this would be a bad idea.
Wow! Europe, the Pacific Ocean what's next? A small island
in the South Pacific where an eccentric millionaire feeds her healthy
food and gives her rubdowns. Her drug of choice was alcohol not
cocaine. I thought I saw coke eyes or a severe case of not
sleeping enough, also known as tiredness. l suppose getting two or
three DUIs should have clued me in but I missed that. Despite her
problems with too much partying, Lindsay is still someone I would like
to wrestle playfully, no strings attached.
Soberism
for one and for all
-
DoctorX,
I am prescribed Vyvanse 60mg which I take everyday
at like 7 in the morning. Coming up is my buddys bachelor party where
there will undoubtedly be cocaine. If I chose to partake, would I be
making a big mistake by combining these two stimulants? Everything I
read says do not combine because of cardiovascular issues, but they dont
reference a time layover. I know about when the medicine starts to
dissipate from my system as my eyes become foggier and my thoughts
become jumbled together. This usually occurs around 5-6 that night, but
can last till 8 depending on how much i eat that day. Now the cocaine
would not be ingested until like 9-10 in the evening probably even later
than that. With 12+ hours in between my vyvanse dose and cocaine, would
it be safe to partake in the cocaine, or are there still too many
traces of the amphetamine in my system? If thats the case then more than
likely if i decide that day to participate, i wont take the vyvanse.
Thanks! Love the Thread
-
I have a question regarding out phasing (dont know the correct
english term) Benzos - mainly Clonezapam, I don't know the exact dosage
but say that I have roughly taken 2mg per day for 7-8 months now. My own
physician gave me a fast schedule with Diazepam 5mg: [Week 1] Half a
pill in the morning, 1 pill in the evening [Week 2] Half morning, half
evening [Week 3] half evening. I personally thought this schedule to be
too fast since Clonezapam is around 10 times stronger than Diaz, but he
told me there is no magic out-phasing schedule, I will still have
withdrawals irregardless.
What are your opinions on this schedule?
He gave me more pills than I need for this schedule in case I would feel
it not working out, so I could go as long as 6 weeks instead of 3. The
reason I'm not going CT is that I am starting college soon and I tried
CT couple of months ago and it made my brain sooo slow... This is my
main concern, not being able to concentrate for 2 cents.
Great thing that you are here for us!
-
I'd just like to thank Drx for being such a help to this community
and a big thanks for the time you take to answer and help out the same,
good on you Drx I think this is a brilliant idea and I'm sure you've
helped loads of people even though I've never asked you anything myself
but from your replies I can see your a good person with a good heart
thanks again Drx much luv, phoboss.
DOCTOR X IS THE MAN/WOMAN XXX MUCH LUV
-
How long does heroin withdrawal last?
Everywhere i read it says
that its over after 5 to 7 days. I quit heroin after 2-3 months of
everyday use and today is my 9th day (will be starting the tenth day in
several hours) and the withdrawal isnt going away. I have a very achy
back and legs and im constantly getting chills and goosebumps, and I
have terrible anxiety and depression and the worst part is that I havent
slept more than 2 or 3 hours a nite since the 1st nite. My body
(especially my legs) is very restless at night and i feel like i have
electricity running thru my body.
So my question is that will this last much longer or is it almost over? I know each person is different but is this normal?
-
So my question is that will this last much longer or is it almost over? I know each person is different but is this normal?
Kratom would be your best bet. Should almost instantly get rid of your lingering withdrawal symptoms.
PAWS (Post Acute Withdrawal Syndrome) can persist for weeks, to months, to years.
It's really down to individual body chemistry, substance, duration, and amount taken.
Shoot me a PM if you need more information.
Vanquish
-
Thanks alot Vanquish you were really helpful! +1
-
I'm in my twenties and have two co-morbid mental illnesses. I take
medication for them, which seems to work-but it makes me VERY tired. So
tired that I had to leave my doctorate program because I could really
not stay awake or motivated enough for serious concentration.
Should I try Modafinil? I don't like caffeine because it tends to make me more jittery than focused.
Also,
I feel as though marijuana has a stabilizing effect on my disorders.
Strangely, with the higher quality cannabis I get here, I do not notice
as much cognitive blunting (burn out) afterwards. Would it be okay to
keep this, or will I inevitably have a major cognitive decline?
Thanx
Rails
-
Hi Doc,
Great
job, just sent some spare coins your way, I strongly encourage
encourage everybody else to do the same (BTW Erowid also has a
fundraiser at the moment, please also consider sending some coins their
way).
I have some questions that I hope answers to which other users will also find valuable:
1.
What kind of drugs for emergency would you recommend to have at hand -
let's say you are in a remote place and would like to have something
when things go south with experiments. (Of course I'm not treating them
as the replacement for proper medical treatment in cases of really
dangerous side effects/ODing, just in super mild ones).
So far I tried to have with me:
- diazepam for bad-trips emergencies with psychedelic drugs
-
prednisone and some antihistamines for every new drug in case of being
allergic for any cutting agent or active substance (also doing allergy
test with very small dose with each new substance/batch)
- some drinkable electrolytes supplements from pharmacy for dehydration (for MDMA and stimulants)
- mild stims (ephedrine) if me or friend shall feel that new depressant shall go to strong (GHB, opioids etc.)
-
proton pump inhibitors when taking things that maybe harsh on a stomach
(like bigger amounts of plants ;) also always before drinking)
-
modafinil in case of drugs that tends to induce partial amnesia or
downers that make sleepy (it works PERFECTLY for this -- you loose less
from the experience and from what I researched is very safe drug)
-
sphygmomanometer (for blood pressure measuring for those unfamiliar
with the name) and glucose meter for checking if everything is okay in
some cases
I would also love to know what's your opinion on the
last one, as I know that mixing uppers and downers is wrong because it
may interact or promote dose abuse, but I'm talking only about
"emergency" use
I also do electrolytes and vitamin supplements prophylactically before and after testing most substances.
So, what would you add to these/would you modify that?
2.
Friend has elevated blood pressure and is significantly overweight --
is there any blood pressure lowering drug that could be taken
temporarily to counteract the heightening effect of some stimulants
(coke in different forms, amphetamine analogue family, some
psychedelics)? I'm not talking about constant treatment, I'm just
talking about 2-3 times a month at most experiments, each time with
something different. In my country getting something prescribed for this
reason is impossible due to legal issues with drugs (use and possession
is illegal).
Alternatively, is there any fast acting drug that
could be taken once pressure would go too high that could be added to
the kit I'm asking about in first question? (Also, as I said we have
pretty decent electronic sphygmomanometer at hand during experiments so
we can control it - so any advice about when such drug/s shall be taken
can also be of value).
Also, if they are types of lowering blood
pressure drugs that may have dangerous interactions with any of drugs
from mentioned categories I would appreciate heads-up (I try to research
such things but of course I can get sometimes drowned within amount of
medical, specialized info).
Many thanks in advance and take care.
1.-
Some of the drugs you propose seem reasonable in the indications you
suggest, other not so in a pharmacological point of view. Benzos can be
very useful in some stimulant or psychedelic complicated situation,
although more incisive drugs (sublingual alprazolam or lorazepam) seem
better in these cases. Prednisone or antihistaminic can control allergic
reactions, although in this case it should be very reccomendable search
for medical help if this reaction is not quickly controlled.
Dehydration from MDMA is really uncommon, and pharmacy electrolytes
taste is in general awful. Any soft-drink is suitable for this purpose.
I
disagree with use of "mild stimulants" to treat problems with
depressants. Neither ephedrine, modafinil and any other stimulants are
used in the treatment of intoxication with depressants. So there is no
evidence of efficacy of this, and I think also that there can be
negative, idiosincratic effects. Naloxone and flumazenil are selective
antidots of opioids and benzodiacepine, respectively, and may be very
useful in these circumpstances. But GHB, cannabis or alcohol
intoxication is never treated with stimulants.
2.- It is
important to distinguish if that person has a diagnosis of arterial
hypertension or not. There is a general confussion between isolated high
blood pressure registrs (very common and not necessarily pathological)
and arterial hypertension disease. In this last case it would be
necessary a personal evaluation of risks.
But in general, common
dosages and occasional use of classical drugs produce moderate raises in
blood pressure, limited in time, and there is no need of
medication to diminish risks. There is no evidence that using
antihypertensive drugs before using recreative drugs has any health
benefit.
As a curiosity, only carvedilol and doxazosine have been
used in combination with MDMA in clinical trials. In the case of
cocaine, it is very important to avoid its combination with selective
beta-blockers (propanolol, atenolol...) as it can increase
cardiovascular risk
-
DoctorX,
I
am prescribed Vyvanse 60mg which I take everyday at like 7 in the
morning. Coming up is my buddys bachelor party where there will
undoubtedly be cocaine. If I chose to partake, would I be making a big
mistake by combining these two stimulants? Everything I read says do not
combine because of cardiovascular issues, but they dont reference a
time layover. I know about when the medicine starts to dissipate from my
system as my eyes become foggier and my thoughts become jumbled
together. This usually occurs around 5-6 that night, but can last till 8
depending on how much i eat that day. Now the cocaine would not be
ingested until like 9-10 in the evening probably even later than that.
With 12+ hours in between my vyvanse dose and cocaine, would it be safe
to partake in the cocaine, or are there still too many traces of the
amphetamine in my system? If thats the case then more than likely if i
decide that day to participate, i wont take the vyvanse. Thanks! Love
the Thread
Half-life
of dexamphetamine is 10-12 hours. It is necessary this time to lower
50% amphetamine levels in body, and additional 10-12 hours to diminish
it to 75%.
Depending on the cause of the prescription and your
general both physical and mental health state, you can contemplate the
possibility of avoiding your medication 1-2 days, in the case you are
using cocaine that day. In order to estimate the risks, it is also very
important to consider the dosage of cocaine. Moderate ocassional amounts
have probably very limited risks, even in the case you don´t suspend
your medication. If you use larger quantities, probably the risks are
higher.
-
I
have a question regarding out phasing (dont know the correct english
term) Benzos - mainly Clonezapam, I don't know the exact dosage but say
that I have roughly taken 2mg per day for 7-8 months now. My own
physician gave me a fast schedule with Diazepam 5mg: [Week 1] Half a
pill in the morning, 1 pill in the evening [Week 2] Half morning, half
evening [Week 3] half evening. I personally thought this schedule to be
too fast since Clonezapam is around 10 times stronger than Diaz, but he
told me there is no magic out-phasing schedule, I will still have
withdrawals irregardless.
What are your opinions on this schedule?
He gave me more pills than I need for this schedule in case I would feel
it not working out, so I could go as long as 6 weeks instead of 3. The
reason I'm not going CT is that I am starting college soon and I tried
CT couple of months ago and it made my brain sooo slow... This is my
main concern, not being able to concentrate for 2 cents.
Great thing that you are here for us!
I
don´t know if your doctor had a particular reason for prescribing that
dosage, but, in a pharmacological point of view, 2 mg of clonazepam are
equivalent to 30-40 mg of diazepam. So that should be, at first at in
general, the dosage useful and tapering down could be done in 4-6 weeks.
-
How long does heroin withdrawal last?
Everywhere
i read it says that its over after 5 to 7 days. I quit heroin after 2-3
months of everyday use and today is my 9th day (will be starting the
tenth day in several hours) and the withdrawal isnt going away. I have a
very achy back and legs and im constantly getting chills and
goosebumps, and I have terrible anxiety and depression and the worst
part is that I havent slept more than 2 or 3 hours a nite since the 1st
nite. My body (especially my legs) is very restless at night and i feel
like i have electricity running thru my body.
So my question is that will this last much longer or is it almost over? I know each person is different but is this normal?
Tolerance
and dependence depend on many personal factors. In general, the idea
"5-7 days" for heroin abstinence ii right but some people have mild
symptoms lasting 48 hours and, in other cases as yours last longer.
Probably symptoms will progresivelly diminish in following days. It is
useful symptomatic management of pain, diarrhea and other physical
symptoms. Use of benzodiacepines can improve sleep.
I don´t agree
with the idea of using kratom. Mitragyna speciosa (kratom) acts
on μ-opioid receptor agonist like morphine, codeine or heroin. It
probably relieves symptomps of abstinence but continues acting on opioid
human system, and it will delay further abstinence symptoms that will
appear later.
-
How long does heroin withdrawal last?
Everywhere
i read it says that its over after 5 to 7 days. I quit heroin after 2-3
months of everyday use and today is my 9th day (will be starting the
tenth day in several hours) and the withdrawal isnt going away. I have a
very achy back and legs and im constantly getting chills and
goosebumps, and I have terrible anxiety and depression and the worst
part is that I havent slept more than 2 or 3 hours a nite since the 1st
nite. My body (especially my legs) is very restless at night and i feel
like i have electricity running thru my body.
So my question is that will this last much longer or is it almost over? I know each person is different but is this normal?
Tolerance
and dependence depend on many personal factors. In general, the idea
"5-7 days" for heroin abstinence ii right but some people have mild
symptoms lasting 48 hours and, in other cases as yours last longer.
Probably symptoms will progresivelly diminish in following days. It is
useful symptomatic management of pain, diarrhea and other physical
symptoms. Use of benzodiacepines can improve sleep.
I don´t agree
with the idea of using kratom. Mitragyna speciosa (kratom) acts
on μ-opioid receptor agonist like morphine, codeine or heroin. It
probably relieves symptomps of abstinence but continues acting on opioid
human system, and it will delay further abstinence symptoms that will
appear later.
The
sleeping disturbance can go on for months, the leg aches can be
dependent on the degree of addiction- I did a home detox after a year of
using up to 10 grams a day smoked of No3 heroin- good quality (60%
heroin by weight on average- UK police were kind enough to get some of
it forensically tested. He he he!), I was still getting unbearable aches
in my legs 2 months later, mainly at night.
Withdrawals can be very
much affected by stress- and can be alleviated by exercise- you
really won't feel like it but should force yourself, it really makes a
difference, but as I said, if you get into a stressful situation, the
withdrawals can reappear with a vengeance- I believe this is connected
with the fact that you tend to produce too much adrenaline when in
withdrawals, which intensifies your bad feelings- if you are exercising,
you are burning up the adrenaline rather than it floating round your
body!
The worst thing you can do after you have started to feel
better is to take any opiate as this will take you right back to the
beginning again, it can be very tempting to just alleviate the
withdrawals for a day for a rest, BUT REFRAIN, honestly, it is the worst
thing to do. All you can do is take each day as it comes- it will take
time! Also remember that once you have shaken it fully, it's as if your
brain is hard wired to opiates- if you resume your habit, it takes a
fraction of the use it would a novice to regain your addiction!
Hope
some of this is some help, the longer you have been using, the more
ingrained your use will get, so get off it earlier than later.
-
in a post you wrote that ketamin in our opinion is addictive.
what are your parameters you use to judge if a substance is addictive?
can you please categorize a few substances and explain why you think they are addictive or not.
-
LSD, DMT, and Psylocibin.
How damaging are they to the human brain, and what citations can you give to support your argument?
Thank you.
-
The
worst thing you can do after you have started to feel better is to take
any opiate as this will take you right back to the beginning again, it
can be very tempting to just alleviate the withdrawals for a day for a
rest, BUT REFRAIN, honestly, it is the worst thing to do. Also remember
that once you have shaken it fully, it's as if your brain is hard wired
to opiates- if you resume your habit, it takes a fraction of the use it
would a novice to regain your addiction!
What
do u mean "after you have started feeling better" ? Do you mean in the
week or two after quitting opiates or do you mean if someone quits
heroin and 2 months later (while still having PAWS) he slips up and does
heroin one night that the withdrawals will go back to the beginning
again??
And what do you mean that my brain is hardwired to
opiates, is that permanent, and what is"fraction of use", can one time
be enough?
-
I'm
in my twenties and have two co-morbid mental illnesses. I take
medication for them, which seems to work-but it makes me VERY tired. So
tired that I had to leave my doctorate program because I could really
not stay awake or motivated enough for serious concentration.
Should I try Modafinil? I don't like caffeine because it tends to make me more jittery than focused.
Also,
I feel as though marijuana has a stabilizing effect on my disorders.
Strangely, with the higher quality cannabis I get here, I do not notice
as much cognitive blunting (burn out) afterwards. Would it be okay to
keep this, or will I inevitably have a major cognitive decline?
Thanx
Rails
It
is impossible to give any advice or orientation without knowing what is
the exact diagnosis of your two mental illnesses and the medications
you have been used. Modafinil is only recommended in narcolepsy,
obstructive sleep apnoea/hypopnoea syndrome and shift work sleep
disorder. Technical sheet of modafinil says that “Caution should be
exercised in giving modafinil to patients with a history of psychiatric
disorders including psychosis, depression, mania, major anxiety,
agitation, insomnia or substance abuse”, so it doesn't seem very useful
in your case. I think you'd better ask your doctor and search for the
best medication for you.
The most noticeable neurocognitive
effect from cannabis is a subtle alteration of short time memory (memory
used, for example, to remember and learn new data). This effect depends
on cannabis dosage, frequency and individual characteristics (some
people are very susceptible to this even with low doses, other don’t
feel it even with high dosages). It is reversible after a few weeks of
complete abstinence. There are no other “cognitive declines” associated
to cannabis use.
-
How long does heroin withdrawal last?
Everywhere
i read it says that its over after 5 to 7 days. I quit heroin after 2-3
months of everyday use and today is my 9th day (will be starting the
tenth day in several hours) and the withdrawal isnt going away. I have a
very achy back and legs and im constantly getting chills and
goosebumps, and I have terrible anxiety and depression and the worst
part is that I havent slept more than 2 or 3 hours a nite since the 1st
nite. My body (especially my legs) is very restless at night and i feel
like i have electricity running thru my body.
So my question is that will this last much longer or is it almost over? I know each person is different but is this normal?
Tolerance
and dependence depend on many personal factors. In general, the idea
"5-7 days" for heroin abstinence ii right but some people have mild
symptoms lasting 48 hours and, in other cases as yours last longer.
Probably symptoms will progresivelly diminish in following days. It is
useful symptomatic management of pain, diarrhea and other physical
symptoms. Use of benzodiacepines can improve sleep.
I don´t agree
with the idea of using kratom. Mitragyna speciosa (kratom) acts
on μ-opioid receptor agonist like morphine, codeine or heroin. It
probably relieves symptomps of abstinence but continues acting on opioid
human system, and it will delay further abstinence symptoms that will
appear later.
The
sleeping disturbance can go on for months, the leg aches can be
dependent on the degree of addiction- I did a home detox after a year of
using up to 10 grams a day smoked of No3 heroin- good quality (60%
heroin by weight on average- UK police were kind enough to get some of
it forensically tested. He he he!), I was still getting unbearable aches
in my legs 2 months later, mainly at night.
Withdrawals can be very
much affected by stress- and can be alleviated by exercise- you
really won't feel like it but should force yourself, it really makes a
difference, but as I said, if you get into a stressful situation, the
withdrawals can reappear with a vengeance- I believe this is connected
with the fact that you tend to produce too much adrenaline when in
withdrawals, which intensifies your bad feelings- if you are exercising,
you are burning up the adrenaline rather than it floating round your
body!
The worst thing you can do after you have started to feel
better is to take any opiate as this will take you right back to the
beginning again, it can be very tempting to just alleviate the
withdrawals for a day for a rest, BUT REFRAIN, honestly, it is the worst
thing to do. All you can do is take each day as it comes- it will take
time! Also remember that once you have shaken it fully, it's as if your
brain is hard wired to opiates- if you resume your habit, it takes a
fraction of the use it would a novice to regain your addiction!
Hope
some of this is some help, the longer you have been using, the more
ingrained your use will get, so get off it earlier than later.
Very interesting and constructive information, thanks +1!
-
in a post you wrote that ketamin in our opinion is addictive.
what are your parameters you use to judge if a substance is addictive?
can you please categorize a few substances and explain why you think they are addictive or not.
In
the strict sense and technically, “dependence” or “addiction” is
defined by the Diagnostic and Statistical Manual of Mental Disorders
(DSM) published by the American Psychiatric Association:
http://www.uscourts.gov/uscourts/federalcourts/pps/fedprob/2006-09/accountability_table1.html
The
diagnosis implies some internationally accepted criteria: tolerance,
dependence and/or lose of control of the substance use. There are many
other definitions for dependence, but this is the most common.
So,
addiction potential of substances is not a question of personal opinion,
but on data based on neurochemistry, animal models and, over all,
studies on population. Some substances as heroin, cocaine, alcohol,
tobacco or ketamine have higher potential of addiction than others as
MDMA or LSD. (View Table 3 of following link)
http://www.sciencedirect.com/science/article/pii/S0140673607604644
In
the concrete case of ketamine, there are enough scientific data to
consider that dependence is one of the possible harms associated to its
use. This does not mean that it is an unavoidable consequence of every
pattern of use, but it is a risk to consider.
http://www.ncbi.nlm.nih.gov/pubmed/12075653
http://www.ncbi.nlm.nih.gov/pubmed/11476262
http://www.ncbi.nlm.nih.gov/pubmed/20214100
http://www.ncbi.nlm.nih.gov/pubmed/12762561
http://www.ncbi.nlm.nih.gov/pubmed/23444938
http://www.ncbi.nlm.nih.gov/pubmed/16869851
http://www.ncbi.nlm.nih.gov/pubmed/10402883
http://www.ncbi.nlm.nih.gov/pubmed/8166324
http://www.ncbi.nlm.nih.gov/pubmed/3247410
http://www.ncbi.nlm.nih.gov/pubmed/23882190
The
case of other recreative drugs, as MDMA or LSD (and psychedelics in
general) is opposite. Treatment presentations for dependence involving
MDMA or LSD as a principal problem drug are rare. They have a low
potential for dependence, although they can have other different risks.
-
Hi DoctorX,
Thanks for giving us this information. It's extremely valuable. I have one question:
My
friends and I are planning to take LSD. Most of the group has done it
before but myself and my friend a first timers. I take no medication at
all and am a fit and healthy person. My best friend is taking 120mg per
day of cymbalta for major depressive disorder and general anxiety
disorder. He has smoked a lot of marijuana lately and doesn't have any
problems but is a little concerned about potential side effects LSD
might have when combined with cymbalta. What would be your advice?
Thanks.
Boogiesteve.
-
Hi DoctorX
Really appreciating the time you spend on this forum. Thank you!
A
friend of mine has had some complications for 4 days now after
comsuming MDMA. During the night he did not feel any unusual negative
effects, they began the day after and include vomiting every day, almost
constant nausea and an upset stomach.
It was almost 1½ years
since his last encounter with MDMA, so he's not a heavy user at all. In
total he consumed 300-350 mg (but he's quite big (~100 kg) oral and
nasal. Also he drank quite a lot of water/juice. He fell asleep OK. Also
worth noting is that he's used MDMA a number of times before and never
had these kind of quite severe complications.
His problems are
less troubling now after 4 days. But the nausea is still there to some
extent. He also says that his sensitivity to alcohol has increased the
last years. He gets much more hung over than before.
I on the
other hand consumed the same MDMA and had no such problems, or other, at
all. Neither of us did take more than usual. For me it was a very
smooth experience, both during the night and the days after. Further we
did not feel it was a stronger experience than usual, or being more
warm.
Can it be his liver/kidneys? Other causes for this?
-
The
worst thing you can do after you have started to feel better is to take
any opiate as this will take you right back to the beginning again, it
can be very tempting to just alleviate the withdrawals for a day for a
rest, BUT REFRAIN, honestly, it is the worst thing to do. Also remember
that once you have shaken it fully, it's as if your brain is hard wired
to opiates- if you resume your habit, it takes a fraction of the use it
would a novice to regain your addiction!
What
do u mean "after you have started feeling better" ? Do you mean in the
week or two after quitting opiates or do you mean if someone quits
heroin and 2 months later (while still having PAWS) he slips up and does
heroin one night that the withdrawals will go back to the beginning
again??
And what do you mean that my brain is hardwired to
opiates, is that permanent, and what is"fraction of use", can one time
be enough?
No,
it wasn't very clear, what I meant was, say you are addicted, you stop
to do a detox, you get 5 days in, at this point you are over the hump,
you don't feel quite as bad, but you decide to do a little heroin as a
"little-pick-me-up", this is the worst you can do, as your withdrawals
will go back to the beginning again, albeit, not as intensely, but all
the 5 days you spent getting better will have been wasted. Even after a
couple of weeks, it will interfere with your recovery, you won't go back
to withdrawing, but the aches in your legs will intensify and the
lethargy will most likely worsen for a few days.
As for the
hard-wiring, it is certainly long-term as in years, probably permanent,
though I believe some drugs can reverse this- such as dmt. I think the
jury is out for being able to say that definitively- it needs more
research. When I say "fraction of use", I mean fraction of the use that
it took you to get addicted to it in the first place, ie, One can
generally take heroin for a week or more without getting properly
addicted (though if you used for over a week, you could certainly expect
to suffer some discomfort after use is stopped!). After you have had
years of addiction, and you have fully detoxed, your brain is
"hard-wired" and it will only take a few days of use to get your
addiction back, ie, if you then stop after the couple of days use, you
will get all the cravings back and your body will feel like shit!
-
Hello DoctorX and everyone.
I am new to this forum, to SR and
to drugs in general. I am thinking of trying some LSD and 2C-b. But
from what I've read, psychedelics are strictly forbidden for people who
have circulatory system conditions. I have a vegeto-vascular dystonia,
and I afraid that 2C-b will only make it worse. Please, explain this to
me.
-
LSD, DMT, and Psylocibin.
How damaging are they to the human brain, and what citations can you give to support your argument?
Thank you.
LSD,
DMT and psilocybin are not neurotoxic. So, from a organic point of
view, they are safe and not toxic physically to human brain cells at any
dosage. There is no need to add citations to this. In science,
demonstration must always be positive. If anyone stated that any of
these three substances are neurotoxic, he should demonstrate the
scientific studies to prove his argument. LSD, DMT, and psilocybin have
been widely studied from more than 60 years in animal models,
neuroimaging and neurochemical studies without evidence of
neurotoxicity.
A different question is mental health issues. In
general, psychedelics don’t produce mental health problems in general
population
http://www.ncbi.nlm.nih.gov/pubmed/23976938
but can
trigger mental health symptoms or problems over all in susceptible,
pre-morbid psychopatological personalities. The occurrence of long-term
problems is uncommon but possible.
http://www.ncbi.nlm.nih.gov/pubmed/19040555
http://www.ncbi.nlm.nih.gov/pubmed/9875725
http://www.ncbi.nlm.nih.gov/pubmed/17207120
Even more rare (anecdotic) are other disorders as Hallucinogen Persisting Perceptual Disorder (HPPD)
http://www.ncbi.nlm.nih.gov/pubmed/12609692
-
The
worst thing you can do after you have started to feel better is to take
any opiate as this will take you right back to the beginning again, it
can be very tempting to just alleviate the withdrawals for a day for a
rest, BUT REFRAIN, honestly, it is the worst thing to do. Also remember
that once you have shaken it fully, it's as if your brain is hard wired
to opiates- if you resume your habit, it takes a fraction of the use it
would a novice to regain your addiction!
What
do u mean "after you have started feeling better" ? Do you mean in the
week or two after quitting opiates or do you mean if someone quits
heroin and 2 months later (while still having PAWS) he slips up and does
heroin one night that the withdrawals will go back to the beginning
again??
And what do you mean that my brain is hardwired to
opiates, is that permanent, and what is"fraction of use", can one time
be enough?
In
general, people who have suffered a dependence problem are prone to
relapse. The process of desintoxication/detoxification implies
deactivating neuronal circuits overactivated by the use of the
substance. Time necessary to recover depends on personal-psychological
factors, type of substance, dosage, route of administration…If someone
quits heroin and 2 months later slips up, the probabilities of problems
are much higher than if you had never used opiates. It does not mean
that you will fall immediately but risks are higher.
Think about
tobacco as an easier example. Most people dependent of tobacco can’t use
it occasionally again once they have quitted. There are exceptions to
this rule but, in general, the example is valid for opiates.
-
I like you. i like you very much. Thank you for being accurate
LSD, DMT, and Psylocibin.
How damaging are they to the human brain, and what citations can you give to support your argument?
Thank you.
LSD,
DMT and psilocybin are not neurotoxic. So, from a organic point of
view, they are safe and not toxic physically to human brain cells at any
dosage. There is no need to add citations to this. In science,
demonstration must always be positive. If anyone stated that any of
these three substances are neurotoxic, he should demonstrate the
scientific studies to prove his argument. LSD, DMT, and psilocybin have
been widely studied from more than 60 years in animal models,
neuroimaging and neurochemical studies without evidence of
neurotoxicity.
A different question is mental health issues. In
general, psychedelics don’t produce mental health problems in general
population
http://www.ncbi.nlm.nih.gov/pubmed/23976938
but can
trigger mental health symptoms or problems over all in susceptible,
pre-morbid psychopatological personalities. The occurrence of long-term
problems is uncommon but possible.
http://www.ncbi.nlm.nih.gov/pubmed/19040555
http://www.ncbi.nlm.nih.gov/pubmed/9875725
http://www.ncbi.nlm.nih.gov/pubmed/17207120
Even more rare (anecdotic) are other disorders as Hallucinogen Persisting Perceptual Disorder (HPPD)
http://www.ncbi.nlm.nih.gov/pubmed/12609692
-
I have heard the opiates slow down peristalses..
From a brain/body standpoint, what exactly is happening to the systems of the body during daily opiate use?
Are there ways to be healthier when using opioid pain medications?
-
Hi DoctorX,
Thanks for giving us this information. It's extremely valuable. I have one question:
My
friends and I are planning to take LSD. Most of the group has done it
before but myself and my friend a first timers. I take no medication at
all and am a fit and healthy person. My best friend is taking 120mg per
day of cymbalta for major depressive disorder and general anxiety
disorder. He has smoked a lot of marijuana lately and doesn't have any
problems but is a little concerned about potential side effects LSD
might have when combined with cymbalta. What would be your advice?
Thanks.
Boogiesteve.
There
are no clinical data about combination between LSD and duloxetine.
Anecdotic reports from users suggest that duloxetine diminish
psychedelic effects from LSD. That is congruent with pharmacokinetic
studies of serotonin reuptake inhibitors and psychedelics, so is
reasonable to think that duloxetine can reduce LSD effects.
In
this kind of situations (people under psychotropic prescription drugs
using psychedelics) it is important to consider not only the
pharmacological interaction, but also the possible impact on the
undelyinig disorder. A major depressive disorder and general anxiety
disorder could be a reason enough to warn against LSD use, at least
during pharmacological treatment. Effects of psychedelics are somehow
more unpredictable than other drugs, but in people with mental health
problems the possibilities of negative experiences are higher.
-
Hello DoctorX and everyone.
I
am new to this forum, to SR and to drugs in general. I am thinking of
trying some LSD and 2C-b. But from what I've read, psychedelics are
strictly forbidden for people who have circulatory system conditions. I
have a vegeto-vascular dystonia, and I afraid that 2C-b will only make
it worse. Please, explain this to me.
“Vegetative-vascular
dystonia” is a very uncommon diagnosis in Werstern European and EE.UU.
medicine. It is a mixture of several autonomic dysfunctions, like
orthostatic hypotension or postural orthostatic tachycardia
syndrome ( changes in blood pressure standing up and down). Symptoms can
be very uncomfortable, but in general don´t mean severe risks or
organic damage (unless they have faints or falls as a consequence).
Cardiovascular
effects of LSD are, in general, moderate. Changes in blood pressure and
heart rate are more related with emotional responses to psychological
LSD effects than a direct effect of the substance. It is possible that
negative effects of LSD have more impact on a person diagnosed of
vegetative-vascular dystonia. If symptoms appear it is important to
remain lied down to avoid falls. Cardiovascular effects of 2C-B
are not studied. On the one hand is a problem in order to estimate
risks, on the other hand psychological effects of 2C-B at low-medium
dosages (5-15 mg) are, in general, more easy to handle with than LSD.
If
you are "new to drugs" it is very important that you search for
reliable information about the substances you are planning to take.
Erowid is a great point to start:
http://www.erowid.org/chemicals/lsd/lsd.shtml
http://www.erowid.org/chemicals/2cb/2cb.shtml
-
I have heard the opiates slow down peristalses..
From a brain/body standpoint, what exactly is happening to the systems of the body during daily opiate use?
Are there ways to be healthier when using opioid pain medications?
Opiates
interact with different systems of the body. The effects depend on the
opiate used, route of administration, pattern of use. Opiates act in
different receptors all over the body. In brain, they act on neuronal
circuits that regulate pleasurable conducts, and also in receptors
modulating pain. With daily use, there are modifications in these
cerebral circuits that are responsible of developing problems as
pharmacological tolerance (need to increase dosages in time to obtain
the same effects) and dependence/addiction
General organic effect include:
- Slow breathing
- Decreased heart rate
- Depressed appetite and thirst
- Diminished sexual desire
- Increased nausea and vomits
- Itching skin
- Constipation
The
healthiest way to use opioid pain medications is only using them for
pain and when there are medical reasons. Risks of dependence and adverse
effects are always there. Some adverse effects can be managed with
medication. Although tolerance to nausea develops in 5-7 days, there are
drugs that can be used in this period (haloperidol, ondansetron…).
These drugs have their own adverse effects, so they should only be used
in clinical settings and with medical advice. Antihistaminics can be
useful to control itching and some laxatives (lactulose,
polyethilenglycole…) can be used in case of constipation.
-
“Vegetative-vascular
dystonia” is a very uncommon diagnosis in Werstern European and EE.UU.
medicine. It is a mixture of several autonomic dysfunctions, like
orthostatic hypotension or postural orthostatic tachycardia
syndrome ( changes in blood pressure standing up and down). Symptoms can
be very uncomfortable, but in general don´t mean severe risks or
organic damage (unless they have faints or falls as a consequence).
Cardiovascular
effects of LSD are, in general, moderate. Changes in blood pressure and
heart rate are more related with emotional responses to psychological
LSD effects than a direct effect of the substance. It is possible that
negative effects of LSD have more impact on a person diagnosed of
vegetative-vascular dystonia. If symptoms appear it is important to
remain lied down to avoid falls. Cardiovascular effects of 2C-B
are not studied. On the one hand is a problem in order to estimate
risks, on the other hand psychological effects of 2C-B at low-medium
dosages (5-15 mg) are, in general, more easy to handle with than LSD.
Thanks.
Though I heard that it's quite notable and important fact about psychs
(esp 2c-b) and cardiovascular conditions. Quoting two separate people
(one of which tried the substance, the other one heard and read about it
a lot) "In general, those who have circulatory and/or psychic
conditions should avoid using psychedelics at all, nevertheless, best
bet will be 2c-b and only sublingually" (I thought that he meant not
snorting it, which surely feels much more impactful). And other one told
me about 2c-b that "People with VVD should think twice before even
trying this drug. Because it can reach for your VVD and amplify it,
especially if you do 2c-berian therapy often enough."
They didn't tell me anything about LSD I didn't read earlier somewhere.
And
thank you for your concern, I am quite well informed about trips,
dosages, sitters and on how to avoid bad trips without strong
medications.
-
Learning and Cocaine.
Doctor -in the news today:
Clearnet: http://www.huffingtonpost.com/2013/08/26/cocaine-decision-making_n_3818400.html
Cocaine Rewires Brain, Overrides Decision-Making After Just One Use, Says Study
Posted: 08/26/2013 6:10 pm EDT | Updated: 08/27/2013 12:41 pm EDT
A
new study at UC San Francisco's Ernest Gallo Clinic and Research Center
has revealed that cocaine may rewire the brain and drastically affect
decision-making after just one use.
While similar studies have
revealed such rewiring in long-term use, the new study's results are
especially alarming, showing that the brain can be altered after one
dose.
Using live mice, researchers from both UC San Francisco and
UC Berkeley studied the frontal lobe -- the area of the brain that
handles decision-making and memory -- when cocaine was introduced to the
body. After one dose, researchers found substantial growth of new
dendritic spines, which are "tiny, twig-like structures that connect
neurons and form the nodes of the brain’s circuit wiring."
According
to researchers, these new spines rewired the brain to seek cocaine,
explaining why the search for the drug might override other priorities
in human users.
"We've long known that when you become a repeated
drug user, the search for more drugs tends to dominate your attention
and decision-making," Linda Wilbrecht, an assistant professor of
psychology and neuroscience at UC Berkeley and the lead author of the
study, explained to The Huffington Post. "But it's quite shocking that
these neurological changes happened after just one use."
A series of brain scans exhibited how the spines changed over several days after exposure to cocaine:
(relevant pictures in article)
The changes were evident not just in the mice's brain scans, but in the animals' behavior.
Before
exposure to cocaine, the mice explored two chambers, differentiated by
scent and design, and selected a preference. They were then given
cocaine and placed in the chamber they did not prefer. Once put back in
the chambers without the drug, the mice overwhelmingly selected the
chamber they did not prefer, presumably seeking more cocaine.
“The
ones that developed the biggest change in preference for the cocaine
side were also the ones that grew the most spines,” Wilbrecht told the
LA Times.
"We have limited real estate in the brain, and this
shows how drugs dominate what its users think about," she told HuffPost.
"Drug exposure fuels drug use, potentially at the expense of other
priorities."
However, Wilbrecht explained, because our brains regularly grow and lose new spines, she is hopeful.
"The
frontal cortex regulates decision-making and, as we grow up, we make
decisions in an increasingly habitual manner," she said. "But the brain
can rewire, and it is rewired by lots of experiences. So even though it
was so much more rewired by the exposure to cocaine than it usually is,
it can return to normal. I see this as evidence that recovery is
possible."
I've
had a very positive learning experience with cocaine as an
undergraduate. Basically, I was failing an organic chemistry class and
needed an A on the final in order to pass the course. I had to memorize a
ton of crap and I thought it was impossible.
One benefit I had was
that all the test material was derived from homework and previous test
material. I had the answers to all of these but still would have to
memorize an inordinate amount of material to pass.
A few days
prior to the test I got a little cocaine and resisted the urge to
"party" (ie get very high) with it. I started creating a huge list
of flash cards for the relevant nomenclature and worked on a Leitner
system of 4 boxes. I would go through the list of cards and as I
memorized every third card (in the last box) -I would 'bump' with
cocaine.
Memorizing the actual chemical reactions were a bit
different. I ended up rote memorizing the steps presented in the
homework solution outline; again bumping with cocaine only when I was
able to repeat the steps.
In the end I passed the class. I don't
remember any of the material long term. I've never (quite frankly)
had to know anything about organic chemistry in my professional life so
there is a lack of context.
I'm not looking for validation.
Illegal cocaine has many adulterants and funds too many narco-terrorists
for validation. (Of course both of these issues would go away if it was
legal.) Cocaine affects everyone differently and some people -I feel;
just can't handle their drugs.
So what is my question... do you
think that this is a placebo effect or do you think that one can cram
like this. I don't deny that I really didn't keep the knowledge from the
class and that it was temporary at best. I have to (once again) study
for a test and I'm looking for something to help me. This new test
is more contextual than that one and perhaps the subject matter is more
boring. I've read things about low doses of 2C-D although I've
never tried it. What are your thoughts on drug aided learning?
-
This question is directed at both Doctor X, and also at all DMT users reading the thread.
For
the past three months the woman described below has continued to
experience a range of psychotic delusions, often of a paranoid
nature. The psychiatric symptoms are not present constantly -- on
some days she seems positive and perfectly normal, while other days I
feel like she ought to be physically restrained to prevent harming
herself and others; though I lack the medical authority to do so.
The
patient continues to firmly believe that her one and only DMT
experience, three-and-a-half months ago, was THE cause of all her
psychological problems, and not merely one element in a complex of
interacting psychological factors.
Of particular concern is a recent claim she made:
I
have been doing a lot of research and it seems that it is common
knowledge among DMT users that you should NOT be sitting on a chair as
we were, and that you should not attempt to talk to someone who is
tripping, which both you and [another person present during her trip]
did. Apparently, both are very dangerous.
I
am not exactly naive about DMT, but I have NEVER heard of these items
of "common knowledge" among users. If you're NOT supposed to do
DMT while sitting on a chair, what IS the appropriate posture, and
why? I could certainly see that some DMT users may not want to be
spoken to during their trips; and if that's the case, they could make
their wishes known. However I'm not aware that this is some kind
of universal law. Has ANYBODY heard of something like these
universal rules of doing DMT?
A
mid-forties female has been suffering recurrent anxiety episodes that
lead to respiratory distress with hyperventilation syndrome.
Following a particularly serious attack of this type, a medical
screening and detailed exam showed "no evidence of any type of acute
emergency process at this time." BP at the time was mildly
elevated -- enough to suggest ongoing treatment for hypertension.
The patient's subjective experience of the recent, particularly serious attack includes the following:
- A multitude of voices shouting in her head, mixed with an overwhelming clamour of noise in general
- "I felt like I was dying"
-
Extreme confusion about her physical location. At different times
during the episode, she clearly stated her location as two different
places that are separated by 100 miles or more.
The patient has a
history of "seizures" that have been recurring infrequently for more
than 20 years. Information about the exact nature of these
episodes is sparse, but some of the incidents did lead to ER visits and
medical exams. At no time did any medical exams produce a
diagnosis of any organic process causing these "seizures," and they have
always been attributed to general anxiety. For much of this
historical period she has been a very heavy smoker of cannabis.
Light drinker, 1/4 pack per day cigarette smoker, no other drugs of
abuse.
Physically the patient is very slender. Her measured
body temperature tends to be lower than normal, yet her skin feels warm
to the touch -- warmer than an average person. She states that
she has had "thyroid problems"in the past but we have no specific
information about those.
Two weeks prior to the most recent spate
of anxiety attacks, the patient used DMT for the first time. This
was her first genuine psychedelic experience of any kind. In the
immediate aftermath of the trip she reported the usual feelings of
wonder, awe, and amazement, expressing a desire to do it again as soon
as possible and try a higher dose to achieve "breakthrough."
However
in the two week period that followed, this already slender woman lost
10 lbs, became increasingly anxious and irritable, and finally began
having the acute anxiety attacks that culminated in something resembling
a psychotic break.
The patient believes that the DMT trip caused, or at least precipitated, her psychiatric symptoms.
Any thoughts?
It
is important to consider that it is not possible to give concrete
diagnosis based on Internet information, although you have explained
very well and detailed the situation. There is only one thing that
sounds strange in the story. The fact that " a multitude of voices
shouting in her head, mixed with an overwhelming clamour of noise in
general" does not coincide with panic attacks. There are some rare
diseases (like temporal epilepsy) that can curse with symptoms like
that. I´m not stating that is the cause of the problem, I´m only
pointing one possibility and the idea that, in general, auditive
alucinations are not typical of panic or anxiety.
Of course DMT
can trigger a psychotic problem. It is an uncommon situation but, in my
experience this can happen more frequently with DMT than other drugs. In
general, these episodies occur in pre-morbid, predisposed
personalities. The symptoms you describe could indicate this (once more,
it is only a possibility, I can´t be 100% sure). Anyway, if she is
experiencing psychotic symptoms I think she should search for
professional help. DMT psychosis usually have an excelent response to
antipsychotics and 2-3 months are enough for most patients. It is
important also to avoid DMT and psychedelics in general.
-
I
am not exactly naive about DMT, but I have NEVER heard of these items
of "common knowledge" among users. If you're NOT supposed to do
DMT while sitting on a chair, what IS the appropriate posture, and
why? I could certainly see that some DMT users may not want to be
spoken to during their trips; and if that's the case, they could make
their wishes known. However I'm not aware that this is some kind
of universal law. Has ANYBODY heard of something like these
universal rules of doing DMT?
[/quote]
well,
unfortunately the prohibition of drugs is more efficent in avoiding
good information to get to users than the drugs themselfs.
I
think this is fairly common sense, if somebody is beamed away as he will
be on DMT for 10 min, let him take his trip. also, if sitting on a
chair and doing a strong dose of DMT, you are likely to fall off. A sofa
will be perfect. I wouldn't lie down, as this might cause trouble
breathing.
Do some more reading on the subject. also, there is a
docu on detroid from drugs inc (motor city rush or something). there you
can see two guys actually smoking DMT and talking about it. just seing
that will let you understand why you don't want to talk to them during
the trip. Or even just after coming down. also many videos of people
talking about using DMT can be found on YT.
doc might supply some rules to you, but there is good info out there too.
-
Thanks so much for your detailed reply. We appreciate it.
Thanks again.
Boogiesteve.
-
Hi DoctorX
Really appreciating the time you spend on this forum. Thank you!
A
friend of mine has had some complications for 4 days now after
comsuming MDMA. During the night he did not feel any unusual negative
effects, they began the day after and include vomiting every day, almost
constant nausea and an upset stomach.
It was almost 1½ years
since his last encounter with MDMA, so he's not a heavy user at all. In
total he consumed 300-350 mg (but he's quite big (~100 kg) oral and
nasal. Also he drank quite a lot of water/juice. He fell asleep OK. Also
worth noting is that he's used MDMA a number of times before and never
had these kind of quite severe complications.
His problems are
less troubling now after 4 days. But the nausea is still there to some
extent. He also says that his sensitivity to alcohol has increased the
last years. He gets much more hung over than before.
I on the
other hand consumed the same MDMA and had no such problems, or other, at
all. Neither of us did take more than usual. For me it was a very
smooth experience, both during the night and the days after. Further we
did not feel it was a stronger experience than usual, or being more
warm.
Can it be his liver/kidneys? Other causes for this?
I´m sorry I missed to answer your question…I reviewed and I should have done yesterday…sorry
Intranasal
use of MDMA facilitates apparition of adverse and toxic effects. If
nausea/vomiting is the only symptom, ha can take some liquids and there
are no other alarm signs (strong abdominal pain, neurologic symptoms,
fever, change of skin or eyes colour…), it is probable that symptoms
will disappear in following days. A toxic effect on liver is possible,
although tipically this happens 1-2 weeks after MDMA and it is very
uncommon. Intranasal way also facilitates neurotoxicity and should be
avoided. If symptoms don´t improve or appear some different, you should
seek for medical advice.
-
Learning and Cocaine.
Doctor -in the news today:
Clearnet: http://www.huffingtonpost.com/2013/08/26/cocaine-decision-making_n_3818400.html
Cocaine Rewires Brain, Overrides Decision-Making After Just One Use, Says Study
Posted: 08/26/2013 6:10 pm EDT | Updated: 08/27/2013 12:41 pm EDT
A
new study at UC San Francisco's Ernest Gallo Clinic and Research Center
has revealed that cocaine may rewire the brain and drastically affect
decision-making after just one use.
While similar studies have
revealed such rewiring in long-term use, the new study's results are
especially alarming, showing that the brain can be altered after one
dose.
Using live mice, researchers from both UC San Francisco and
UC Berkeley studied the frontal lobe -- the area of the brain that
handles decision-making and memory -- when cocaine was introduced to the
body. After one dose, researchers found substantial growth of new
dendritic spines, which are "tiny, twig-like structures that connect
neurons and form the nodes of the brain’s circuit wiring."
According
to researchers, these new spines rewired the brain to seek cocaine,
explaining why the search for the drug might override other priorities
in human users.
"We've long known that when you become a repeated
drug user, the search for more drugs tends to dominate your attention
and decision-making," Linda Wilbrecht, an assistant professor of
psychology and neuroscience at UC Berkeley and the lead author of the
study, explained to The Huffington Post. "But it's quite shocking that
these neurological changes happened after just one use."
A series of brain scans exhibited how the spines changed over several days after exposure to cocaine:
(relevant pictures in article)
The changes were evident not just in the mice's brain scans, but in the animals' behavior.
Before
exposure to cocaine, the mice explored two chambers, differentiated by
scent and design, and selected a preference. They were then given
cocaine and placed in the chamber they did not prefer. Once put back in
the chambers without the drug, the mice overwhelmingly selected the
chamber they did not prefer, presumably seeking more cocaine.
“The
ones that developed the biggest change in preference for the cocaine
side were also the ones that grew the most spines,” Wilbrecht told the
LA Times.
"We have limited real estate in the brain, and this
shows how drugs dominate what its users think about," she told HuffPost.
"Drug exposure fuels drug use, potentially at the expense of other
priorities."
However, Wilbrecht explained, because our brains regularly grow and lose new spines, she is hopeful.
"The
frontal cortex regulates decision-making and, as we grow up, we make
decisions in an increasingly habitual manner," she said. "But the brain
can rewire, and it is rewired by lots of experiences. So even though it
was so much more rewired by the exposure to cocaine than it usually is,
it can return to normal. I see this as evidence that recovery is
possible."
I've
had a very positive learning experience with cocaine as an
undergraduate. Basically, I was failing an organic chemistry class and
needed an A on the final in order to pass the course. I had to memorize a
ton of crap and I thought it was impossible.
One benefit I had was
that all the test material was derived from homework and previous test
material. I had the answers to all of these but still would have to
memorize an inordinate amount of material to pass.
A few days
prior to the test I got a little cocaine and resisted the urge to
"party" (ie get very high) with it. I started creating a huge list
of flash cards for the relevant nomenclature and worked on a Leitner
system of 4 boxes. I would go through the list of cards and as I
memorized every third card (in the last box) -I would 'bump' with
cocaine.
Memorizing the actual chemical reactions were a bit
different. I ended up rote memorizing the steps presented in the
homework solution outline; again bumping with cocaine only when I was
able to repeat the steps.
In the end I passed the class. I don't
remember any of the material long term. I've never (quite frankly)
had to know anything about organic chemistry in my professional life so
there is a lack of context.
I'm not looking for validation.
Illegal cocaine has many adulterants and funds too many narco-terrorists
for validation. (Of course both of these issues would go away if it was
legal.) Cocaine affects everyone differently and some people -I feel;
just can't handle their drugs.
So what is my question... do you
think that this is a placebo effect or do you think that one can cram
like this. I don't deny that I really didn't keep the knowledge from the
class and that it was temporary at best. I have to (once again) study
for a test and I'm looking for something to help me. This new test
is more contextual than that one and perhaps the subject matter is more
boring. I've read things about low doses of 2C-D although I've
never tried it. What are your thoughts on drug aided learning?
There
are not many neuropharmacological studies to evaluate cocaine as a
congnitive enhancer. Studies on memory are little and give no clues
about its efficacy or not. Even in the case of efficacy, you should
consider negative effects of cocaine: anxiety, restlessness,
irritability, impulsivity…that can play a role in your performance.
There
are some studies on amphetamines for this purpose, although, in
general, studies are designed with patients with neurological diseases
(ADHD, Parkinson, Alzheimer…) and they may not representative of effect
on young, healthy people. They are done in laboratory conditions, and
its repercussion in real life conditions can be relative. One of the
best designed studies on this issue is this:
http://www.ncbi.nlm.nih.gov/pubmed/22884611
Results
show that mixed amphetamine salts have no more than small effect on
healthy cognition, although the drug is subjectively viewed as
cognitively beneficial.
A recent complete review of cognitive
enhancers shows that, in healthy people, mental training seems far more
effective than drugs to improve memory.
http://www.sciencedirect.com/science/journal/00283908/64
-
This question is directed at both Doctor X, and also at all DMT users reading the thread.
For
the past three months the woman described below has continued to
experience a range of psychotic delusions, often of a paranoid
nature. The psychiatric symptoms are not present constantly -- on
some days she seems positive and perfectly normal, while other days I
feel like she ought to be physically restrained to prevent harming
herself and others; though I lack the medical authority to do so.
The
patient continues to firmly believe that her one and only DMT
experience, three-and-a-half months ago, was THE cause of all her
psychological problems, and not merely one element in a complex of
interacting psychological factors.
Of particular concern is a recent claim she made:
I
have been doing a lot of research and it seems that it is common
knowledge among DMT users that you should NOT be sitting on a chair as
we were, and that you should not attempt to talk to someone who is
tripping, which both you and [another person present during her trip]
did. Apparently, both are very dangerous.
I
am not exactly naive about DMT, but I have NEVER heard of these items
of "common knowledge" among users. If you're NOT supposed to do
DMT while sitting on a chair, what IS the appropriate posture, and
why? I could certainly see that some DMT users may not want to be
spoken to during their trips; and if that's the case, they could make
their wishes known. However I'm not aware that this is some kind
of universal law. Has ANYBODY heard of something like these
universal rules of doing DMT?
A
mid-forties female has been suffering recurrent anxiety episodes that
lead to respiratory distress with hyperventilation syndrome.
Following a particularly serious attack of this type, a medical
screening and detailed exam showed "no evidence of any type of acute
emergency process at this time." BP at the time was mildly
elevated -- enough to suggest ongoing treatment for hypertension.
The patient's subjective experience of the recent, particularly serious attack includes the following:
- A multitude of voices shouting in her head, mixed with an overwhelming clamour of noise in general
- "I felt like I was dying"
-
Extreme confusion about her physical location. At different times
during the episode, she clearly stated her location as two different
places that are separated by 100 miles or more.
The patient has a
history of "seizures" that have been recurring infrequently for more
than 20 years. Information about the exact nature of these
episodes is sparse, but some of the incidents did lead to ER visits and
medical exams. At no time did any medical exams produce a
diagnosis of any organic process causing these "seizures," and they have
always been attributed to general anxiety. For much of this
historical period she has been a very heavy smoker of cannabis.
Light drinker, 1/4 pack per day cigarette smoker, no other drugs of
abuse.
Physically the patient is very slender. Her measured
body temperature tends to be lower than normal, yet her skin feels warm
to the touch -- warmer than an average person. She states that
she has had "thyroid problems"in the past but we have no specific
information about those.
Two weeks prior to the most recent spate
of anxiety attacks, the patient used DMT for the first time. This
was her first genuine psychedelic experience of any kind. In the
immediate aftermath of the trip she reported the usual feelings of
wonder, awe, and amazement, expressing a desire to do it again as soon
as possible and try a higher dose to achieve "breakthrough."
However
in the two week period that followed, this already slender woman lost
10 lbs, became increasingly anxious and irritable, and finally began
having the acute anxiety attacks that culminated in something resembling
a psychotic break.
The patient believes that the DMT trip caused, or at least precipitated, her psychiatric symptoms.
Any thoughts?
It
is important to consider that it is not possible to give concrete
diagnosis based on Internet information, although you have explained
very well and detailed the situation. There is only one thing that
sounds strange in the story. The fact that " a multitude of voices
shouting in her head, mixed with an overwhelming clamour of noise in
general" does not coincide with panic attacks. There are some rare
diseases (like temporal epilepsy) that can curse with symptoms like
that. I´m not stating that is the cause of the problem, I´m only
pointing one possibility and the idea that, in general, auditive
alucinations are not typical of panic or anxiety.
Of course DMT
can trigger a psychotic problem. It is an uncommon situation but, in my
experience this can happen more frequently with DMT than other drugs. In
general, these episodies occur in pre-morbid, predisposed
personalities. The symptoms you describe could indicate this (once more,
it is only a possibility, I can´t be 100% sure). Anyway, if she is
experiencing psychotic symptoms I think she should search for
professional help. DMT psychosis usually have an excelent response to
antipsychotics and 2-3 months are enough for most patients. It is
important also to avoid DMT and psychedelics in general.
Discussions
about causes of mental health problems and the role of psychedelics are
theoretical. In a practical case, it is not really important if she
believes that her problem has been “caused”, “trigged” or “exaggerated”
by DMT use. The thing is, as you say, that a person is suffering from
periodic symptomps that seems psychotic in their nature (disorientation,
voices shouting in head, anxiety…).n this case a real face to face
medical evaluation is important for obvious reasons. Some rare
epilepsies look similar to this women's symptoms. maybe is the
consequence of DMT use or maybe not, but it would be important to
clarify the diagnosis and use a specific treatment in order to reduce
her symptoms and avoid problems (for her and for other people). Some
psychotropic drugs, used for weeks or maybe months, are extremely
effective for this problems. We don´t know what is the role of DMT in
this case, but, as a preventive measure, she should avoid using
psychedelics.
There is no logical reason not to stay sitting down
while using DMT. In fact, to sit down or to lie down are the best way to
avoid falls or accidents in a modified state of consciousness. The
closer one's head is to the ground the better since falls are a common
risk factor for most drugs. On psychedelics, some people prefer to
concentrate in their inner world and avoid communication. For other
people is different. But there is no “sacred rule” that prohibits oral
communication and this should not trigger any psychotic problem.
-
Hi Doc! Thanks for helping all of us - you are making the world a safer place!
Concerning
the two phenethylamines 2C-T-2 and 2C-T-7, can you tell me more about
neurotoxicity? I know research is scarce, but if you know about any
experiments done or can make a somewhat safe logical judgement that
would be great!
You rock my world
Janusdidgeridoo
-
Hi! Thanks for answering all these questions.
I asked
in another forum, but do you know if fentynal will show up in my drug
test at the pain clinic? I was tested when I came in to pick up my
regular medications (morphine). I made sure to take some that morning so
they would show up, but I was taken by surprise with the U.A., because
they usually do that during my appointments, NOT when I am just picking
up med slips. Anyway, YEARS ago, the same thing happened at a different
clinic, but I hadn't take any of my regular meds and NOTHING showed up
(which can also be an issue). This gives me hope that maybe they
won't catch the fentanyl in my urine analysis? Plus, I would think
they would have called by now. I don't want to be surprised when I go
to pick up my med slips on the 12th or when I go to my next appointment
in October.
Any thoughts?
-
http://dkn255hz262ypmii.onion/index.php?topic=208921.0
Not sure if it adds anything... but almost everything can be mixed.. yes even alcohol benzo's ketamine and ghb.
But, it's dangerous.
You
can be on a lot of meds, which would suck because drugs dont work like
their should anymore, you need more, you spend more, you'll lose more.
But being really anxious is also bad.
Not sure if this is alright.. but try to relax.. combinations can be done. Then again, some people die from 1-2 drugs alone..
-
Adding this:
http://dkn255hz262ypmii.onion/index.php?topic=208932.0
After the mdpv my hearth rate must have been 200+
After benzo's (75mg oxa) and beer it's lower...
Now
when I do not take benzo's (and 75mg is a lot, and sometimes I need
10mgs valium + beer to not shake like shit... and I cant shake like shit
because I need amph as well to calm down a bit).
This is going terribly wrong and I hope this thread can help a bit...
I hate taking benzo's... Perhaps not care and take a lot and antipsychotics and get a lot of weed for a week.. or what?
-
Oh and mxe works, but then I cant walk normally all day. Plus
once I was convinced that if I washed speed with acetone and then with
ethanol + ether and burning it it would become pure really fast.
Ofcourse a lot of speed evaporated and what was left of fucking much grams was ash...
Besides
that it was very beatiful seeing all my speed being burned and the
whole room being a gas chamber I've had no advantage. And all my drugs
were and are gone (probably decided it kills me and threw it away)...
-
OPIOIDS
I tried poppy pod tea, opium and oxycontin.
None of them produced any feelings of comfort or relaxation.
I only got slight nausea and itching.
Another guy who took the same drugs said the effects were nice.
I
wonder why they don't work for me. It's a puzzle. (Not that it would be
a problem, this stuff is too dangerous to play around with anyway.)
I am also on SSRIs. Could they interfere with opioids?
Thanks.
-
Hi Doc! Thanks for helping all of us - you are making the world a safer place!
Concerning
the two phenethylamines 2C-T-2 and 2C-T-7, can you tell me more about
neurotoxicity? I know research is scarce, but if you know about any
experiments done or can make a somewhat safe logical judgement that
would be great!
You rock my world
Janusdidgeridoo
There
are no scientific investigation data in humans about 2C-T-2
(2,5-dimethoxy-4-ethylthiophenethylamine) and 2C-T-7
(2,5-dimethoxy-4-propylthiophenethylamine) .There are only a few studies
about its general metabolism in rats and even data on animal
neurochemistry are scarce. Nevertheless, they are substances with
15-20 years of recreative human experience, even have been sold as
“legal party pills” during the mid-nineties and, with this perspective,
the possibility of important Public Health problems seem limited.
Because
of its chemical structure(phenethylamine derivatives substituted with
an alkylthio group) it is theoretically possible that 2C-T-7 and, to a
lesser extent, 2C-T-2 could have some monoaminooxidase inhibitor effect,
that could facilitate MDMA toxicity. There are no deaths associated to
2C-T-2 use, but 2C-T-7 seems to be very toxic if used by insufflation,
even at moderate dosages
http://www.ncbi.nlm.nih.gov/pubmed/14607005
-
Hi! Thanks for answering all these questions.
I
asked in another forum, but do you know if fentynal will show up in my
drug test at the pain clinic? I was tested when I came in to pick up my
regular medications (morphine). I made sure to take some that morning so
they would show up, but I was taken by surprise with the U.A., because
they usually do that during my appointments, NOT when I am just picking
up med slips. Anyway, YEARS ago, the same thing happened at a different
clinic, but I hadn't take any of my regular meds and NOTHING showed up
(which can also be an issue). This gives me hope that maybe they
won't catch the fentanyl in my urine analysis? Plus, I would think
they would have called by now. I don't want to be surprised when I go
to pick up my med slips on the 12th or when I go to my next appointment
in October.
Any thoughts?
In
general, drug test are specific. Each drug (or group of drugs) has
their own specific test to react positive. Although fentanyl is an
opiate, the chemical structure is very different from morphine or
heroin, which leads to different methods of metabolism in the body. So
it would be necessary an specific test for fentanyl. These test exist:
http://www.ncbi.nlm.nih.gov/pubmed/21281622
But in general are used for investigation and is not available in most hospitals or clinics as routine screening drug test.
-
Oh
and mxe works, but then I cant walk normally all day. Plus once I
was convinced that if I washed speed with acetone and then with ethanol
+ ether and burning it it would become pure really fast.
Ofcourse a lot of speed evaporated and what was left of fucking much grams was ash...
Besides
that it was very beatiful seeing all my speed being burned and the
whole room being a gas chamber I've had no advantage. And all my drugs
were and are gone (probably decided it kills me and threw it away)...
I
don´t know exactly what kind of question or thought you try to say. In
your messages you communicate disconfort, anxiety, nuissance. In my
opinion, drugs should be used for experimentation, auto-knowledge, fun,
exploration of different states of consciousness...but you seem to be
suffering. This should be enough to think about the role drugs are
playing in your life, if you feel good with this and the ways to change
it, alone or with help of other people.
-
OPIOIDS
I tried poppy pod tea, opium and oxycontin.
None of them produced any feelings of comfort or relaxation.
I only got slight nausea and itching.
Another guy who took the same drugs said the effects were nice.
I
wonder why they don't work for me. It's a puzzle. (Not that it would be
a problem, this stuff is too dangerous to play around with anyway.)
I am also on SSRIs. Could they interfere with opioids?
Thanks.
Anti-drug
propaganda has promoted the idea that opiates are so extremely
pleasurable that, with an occasional use, you will get a high much
better than the best of your orgasms multiplied by hundred, so you will
become irremediabily addicted for ever. Of course, opiates have very
pleasurable effects (and that is one of the causes of the high addictive
potential), but the effects you say (nausea, itching and constipation)
are also part of the opioid experience. With regular use there is some
tolerance to these effects, and that makes easy to take notice of
pleasurable effects. The problem is that the development of tolerance is
associated to a higher risk of addiction, and, as you say, it is a
dangerous game.
There are also individual differences. Some people
don´t notice too much these negative physical effects. Logically, they
are more prone to have problems with opioids.
Use of SSRI should not interfere significantlly with effects, as different cerebral routes are involved.
-
I hope im not double posting but i did a quick search and came up with nothing.
What
is the acceptable time frame to inject after prepping a shot of H? I
sometimes prep a shot and later decide not to take it, leaving it in the
fridge for a few hours before taking it. I reheat it with worm water
under the sink, and it seems fine. I have heard people holding onto
prepped rigs for several days before shooting them.
What would be
Safe? I use sterilized everything and distilled bottled water. I know
immediately would be "safest" but if one waited how long is to long to
wait before shooting it?
Thank ya DOC
Chim
-
I hope yawl passing what coin you can this guys way . He / She /
They / It putting in a lot of effort , that .0003 btc sitting in you
account aint going to buy you anything but it would show gratitude to
someone who seems to care
-
Hi DoctorX, great thing your doing here! ;D
I have a
condition called idiopathic intracranial hypertension, and take
acetazolamide for it. Do you think there is an increased risk for me
taking mdma? I have taken it a few times now and been fine.
Just
wondering what you thought, I read something about pressure on the brain
and somebody dieing after drinking too much, and as I already have a
problem controlling the pressure in my head got me a little
worried! :-\
-
ld 95 in humans pentobarbital oral pill/ how much zopfran?
-
I hope im not double posting but i did a quick search and came up with nothing.
What
is the acceptable time frame to inject after prepping a shot of H? I
sometimes prep a shot and later decide not to take it, leaving it in the
fridge for a few hours before taking it. I reheat it with worm water
under the sink, and it seems fine. I have heard people holding onto
prepped rigs for several days before shooting them.
What would be
Safe? I use sterilized everything and distilled bottled water. I know
immediately would be "safest" but if one waited how long is to long to
wait before shooting it?
Thank ya DOC
Chim
As
you say, the 100% safest is immediate use of steril material. It is
difficult to calculate exactly the risks, but basically it depends on
the conditions of conservation. If syringe, water and needles are
sterilized and mixture is kept on the fridge (re-heating after as you
say) probably "a few hours" does not increase risks too much.
Cleanliness of needle is the most important part, so you should use a
clean steril new one for injection. Leaving at air conditions syringes
is not so important than needle, that should always be new. Waiting
"several days" will undoubtedly contaminate the preparation,
increasing risk of infectious problems.
-
Hi DoctorX, great thing your doing here! ;D
I
have a condition called idiopathic intracranial hypertension, and take
acetazolamide for it. Do you think there is an increased risk for me
taking mdma? I have taken it a few times now and been fine.
Just
wondering what you thought, I read something about pressure on the brain
and somebody dieing after drinking too much, and as I already have a
problem controlling the pressure in my head got me a little
worried! :-\
It
is unlikely that ocassional use of moderate MDMA dosages has a negative
repercussion in your disease. MDMA itself does not affect intracraneal
pressure. But this is possible in concrete situations. Hyperthermia is
the most feared MDMA complication and an adequate hydration is
recommended while on MDMA. But drinking too much water can be very
dangerous, also. There are described cases of cerebral oedema in people
taking excessive amount of water (more than 5-10 liters) under MDMA
effects. In this case intracraneal pressure increases and consequences
would be even worse in people with previous intracraneal hypertension.
So it is enough to drink "normal" amounts of water (or better, isotonic
drinkings) to avoid this problem.
-
Two short questions about Ketamin:
Recent studies suggest
that K can help with depressions. What doeses are used i taht studies
and how are they administered?
Also, have you heard about
people using small doses of K to practise sports? Eg. to take different
advantage of the different "feeling for your body" ?
-
Two short questions about Ketamin:
Recent
studies suggest that K can help with depressions. What doeses are used i
taht studies and how are they administered?
Also, have
you heard about people using small doses of K to practise sports? Eg. to
take different advantage of the different "feeling for your body" ?
Recent
studies show that ketamine has strong antidepressant properties.
Typical dosage is 0.5 mg/kg intravenous in infussion in 30-40 minutes;
oral route seems also effective at that dosage (0.5 mg/kg). The effect
is fast and strong but not lasting in time, it disappears in hours or
days and further dosages do not reply this effect. With actual
knowledge, Ketamin may prove useful in a select group of patients but
current medical knowledge looks to other treatments as the first line
against depression
http://www.ncbi.nlm.nih.gov/pubmed/23661785
http://www.ncbi.nlm.nih.gov/pubmed/23805864
http://www.ncbi.nlm.nih.gov/pubmed/23825857
http://www.ncbi.nlm.nih.gov/pubmed/23893490
I have never heard about small doses of K and sports...and in fact it sounds a bit bizarre 8)
-
I have never heard about small doses of K and sports...and in fact it sounds a bit bizarre 8)
I
had 2 professional athlets (martial arts) tell me they did use it for
that purpose and credited K with helping them to improve quite a bit. I
tried it too, but not enought times to say if it does any good. as it
dissociates you from you body, the idea does not sound to weird to me,
especially when talking about sport where you must drill the same moves
over and over again (like in martials arts). people also talk about K
improving their dancing skills in club settings.
might be studied in the future... :)
-
Too bad this is all 007 and stuff, I have lost replies that
undoubtedly would have been widely read and reported about, maybe
anyway...
1) The drug closest to providing sex like intensity is__ ?
2) Why do people die after ingesting MDMA? Are high performance sports drinks any better than water?
3) Is Gareth Bale worth all those millions?
4) What drugs can be used to enhance football prowess?
-
DoctorX thanks for posting and replying often in the thread, your
contributions are much appreciated! I apologize if this was already
addresses but hard to skim 40 pages quick :(
With regard to
rectal administration (plugging) of medicine and recreational
substances. Is it a generally safe method of administration for long
term periods, if its done carefully in moderation? Ive researched this
topic and see that some medicine is regularly used this way ie Morphine
Sulphate Suppositories. What about pure Amphetamine Sulphate, I know it
can be done safely on occasion, but what about extended periods of use
(low dose, pure Amp Sulphate dissolved in water solution). Clearly there
are risks with insufflation, and we know all about the long term damage
coke and amp can cause to sensitive nasal membranes over time. However,
many times its the cut or the dry power doing the damage right, rather
than a neutral PH saline solution? Im specifically asking about pure
Amphetamine Salts, not MDMA or Methamphetamine....
Also, Amp
Sulphate just how severe is its Hepatotoxicity? This is another point of
confusion from my research, but from what I read its relatively mild on
the liver, even with chronic use as compared to something like
Acetaminophen...
Thanks for any feedback on this!!
-
Too
bad this is all 007 and stuff, I have lost replies that undoubtedly
would have been widely read and reported about, maybe anyway...
1) The drug closest to providing sex like intensity is__ ?
2) Why do people die after ingesting MDMA? Are high performance sports drinks any better than water?
3) Is Gareth Bale worth all those millions?
4) What drugs can be used to enhance football prowess?
With you it is a bit difficult to distinguish between questions and jokes, but I will try…
1) It depends on the intensity of your sexual life
2)
Toxicity and deaths caused by MDMA are exaggerated by media and
anti-drug propaganda. Hyperthermia, hyponatremia and acute
hepatotoxicity are the three main causes of MDMA related deaths.
Exposition to excessive heat, or combination of heat and humidity, that
crushes the body heat-regulating mechanisms can cause dead in
combination with MDMA. But in real life this happens very rarely. An
article published in British Medical Journal in 2002 showed that deaths
related to ecstasy are statistically similar to those produced by
aspirin.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1123822/
It
does not mean that MDMA is “ intrinsically safe”, and the user’s
behaviour is fundamental to avoid problems. But the “Russian roulette”
image does not seem coherent with scientific data. Fortunately, MDMA is
safe from a pharmacological point of view in acute administration
compared with many legal and illegal drugs.In theory, using isotonic
drinks is better than water in order to avoid hyponatremia risks,
although the risk of hyponatremia is small drinking reasonable amounts
of liquid.
3) & 4) No comment…
-
I recently asked this question to a friend of mine who works as a pediatric neurologist but he was unsure of the answer.
Cocaine
acts as a reuptake inhibitor of seratonin/dopamine/norepinephrine,
meaning that the pharmacodynamics of the drug specifically does not
result in increased production of the aforementioned
neurotransmitters. Given this, why is there a reported "rush" when
users inject/snort the drug? Logically, I'd expect that
specifically acts as a reuptake inhibitor would only provide a rush if
the production/depletion cycle was quite short.
-
Thanks for doing this thread!
My pupil size is uneven during
amphetamine and/or GHB usage. Why ? High blood pressure? Friend said
that drugs that work on dopamine can cause this effect.
-
DoctorX
thanks for posting and replying often in the thread, your contributions
are much appreciated! I apologize if this was already addresses but
hard to skim 40 pages quick :(
With regard to rectal
administration (plugging) of medicine and recreational substances. Is it
a generally safe method of administration for long term periods, if its
done carefully in moderation? Ive researched this topic and see that
some medicine is regularly used this way ie Morphine Sulphate
Suppositories. What about pure Amphetamine Sulphate, I know it can be
done safely on occasion, but what about extended periods of use (low
dose, pure Amp Sulphate dissolved in water solution). Clearly there are
risks with insufflation, and we know all about the long term damage coke
and amp can cause to sensitive nasal membranes over time. However, many
times its the cut or the dry power doing the damage right, rather than a
neutral PH saline solution? Im specifically asking about pure
Amphetamine Salts, not MDMA or Methamphetamine....
Also, Amp
Sulphate just how severe is its Hepatotoxicity? This is another point of
confusion from my research, but from what I read its relatively mild on
the liver, even with chronic use as compared to something like
Acetaminophen...
Thanks for any feedback on this!!
In
general, rectal administration of drugs implies some changes in its
distribution and effects. A higher proportion of the drug reaches brain
without passing through liver an it produces a faster onset, shorter
peak, and shorter duration than the oral route. The absorption can be
conditioned by the presence and quantity of faeces in rectum and colon,
but in general dosages should be 10-20% lesser than oral route. In
moderate use and using hygienic measures risks should not be different
to oral route and there are no communicated cases of serious adverse
effects using this route (although it is not very common). Not every
drug is suitable for this method, but morphine, cocaine and amphetamine
work.
Amphetamines can produce hepatotoxicity, in general in a
dose-dependent way. It is a possible problem for this substance but not a
very common problem in moderate doses/frequencies.
-
Hi DoctorX!
What you're offering here is simply amazing, big
thanks for this. I'm new here but I'll definitely donate some coins to
you whenever I can.
I'll describe my question in spanish first
since is my native language and we can understand each other better.
Below I'll transcribe it to english for the rest.
ESPAÑOL:
No
tengo muchisima experiencia con drogas fuertes. He tomado algunas
pastillas de extasis en un pasado (hace 5-6 años y nunca más). Fumo
marihuana ocasionalmente, un par de secas por semana. Y en este ultimo
tiempo he probado LSD en dos ocasiones (medio 'tab' en cada ocasión).
Estoy
queriendo hacer uso de LSD y MDMA de calidad, pero no unicamente para
recreación, si no que estoy buscando una experiencia mas "espiritual" si
se quiere, trabajar ciertos aspectos de mi personalidad.
Soy un
joven de 25 años, saludable, aunque bastante ansioso y un poco obsesivo
en general, tiendo a sobre-preocuparme y sobre-pensar todo, me resulta
dificil relajarme por completo y "dejarme ir". He ido al psicologo
durante un buen tiempo, no tengo ninguna patología
psicologica/psiquiatrica, ni nada por el estilo, simplemente soy ansioso
y me cuesta relajarme. Es algo que me gustaría mejorar y creo que este
tipo de experiencias (junto con otras como meditar, modificar ciertos
habitos de mi vida, etc) me pueden ayudar.
Como la salud es algo
muy importante para mi estoy buscando que estas experiencias sean lo
menos dañinas posibles. He leido algunas guias sobre el MDMA
(rollsafe.org me gustó bastante) y LSD. Dado que el acido solo me
produjo cierta ansiedad durante el viaje, he leido que combinarlo con
MDMA puede ayudar a que uno se relaje y pueda tener un viaje mas ameno.
Entonces mis pregunta son:
Cual seria la mejor forma en terminos de dosis, tiempos y suplementos de abordar dicha experiencia?
Hay algun suplemento de los que recomiendan en rollsafe.org que no deberia ingerir si voy a tomar LSD?
Deberia tomar 1 dosis (100-200ug) de LSD + 1 de MDMA (100mg) o por combinarlas deberian ser menos de cada una?
Basicamente cualquier información sobre el uso combinado de estas dos sustancias me seria muy útil.
Perdón por la extensión de mi pregunta, es la obsesión manifestandose jajaja.
--------
ENGLISH:
I
don't have much experience with 'strong' drugs. I've taken some exctasy
pills in the past (5-6 years ago and never more). I smoke weed
ocassionaly, some puffs a week. Lately I've taken LSD in two ocassions
(half a tab each time).
I'm willing to make use of quality LSD +
MDMA, not only for recreation, but seeking to have a more 'spiritual'
experience that allows me to work on some aspects of my personality.
I'm
a 25-year old healthy male, altough I'm a bit anxious and obsessive in
general, I tend to over-think and over-worry a little and it's hard for
me to relax completely, to "let go". I've done therapy for a good time
in the past and I don't have any real psychological/psychiatric
pathology, I'm just an anxious and hard-to-relax guy. That's something
I'd want to work on and I think these kind of experiences (along with
others like meditation and modifying certain habits of my life) can help
me.
Because health is something important to me, I want these
experiences to be as harmless as possible. I've read some MDMA
(rollsafe.org is great) and LSD guides. Considering acid alone made me a
bit anxious during the trip, I've read that combining it with MDMA can
help one to relax and have a better trip.
So my questions are:
Which would be the best way in terms of dose, times and supplements to approach this experience?
Is there any of the rollsafe.org recommended supplements that I should take if I'm also doing LSD?
Should I take 1 dose (100-200ug) of LSD + 1 of MDMA (100mg) or because I'm combining them I should take less of each?
Basically, any information about combining both substances would be helpful.
Sorry for the long question, it's the obsession manifesting itself hahaha.
-
you don't need supplements for LSD.
don't take LSD and MDMA at the same moment, there are other threads on candyflip where you can find more info, not medical one.
-
Hi Doc!
I am curious as to how much damage smoking off of aluminum/tin foil causes, and if you know any safer alternatives.
Thanks.
-
I recently asked this question to a friend of mine who works as a pediatric neurologist but he was unsure of the answer.
Cocaine
acts as a reuptake inhibitor of seratonin/dopamine/norepinephrine,
meaning that the pharmacodynamics of the drug specifically does not
result in increased production of the aforementioned
neurotransmitters. Given this, why is there a reported "rush" when
users inject/snort the drug? Logically, I'd expect that
specifically acts as a reuptake inhibitor would only provide a rush if
the production/depletion cycle was quite short.
Human
brain is a very complex structure. In fact, we don´t know perfectly how
it works. Compared to other human organs (stomach, liver...) knowledge
about human consciousness and mechanisms of action of drugs that act on
brain is much limited. This is a valid idea for illegal drugs and also
for prescription drugs as antidepressives, which mechanisms of actions
are based in experimental and animal models.
There are different
theories about mechanisms of reinforcing drugs, but the most accepted is
the circuits of rewards. Explained in an easy way, there are neuronal
circuits that produce "pleasure", and are genetically created to rewards
activities that are necessary for survival of the species: drinking ,
eating or having sex for example. These activities are perceived as
pleasurable and repeated by activation of an ancient cerebral circuit
present in all vertebrates: the dopaminergic-mesocorticolimbic way.
According to this hypothesis some drugs produce "rush" (and are able to
cause repeated self-administration and dependence) because they overload
this circuits. This hypothesis is based in animal models and have some
critics actually, but is the most admitted to explain effects of several
drugs.
This article explains these concepts in a deep way:
http://ciitn.missouri.edu/2007009/group25_drugaddiction.pdf
-
Thanks for doing this thread!
My
pupil size is uneven during amphetamine and/or GHB usage. Why ? High
blood pressure? Friend said that drugs that work on dopamine can cause
this effect.
I
am not sure what you mean with "uneven". If you mean "assimetry" or
that both pupils do not have the same size I think you should consult
with a doctor. I´m not scaring you, I don´t mean that it is necessary a
severe health problem. Pupilar assimetry can be a symptom of different
neurological disease or maybe only a variation of normality. If you
don´t have any other symptom probably is the second chance (a
constitutional difference) but it would be better if your doctor or
ophtalmologist explored the motility of your eyes to be sure that there
is no problem.
-
Hi DoctorX!
What
you're offering here is simply amazing, big thanks for this. I'm new
here but I'll definitely donate some coins to you whenever I can.
I'll
describe my question in spanish first since is my native language and
we can understand each other better. Below I'll transcribe it to english
for the rest.
ESPAÑOL:
No tengo muchisima experiencia con
drogas fuertes. He tomado algunas pastillas de extasis en un pasado
(hace 5-6 años y nunca más). Fumo marihuana ocasionalmente, un par de
secas por semana. Y en este ultimo tiempo he probado LSD en dos
ocasiones (medio 'tab' en cada ocasión).
Estoy queriendo hacer uso de
LSD y MDMA de calidad, pero no unicamente para recreación, si no que
estoy buscando una experiencia mas "espiritual" si se quiere, trabajar
ciertos aspectos de mi personalidad.
Soy un joven de 25 años,
saludable, aunque bastante ansioso y un poco obsesivo en general, tiendo
a sobre-preocuparme y sobre-pensar todo, me resulta dificil relajarme
por completo y "dejarme ir". He ido al psicologo durante un buen tiempo,
no tengo ninguna patología psicologica/psiquiatrica, ni nada por el
estilo, simplemente soy ansioso y me cuesta relajarme. Es algo que me
gustaría mejorar y creo que este tipo de experiencias (junto con otras
como meditar, modificar ciertos habitos de mi vida, etc) me pueden
ayudar.
Como la salud es algo muy importante para mi estoy
buscando que estas experiencias sean lo menos dañinas posibles. He leido
algunas guias sobre el MDMA (rollsafe.org me gustó bastante) y LSD.
Dado que el acido solo me produjo cierta ansiedad durante el viaje, he
leido que combinarlo con MDMA puede ayudar a que uno se relaje y pueda
tener un viaje mas ameno.
Entonces mis pregunta son:
Cual seria la mejor forma en terminos de dosis, tiempos y suplementos de abordar dicha experiencia?
Hay algun suplemento de los que recomiendan en rollsafe.org que no deberia ingerir si voy a tomar LSD?
Deberia tomar 1 dosis (100-200ug) de LSD + 1 de MDMA (100mg) o por combinarlas deberian ser menos de cada una?
Basicamente cualquier información sobre el uso combinado de estas dos sustancias me seria muy útil.
Perdón por la extensión de mi pregunta, es la obsesión manifestandose jajaja.
--------
ENGLISH:
I
don't have much experience with 'strong' drugs. I've taken some exctasy
pills in the past (5-6 years ago and never more). I smoke weed
ocassionaly, some puffs a week. Lately I've taken LSD in two ocassions
(half a tab each time).
I'm willing to make use of quality LSD +
MDMA, not only for recreation, but seeking to have a more 'spiritual'
experience that allows me to work on some aspects of my personality.
I'm
a 25-year old healthy male, altough I'm a bit anxious and obsessive in
general, I tend to over-think and over-worry a little and it's hard for
me to relax completely, to "let go". I've done therapy for a good time
in the past and I don't have any real psychological/psychiatric
pathology, I'm just an anxious and hard-to-relax guy. That's something
I'd want to work on and I think these kind of experiences (along with
others like meditation and modifying certain habits of my life) can help
me.
Because health is something important to me, I want these
experiences to be as harmless as possible. I've read some MDMA
(rollsafe.org is great) and LSD guides. Considering acid alone made me a
bit anxious during the trip, I've read that combining it with MDMA can
help one to relax and have a better trip.
So my questions are:
Which would be the best way in terms of dose, times and supplements to approach this experience?
Is there any of the rollsafe.org recommended supplements that I should take if I'm also doing LSD?
Should I take 1 dose (100-200ug) of LSD + 1 of MDMA (100mg) or because I'm combining them I should take less of each?
Basically, any information about combining both substances would be helpful.
Sorry for the long question, it's the obsession manifesting itself hahaha.
There
are no medical/scientific reports on combination of LSD and MDMA. So
most of the information comes from experiences from users. Organic
toxicity and risk of severe adverse effects of this combination seems
low, as there no exist toxicological reports of this combination.
Anyway, it is important to have enough experience with both substances
and take all risk-reduction and common sense measures. As both
substances act on serotonin receptors and have sinergistic properties, I
would recommend reducing dosages of both. It is better to repeat
further experiences than being overwhelmed or disconnected.
About
timing, there are all kind of opinions. I think there is not a unique,
right way to do this. For people without experience or anxiety, MDMA
first has the adventage to induce a calm state of consciousness that
will make easier the LSD. On the other hand experience can be too long
and after-effects more noticeable. Using LSD first has the
inconvenient that psychedelic effects can be more noticeable than
empathogenic, but is much shorter. 1.5-2 hours between substances seems a
reasonable timing.
Anyway, personal reactions and effects can be
difficult to predict and it is important to act with caution, in a safe
environment, good company and common sense
I recommend you the
Spanish forum in www.energycontrol.org, there are several posts about
candyflipping and you can ask for more opinions
-
Thanks for doing this thread!
My
pupil size is uneven during amphetamine and/or GHB usage. Why ? High
blood pressure? Friend said that drugs that work on dopamine can cause
this effect.
I
am not sure what you mean with "uneven". If you mean "assimetry" or
that both pupils do not have the same size I think you should consult
with a doctor. I´m not scaring you, I don´t mean that it is necessary a
severe health problem. Pupilar assimetry can be a symptom of different
neurological disease or maybe only a variation of normality. If you
don´t have any other symptom probably is the second chance (a
constitutional difference) but it would be better if your doctor or
ophtalmologist explored the motility of your eyes to be sure that there
is no problem.
Thanks
for your reply. I looked it up on Wikipedia
(https://en.wikipedia.org/wiki/Anisocoria) and one of the causes is
¨Pharmacological agents¨ which is probably the cause because it does not
happen when I am sober or on a small amount of drugs.
[off-topic]The
picture on your website should be made into a Good Guy meme: ¨Good Guy
Doctor, answers your questions for free on Silk Road.¨ ;) [/off-topic]
-
I hope im not double posting but i did a quick search and came up with nothing.
What
is the acceptable time frame to inject after prepping a shot of H? I
sometimes prep a shot and later decide not to take it, leaving it in the
fridge for a few hours before taking it. I reheat it with worm water
under the sink, and it seems fine. I have heard people holding onto
prepped rigs for several days before shooting them.
What would be
Safe? I use sterilized everything and distilled bottled water. I know
immediately would be "safest" but if one waited how long is to long to
wait before shooting it?
Thank ya DOC
Chim
As
you say, the 100% safest is immediate use of steril material. It is
difficult to calculate exactly the risks, but basically it depends on
the conditions of conservation. If syringe, water and needles are
sterilized and mixture is kept on the fridge (re-heating after as you
say) probably "a few hours" does not increase risks too much.
Cleanliness of needle is the most important part, so you should use a
clean steril new one for injection. Leaving at air conditions syringes
is not so important than needle, that should always be new. Waiting
"several days" will undoubtedly contaminate the preparation,
increasing risk of infectious problems.
-
Hi Doc!
I am curious as to how much damage smoking off of aluminum/tin foil causes, and if you know any safer alternatives.
Thanks.
There
have been some cases published of a rare cerebral disease called
progressive spongiform leukoencephalopathy in people using aluminium or
tin foil to smoke heroin.
http://www.ncbi.nlm.nih.gov/pubmed/10563626
http://www.ncbi.nlm.nih.gov/pubmed/16419370
http://www.ncbi.nlm.nih.gov/pubmed/19515634
Considering
the high number of heroin smokers and the rarity of this problem, the
causal association is inconclusive. Boiling point of heroin is 273ºC and
melting and boiling point of aluminium are 660ºC and 2400ºC. So the
metal does not vaporize to a significant extent. Impurities of heroin or
plastic covering aluminium foil can be a problem, the last can be
avoided using the matt surface instead the brilliant one (in commercial
aluminium foil for wrapping food) and passing quickly a flame over the
surface to burn plastic.
A glass pipe (the kind used for meth) can be an alternative, although it is easier to burn and waste heroin.
-
Thanks for doing this thread!
My
pupil size is uneven during amphetamine and/or GHB usage. Why ? High
blood pressure? Friend said that drugs that work on dopamine can cause
this effect.
I
am not sure what you mean with "uneven". If you mean "assimetry" or
that both pupils do not have the same size I think you should consult
with a doctor. I´m not scaring you, I don´t mean that it is necessary a
severe health problem. Pupilar assimetry can be a symptom of different
neurological disease or maybe only a variation of normality. If you
don´t have any other symptom probably is the second chance (a
constitutional difference) but it would be better if your doctor or
ophtalmologist explored the motility of your eyes to be sure that there
is no problem.
Thanks
for your reply. I looked it up on Wikipedia
(https://en.wikipedia.org/wiki/Anisocoria) and one of the causes is
¨Pharmacological agents¨ which is probably the cause because it does not
happen when I am sober or on a small amount of drugs.
[off-topic]The
picture on your website should be made into a Good Guy meme: ¨Good Guy
Doctor, answers your questions for free on Silk Road.¨ ;) [/off-topic]
Notice
that Wikipedia entry says: "Pharmacological agents will cause
anisocoria if instilled in one eye". Anisocoria caused by oral route
seems, at least, unusal.
-
Non-native English speaker so I didnt notice that.
Maybe it has
something to do with blood pressure, it gets insanely high with the
combination GHB (sometimes combined with amphetamine). Trying to quit
now, if this eye thing doesn't happen again I will not seek a doctor.
Thanks for the advice.
Will pass you some BTC.
-
Thank you.
-
Doctor X: I have a rather unique problem, I think.
It
appears that GHB does not work on me. I have bought it from a reputable
vendor (xanax king), and have taken it always on an empty stomach in
varying does, from 1 to 6 grams. Effects range from nothing on the low
end, to mild positive effects in the middle, to felling kind of fucked
up at 6 grams. Little 20 min nap, and I was fine and pretty sober
feeling. What gives?
I will note that I have abused etizolam
recently, a couple months ago, almost every day for about 2 months in
doses ranging from 2-12 mg. I now get greatly reduced effects from the
etizolam. And xanax for that matter. Although they definitely still
work, and I still enjoy them. Could this be related the ineffectiveness
of the ghb?
Thank you for your time.
-
Doctor X: I have a rather unique problem, I think.
It
appears that GHB does not work on me. I have bought it from a reputable
vendor (xanax king), and have taken it always on an empty stomach in
varying does, from 1 to 6 grams. Effects range from nothing on the low
end, to mild positive effects in the middle, to felling kind of fucked
up at 6 grams. Little 20 min nap, and I was fine and pretty sober
feeling. What gives?
I will note that I have abused etizolam
recently, a couple months ago, almost every day for about 2 months in
doses ranging from 2-12 mg. I now get greatly reduced effects from the
etizolam. And xanax for that matter. Although they definitely still
work, and I still enjoy them. Could this be related the ineffectiveness
of the ghb?
Thank you for your time.
Cross-tolerance
is a pharmacological phenomenon, in which there is a decrease in
response to one drug due to frequent exposure to another similar acting
drug. This phenomenon is described between alcohol and GHB ( people who
use alcohol frequently develops tolerance not only to alcohol, but also
to GHB). This phenomenon is not described between GHB and
benzodiacepines, but according to its mechanism of action, seems a very
likely possibility. It is possible (at least in theory) that abuse of
etizolam or alprazolam creates some degree of resistance to GHB,
diminishing effects.
Probably this phenomenon will diminish with
several months of abstinence of depressors. It is important also never
use GHB and benzos at the same time, as toxic effects will appear more
easily.
-
Doctor X: I have a rather unique problem, I think.
It
appears that GHB does not work on me. I have bought it from a reputable
vendor (xanax king), and have taken it always on an empty stomach in
varying does, from 1 to 6 grams. Effects range from nothing on the low
end, to mild positive effects in the middle, to felling kind of fucked
up at 6 grams. Little 20 min nap, and I was fine and pretty sober
feeling. What gives?
I will note that I have abused etizolam
recently, a couple months ago, almost every day for about 2 months in
doses ranging from 2-12 mg. I now get greatly reduced effects from the
etizolam. And xanax for that matter. Although they definitely still
work, and I still enjoy them. Could this be related the ineffectiveness
of the ghb?
Thank you for your time.
Cross-tolerance
is a pharmacological phenomenon, in which there is a decrease in
response to one drug due to frequent exposure to another similar acting
drug. This phenomenon is described between alcohol and GHB ( people who
use alcohol frequently develops tolerance not only to alcohol, but also
to GHB). This phenomenon is not described between GHB and
benzodiacepines, but according to its mechanism of action, seems a very
likely possibility. It is possible (at least in theory) that abuse of
etizolam or alprazolam creates some degree of resistance to GHB,
diminishing effects.
Probably this phenomenon will diminish with
several months of abstinence of depressors. It is important also never
use GHB and benzos at the same time, as toxic effects will appear more
easily.
That
seems most likely to me. However, alprazolam or etizolam will still
knock me out at higher doses, but the ghb won't put me into a coma for
four hours as it should. But the body is a complex thing. You're right
that a break is in order. Thank you for the reply.
-
Dear Dr. X,
I wonder if you could tell me if it's dangerous
to take amphetamines while also taking Moclobemide, a reversible MAOI,
which only slightly (and reversibly?) inhibits MAO-B, and mostly works
on MAO-A. Both would be taken in "therapeutic doses", ie. no more than
600mg Moclobemide a day and small amounts of amphetamine throughout the
day.
I know that one should never take amphetamines with
"regular" MAOIs and I also know that one should never take the way more
serotonergic MDMA with Moclobemide, but from my understanding and the
few results a search on Google revealed regular amphetamines should not
be a problem, unless taken in huge quantities.
Is my understanding
correct? Or might there be other problems (as far as I understand the
obvious problem would be causing a hypertensive crisis), like increased
neurotoxicity if taken together? Or might there even be less
neurotoxicity? (A study found that Ritalin could lessen the neurotoxic
effects of methamphetamine and probably amphetamines as well, even
though I have to little knowledge to understand the mechanism behind
that process, so I thought maybe this reversible MAOI might even have a
similar effect)
-
Dear Dr. X,
I
wonder if you could tell me if it's dangerous to take amphetamines
while also taking Moclobemide, a reversible MAOI, which only slightly
(and reversibly?) inhibits MAO-B, and mostly works on MAO-A. Both would
be taken in "therapeutic doses", ie. no more than 600mg Moclobemide a
day and small amounts of amphetamine throughout the day.
I know
that one should never take amphetamines with "regular" MAOIs and I also
know that one should never take the way more serotonergic MDMA with
Moclobemide, but from my understanding and the few results a search on
Google revealed regular amphetamines should not be a problem, unless
taken in huge quantities.
Is my understanding correct? Or might there
be other problems (as far as I understand the obvious problem would be
causing a hypertensive crisis), like increased neurotoxicity if taken
together? Or might there even be less neurotoxicity? (A study found that
Ritalin could lessen the neurotoxic effects of methamphetamine and
probably amphetamines as well, even though I have to little knowledge to
understand the mechanism behind that process, so I thought maybe this
reversible MAOI might even have a similar effect)
Side
effects and interactions of moclobemide are much less important than
non-selective MAOIs as phenelzine and tranylcypromine. There are
not reported cases of toxicity or deaths in association with
amphetamine. In fact the technical sheet of moclobemide does not mention
anytjing about amphetamine although it states that "The pharmacologic
action of systemic regimens of sympathomimetic agents may possibly be
intensified and prolonged by concurrent treatment with moclobemide.".
That means that, at least in theory, it should be recommendable
diminishing doses of amphetamine if using moclobemids simultaneously.
If
you are using "small amounts of amphetamine" neurotoxicity should not
be a problem of importance. Anyway, there are no data to estimate if use
of moclobemide could improve or worsen this hypothetical problem
-
Dear Dr. X,
thanks a lot for your reply, that was very helpful indeed.
-
I'm using Nardil for depression from a long time. I have read that I
have to be very careful with drugs...what drugs can I use?
-
Hey DoctorX,
I tried LSD and MDMA on separate occasion and
enjoyed both very much, but candyflipping is just the best thing ever in
my experience. I read somewhere that in order to use MDMA safely 2-3
times a year is the max. I follow this rule right now but I wonder if it
is safe to do it more often. The best answer I could wish for is like 6
times a year, I'm not going to do it more than that anyway. I also read
your post about candyflipping where you state "As both substances act
on serotonin receptors and have sinergistic properties, I would
recommend reducing dosages of both." I would like to up my dose of LSD
but I don't think I need that much MDMA. Last time I did it I ended up
puking out most of my MDMA and still had the best time ever. So I would
like to take between 360-450ug of LSD (3 tabs), how much MDMA can I take
safely?
I found this combinations so great because I was very
euphoric and my thought train was like when I looked one step back in
thinking it was too broad to understand, like life, stuff, things etc.
Do you know any other drugs or combinations that could set me in such a
mindspace and is there like a scientific name for that?
Thank you very much for your time, I wouldn't go see my regular doctor to ask stuff like this, so yeah :)
-
I'm using Nardil for depression from a long time. I have read that I have to be very careful with drugs...what drugs can I use?
Nardil
(Phenelzine) is a very effective drug, but it belongs to a family of
drugs (MAOI) with many pharmacological interactions (prescription drugs,
illegal drugs and foods, as you know). It is particularly dangerous to
mix with MDMA and, probably, amphetamine derivatives (meth, MDA...)
http://www.ncbi.nlm.nih.gov/pubmed/2884326
http://www.ncbi.nlm.nih.gov/pubmed/1346952
It has been used for treatment of cocaine dependence, so probably interactions are not dangerous
http://www.ncbi.nlm.nih.gov/pubmed/3235232
Interactions
with benzos and weed are not notified, so they probably don´t exist.
According to pharmacological mechanisms it is possibly safe with
opiates, GHB and, maybe, ketamine, although you should consider the
problems of these drugs.
Anyway, you should also consider the impact
that using drugs can have, not only in a pharmacological point of view
(pharmacological interactions), but also in your depression. Some drugs
an patterns of use can affect this.
-
Good evening doctor, a flying visit so will cut to the chase.
Easiest
or most commonly 'cut'; drug? We voted cocaine in my works because we
know idiots using 10% (at most) and coke is almost 'normal' now, a lot
of kids get peer group pressure aged 12+ to use drugs.
So what do think sir?
What is the most common easy to fake or dulite drug?
Alcohol is easy but no pub will water down Whiskey!
But coke dealers will cut 9-1 with their 'coke'.
LSD is hard to fake but with all these RCs out there who knows.
First to synth a substance to mimic coke will be a multi millionaire in months.
And I hate fakers.
Thanks doc, oh, I caught the clap but I'll be ok,
Redalloverthedoctorssurgery
-
Alcohol is easy but no pub will water down Whiskey!
they put cheap whiskey in expensive bottles :\
First to synth a substance to mimic coke will be a multi millionaire in months.
I read MDPV is similar, didn't tried yet. but you need to cut cause .1 of MDPV make you crazy.
-
Dear Redalloverandtheguyhere,
Could you advise us what your name means, if you don't mind of course.
Seems to me DrX should know what people have bought like vendors do.
Mr. Cleansober
-
Hi DoctorX
I hope you can answer my question. Last week i
took teaspoonful of Phenibut at 8.pm night. I have never used it before,
but i hoped relaxing effects. After two hours of consuming i didn't
notice any major effects and decided to go to sleep. In the mirror of
bathroom i noticed my pupils were slightly dilated(and i had blur in my
vision), reminding me of MDMA. I felt suddenly anxious and after sitting
to a chair i shacked or shivered(no temperature feelings) about 10
minutes until it stopped. Since i didn't feel otherwise much different
than usual except "maybe" bit less anxious that usual(i have anxiety
disorder) i went to sleep that was extremely disturbing. Not really
relaxing as promised and morning i had my usual anxiety.
What
happened? Did i took too much/little or could it be Phenibut doesn't fit
to me as substance at all? Because i dont know what happened, i haven't
tried it second time so far.
Thank you for your time.
-
Hey doctorX
if you have time to help me here I would appreciate it http://dkn255hz262ypmii.onion/index.php?topic=211153.0
-
Hey DoctorX,
I
tried LSD and MDMA on separate occasion and enjoyed both very much, but
candyflipping is just the best thing ever in my experience. I read
somewhere that in order to use MDMA safely 2-3 times a year is the max. I
follow this rule right now but I wonder if it is safe to do it more
often. The best answer I could wish for is like 6 times a year, I'm not
going to do it more than that anyway. I also read your post about
candyflipping where you state "As both substances act on serotonin
receptors and have sinergistic properties, I would recommend reducing
dosages of both." I would like to up my dose of LSD but I don't think I
need that much MDMA. Last time I did it I ended up puking out most of my
MDMA and still had the best time ever. So I would like to take between
360-450ug of LSD (3 tabs), how much MDMA can I take safely?
I found
this combinations so great because I was very euphoric and my thought
train was like when I looked one step back in thinking it was too broad
to understand, like life, stuff, things etc. Do you know any other drugs
or combinations that could set me in such a mindspace and is there like
a scientific name for that?
Thank you very much for your time, I wouldn't go see my regular doctor to ask stuff like this, so yeah :)
Recommendations
about MDMA dosage are based in personal reports and general
characteristics of the substance. There is not a rule for frequency,
but, in general, it is recommended not to use it in a regular way. Ann
Shulgin said that " I found out, for myself, that using MDMA more often
than four times a year was not wise", but other authors recommend "twice
a year" or "no more than once a month". In general, once a year is
better than once a month, and much better than every weekend. I think
that 6 times a year can be an adequate pattern of use,if used properly
and with caution.
450 ug of LSD is a really very heavy dosage. I
don't think it is an adequate dosage for candyflipping, neither for LSD
alone. If you have calculated this dosage according to a seller, it is
very possible that real dosage is much lesser. In our Drug Testing
Service (www.energycontrol.org), most LSD marketed as "150 ug" contain
really 40-50 ug when submitted to analytical quantification techniques.
If you feel that 3 tabs is good for you, that's right, but be careful
when testing a new batch, as quantity of LSD in different batchs can be
very variable. 100 ug of LSD in combination with 80-100 mg of MDMA is
enough for a first experience, according to users experiences and
communications. These sources say that MDMA + 2C-B can be an interesting
combination, both in quality of the experience and pharmacological
safety.
-
Good evening doctor, a flying visit so will cut to the chase.
Easiest
or most commonly 'cut'; drug? We voted cocaine in my works because we
know idiots using 10% (at most) and coke is almost 'normal' now, a lot
of kids get peer group pressure aged 12+ to use drugs.
So what do think sir?
What is the most common easy to fake or dulite drug?
Alcohol is easy but no pub will water down Whiskey!
But coke dealers will cut 9-1 with their 'coke'.
LSD is hard to fake but with all these RCs out there who knows.
First to synth a substance to mimic coke will be a multi millionaire in months.
And I hate fakers.
Thanks doc, oh, I caught the clap but I'll be ok,
Redalloverthedoctorssurgery
In
a non-controlled market, all drugs can be adulterated. This depend on
many factors (number of persons that manipulate a determined batch,
geographical situation...) but most important is physical
characteristics: presentation in powder, liquid or crystal are much
easier to adulterate than pills or blotters. Levamisole (an anti-parasit
drug) is a common adulterant for cocaine, that, in high dosages can
produce dermatological or immunological problems. Aproximatelly 50% of
cocaine incautations have some degree of this adulteration. Speed only
contains normally 5-15% of amphetamine, the rest is normally caffeine or
paracetamol.
Other significant adulteration is for LSD: in street
market some 25-NBomE blotters are being sold as LSD. MDMA pills are, in
general, less adulterated, although in some moments and places they
contain different substances as pyperazine derivatives (m-CPP)
-
Hi DoctorX
I
hope you can answer my question. Last week i took teaspoonful of
Phenibut at 8.pm night. I have never used it before, but i hoped
relaxing effects. After two hours of consuming i didn't notice any major
effects and decided to go to sleep. In the mirror of bathroom i noticed
my pupils were slightly dilated(and i had blur in my vision), reminding
me of MDMA. I felt suddenly anxious and after sitting to a chair i
shacked or shivered(no temperature feelings) about 10 minutes until it
stopped. Since i didn't feel otherwise much different than usual except
"maybe" bit less anxious that usual(i have anxiety disorder) i went to
sleep that was extremely disturbing. Not really relaxing as promised and
morning i had my usual anxiety.
What happened? Did i took too
much/little or could it be Phenibut doesn't fit to me as substance at
all? Because i dont know what happened, i haven't tried it second time
so far.
Thank you for your time.
Phenibut
is a phenyl derivative of GABA. Investigation and human experience with
this substance is very limited. Supossed properties are reduction of
stress and anxiety, improvement of impaired sleep, and potentiation of
the effects of tranquilizers, narcotics, and neuroleptics. But data are
limited and there is not a well stablished dosage in humans, so "a
teaspoon full" is an undetermined dosage that could be not enough or,
more probably, a very high dosage. People with anxiety disorders are
more prone to have uncommon reactions to some psychotropic drugs. I
would recommend to try another substance for improve your sleep, or
better, talk with your doctor and search for an adequate pharmacological
alternative
-
Hey doctorX
if you have time to help me here I would appreciate it http://dkn255hz262ypmii.onion/index.php?topic=211153.0
I
am sorry that through Internet is impossible to offer help of this
kind. But your symptoms and antecedents (heavy use of ketamine) seem so
important to recommend to seek for immediate medical evaluation, to rule
out the possibilitiy of severe problems.
-
Hey Doc,
Not sure if you can help me out here but i have a question regarding sexual health......
I
have recently received some Viagra, i don't necessarily need it but i
wanted to try and boost my sexual performance.So to try it out, i took
half a 100mg pill,waited about half an hour and then started
masturbating. However,as i began masturbating, i felt an uncomfortable
feeling in my lower penis, not pain as such,just an aching sensation.
Is
this normal with Viagra usage, is it safe to continue usage? I can
still feel a slight aching sensation in my lower penis when i become
aroused now. Should i be worried? Would you recommend stopping use of
the Viagra?
Many thanks Doc, your work here is much appreciated i have to say.
-
what could be problematic concerning large doses of lsd (.5 mg+) ?
weren't doses of even 1mg+ used in therapy ?
-
Hey Doc,
I've got a few questions:
1. Is it OK to take
MDMA or psychedelics whilst on terbinafine? I read that terbinafine
inhibits one of the enzymes that metabolizes MDMA, although it's not
clear how important that particular enzyme is or if this would be
dangerous.
2. Is using noopept or piracetam in combination with
MDMA likely to cause harm? From reading it looks like these racetam
drugs do not cause any damage and I can't see how it would make MDMA
more harmful.
3. In your opinion how probable is it that
2C-x-NBOMe's cause long-term damage (with normal dosages)? I have so far
(perhaps naively) assumed that since it's pharmacology and short-term
effects are so similar to DOx that it probably won't cause any long term
damage (unless you overdose).
Thanks very much!
-
Hey Doc,
Not sure if you can help me out here but i have a question regarding sexual health......
I
have recently received some Viagra, i don't necessarily need it but i
wanted to try and boost my sexual performance.So to try it out, i took
half a 100mg pill,waited about half an hour and then started
masturbating. However,as i began masturbating, i felt an uncomfortable
feeling in my lower penis, not pain as such,just an aching sensation.
Is
this normal with Viagra usage, is it safe to continue usage? I can
still feel a slight aching sensation in my lower penis when i become
aroused now. Should i be worried? Would you recommend stopping use of
the Viagra?
Many thanks Doc, your work here is much appreciated i have to say.
I
don´t think your symptoms can be related to use of silfenafil. Common
adverse effects include headache, flushing, nasal congestion or impaired
digestion, but local symptoms in penis are very rare. Sildenafil could
cause priapism ( erect penis does not return to its flaccid state)
although it is extremely rare. And it is very strange also that a
single, ocassional dose, could cause symptoms persisting in time.
By
the way, in healthy young persons I think 25 mg should be enough as a
recreative dosage for most people. Increasing dose causes more adverse
effects.
-
what could be problematic concerning large doses of lsd (.5 mg+) ?
weren't doses of even 1mg+ used in therapy ?
LSD
is considered to be a very pharmacologically safe substance. LSD is not
associated with disease or damage to any organ or system. Several
hundred studies in various animal species have indicated the low
toxicity of LSD and long-term effects are not demonstrated. The most
common acute adverse effects of LSD are all psychological: anxiety,
panic attacks, a prolonged unpleasant experience (or “bad trip”) and
psychotic reactions. Transient anxiety or depression after taking LSD
have been reported. In general, these reactions are more frequent in
people using large doses. So a high dose will have a greater chance to
produce these effects but there are not long-term consequences.
In
the fifties and sixties of last century there were some therapeutic
studies with high doses of LSD but they did not show benefits compared
to normal doses. Actual protocols dosage is 200 ug.
http://www.maps.org/research/lsd/swisslsd/LDA1010707.pdf
-
I just want to Thank You for answering me :) DoctorX
cheers
-
Hi Doc,
Many thanks for answers!
I have some new questions.
1. In one place in this thread you say:
you could try short-acting well-studied psychedelics like psilocibin, 2C-B or 4-Aco-DMT
Is
that correct? Erowid states that 4-Aco-DMT is still considered research
chemical. [clearnet]
http://www.erowid.org/chemicals/4_acetoxy_dmt/4_acetoxy_dmt.shtml
Didn't you mean 5-Meo-DMT?
Also, in other place:
In
my opinion, if you are planning to stop a LSD trip because is too long,
one alternative is to choose another short-acting psychedelic instead
(4-AcO-DMT or even psilocybes).
Again,
5-Meo-DMT is much shorter lasting than 4-Aco-DMT, so maybe you meant
this one? (I know that it is considered really strong though).
2.
Benzos and driving -- which of the top four most popular anxyliotic
benzos you know to be safest to use when one has to drive? Apart from
obvious conclusion that everybody needs to test how affects his or hers
body etc. I'm more interested is there are studied contradictions for
some of the specific benzos (I'm interested in diazepam, clonazepam,
alfoprazolam and lorazepam especially since they are most common and
easy to get). I'm talking about occasional use in very stressful
situations.
Thanks a lot again!
-
Hey Doc,
I've got a few questions:
1.
Is it OK to take MDMA or psychedelics whilst on terbinafine? I read
that terbinafine inhibits one of the enzymes that metabolizes MDMA,
although it's not clear how important that particular enzyme is or if
this would be dangerous.
2. Is using noopept or piracetam in
combination with MDMA likely to cause harm? From reading it looks like
these racetam drugs do not cause any damage and I can't see how it would
make MDMA more harmful.
3. In your opinion how probable is it
that 2C-x-NBOMe's cause long-term damage (with normal dosages)? I have
so far (perhaps naively) assumed that since it's pharmacology and
short-term effects are so similar to DOx that it probably won't cause
any long term damage (unless you overdose).
Thanks very much!
1.
There is a big difference between theorical interactions and
pharmacological interactions with clinical relevance. Many of these
interactions don't have importance in real conditions. There are no
cases reported in scientific literature of adverse events or toxicity
associating MDMA and terbinafine. Clinical protocols of MDMA research in
humans do not exclude people using this drug, so the combination is
probably safe.
2. There are no reports of toxicity in combinating
MDMA and piracetam. By the way, piracetam does not have demonstrated
effects in healthy people. Probably there is no impact by combinating
two drugs, piracetam seems harmless but useless also.
3. There is
no way to predict toxicity of drugs according only to its chemical
structure. We can take the example of alcohol. Ethanol is the main
component of alcoholic drinks. If you quit one single atom of carbon you
will have methanol, that is extremely toxic for human optic nerve and
can make blind with a toxic dosage. 2C-NBOME family are substances with
no human experience and short and long time risks are impredictible.
Classic hallucinogens (LSD, psilocibin, DMT...) have a much higher
profile of security
-
I recently asked this question to a friend of mine who works as a pediatric neurologist but he was unsure of the answer.
Cocaine
acts as a reuptake inhibitor of seratonin/dopamine/norepinephrine,
meaning that the pharmacodynamics of the drug specifically does not
result in increased production of the aforementioned
neurotransmitters. Given this, why is there a reported "rush" when
users inject/snort the drug? Logically, I'd expect that
specifically acts as a reuptake inhibitor would only provide a rush if
the production/depletion cycle was quite short.
Human
brain is a very complex structure. In fact, we don´t know perfectly how
it works. Compared to other human organs (stomach, liver...) knowledge
about human consciousness and mechanisms of action of drugs that act on
brain is much limited. This is a valid idea for illegal drugs and also
for prescription drugs as antidepressives, which mechanisms of actions
are based in experimental and animal models.
There are different
theories about mechanisms of reinforcing drugs, but the most accepted is
the circuits of rewards. Explained in an easy way, there are neuronal
circuits that produce "pleasure", and are genetically created to rewards
activities that are necessary for survival of the species: drinking ,
eating or having sex for example. These activities are perceived as
pleasurable and repeated by activation of an ancient cerebral circuit
present in all vertebrates: the dopaminergic-mesocorticolimbic way.
According to this hypothesis some drugs produce "rush" (and are able to
cause repeated self-administration and dependence) because they overload
this circuits. This hypothesis is based in animal models and have some
critics actually, but is the most admitted to explain effects of several
drugs.
This article explains these concepts in a deep way:
http://ciitn.missouri.edu/2007009/group25_drugaddiction.pdf
Sorry it took so long for me to reply, I havn't been on the forums in quite a while.
If
I understand your response correctly, you are saying that the rush I
referred to is due to the physical process of administering the drug
itself, I assume through some positive/negative re-enforcement
dynamics. Does this mean that first time users shouldn't
experience an initial rush whatsoever?
-
Hey Doc, I had a buddy of mine went on a binge doin coke, and
in the middle of his party he swore he saw me and someone else he knew
go into the hotel room next to his and he claimed he could hear us
talking about him thru the wall so he goes and gets the manager and has
him open the door and no one was there so he thinks we ran off and were
messing with him. Seems like he was hallucinating and had a little
break with reality. Is there anything that can stabilize him
besides opiates? Benzos possibly?
-
Thanks for answering so quickly :)
I'd like to discuss the third point a little though:
3.
There is no way to predict toxicity of drugs according only to its
chemical structure. We can take the example of alcohol. Ethanol is the
main component of alcoholic drinks. If you quit one single atom of
carbon you will have methanol, that is extremely toxic for human optic
nerve and can make blind with a toxic dosage. 2C-NBOME family are
substances with no human experience and short and long time risks are
impredictible. Classic hallucinogens (LSD, psilocibin, DMT...) have a
much higher profile of security
The
example with alcohol is certainly a good demonstration of how the
chemical structure doesn't tell you anything on its own, but I think
that we have more information about NBOMes than to just say we have no
idea at all about how safe it is.
The 25I-NBOMe have been tested in
man by what must be a fairly large number of people by now, and it is
known that they are not so horribly toxic as to make you drop dead or go
blind with high probability. The receptor affinity/efficacy is also
known, so we know that it isn't really acting anywhere other than at
5HT2A & 5HT2C. If it had never been tested in man, we wouldn't know
if it also acts as a reuptake inhibitor or an allosteric modulator etc.
at a totally different site by chance.
We do know that it can
cause severe vasoconstriction, seizures and death; particularly in
higher doses. These effects are very similar to DOB, which shares the
property of having a very high efficacy at the 5HT2A receptor when
compared to classical psychedelics (LSD/Mescaline/4-HO-DMT etc.). It
seems to me to that the safety profiles of drugs such as LSZ and AL-LAD
are probably quite similar to that of LSD and 4-HO-DMT, whereas the
safety of 25I-NBOMe is probably similar to that of DOB (obviously
nothing is definite but I don't think it's unreasonable to think this is
likely).
What I want to know is if a similar line of reasoning
can be followed for the long-term effects. I don't really know what can
cause long-term effects, other than highly reactive molecules damaging
parts of the cell (e.g. degradation of axons by MDMA when the enzymes to
prevent this are at too high of a temperature, or having too much of a
reactive chemical in the liver so that there is not enough enzyme to go
round). Are there mechanisms by which long-term damage has been caused,
but would be totally unpredictable and wouldn't show significant
short-term symptoms?
Note: I am in no way trying to argue that RCs are safe, it's obviously much better to stick to drugs that are known to be safe.
-
Hello dear Dr. Fernando:
I really consider your post as a
priceless help to guide our experiences. So I´d like to discuss my
experience to get your opinion.
More than a year ago I discovered the help of psychedelics as synergistic tools in the understanding of my vision of cosmos.
Along
some months, I experimented few but greatly rewarding experiences with
Salvia divinorum, ayahuasca, magic mushrooms and HBWR.
I
considered all these experiences as very insightful and overally
pleasant, but at some point I suffered a few weeks of stress at my job
and severe familiar problems. These circumstances maybe added to the
effects of some of my tryptamine experiences led me to an acute episode
of anxiety that made me visit the doctor and start a treatment.
At
first, my prescription was citalopram an alprazolam... and that was the
beginning of the worse week of my life. In fact I use to say I´ve
visited paradise (specially one of my ayahuasca experiences) and hell
(that terrible week with citalopram).
After that, my psychiatrist
changed the citalopram for sertaline, and that was the beginning of my
recovery. In fact, in less than two months, with the help of my
psychiatrist, the treatment and my wife, gradually my point of view of
all the problems sorrounding me improved totally (of course, I did not
dare to take entheogens during that recovery proccess.)
And that
brings me to the present day. About one month ago, my psychiatrist
considered that I was ready to quit gradually my sertraline treatment
(in fact quit taking alprazolam some months ago because I no longer
needed it).
Some weeks ago, I began cautiously to try Salvia, HBWR, DMT and tentative doses of 25-I-NBOME, allylescaline, LSD and 2-CB.
I
succeeded to get pleasurable experiences with all of them. Nevertheless
There is a significant difference with my old experiences: The visuals
are almost absolutely gone! The other effects are still there with my
previously known substances, but when took 25-I-NBOME, allylescaline,
LSD and 2-CB, did it to experiment the visuals and could not perceive
them with any of these.
I´m quite sad about this issue. I´m still
reducing my sertraline gradually to minimize the bad effects and I have
the hope to recover my inner sight as soon as my brain gets to its
pre-sertraline state.
My question for you is, do you think I´ll
recover my ability to feel the visuals? Is there anything you
could recommend me to do or to take in order to reopen my eye?
Thanks a lot in advance, Dr.
Peace.
-
Hi Doc,
Many thanks for answers!
I have some new questions.
1. In one place in this thread you say:
you could try short-acting well-studied psychedelics like psilocibin, 2C-B or 4-Aco-DMT
Is
that correct? Erowid states that 4-Aco-DMT is still considered research
chemical. [clearnet]
http://www.erowid.org/chemicals/4_acetoxy_dmt/4_acetoxy_dmt.shtml
Didn't you mean 5-Meo-DMT?
Also, in other place:
In
my opinion, if you are planning to stop a LSD trip because is too long,
one alternative is to choose another short-acting psychedelic instead
(4-AcO-DMT or even psilocybes).
Again,
5-Meo-DMT is much shorter lasting than 4-Aco-DMT, so maybe you meant
this one? (I know that it is considered really strong though).
2.
Benzos and driving -- which of the top four most popular anxyliotic
benzos you know to be safest to use when one has to drive? Apart from
obvious conclusion that everybody needs to test how affects his or hers
body etc. I'm more interested is there are studied contradictions for
some of the specific benzos (I'm interested in diazepam, clonazepam,
alfoprazolam and lorazepam especially since they are most common and
easy to get). I'm talking about occasional use in very stressful
situations.
Thanks a lot again!
1.-
There is no universal definition for "research chemicals". 4-AcO-DMT is
really a prodrug for psilocin, it was syntethized and marketed in the
sixties of last century and, in my personal opinion, it is a bit
exagerated to consider it as a "research chemical". In that thread we
were talking about psychedelics compared to LSD. Experience with
4-AcO-DMT is shorter than LSD but qualitatively similar. 5-MeO-DMT is
not active orally, its effects are very short (minutes) and very
different to classical psychedelics. That´s why I talked about 2C-B or
4-AcO instead of 5-MeO in that example
2.- I have been searching
about this issue but I haven´t find anything clear. The general idea is
that benzodiacepines impairs driving, and risks of accidents are higher
under its effects. Some studies show that risks are higher in ocassional
users than in regular, probably by tolerance development. I have only
found specific studies on Lorazepam, showing that a dose of 2 mg
produces more potent effects than heavy alcohol:
http://www.ncbi.nlm.nih.gov/pubmed/24007754
I
think in this sense is more important the dosage than the concrete
benzo, obviously avoiding those with a more sedative profile. Anyway,
benzos and driving are never a very good combination.
-
Hello,
Two questions further down:
A friend's goldfish has
been buying (probably illicitly) morphine for back/sciatica pain. It
always had an addictive personality and used opiates for recreational
purposes sometimes. Usually it tried to keep the dose to a minimum
25mg-50mg once or twice a day, sometimes three times. And sometimes when
the fish has a rough day or does hard exercise that agitates it's back,
it will say F**K it and take a whole 100mg-180mg. It doesn't like the
constipation that goes hand in hand with any sort of prolonged use, nor
does it like feeling controlled by a substance.
It has decided that it wants to investigate suboxone as a method for discontinuing use in conjunction with physical therapy.
So, the goldfish's questions are:
1)
Would the 8mg/2mg suboxone seem like a standard dose? How often should
this 180 pound fish take said dose? The half life would seem to suggest
possibly as infrequently as once every three days...
2) Are
opiates gentle on the body? The fish has GI issues from NSAIDs and
decided liver damage is likely from Tylenol (both used as pain relief at
times, and from past abuse of opioid-containing products, and
concurrent alcohol consumption). It would appear that since there are
opioid receptors throughout the body, it would be a substance that is
expected to be consumed, biologically speaking. It also seems to slow
down aging and doesn't harm any organs (so long as one takes time away
from it every other day enough to poop). Is this correct? Or what causes
physiological damage/what is damaged?
Thank you very much for your response, the fish is "itching" to know!
You can also PM me.
-
Sorry it took so long for me to reply, I havn't been on the forums in quite a while.
If
I understand your response correctly, you are saying that the rush I
referred to is due to the physical process of administering the drug
itself, I assume through some positive/negative re-enforcement
dynamics. Does this mean that first time users shouldn't
experience an initial rush whatsoever?
Well,
in a pharmacological point of view, all drugs act physically on
different parts of the body and their effects are always explained by
these interactions. This is valid for legal prescription drugs and for
any other kind of drug. In fact I think to distinguish between
“physical” and “psychological” is somehow artificial. Psychological
effects of drugs have a neurological correlation and vice versa.
“Rush”
is uncommon in first experiences with some drugs. Effects of drugs are
explained mainly by neuropharmacology but there are also psychological
and social factors. Learning processes are important to recognize and
process effects of drugs, so first experiences are not necessarily the
best. Regular use is more associated with “rush” than occasional
experiences. But, for example, administration of intranasal placebo
(local anesthesic) to cocaine addicts can produce physical effects
(tachycardia, raise of blood pressure) similar to cocaine. So even
placebo effect can explain ( a part) of some drug effects.
-
Hey
Doc, I had a buddy of mine went on a binge doin coke, and in the
middle of his party he swore he saw me and someone else he knew go into
the hotel room next to his and he claimed he could hear us talking about
him thru the wall so he goes and gets the manager and has him open the
door and no one was there so he thinks we ran off and were messing with
him. Seems like he was hallucinating and had a little break with
reality. Is there anything that can stabilize him besides
opiates? Benzos possibly?
I
think it sounds more like a paranoid reaction than hallucination. There
is no real break with reality but a false belief that he could hear you
talking about him in a bad way. Paranoid reactions are very typical of
high dosages of stimulants (cocaine, amphetamines or methamphetamine).
If this disappears in a few hours, nothing else is necessary to do.
Anyway, some people are prone to this effect and he should know this and
be very careful with stimulant dosages. He should think about this once
the cocaine effects have passed, analyzing the situation again and
realizing that this was not true.
If these unreal ideas persist
hours or days after cocaine use or if the paranoid ideas are out of
reality (for example, you and your friends are aliens that are laughing
at him) it should be necessary medical-psychiatric evaluation and
specific medication. It is not worthy to try benzos (or worse, opiates)
without medical prescription. A paranoid person can be dangerous (for
himself or others), as he feels fear. He could feel, for example, that
he is going to be poisoned if he is offered medication. So, if the
strange ideas do not disappear in a few hours I would recommend medical
evaluation
-
Thanks for answering so quickly :)
I'd like to discuss the third point a little though:
3.
There is no way to predict toxicity of drugs according only to its
chemical structure. We can take the example of alcohol. Ethanol is the
main component of alcoholic drinks. If you quit one single atom of
carbon you will have methanol, that is extremely toxic for human optic
nerve and can make blind with a toxic dosage. 2C-NBOME family are
substances with no human experience and short and long time risks are
impredictible. Classic hallucinogens (LSD, psilocibin, DMT...) have a
much higher profile of security
The
example with alcohol is certainly a good demonstration of how the
chemical structure doesn't tell you anything on its own, but I think
that we have more information about NBOMes than to just say we have no
idea at all about how safe it is.
The 25I-NBOMe have been tested in
man by what must be a fairly large number of people by now, and it is
known that they are not so horribly toxic as to make you drop dead or go
blind with high probability. The receptor affinity/efficacy is also
known, so we know that it isn't really acting anywhere other than at
5HT2A & 5HT2C. If it had never been tested in man, we wouldn't know
if it also acts as a reuptake inhibitor or an allosteric modulator etc.
at a totally different site by chance.
We do know that it can
cause severe vasoconstriction, seizures and death; particularly in
higher doses. These effects are very similar to DOB, which shares the
property of having a very high efficacy at the 5HT2A receptor when
compared to classical psychedelics (LSD/Mescaline/4-HO-DMT etc.). It
seems to me to that the safety profiles of drugs such as LSZ and AL-LAD
are probably quite similar to that of LSD and 4-HO-DMT, whereas the
safety of 25I-NBOMe is probably similar to that of DOB (obviously
nothing is definite but I don't think it's unreasonable to think this is
likely).
What I want to know is if a similar line of reasoning
can be followed for the long-term effects. I don't really know what can
cause long-term effects, other than highly reactive molecules damaging
parts of the cell (e.g. degradation of axons by MDMA when the enzymes to
prevent this are at too high of a temperature, or having too much of a
reactive chemical in the liver so that there is not enough enzyme to go
round). Are there mechanisms by which long-term damage has been caused,
but would be totally unpredictable and wouldn't show significant
short-term symptoms?
Note: I am in no way trying to argue that RCs are safe, it's obviously much better to stick to drugs that are known to be safe.
I
am sorry but I don’t agree with some of your arguments. I understand
your reasoning but I think it is not based in right ideas. Compared with
classical recreational drugs, even with drugs like GHB or ketamine,
life of 25I-NBOME is very short. The number of persons that have used it
is really limited compared with many substances. It was synthetized in
2003 and first reports of recreational use are no longer than two years.
Chemical and pharmacological properties are based in incomplete
in-vitro and animal studies and there are not enough data to know about
its security, neither short and long term. Maybe you are right when you
say that it is not “horribly toxic” as it is true that it is being
tested by hundreds (maybe thousands) of persons in this moment, persons
that are acting as guinea pigs as animal data on 25I-NBOME are scarce.
I
understand the logical reasoning under your hypothesis about toxicity,
but it is a theoretical speculation. It may be right or maybe not. The
only way to evaluate long-time effects of drugs is waiting years or
decades until these effects appear. This happens to prescription drugs:
some of them are retired from market years after commercialization
because of unexpected serious adverse long-time effects . There are many
recent examples in human pharmacology (clozapine, rosiglitazone,
celecoxib, rimonabant…). Knowledge about its chemical structures has not
been useful to predict toxicity or long time effects.
I think
the ketamine example can be illustrative enough. Ketamine has been used
in human and animal anesthesia during more than 50 years. And a serious,
long time toxic effect (hemorrhagic cisthopaty, ketamine bladder) has
only been described in the last 5 years, associated to the exponential
growth in its recreational use in the last two decades. This effect is
probably associated with intranasal route and very intensive patterns of
use, as it has not been described in 50 years of clinical use in
animals or humans. And I think it shows the difficulties to predict
toxic effects even with relatively known drugs.
I don´t
like to sound alarmist and maybe I am repetitive advising against new
drugs. Everyone should be free to take their decisions but having all
the data. And, as you say in your last line, it's obviously much better
to stick to drugs that are known to be safe.
-
Hi Doctor,
What are the harmful effects, if any, of taking
small doses of LSD on a fairly regular basis? I have been experimenting
with doses of less that 15 micrograms. I am currently taking 5
micrograms once a week. Is this harmful in any way? Would it be harmful
to take 5 micrograms of LSD more frequently, such as 3 times a week?
Thank you for your time
-
Hello dear Dr. Fernando:
I
really consider your post as a priceless help to guide our experiences.
So I´d like to discuss my experience to get your opinion.
More than a year ago I discovered the help of psychedelics as synergistic tools in the understanding of my vision of cosmos.
Along
some months, I experimented few but greatly rewarding experiences with
Salvia divinorum, ayahuasca, magic mushrooms and HBWR.
I
considered all these experiences as very insightful and overally
pleasant, but at some point I suffered a few weeks of stress at my job
and severe familiar problems. These circumstances maybe added to the
effects of some of my tryptamine experiences led me to an acute episode
of anxiety that made me visit the doctor and start a treatment.
At
first, my prescription was citalopram an alprazolam... and that was the
beginning of the worse week of my life. In fact I use to say I´ve
visited paradise (specially one of my ayahuasca experiences) and hell
(that terrible week with citalopram).
After that, my psychiatrist
changed the citalopram for sertaline, and that was the beginning of my
recovery. In fact, in less than two months, with the help of my
psychiatrist, the treatment and my wife, gradually my point of view of
all the problems sorrounding me improved totally (of course, I did not
dare to take entheogens during that recovery proccess.)
And that
brings me to the present day. About one month ago, my psychiatrist
considered that I was ready to quit gradually my sertraline treatment
(in fact quit taking alprazolam some months ago because I no longer
needed it).
Some weeks ago, I began cautiously to try Salvia, HBWR, DMT and tentative doses of 25-I-NBOME, allylescaline, LSD and 2-CB.
I
succeeded to get pleasurable experiences with all of them. Nevertheless
There is a significant difference with my old experiences: The visuals
are almost absolutely gone! The other effects are still there with my
previously known substances, but when took 25-I-NBOME, allylescaline,
LSD and 2-CB, did it to experiment the visuals and could not perceive
them with any of these.
I´m quite sad about this issue. I´m still
reducing my sertraline gradually to minimize the bad effects and I have
the hope to recover my inner sight as soon as my brain gets to its
pre-sertraline state.
My question for you is, do you think I´ll
recover my ability to feel the visuals? Is there anything you
could recommend me to do or to take in order to reopen my eye?
Thanks a lot in advance, Dr.
Peace.
Changes
in psychedelic effects are very probably related to the action of SSRI
(sertraline). SSRI action is not immediate, but gradual, and it
takes several weeks to revert some of the neurobiological changes
induced. The effects of 25-I-NBOME, allylescaline, LSD and 2-CB depend
on serotonin so it is logical that sertraline has effect on this.
In
my opinion, using psychedelics for personal growth or spiritual
purposes makes necessary that use is sporadic, ocassiona, selecting very
well time, substance and setting. I think it is more important to
integrate and learn from the experiences in the normal life,
non-alterated state of consciousness than the experience itself. Once
you have learnt something with a substance it is no worthy repeating and
repeating again. I think psychedelics should be used ocassionaly (no
more than once a month, or less if possible) when used for spiritual or
personal growth. If you are trying different substances every week you
will have a psychedelic salad but it is very difficult to learn
something there.
Anyway, if you have been passing a bad mood
time,I think it should be wise to wait until your complet recovery
before you start using psychedelics again
-
Hello,
Two questions further down:
A
friend's goldfish has been buying (probably illicitly) morphine for
back/sciatica pain. It always had an addictive personality and used
opiates for recreational purposes sometimes. Usually it tried to keep
the dose to a minimum 25mg-50mg once or twice a day, sometimes three
times. And sometimes when the fish has a rough day or does hard exercise
that agitates it's back, it will say F**K it and take a whole
100mg-180mg. It doesn't like the constipation that goes hand in hand
with any sort of prolonged use, nor does it like feeling controlled by a
substance.
It has decided that it wants to investigate suboxone as a method for discontinuing use in conjunction with physical therapy.
So, the goldfish's questions are:
1)
Would the 8mg/2mg suboxone seem like a standard dose? How often should
this 180 pound fish take said dose? The half life would seem to suggest
possibly as infrequently as once every three days...
2) Are
opiates gentle on the body? The fish has GI issues from NSAIDs and
decided liver damage is likely from Tylenol (both used as pain relief at
times, and from past abuse of opioid-containing products, and
concurrent alcohol consumption). It would appear that since there are
opioid receptors throughout the body, it would be a substance that is
expected to be consumed, biologically speaking. It also seems to slow
down aging and doesn't harm any organs (so long as one takes time away
from it every other day enough to poop). Is this correct? Or what causes
physiological damage/what is damaged?
Thank you very much for your response, the fish is "itching" to know!
You can also PM me.
1)
First of all, I would not recommend the fish to do this on his own.
Guidelines for detoxification from heroin using subuxone are clear, but
it is not so easy using oral morphine. I think it would be easier just
tappering down oral morphine dosage. If pain is being a problem, it
should be necessary controlling it with an adequate medication,
otherwise pain would be an added problem to achieve detoxification.
Anyway,
in order to start a detoxification from opiates, subuxone 2 mg/ 0.5 mg
is more adequate than subuxone 8/2. First dosage should be used when
first signs of abstinence appear. Initial induction dosage (first day of
treatment) should nbe in the rank of 2/0.5 ( 1 pill) to 8/2 mg (4
pills). In the following days dosage should be adjusted to a maximum of
24/6 mg, dependind on physical and psychological symptoms, and then
tappering down during several weeks (rate depend on initial dosage and
clinical symptoms).
2) Opiate toxicity for human body is very
low. The main problems are tolerance, dependence, psychological symptoms
and constipation. But opiates are not adequate for all kinds of pain.
In fact, there are much better options for back pain/ciatic than
morphine.
-
1)
First of all, I would not recommend the fish to do this on his own.
Guidelines for detoxification from heroin using subuxone are clear, but
it is not so easy using oral morphine. I think it would be easier just
tappering down oral morphine dosage. If pain is being a problem, it
should be necessary controlling it with an adequate medication,
otherwise pain would be an added problem to achieve detoxification.
Anyway,
in order to start a detoxification from opiates, subuxone 2 mg/ 0.5 mg
is more adequate than subuxone 8/2. First dosage should be used when
first signs of abstinence appear. Initial induction dosage (first day of
treatment) should nbe in the rank of 2/0.5 ( 1 pill) to 8/2 mg (4
pills). In the following days dosage should be adjusted to a maximum of
24/6 mg, dependind on physical and psychological symptoms, and then
tappering down during several weeks (rate depend on initial dosage and
clinical symptoms).
2) Opiate toxicity for human body is very
low. The main problems are tolerance, dependence, psychological symptoms
and constipation. But opiates are not adequate for all kinds of pain.
In fact, there are much better options for back pain/ciatic than
morphine.
Thank you for the response!
Pain
has definitely been a problem for relapse because when no potent
substance is used, it cannot perform exercise such as running or picking
up dirty clothing from the floor. Quitting morphine cold turkey doesn't
cause withdrawls that are super intense, just a day or two of feeling a
little lame. But then the pain comes back and makes all 24 hours of the
day excruciating. So, an illicit use of this substance has allowed
sleep and normal ADL's. There is definitely an addiction issue beyond
physical symptoms arising from the euphoria that morphine, oxy, H, or
any opiate provides.
1)So, would the suboxone reduce the
cravings for opiates as the pain issue heals (hopefully) through
physical therapy and an epidural steroid? And, would it help to mitigate
the pain in the meantime?
2)You said that morphine is not the
most effective drug for this type of pain. What is more effective/better
suited for lumbar issues/sciatica? Marijuana actually helps as much or
more than morphine sometimes, or, it can complete the relief when MS
isn't taking it all away.
The info is very useful! Thank you very much!
-
Hello dear Dr. Fernando:
I
really consider your post as a priceless help to guide our experiences.
So I´d like to discuss my experience to get your opinion.
More than a year ago I discovered the help of psychedelics as synergistic tools in the understanding of my vision of cosmos.
Along
some months, I experimented few but greatly rewarding experiences with
Salvia divinorum, ayahuasca, magic mushrooms and HBWR.
I
considered all these experiences as very insightful and overally
pleasant, but at some point I suffered a few weeks of stress at my job
and severe familiar problems. These circumstances maybe added to the
effects of some of my tryptamine experiences led me to an acute episode
of anxiety that made me visit the doctor and start a treatment.
At
first, my prescription was citalopram an alprazolam... and that was the
beginning of the worse week of my life. In fact I use to say I´ve
visited paradise (specially one of my ayahuasca experiences) and hell
(that terrible week with citalopram).
After that, my psychiatrist
changed the citalopram for sertaline, and that was the beginning of my
recovery. In fact, in less than two months, with the help of my
psychiatrist, the treatment and my wife, gradually my point of view of
all the problems sorrounding me improved totally (of course, I did not
dare to take entheogens during that recovery proccess.)
And that
brings me to the present day. About one month ago, my psychiatrist
considered that I was ready to quit gradually my sertraline treatment
(in fact quit taking alprazolam some months ago because I no longer
needed it).
Some weeks ago, I began cautiously to try Salvia, HBWR, DMT and tentative doses of 25-I-NBOME, allylescaline, LSD and 2-CB.
I
succeeded to get pleasurable experiences with all of them. Nevertheless
There is a significant difference with my old experiences: The visuals
are almost absolutely gone! The other effects are still there with my
previously known substances, but when took 25-I-NBOME, allylescaline,
LSD and 2-CB, did it to experiment the visuals and could not perceive
them with any of these.
I´m quite sad about this issue. I´m still
reducing my sertraline gradually to minimize the bad effects and I have
the hope to recover my inner sight as soon as my brain gets to its
pre-sertraline state.
My question for you is, do you think I´ll
recover my ability to feel the visuals? Is there anything you
could recommend me to do or to take in order to reopen my eye?
Thanks a lot in advance, Dr.
Peace.
Changes
in psychedelic effects are very probably related to the action of SSRI
(sertraline). SSRI action is not immediate, but gradual, and it
takes several weeks to revert some of the neurobiological changes
induced. The effects of 25-I-NBOME, allylescaline, LSD and 2-CB depend
on serotonin so it is logical that sertraline has effect on this.
In
my opinion, using psychedelics for personal growth or spiritual
purposes makes necessary that use is sporadic, ocassiona, selecting very
well time, substance and setting. I think it is more important to
integrate and learn from the experiences in the normal life,
non-alterated state of consciousness than the experience itself. Once
you have learnt something with a substance it is no worthy repeating and
repeating again. I think psychedelics should be used ocassionaly (no
more than once a month, or less if possible) when used for spiritual or
personal growth. If you are trying different substances every week you
will have a psychedelic salad but it is very difficult to learn
something there.
Anyway, if you have been passing a bad mood
time,I think it should be wise to wait until your complet recovery
before you start using psychedelics again
Thanks for your answer, Fernando. I really appreciate your devotion in helping us, people hungry for answers...
Peace.
-
I have had major depression and anxiety for years... I've tried
every med available for these conditions ( just started prestiq last
week )
Several months ago, hemroid surgery left me with a stricture (found by colonoscopy).
After
taking 10 mg Percocet for a few weeks, I realized that my depression,
panic, anxiety, was greatly reduced. I have quit taking opiates for a
few days, on several occasions - I start with a nervous breakdown and
about 4 days later just feel back to my "normal" levels of depression
and anxiety. A few days of that, and I'm back to percs. What is the real
reason that treating depression, anxiety, fymbromyelga, etc. with
opiates is such a huge no-no? Aside from the obvious media and
government hype about how awful they are. I'm thinking long-term, it is
safer than alcohol in several respects; I have a doctor in the family
who has almost eluded such?
Also have a private question I will PM.
Thank you,
-
Ive read that anti-oxidants can be used to combat MDMA neurotoxicity
and reduce most of the damage it causes to the human brain.
Specifically, I read that Alpha Lipoic Acid is one of the best
anti-oxidants for such a thing because it helps combat free radicals. I
recently took 90mg MDMA and 30mg MDA at the same time. An hour before
taking it I took: 1g Vitamin C, 200mg ALA, and 100mg Co-Enzyme Q10.
During the experience I also took 200mg of ALA every hour for 6 hours
until I had finally consumed around 1.5g of it by the end. I also took
some before going to bed, and in the morning the next day when I woke
up. The next day, my insides has essentially liquified from all the ALA
im assuming and I had extreme diarrhea for a couple hours but felt fine
other then that.
The next few days my mood was actually lifted
and I felt fantastic. My question is: Is it necessary to take a fair
dose of Anti-Oxidants (such as 200mg of ALA) every hour to fully combat
neuro-toxicity from free radicals, or is one dose before taking MDMA,
during it, and after it ok? As much as I would like to think the
constant redosing of anti-oxidants helped, the "shitty" experience the
next day was really a downside and would not make me want to do that on
every trip.
Thanks! 8)
-
Hi Doctor,
What
are the harmful effects, if any, of taking small doses of LSD on a
fairly regular basis? I have been experimenting with doses of less that
15 micrograms. I am currently taking 5 micrograms once a week. Is this
harmful in any way? Would it be harmful to take 5 micrograms of LSD more
frequently, such as 3 times a week?
Thank you for your time
Toxicity
of LSD to human organ or systems is extremely low. Threshold is 20
micrograms, so 5 micrograms will not have probably noticeable effects.
LSD causes pharmacological tolerance very quickly. This can be
noticeable even once a week, so three times a week will cause that
possible subtle effects will dissapear if not increasing dosage. With
these pattern of use toxic effects are not expected, but neither
biological activity.
-
1)
First of all, I would not recommend the fish to do this on his own.
Guidelines for detoxification from heroin using subuxone are clear, but
it is not so easy using oral morphine. I think it would be easier just
tappering down oral morphine dosage. If pain is being a problem, it
should be necessary controlling it with an adequate medication,
otherwise pain would be an added problem to achieve detoxification.
Anyway,
in order to start a detoxification from opiates, subuxone 2 mg/ 0.5 mg
is more adequate than subuxone 8/2. First dosage should be used when
first signs of abstinence appear. Initial induction dosage (first day of
treatment) should nbe in the rank of 2/0.5 ( 1 pill) to 8/2 mg (4
pills). In the following days dosage should be adjusted to a maximum of
24/6 mg, dependind on physical and psychological symptoms, and then
tappering down during several weeks (rate depend on initial dosage and
clinical symptoms).
2) Opiate toxicity for human body is very
low. The main problems are tolerance, dependence, psychological symptoms
and constipation. But opiates are not adequate for all kinds of pain.
In fact, there are much better options for back pain/ciatic than
morphine.
Thank you for the response!
Pain
has definitely been a problem for relapse because when no potent
substance is used, it cannot perform exercise such as running or picking
up dirty clothing from the floor. Quitting morphine cold turkey doesn't
cause withdrawls that are super intense, just a day or two of feeling a
little lame. But then the pain comes back and makes all 24 hours of the
day excruciating. So, an illicit use of this substance has allowed
sleep and normal ADL's. There is definitely an addiction issue beyond
physical symptoms arising from the euphoria that morphine, oxy, H, or
any opiate provides.
1)So, would the suboxone reduce the
cravings for opiates as the pain issue heals (hopefully) through
physical therapy and an epidural steroid? And, would it help to mitigate
the pain in the meantime?
2)You said that morphine is not the
most effective drug for this type of pain. What is more effective/better
suited for lumbar issues/sciatica? Marijuana actually helps as much or
more than morphine sometimes, or, it can complete the relief when MS
isn't taking it all away.
The info is very useful! Thank you very much!
1)
Yes, subuxone, if used properly, will reduce the craving for opiates.
But I don´t think it will have a significant impact on pain
2) I
think you should ask this to your doctor. Prescription is much more than
giving a drug for each problem. It would be necessary to know exactly
what is your "lumbar issue", what image tests have been performed and
the results, what drugs have you used previously, possible interactions
and contraindications....There can be used different drugs:
Non-steroidal-antiinflamatory drugs (ibuprofen, naproxen,
aceclofenac...), analgesics (metamizole), steroids, gabapentin,
tryciclic antidepressives...can be different options dependind on the
characteristics of patient. It is not that I don´t want to give you the
information, but I think that information through Internet is only valid
and adequate to a limit, and sometimes (as your case) is necessary a
personalized professional evaluation.
-
I
have had major depression and anxiety for years... I've tried every med
available for these conditions ( just started prestiq last week )
Several months ago, hemroid surgery left me with a stricture (found by colonoscopy).
After
taking 10 mg Percocet for a few weeks, I realized that my depression,
panic, anxiety, was greatly reduced. I have quit taking opiates for a
few days, on several occasions - I start with a nervous breakdown and
about 4 days later just feel back to my "normal" levels of depression
and anxiety. A few days of that, and I'm back to percs. What is the real
reason that treating depression, anxiety, fymbromyelga, etc. with
opiates is such a huge no-no? Aside from the obvious media and
government hype about how awful they are. I'm thinking long-term, it is
safer than alcohol in several respects; I have a doctor in the family
who has almost eluded such?
Also have a private question I will PM.
Thank you,
Opiates
have antidepressant and antipsychotic properties. There is enough
evidence about this, although opiates are not usually prescribed for
this. There are drugs that, at least in theory, are pharmacologically
safer, less toxic, less addictive and with less adverse effects than
opiates. Of course there are also other factors, and moral prejudices
against opiates are one of them. Even with pain management, the
principal medical indication for opiates, prescription is much lower
than it should be due to these prejudices and this has been shown in
different studies.
There is some evidence that oxicodone can be useful in very severe depressions:
http://www.ncbi.nlm.nih.gov/pubmed/10588427
http://www.ncbi.nlm.nih.gov/pubmed/22901349
http://ajp.psychiatryonline.org/article.aspx?articleid=173886#R15612BCFGBDJI
http://www.opioids.com/antidepressant/opiates.html
This
does not mean that is the best drug, or indicated for every kind of
depression. I can't even say if it is adequate for you or not. But there
is a logic in the fact your symptoms improve with Percocet. You should
discuss this with your physician, and search for the best option for
you, valorating all pros and cons.
-
Ive
read that anti-oxidants can be used to combat MDMA neurotoxicity and
reduce most of the damage it causes to the human brain. Specifically, I
read that Alpha Lipoic Acid is one of the best anti-oxidants for such a
thing because it helps combat free radicals. I recently took 90mg MDMA
and 30mg MDA at the same time. An hour before taking it I took: 1g
Vitamin C, 200mg ALA, and 100mg Co-Enzyme Q10. During the experience I
also took 200mg of ALA every hour for 6 hours until I had finally
consumed around 1.5g of it by the end. I also took some before going to
bed, and in the morning the next day when I woke up. The next day, my
insides has essentially liquified from all the ALA im assuming and I had
extreme diarrhea for a couple hours but felt fine other then that.
The
next few days my mood was actually lifted and I felt fantastic. My
question is: Is it necessary to take a fair dose of Anti-Oxidants (such
as 200mg of ALA) every hour to fully combat neuro-toxicity from free
radicals, or is one dose before taking MDMA, during it, and after it ok?
As much as I would like to think the constant redosing of anti-oxidants
helped, the "shitty" experience the next day was really a downside and
would not make me want to do that on every trip.
Thanks! 8)
you forgot 5-htp ;) for serotonine, and green tea extract as anti-oxidant
btw, while waiting for DoctorX answer, you can find some info on ***CLEARNET*** rollsafe.org, and other sites too.
-
Hi Doctor, hope your well (like if your not, were all going to wonder how good a doc you are!)
So,
my thing is the usual colds going around. I always say the best
palative for a cold is to eat 2 grams of hash and stay inside, keep warm
but wrap up and walk a few miles, likely before eating the 2 or 1 gram
of hash.
Smoking hash will obviously not help a cold or flu, so eating it, I would argue that it is a good thing to do.
However, not every likes cannabis so this 'cure' or palative for a common cold is for cannabis lovers only.
2 grams for hardened tokers
1 gram for little tokers
Half gram for non tokers.
Don't drive for 24 hr after you ingest.
Watch some nice DVDs or something.
Do take that walk!
I
would also like to say to everyone - please do walk, if you can.
Walking is THE best preventative medicine (unless you live in Compton or
some bad area)
Thanks doc!
In advance!
-
you forgot 5-htp ;) for serotonine, and green tea extract as anti-oxidant
btw, while waiting for DoctorX answer, you can find some info on ***CLEARNET*** rollsafe.org, and other sites too.
5-HTP
is taken afterwards, I was referring to harm reduction from
anti-oxidants not regenerating lost serotonin. Ive read several reports
saying 5-htp before or during the roll changes it somewhat which I would
like to avoid. As I said, I took ALA/Vit C/COQ10 instead of gren tea
extract. It doesn't matter what anti-oxidant you take in my experience,
as long as you take enough to fight all free radicals swimming around in
your brain.
The idea for this experiment I did, (with taking
200mg of ALA every hour during the roll) I actually got from RollSafe,
which is why I asked the doctor here. I followed the rollsafe guidelines
and was not expecting the after-effects the next morning :P
My
question was more regarding the prevention of damage through
anti-oxidants and how long the anti-oxidants effects will last before
they start becoming less effective and free radicals start forming
again. I appreciate your advice though
-
Doctor, I'm kind of desperate. I am more than willing to pay for
aid. Because it's personal, I have PGPed it and have left my PGP key as
well. It's kind of urgent--thank you.
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This is my public key for response:
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-
you forgot 5-htp ;) for serotonine, and green tea extract as anti-oxidant
btw, while waiting for DoctorX answer, you can find some info on ***CLEARNET*** rollsafe.org, and other sites too.
5-HTP
is taken afterwards, I was referring to harm reduction from
anti-oxidants not regenerating lost serotonin. Ive read several reports
saying 5-htp before or during the roll changes it somewhat which I would
like to avoid. As I said, I took ALA/Vit C/COQ10 instead of gren tea
extract. It doesn't matter what anti-oxidant you take in my experience,
as long as you take enough to fight all free radicals swimming around in
your brain.
The idea for this experiment I did, (with taking
200mg of ALA every hour during the roll) I actually got from RollSafe,
which is why I asked the doctor here. I followed the rollsafe guidelines
and was not expecting the after-effects the next morning :P
My
question was more regarding the prevention of damage through
anti-oxidants and how long the anti-oxidants effects will last before
they start becoming less effective and free radicals start forming
again. I appreciate your advice though
ops sorry! I read fast and missed some points.
btw 5-htp can be taken previous roll too, not 24h before or after, too increase serotonine level, I have no idea if it's true.
Thanks
for your questions, I'm interested too, but MDMA it's one of the most
studied substance and it's already hard to say what can prevent damage
:S
-
Hi Doctor,
What
are the harmful effects, if any, of taking small doses of LSD on a
fairly regular basis? I have been experimenting with doses of less that
15 micrograms. I am currently taking 5 micrograms once a week. Is this
harmful in any way? Would it be harmful to take 5 micrograms of LSD more
frequently, such as 3 times a week?
Thank you for your time
Toxicity
of LSD to human organ or systems is extremely low. Threshold is 20
micrograms, so 5 micrograms will not have probably noticeable effects.
LSD causes pharmacological tolerance very quickly. This can be
noticeable even once a week, so three times a week will cause that
possible subtle effects will dissapear if not increasing dosage. With
these pattern of use toxic effects are not expected, but neither
biological activity.
Thanks for answering my queston, Doc! A small donation has been made to your tip jar ;D
Many blessings to you and your family!
-
what is death?
-
what is death?
No
offense, but can we keep this a troll-free/non-philosophical zone. This
is an invaluable resource for a lot of people here who would otherwise
be shunned as soon as they mentioned drugs.
-
Hello Doctor, thank you for your good work !
i want to know
what are the best things to eat after an mdma night to preserve the
brain? like vitamines herbs or something like that , thank you !
Kind regards
-
im not doing either, I just don't know what death is. so I would like to be told by a doctor.
-
Ive
read that anti-oxidants can be used to combat MDMA neurotoxicity and
reduce most of the damage it causes to the human brain. Specifically, I
read that Alpha Lipoic Acid is one of the best anti-oxidants for such a
thing because it helps combat free radicals. I recently took 90mg MDMA
and 30mg MDA at the same time. An hour before taking it I took: 1g
Vitamin C, 200mg ALA, and 100mg Co-Enzyme Q10. During the experience I
also took 200mg of ALA every hour for 6 hours until I had finally
consumed around 1.5g of it by the end. I also took some before going to
bed, and in the morning the next day when I woke up. The next day, my
insides has essentially liquified from all the ALA im assuming and I had
extreme diarrhea for a couple hours but felt fine other then that.
The
next few days my mood was actually lifted and I felt fantastic. My
question is: Is it necessary to take a fair dose of Anti-Oxidants (such
as 200mg of ALA) every hour to fully combat neuro-toxicity from free
radicals, or is one dose before taking MDMA, during it, and after it ok?
As much as I would like to think the constant redosing of anti-oxidants
helped, the "shitty" experience the next day was really a downside and
would not make me want to do that on every trip.
Thanks! 8)
Some
aspects of this issue have been previously discussed in the thread.
Here are a bit of information about neurotoxicity of MDMA, after-effects
and the role of supplements:
http://dkn255hz262ypmii.onion/index.php?topic=147607.75
http://dkn255hz262ypmii.onion/index.php?topic=147607.90
http://dkn255hz262ypmii.onion/index.php?topic=147607.msg1166735;topicseen#msg1166735
The
question is, none of the pre-load or post-load guidances are based on
scientific research in humans because these studies do not exist.
Studies with mega-doses of MDMA and mega-doses neuroprotective agents
are performed in order to understand the mechanisms of neurotoxicity.
But doses used, both of MDMA and neuroprotectives are never extrapolable
to humans.
The main study on alpha-lipoic acid and MDMA is this:
http://www.ncbi.nlm.nih.gov/pubmed/10619665
They
used 20 mg/kg of MDMA and 100 mg/kg of ALA twice a day injected to
achieve the neuroprotective effect. So you (supposing a weight of 70
kg) would have to inject 1400 mg of MDMA and 7 gr of ALA to do
this. Please don't try because you will definetly die, as the rats do.
There
is no evidence that ocassional, moderate dosages of MDMA produce
neurotoxicity in humans. There is no evidence of efficace for
neuroprotective to diminish neurotoxicity neither for after-effects.
30-50% of the effect of any pain-killer is explained by placebo effect,
so the role of ALA (and any other supplement) is unknown, and probably
useless. Using MDMA moderately and in controlled settings is the best
way to avoid this problems. All the rest is probably harmless but
useless too.
-
you forgot 5-htp ;) for serotonine, and green tea extract as anti-oxidant
btw, while waiting for DoctorX answer, you can find some info on ***CLEARNET*** rollsafe.org, and other sites too.
I
regret all the objections made in previous message done for
Alpha-lipoic-acid are applicable to 5-HTP and green tea extract.
Harmless but without any evidence of usefulness.
-
Hi Doctor, hope your well (like if your not, were all going to wonder how good a doc you are!)
So,
my thing is the usual colds going around. I always say the best
palative for a cold is to eat 2 grams of hash and stay inside, keep warm
but wrap up and walk a few miles, likely before eating the 2 or 1 gram
of hash.
Smoking hash will obviously not help a cold or flu, so eating it, I would argue that it is a good thing to do.
However, not every likes cannabis so this 'cure' or palative for a common cold is for cannabis lovers only.
2 grams for hardened tokers
1 gram for little tokers
Half gram for non tokers.
Don't drive for 24 hr after you ingest.
Watch some nice DVDs or something.
Do take that walk!
I
would also like to say to everyone - please do walk, if you can.
Walking is THE best preventative medicine (unless you live in Compton or
some bad area)
Thanks doc!
In advance!
I'm
sorry but there are not scientific data for supporting the idea. If you
are a heavy cannabis user and feels right for you, I can't convince you
not to do that. But, in general, I can't reccomend that for cold or
flu. I agree with the idea of not driving while your treatment...:)
-
Doctor,
I'm kind of desperate. I am more than willing to pay for aid. Because
it's personal, I have PGPed it and have left my PGP key as well. It's
kind of urgent--thank you.
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I answer on PM. Please use PM for encrypted messages.
-
I saw the link to this thread on the main site. +1 for taking the time out to answer all these questions :)
-
what is death?
In
medicine there is a difference between "clinical death": cessation of
breathing and heart beat and "biological death":lack of cerebral
electrical activity, that indicates that a person is definetly and
irreversibly dead. Clinical death can be reversed (by techniques of
cardio pulmonar resucitation. Biological death no.
-
Hello Doctor, thank you for your good work !
i
want to know what are the best things to eat after an mdma night to
preserve the brain? like vitamines herbs or something like that , thank
you !
Kind regards
We were talking yesterday about this:
https://dkn255hz262ypmii.onion.lu/index.php?topic=147607.msg1546636#msg1546636
Supplements
have no efficacy proved and there is no need for a concrete
alimentation. It is not proved that common occasional recreative dosages
of MDMA (120-140 mg and a booster of a half two hours later) have
neurotoxic effects. And it is no proved that any supplement would be
effective in human in neurotoxicity produced by high dosages or
frequencies of MDMA. So, to preserve the brain the only way is using
MDMA safely and with moderation. Lack of appetite is a typical after
effect so you should eat sweet or soft meals, but it is no related to
brain
-
DoctorX,
Do you think the pain killing properties of
marijuana might cause lack of response in the affected
individual's pain receptors which could result in an avoidable
injury? For example, a runner who feels no pain, or less pain than
normal, causes damage to his health by running too much while
high. I suppose the same thing could happen with any pain killing
drug if it does happen at all. Too much happiness.
Police
and public health officials report certain drugs seem to cause some
users to be unstoppable or react in extremely aggressive manner. We read
reports of how someone was hyped up on something and it took six people
to subdue them. Can you comment on this reported aggressive
reaction some users have to some drugs?
Why is it that
whenever there is a report of violence associated with drug purchases
gone bad, it is always a fact that drugs, or the personal craving for
drugs among loser criminal types, caused the senseless violence?
Poverty has no blame for these wanton evil acts. This may require
the rest of my life to figure out, but at least now the drugs are safer
to buy, here, on the dark web. Governments have defacto become
drug distribution networks. Ironic isn't it?
By the way Doc didn't mean to dis you bout the x instead of X. What is your preference anyway?
Thanks,
Clean
-
Hi Doc,
Many thanks again! And some follow-up questions:
1.
If any type benzo + driving is bad idea in general then is there any
good medicine for acute anxiety control that doesn't impair driving?
2.
I heard of nausea on some stronger opiates (on lighter I had no problem
with it though), like methadone, and that drugs used to treat
locomotive nausea are of no use (if this is incorrect please correct).
So
my question is: what would be recommended drugs to deal with it, and
thietylperazinum will be okay? (Have already at hand so it would make
things easier. I saw leaflet on these and it says only to "inform
doctor" if using painkillers or sedatives (among others), no other or
direct warnings of interactions. Also - will it be effective for nausea
caused by strong opiates?
Additionally - the same questions for
4-MeO-DMT (it's great and unique experience, but I get strong nausea
during peak that is a lot
3. Is nicotine and caffeine okay with
opiates in general or are a no go? (I'm asking because they are also
stims -- especially snuffed tobacco have strong stimulating effect for
me).
4. You've recommended "more incisive" benzo for bad trip
emergency, like sublingual alprazolam or lorazepam -- on the Road there
is only sublingual lorazepam. And when I look at benzos comparison
charts, it has much longer time to peak/onset of action (2-4 hours),
while normal alprazolam or diazepam have 1-2 or 1-1,5. So question is if
sublingual lorazepam will be faster to act, or is it better idea to use
alprazolam (and crush it for faster absorption or something)
Thanks again!
(BTW
I've sent again some coins your way, also encourage strongly anybody
else to do it -- please don't just say you appreciate Doc's time and
help, but show that you do)
-
Dr. X,
Hello I have a problem called Patulous Eustachian
Tube, it is basically a type of dysfunction in the eustachian tube. I
have tried many different things like stimulants adderral, benzos, ssri,
nothing really seems to help or is very short lasting. I have issues
with focusing/brain fog/out of it lightheaded feeling all of the time
and also I have very distorted hearing. They think it could be related
to my TMJ like a muscular issue but were not sure. It causes me a lot of
social anxiety since I can hear my voice echoing inside my head and
also from the out of it feeling stupid feeling. It feels like I am off
balance in a way. Ive also always had acid reflux but once the ear issue
started, I started having issues with gluten intolerance and processed
foods. It does say online that gluten, dairy, soy can make the ear issue
worse so there seems to be a correlation. Marijuana does help me to
relax and not care about the issue as much but it also can make me very
lazy/tired not wanting to do as much. I was just curious if you possibly
knew of a certain strain that could be helpful to me or any other type
of medicine or treatment that may help my focusing out of it issues or
make it easier to cope with all of my symptoms.
Thanks,
Td
-
DoctorX, let me first say you're awesome for doing this. :)
I have a question about tolerance. First some short history:
I've
taken pseudoefedrine. The first day (60mg) was awesome. The second day
(60mg) I had some clear effects, but my thoughts also quickly became
dark. Signs I believe I had depleted my dopamine. When I take it now,
all it does is clear up my sinuses so I'm not taking it anymore (unless I
have a cold). The first two days, pseudoefedrine took my visual snow:
https://en.wikipedia.org/wiki/Visual_snow away.
I've taken
caffeine. 200-300mg does absolutely nothing for me when I had a good
night sleep, so I guess my adenosine levels are just fine. At 600mg (yes
I know I am insane) I got some decent effect, but it was only once I
took 800mg (I know, it's a lot) that I really felt great. At 800mg it
also took my visual snow away. Due to side effects, I lowered the dose
again and tapered off. After I had been clean for a week (apart from
some very low amounts in milk chocolate), I once again took 800mg. This
time I had far fewer side effects, but the positive effects were not as
pronounced either. My visual snow did not go away this time.
Apart from some very low amounts in milk chocolate, I stopped using caffeine.
Now
I'm on modafinil. A fairly low dose of just 100mg/day. I really liked
the first few days. But in less than a week, I feel like the effects are
not as strong anymore. I'm afraid once again I might be developing
tolerance.
This madness has to stop. Not using medication is not
an option for me (believe me, I would if I could). I just have to stop
developing tolerance.
I've read about anti-tolerance drugs,
NMDA-antagonists like dextromethorphan or (prescription) memantine.
Would this be the way to go?
-
Dr. X,
Now that was interesting. Yesterday I had what I'd
guess was a panic attack (high BP (up to 173/100 when I was able to
measure), high HR, scared shitless, sweating, chest pain, and so on).
I'm not sure what exactly caused it, but I guess it was dosing up
amphetamine too fast in only a few days (a week or so) with Moclobemide
being present, and maybe the (not related to both drugs) little sleep I
had the last weeks.
Just to be specific: I was at 3x8mg
d/l-amphetamine throughout the day, and I only had slightest if any
changes in BP throughout the day, while also taking 600mg moclobemide as
prescribed. The amphetamine worked wonders for my adhd even after the
in that case undesired euphoria disappeared, and only in the afternoon I
felt a bit "wired". The panic attack happened in the evening, probably
three or four hours or so after the last dose.
Of course I stopped
taking any amphetamine the next day and will probably only and carefully
try it again when I get my hands on some dextroamphetamine, because
without the l-amphetamin it should probably have less effect on
noradrenaline and so cause less bp issues or anxiety, as far as I know.
So
now my question is: If something like that happened again, could/should
I take a benzo as it seems to be recommended for "general" amphetamine
overdoses and/or rebound, or would the combination of moclobemide,
amphetamine and a benzo do bad things? From what I know moclobemide only
slows the breakdown of the benzos and one should take a smaller dose.
And
if it would be the right option in an situation like that, is there any
recommended benzo for that purpose? I might be able to get some
sublingual lorazepam, would that be OK? And at which dose?
Thanks again for your work, by the way, I guess I should get some coin and send it to you asap. :)
-
I
have had major depression and anxiety for years... I've tried every med
available for these conditions ( just started prestiq last week )
Several months ago, hemroid surgery left me with a stricture (found by colonoscopy).
After
taking 10 mg Percocet for a few weeks, I realized that my depression,
panic, anxiety, was greatly reduced. I have quit taking opiates for a
few days, on several occasions - I start with a nervous breakdown and
about 4 days later just feel back to my "normal" levels of depression
and anxiety. A few days of that, and I'm back to percs. What is the real
reason that treating depression, anxiety, fymbromyelga, etc. with
opiates is such a huge no-no? Aside from the obvious media and
government hype about how awful they are. I'm thinking long-term, it is
safer than alcohol in several respects; I have a doctor in the family
who has almost eluded such?
Also have a private question I will PM.
Thank you,
Opiates
have antidepressant and antipsychotic properties. There is enough
evidence about this, although opiates are not usually prescribed for
this. There are drugs that, at least in theory, are pharmacologically
safer, less toxic, less addictive and with less adverse effects than
opiates. Of course there are also other factors, and moral prejudices
against opiates are one of them. Even with pain management, the
principal medical indication for opiates, prescription is much lower
than it should be due to these prejudices and this has been shown in
different studies.
There is some evidence that oxicodone can be useful in very severe depressions:
http://www.ncbi.nlm.nih.gov/pubmed/10588427
http://www.ncbi.nlm.nih.gov/pubmed/22901349
http://ajp.psychiatryonline.org/article.aspx?articleid=173886#R15612BCFGBDJI
http://www.opioids.com/antidepressant/opiates.html
This
does not mean that is the best drug, or indicated for every kind of
depression. I can't even say if it is adequate for you or not. But there
is a logic in the fact your symptoms improve with Percocet. You should
discuss this with your physician, and search for the best option for
you, valorating all pros and cons.
Hi Doctor
Thanks very much for all the information in these Q&A it's very helpful.
A bit about my history - I have used caffeine regularly since 14-15y.o. and am a daily 'addict'
- Alcohol regularly since 18y.o.
- Cannabis since 19y.o. (irregular)
- Codeine since 19.y.o (rarely)
Used to be addicted to tobacco but have quit for over a year now.
- Have used MDMA a few times.
- Maybe couple lines of ritalin.
I
am in my early twenties still but am having trouble getting motivated.
There is a history of alcohol addiction in the family and unfortunately I
find it quite enjoyable myself. I have managed to give it up entirely
in the past for 1-2 months at a time. Cannabis I can go without easily
for six months at a time in fact, I've only smoked a few times in about
the last 8 months.
What I'm wondering is if genetics may have led
me down paths of addiction? My father is a daily drinker, only stopped
for the week or so when hospitalised for 3 heart attacks now in the past
few years.
Also my thoughts always seem so constant like I just
can't stop worrying about things? I've managed to reduce my alcohol
consumption to just one or two drinks per week; Haven't binged since 3
months ago.
I talk to people that say in the days after using MDMA
that they feel 'scattered' or down. For me it is just "back to normal
feeling" definitely not happy the week after but it's still like my
thoughts are always leaving me to be a "dreamer"
These days I am regularly sober except for caffeine use.
My
biggest problem is that after 3 years of university study I quit
because of a lack of motivation. I also seem very indecisive all the
time. Alcohol and cannabis are probably two things that I enjoy.
In
fact since my reduced consumption of substances lately I have become
even more withdrawn socially then when I used to go out partying with
friends; or just generally being chatty. Actually that's what I miss
about smoking cigarettes.
I know this is hard for you to answer
as you have said before it depends on the individual, but in your
professional opinion would it be better to treat depression/anxiety
symptoms (or just general malaise) with drugs/pharmaceuticals? Or would
abstinence from all substances be better?
I am also asking as
I was concerned when my brother went onto antidepressants - notably
"Pristiq" He didn't even last two months and went off them because they
were making him feel so bad. Actually he is a almost daily pot smoker
and finds that better.
-
DoctorX,
Do
you think the pain killing properties of marijuana might cause lack of
response in the affected individual's pain receptors which could
result in an avoidable injury? For example, a runner who feels no pain,
or less pain than normal, causes damage to his health by running too
much while high. I suppose the same thing could happen with any
pain killing drug if it does happen at all. Too much happiness.
Police
and public health officials report certain drugs seem to cause some
users to be unstoppable or react in extremely aggressive manner. We read
reports of how someone was hyped up on something and it took six people
to subdue them. Can you comment on this reported aggressive
reaction some users have to some drugs?
Why is it that
whenever there is a report of violence associated with drug purchases
gone bad, it is always a fact that drugs, or the personal craving for
drugs among loser criminal types, caused the senseless violence?
Poverty has no blame for these wanton evil acts. This may require
the rest of my life to figure out, but at least now the drugs are safer
to buy, here, on the dark web. Governments have defacto become
drug distribution networks. Ironic isn't it?
By the way Doc didn't mean to dis you bout the x instead of X. What is your preference anyway?
Thanks,
Clean
Definitely
not. “Pain” is a general word for very different physical sensations.
It is not the same the kind of pain produced by a sprained ankle
(inflammatory pain), pain produced by constipation (visceral pain) or
herpes (neuropathic pain). In fact cannabis is more effective for
neuropathic pain than for other kind of pain. And all analgesic
medications don’t just make disappear completely painful sensations, but
only diminish it.
Drugs do not “cause” these reactions, but increase
previous characteristics of personality. Violent behaviour is more
frequent after stimulant use but not everybody become aggressive after
taking these drugs. Alcohol is other drug frequently related to
aggressive behaviour.
I prefer X rather than x ;)
-
Hi Doc,
Many thanks again! And some follow-up questions:
1.
If any type benzo + driving is bad idea in general then is there any
good medicine for acute anxiety control that doesn't impair driving?
2.
I heard of nausea on some stronger opiates (on lighter I had no problem
with it though), like methadone, and that drugs used to treat
locomotive nausea are of no use (if this is incorrect please correct).
So
my question is: what would be recommended drugs to deal with it, and
thietylperazinum will be okay? (Have already at hand so it would make
things easier. I saw leaflet on these and it says only to "inform
doctor" if using painkillers or sedatives (among others), no other or
direct warnings of interactions. Also - will it be effective for nausea
caused by strong opiates?
Additionally - the same questions for
4-MeO-DMT (it's great and unique experience, but I get strong nausea
during peak that is a lot
3. Is nicotine and caffeine okay with
opiates in general or are a no go? (I'm asking because they are also
stims -- especially snuffed tobacco have strong stimulating effect for
me).
4. You've recommended "more incisive" benzo for bad trip
emergency, like sublingual alprazolam or lorazepam -- on the Road there
is only sublingual lorazepam. And when I look at benzos comparison
charts, it has much longer time to peak/onset of action (2-4 hours),
while normal alprazolam or diazepam have 1-2 or 1-1,5. So question is if
sublingual lorazepam will be faster to act, or is it better idea to use
alprazolam (and crush it for faster absorption or something)
Thanks again!
(BTW
I've sent again some coins your way, also encourage strongly anybody
else to do it -- please don't just say you appreciate Doc's time and
help, but show that you do)
1.-
In general, benzos and driving are a bad idea but the degree of driving
impairment depends on characteristics of the benzo and dosage. Main
risk is sedation and increasing risk of crashing but it is not the same
flunitrazepam 2 mg (would be very risky) than 1.5 bromazepam, for
example (probably much safer). To be honest, doctors forget very
frequently warning about this to patients when prescribing benzos. One
possible option would be a beta-blocker (propranolol). This drug affect
only on the somatic-organic component of anxiety leaving mental
functions unaffected. Propanolol is contraindicated in persons with
asthma and some arterial problems.
In clinical use of opiates,
haloperidol and chlorpromazine are elective drugs to treat nausea
associated to opiates. Adverse and psychoactive effects of these drugs
make them unadequate for most recreative users, I think adverse effects
should be greater than desired effects, but in theory they should be the
most effective drugs. Serotonin antagonists (ondansetron) are effective
but very expensive. Metoclopramide and antihistaminics could be
adequate too, but it also has a sedative effect. Effect of
thietylperazinum is probably weak but risk of interactions is very low.
There
is a lot of experience with opiates, as they are used in medicine. But
advice of 4-AcO is much difficult, as there is no clinical experience.
Combination with the previously mentioned drugs probably affect to the
psychedelic experience (except, maybe, antihistaminics)
3.- No
clinical guide says that opiates prescription or dosage should be
modified in people using nicotine or caffeine so, in general, risks,
effects and problems are similar to no users.
4.- Lorazepam is more
easily sublingual-absorbed than other benzos. Time to peak is much
shorter for lorazepam used by sublingual than oral route, so that
is why it should be a good option.
-
DocX,
Do you prefer to be addressed as DoctorX , DocX,
X, or as I have only seen once, Doctor X? What about your real
name? Personally I like the X along, simple yet many hidden meanings can
be assigned to it. Perhaps my many years of repeatedly studying
the elements of algebra have contributed to my being partial to the
horizontal or X axis? In fact, I do prefer horizontal over the vertical
so is seems my bias is a learned one. I prefer to be called and
call myself, Clean when attempting to evoke levity or informality while
in serious situations Cleansober seems better, but whatever, as
long as I'm not called an inmate.
Clean
-
Gunhit's September 21, 2013, 11:29 am question is a great one I think. He hits on a huge issue when he says, "
My biggest problem is that after 3 years of university study I quit because of a lack of motivation.
" What percentage of your fellow students do graduate? Many
universities have quite low graduation rates so this may be
normal. There are some radicals out there who say universities are
huge failures and students are their victims. You don't lack
motivation, you lack an interest in boring lectures with no practical
value or payout.
I
know this is hard for you to answer as you have said before it depends
on the individual, but in your professional opinion would it be better
to treat depression/anxiety symptoms (or just general malaise) with
drugs/pharmaceuticals? Or would abstinence from all substances be
better?
My
unprofessional recommendation is for you to study tantric yoga
kamasutra type sex practices. Although sensual sex is not a drug
it is the most fun possible while awake. Before you know it you
will be hanging fifty pound weights off your testicles and liking
it. If you get lucky you may even find a partner.
A quote taken from the internet regarding erectile dysfunction drugs follows:
In
fact, Caverject produces perfect erections — with or without sexual
excitement. And because it is so effective, Caverject is used by adult
film models during production. In fact, I am told that several studios
include money in their video budgets for supplies of Caverject and/or
Viagra (often for men in their late teens or early 20's). Other
companies place the responsibility on the models by stipulating in their
contract that an erection must be maintained during the hours of the
shoot or the model will not be paid in full.
And I thought it was normal to have two hour erections. I wonder
what drug they use to stop erections lasting longer than four hours?
Also
if you drink just one or two drinks a week the last three months, I
would think alcoholism would be a surmountable foe on your way to your
unreachable dream.
Good luck and I look forward to reading X's reply.
Clean
-
Dr. X,
Hello
I have a problem called Patulous Eustachian Tube, it is basically a
type of dysfunction in the eustachian tube. I have tried many different
things like stimulants adderral, benzos, ssri, nothing really seems to
help or is very short lasting. I have issues with focusing/brain fog/out
of it lightheaded feeling all of the time and also I have very
distorted hearing. They think it could be related to my TMJ like a
muscular issue but were not sure. It causes me a lot of social anxiety
since I can hear my voice echoing inside my head and also from the out
of it feeling stupid feeling. It feels like I am off balance in a way.
Ive also always had acid reflux but once the ear issue started, I
started having issues with gluten intolerance and processed foods. It
does say online that gluten, dairy, soy can make the ear issue worse so
there seems to be a correlation. Marijuana does help me to relax and not
care about the issue as much but it also can make me very lazy/tired
not wanting to do as much. I was just curious if you possibly knew of a
certain strain that could be helpful to me or any other type of medicine
or treatment that may help my focusing out of it issues or make it
easier to cope with all of my symptoms.
Thanks,
Td
Cannabis
or psychoactives can be useful for management of symptoms of several
diseases but they are not always the best option for all of them. In
your case (patulous Eustachian tube) I don`t think that psychoactives
may help you. Varieties of cannabis rich in cannabidiol (CBD) have a
more relaxant effect than those rich in tetrahydrocannabinol (THC)
although, as you say, they can make you tired/lazy. There are some more
specific treatments (as estrogen nasal drops) or oral administration of
saturated solution of potassium iodide) or even surgical therapy. Ask
an otorhinolaryngologist for the best option
Cannabis or ps
-
Cleansober,
Thanks very much for your perspective. I take it into serious account.
Actually
I could do with better sex. I have a medical condition that effectively
leaves me with one useful nut. The women always wonder why it takes so
long for me to cum, even after couple hours going straight it still
doesn't happen for me.
gunhit
-
DoctorX, let me first say you're awesome for doing this. :)
I have a question about tolerance. First some short history:
I've
taken pseudoefedrine. The first day (60mg) was awesome. The second day
(60mg) I had some clear effects, but my thoughts also quickly became
dark. Signs I believe I had depleted my dopamine. When I take it now,
all it does is clear up my sinuses so I'm not taking it anymore (unless I
have a cold). The first two days, pseudoefedrine took my visual snow:
https://en.wikipedia.org/wiki/Visual_snow away.
I've taken
caffeine. 200-300mg does absolutely nothing for me when I had a good
night sleep, so I guess my adenosine levels are just fine. At 600mg (yes
I know I am insane) I got some decent effect, but it was only once I
took 800mg (I know, it's a lot) that I really felt great. At 800mg it
also took my visual snow away. Due to side effects, I lowered the dose
again and tapered off. After I had been clean for a week (apart from
some very low amounts in milk chocolate), I once again took 800mg. This
time I had far fewer side effects, but the positive effects were not as
pronounced either. My visual snow did not go away this time.
Apart from some very low amounts in milk chocolate, I stopped using caffeine.
Now
I'm on modafinil. A fairly low dose of just 100mg/day. I really liked
the first few days. But in less than a week, I feel like the effects are
not as strong anymore. I'm afraid once again I might be developing
tolerance.
This madness has to stop. Not using medication is not
an option for me (believe me, I would if I could). I just have to stop
developing tolerance.
I've read about anti-tolerance drugs,
NMDA-antagonists like dextromethorphan or (prescription) memantine.
Would this be the way to go?
Tolerance
is a intrinsic characteristic of some drugs; depending on the drug it
takes more or less time to develop. There is no significant tolerance in
two days to pseudoefedrine, the change of effects you explain in two
days should be explained by other factors (probably, psychological
predisposition) but not for pharmacological tolerance. In clinical use
of modafinil there is no need to increase the dosage after a week of
use. It is not a question of pharmacological tolerance, it is probably
the way you are using the drug that makes increase dosage.
It is not
clear in your message why do you need to use medication. If your problem
is visual snow, in general use of psychoactives (except some benzos
like clonazepam) increases symptoms. If you are suffering other
condition it seems that your auto-medication with stimulants is
not helping, so you may consider asking a doctor for your best treatment
option.
Dextromethorphan or memantine are not useful for diminishing tolerance in clinical, real-life situations.
-
Dr. X,
Now
that was interesting. Yesterday I had what I'd guess was a panic attack
(high BP (up to 173/100 when I was able to measure), high HR, scared
shitless, sweating, chest pain, and so on). I'm not sure what exactly
caused it, but I guess it was dosing up amphetamine too fast in only a
few days (a week or so) with Moclobemide being present, and maybe the
(not related to both drugs) little sleep I had the last weeks.
Just
to be specific: I was at 3x8mg d/l-amphetamine throughout the day, and I
only had slightest if any changes in BP throughout the day, while also
taking 600mg moclobemide as prescribed. The amphetamine worked wonders
for my adhd even after the in that case undesired euphoria disappeared,
and only in the afternoon I felt a bit "wired". The panic attack
happened in the evening, probably three or four hours or so after the
last dose.
Of course I stopped taking any amphetamine the next day
and will probably only and carefully try it again when I get my hands on
some dextroamphetamine, because without the l-amphetamin it should
probably have less effect on noradrenaline and so cause less bp issues
or anxiety, as far as I know.
So now my question is: If something
like that happened again, could/should I take a benzo as it seems to be
recommended for "general" amphetamine overdoses and/or rebound, or
would the combination of moclobemide, amphetamine and a benzo do bad
things? From what I know moclobemide only slows the breakdown of the
benzos and one should take a smaller dose.
And if it would be the
right option in an situation like that, is there any recommended benzo
for that purpose? I might be able to get some sublingual lorazepam,
would that be OK? And at which dose?
Thanks again for your work, by the way, I guess I should get some coin and send it to you asap. :)
I
am not sure that moclobemide and amphetamine combination is a good
idea. Moclobemide is much safer than other MAOIs but combination with
amphetamine should be done with caution. It is possible (but not sure)
that combination of both substances has caused your problem. It is
possible that d-amphetamine has fewer effects, but I do not recommend
combining with moclobemide, anyway.
Combination of benzos with
moclobemide and amphetamine is probably safe. Lorazepam 1 mg sublingual
is useful for panic attacks. But we can`t be sure that your problem was
this. So if you are suffering again it should be prudent to confirm
diagnosis before using benzos.
-
Thanks a lot, once more.
I have to admit I'm a bit reluctant
not to try d-amph and moclobemide, because I neither want to give up the
moclobemide (since it is the first thing to help with my chronic
depression) nor want to leave the adhd untreated. But I'll be very
careful indeed, even more careful than before, because that was not a
situation I't like to be in again.
Maybe I'll be able to have all
this done and surveilled by a doctor, but I doubt it. It's hard enough
to acually find one who'd be willing to prescribe (d-)amphetamine, much
less one who'd prescribe it with moclobemide and/or give advice on
benzos without thinking I'm only "in it for the drugs".
I
actually tried to have a doctor check me out when I felt able to do
anything again. But since I was better once I had arrived there I was
just sent home and told to "relax".
-
Dear Mr. Gunhit,
Seems cum flow trouble would be a separate
symptom from the nut issue? I'm not a docter, can't even spell it,
but maybe you need acupuncture to open up the kumdulini?
Does
anyone read this stuff I write? Sometimes I think my jokes fall so
flat they are like the sound in the forest that no ones hears, does it
exist? Can anyone point out the joke in the previous
sentence. Ok, let me try again.
Dear Mr. Gun,
Perhaps you should start with only 15 pounds with the weight lifting routine given your health condition.
Clean
Furthermore,
what are the limits of legitimate questions here? Should I ask X
about my back pain since who knows, I might get a pain killer and end up
needing to know how to kick it? Doc X has already told us he
cannot provide enlightenment to questioners. He admits he is
flawed therefore all his advice must be taken with a grain of
salt. Until he can speak infallibly then all his answers are
potentially flawed. Sorry to be so harsh, but I am trying
reconcile web reality with real reality. I'm seeking the perfect flame
of web reality to stoke my inner gps.
Also, how can I
mention the "MUSE of Europe" that appears to be ready soon in a cream
application and get no comments? Can you imagine, men putting
cream on their penises that initiates perfect two hour hard-ons?
First men will need to get over their shyness about putting creams and
oils and lord knows what on their "Johnsons".
Additionally should we be calling X by his real name? And what it his preference in all this?
Thanks for the memories.
Love you all,
Cleansober
Clean, still editing...
-
DoctorX,
Do
you think the pain killing properties of marijuana might cause lack of
response in the affected individual's pain receptors which could
result in an avoidable injury? For example, a runner who feels no pain,
or less pain than normal, causes damage to his health by running too
much while high. I suppose the same thing could happen with any
pain killing drug if it does happen at all. Too much happiness.
Police
and public health officials report certain drugs seem to cause some
users to be unstoppable or react in extremely aggressive manner. We read
reports of how someone was hyped up on something and it took six people
to subdue them. Can you comment on this reported aggressive
reaction some users have to some drugs?
Why is it that
whenever there is a report of violence associated with drug purchases
gone bad, it is always a fact that drugs, or the personal craving for
drugs among loser criminal types, caused the senseless violence?
Poverty has no blame for these wanton evil acts. This may require
the rest of my life to figure out, but at least now the drugs are safer
to buy, here, on the dark web. Governments have defacto become
drug distribution networks. Ironic isn't it?
By the way Doc didn't mean to dis you bout the x instead of X. What is your preference anyway?
Thanks,
Clean
Definitely
not. “Pain” is a general word for many different physical sensations.
It is not the same a runner`s pain produced by a sprained ankle
(inflammatory pain), pain produced by constipation (visceral pain) or
pain as herpes (neuropathic pain). In fact cannabis is more effective
for neuropathic pain than for other kind of pain. And all analgesic
medications don’t just make disappear completely painful sensations, but
only diminish it.
Drugs do not “cause” these reactions, but increase
pre-existing characteristics of personality. Violent behaviour is more
frequent after stimulant use but not everybody become aggressive after
taking these drugs. Alcohol is another drug frequently related to
aggressive behaviour.
I prefer X rather than x ;)
-
I
have had major depression and anxiety for years... I've tried every med
available for these conditions ( just started prestiq last week )
Several months ago, hemroid surgery left me with a stricture (found by colonoscopy).
After
taking 10 mg Percocet for a few weeks, I realized that my depression,
panic, anxiety, was greatly reduced. I have quit taking opiates for a
few days, on several occasions - I start with a nervous breakdown and
about 4 days later just feel back to my "normal" levels of depression
and anxiety. A few days of that, and I'm back to percs. What is the real
reason that treating depression, anxiety, fymbromyelga, etc. with
opiates is such a huge no-no? Aside from the obvious media and
government hype about how awful they are. I'm thinking long-term, it is
safer than alcohol in several respects; I have a doctor in the family
who has almost eluded such?
Also have a private question I will PM.
Thank you,
Opiates
have antidepressant and antipsychotic properties. There is enough
evidence about this, although opiates are not usually prescribed for
this. There are drugs that, at least in theory, are pharmacologically
safer, less toxic, less addictive and with less adverse effects than
opiates. Of course there are also other factors, and moral prejudices
against opiates are one of them. Even with pain management, the
principal medical indication for opiates, prescription is much lower
than it should be due to these prejudices and this has been shown in
different studies.
There is some evidence that oxicodone can be useful in very severe depressions:
http://www.ncbi.nlm.nih.gov/pubmed/10588427
http://www.ncbi.nlm.nih.gov/pubmed/22901349
http://ajp.psychiatryonline.org/article.aspx?articleid=173886#R15612BCFGBDJI
http://www.opioids.com/antidepressant/opiates.html
This
does not mean that is the best drug, or indicated for every kind of
depression. I can't even say if it is adequate for you or not. But there
is a logic in the fact your symptoms improve with Percocet. You should
discuss this with your physician, and search for the best option for
you, valorating all pros and cons.
Hi Doctor
Thanks very much for all the information in these Q&A it's very helpful.
A bit about my history - I have used caffeine regularly since 14-15y.o. and am a daily 'addict'
- Alcohol regularly since 18y.o.
- Cannabis since 19y.o. (irregular)
- Codeine since 19.y.o (rarely)
Used to be addicted to tobacco but have quit for over a year now.
- Have used MDMA a few times.
- Maybe couple lines of ritalin.
I
am in my early twenties still but am having trouble getting motivated.
There is a history of alcohol addiction in the family and unfortunately I
find it quite enjoyable myself. I have managed to give it up entirely
in the past for 1-2 months at a time. Cannabis I can go without easily
for six months at a time in fact, I've only smoked a few times in about
the last 8 months.
What I'm wondering is if genetics may have led
me down paths of addiction? My father is a daily drinker, only stopped
for the week or so when hospitalised for 3 heart attacks now in the past
few years.
Also my thoughts always seem so constant like I just
can't stop worrying about things? I've managed to reduce my alcohol
consumption to just one or two drinks per week; Haven't binged since 3
months ago.
I talk to people that say in the days after using MDMA
that they feel 'scattered' or down. For me it is just "back to normal
feeling" definitely not happy the week after but it's still like my
thoughts are always leaving me to be a "dreamer"
These days I am regularly sober except for caffeine use.
My
biggest problem is that after 3 years of university study I quit
because of a lack of motivation. I also seem very indecisive all the
time. Alcohol and cannabis are probably two things that I enjoy.
In
fact since my reduced consumption of substances lately I have become
even more withdrawn socially then when I used to go out partying with
friends; or just generally being chatty. Actually that's what I miss
about smoking cigarettes.
I know this is hard for you to answer
as you have said before it depends on the individual, but in your
professional opinion would it be better to treat depression/anxiety
symptoms (or just general malaise) with drugs/pharmaceuticals? Or would
abstinence from all substances be better?
I am also asking as
I was concerned when my brother went onto antidepressants - notably
"Pristiq" He didn't even last two months and went off them because they
were making him feel so bad. Actually he is a almost daily pot smoker
and finds that better.
The
role of genetics in human diseases is, in general, less important than
people think. Several morphological characteristics are genetically
determined. For most diseases, there is a genetic predisposition but
there exist also environmental factors that condition the fact that an
illness appear and its severity. Genetic diseases are rare and none of
them is psychological. So characteristics of personality (impulsivity,
shyness, addictive behaviours…) have a hereditary component that implies
a certain tendency, modulated by education, motivation, determination,
personal decisions and life-experience. So the fact that in your family
there is an alcohol problem does not mean that it is “genetically”
transmitted to you.
I can`t be sure if in your case it is better to
treat depression/anxiety with drugs or not. But I don`t think that
auto-medicate psychological symptoms with psychoactives is a good idea,
regardless if they are legal or not. In fact I don`t think
auto-medication is good, except if you have a flu or something like
that. On the one hand, there is the knowledge factor. Drug prescription
is much more than choosing a drug depending on symptoms. But, most
important, a person can`t be objective with himself. I`m a doctor but,
when I have a health problem I search for an independent, unbiased
opinion. If we are talking about psychological problems and psychoactive
drugs I think this is particularly important. Cannabis can be useful
for certain psychological conditions but, in general, it is not a good
antidepressant.
-
Thanks a lot, once more.
I
have to admit I'm a bit reluctant not to try d-amph and moclobemide,
because I neither want to give up the moclobemide (since it is the first
thing to help with my chronic depression) nor want to leave the adhd
untreated. But I'll be very careful indeed, even more careful than
before, because that was not a situation I't like to be in again.
Maybe
I'll be able to have all this done and surveilled by a doctor, but I
doubt it. It's hard enough to acually find one who'd be willing to
prescribe (d-)amphetamine, much less one who'd prescribe it with
moclobemide and/or give advice on benzos without thinking I'm only "in
it for the drugs".
I actually tried to have a doctor check me out
when I felt able to do anything again. But since I was better once I
had arrived there I was just sent home and told to "relax".
I made some commentaries about auto-medication in the previous post. Maybe can interest you
-
Hi doc, thank you so much for your advices is really helpful :)
I
would like to ask about drug consumption related to sports practice and
exercise. Recently I've been training to run marathons and taking
gym workouts, although I've been doing sports in a semi-competitive
level almost all my life. I try to have a healthy diet and a healthy
lifestyle in general.
Sometimes I do drugs like cannabis, LSD,
25-nombs, mdma, 2-cb and cocaine, never mix them and always having
control with dose, purity, time between experiences, etc. Getting to the
point:
- if I take any of them and the next day I have a sport practice, will it affect my performance?
- how many time should I wait after a "high" to have a 100% physical recovery?
- any of those drugs is hurting directly my physical gains?
- any warning about this topic?
thank you and keep on the road!!
-
Hi Doc X, quick question:
A friend of mine wants to try MDMA
but she has vasculitis and is not sure if she can take it. Can she? I'm
not sure about how MDMA affects blood.
Thank you verrrry muchh!
-
Hello DoctorX, and thank you SO much for your time and generous advice. It is so appreciated.
My history:
I
have been a recreational user of oral oxycodone for about 2 years. I
started off feeling a great buzz with just 7.5 mg of oxycodone, and now
two years later it takes me 30mg to feel the same buzz. (Tolerance
is a lovely thing.) When I make an oxy purchase, I usually go a
little nuts and take about 60mgs over the course of a day, usually 5
times per week. When I run out, it's no big deal. I
don't get terrible withdrawals-- just some (mostly amusing) restless
legs/arms which go away with one 50mg tramadol before bed for a few days
and that's it. (I'm lucky.)
My question:
I have to get a
wisdom tooth pulled in a few weeks. Am I going to be in agony as I try
to ease the legitimate tooth pain because of my opiate tolerance?
Should I make sure I have a stockpile of oxy for when I get my tooth
pulled? I know my dentist will prescribe me a few 5mg
hydrocodones, but I can't imagine they'll be very helpful.
What
will happen, heaven forbid, if I need surgery or something someday? Will
any medication be able to ease my legitimate pain? Would I have
to tell my doctor about my oxy use?
Thanks again.
--chakrakhan
ps:
For the record, I feel VERY blessed that I don't feel any physical or
psychological addiction t oxy. I enjoy it very much, but if you
told me I could never have it again, I'd say "OK" and then I'd go have a
sandwich.
-
Hi doc, thank you so much for your advices is really helpful :)
I
would like to ask about drug consumption related to sports practice and
exercise. Recently I've been training to run marathons and taking
gym workouts, although I've been doing sports in a semi-competitive
level almost all my life. I try to have a healthy diet and a healthy
lifestyle in general.
Sometimes I do drugs like cannabis, LSD,
25-nombs, mdma, 2-cb and cocaine, never mix them and always having
control with dose, purity, time between experiences, etc. Getting to the
point:
- if I take any of them and the next day I have a sport practice, will it affect my performance?
- how many time should I wait after a "high" to have a 100% physical recovery?
- any of those drugs is hurting directly my physical gains?
- any warning about this topic?
thank you and keep on the road!!
The
effects of taking drugs the day before a sport practice depend on many
factors (kind of drug, dosage, degree of physical activity, tolerance…).
In general, you should be careful if you are using stimulants (cocaine,
amphetamines, MDMA…) and practising sport the day after, as there might
be residual effects on blood pressure or heart rate. 1-3 days seems a
reasonable time to wait before doing intense sport, although it depends
on substance and dosage. It is not the same a few puffs of cannabis than
a high dosage of LSD or MDMA. If used occasionally and in controlled
conditions, there are no data to suppose that these substances could
affect your physical gains. The exception is 25-NBOMe family. As I have
explained several times in this thread, the lack of data about its
effects and toxicity make these substances much more risky (at least,
potentially) than cannabis, LSD, 2C-B, MDMA or cocaine
-
Hi Doc X, quick question:
A
friend of mine wants to try MDMA but she has vasculitis and is not sure
if she can take it. Can she? I'm not sure about how MDMA affects blood.
Thank you verrrry muchh!
Vasculitis
is a wide group of disorders that destroy blood vessels by
inflammation. Many vasculitis are limited to the skin, with limited
damage to small superficial areas, in other cases other organs are
affected (lungs, heart, kidney…). MDMA has immunosuppressive properties,
so if she is using prednisone, cyclophosphamide or other
immunomodulating drugs commonly used for vasculitis she should not take
MDMA. There are anecdotic reports of renal vasculitis associated to
MDMA, it is possible that people with previous vasculitis are prone to
this effect, although it is not confirmed:
http://www.ncbi.nlm.nih.gov/pubmed/10193849
http://www.ncbi.nlm.nih.gov/pubmed/9794581
Anyway, it should be necessary to know exactly the kind of vasculitis and pharmacological treatment to assess risks.
-
Hello DoctorX, and thank you SO much for your time and generous advice. It is so appreciated.
My history:
I
have been a recreational user of oral oxycodone for about 2 years. I
started off feeling a great buzz with just 7.5 mg of oxycodone, and now
two years later it takes me 30mg to feel the same buzz. (Tolerance
is a lovely thing.) When I make an oxy purchase, I usually go a
little nuts and take about 60mgs over the course of a day, usually 5
times per week. When I run out, it's no big deal. I
don't get terrible withdrawals-- just some (mostly amusing) restless
legs/arms which go away with one 50mg tramadol before bed for a few days
and that's it. (I'm lucky.)
My question:
I have to get a
wisdom tooth pulled in a few weeks. Am I going to be in agony as I try
to ease the legitimate tooth pain because of my opiate tolerance?
Should I make sure I have a stockpile of oxy for when I get my tooth
pulled? I know my dentist will prescribe me a few 5mg
hydrocodones, but I can't imagine they'll be very helpful.
What
will happen, heaven forbid, if I need surgery or something someday? Will
any medication be able to ease my legitimate pain? Would I have
to tell my doctor about my oxy use?
Thanks again.
--chakrakhan
ps:
For the record, I feel VERY blessed that I don't feel any physical or
psychological addiction t oxy. I enjoy it very much, but if you
told me I could never have it again, I'd say "OK" and then I'd go have a
sandwich.
Oxycodone
causes drug tolerance (need to increase of dosage to achieve the
desired effects). It also causes cross-tolerance with all strong opiates
that work through opioid receptors (hydrocodone, fentanyl, heroin,
morphine, codein, methadone…). If you are ever prescribed any of these
medications and you are a regular user of oxycodone, you will need
higher dosages to achieve analgesic effects, so you you should tell your
doctor abour your oxycodone usage, or suffer pain ;(
Tolerance
and cross-tolerance dissapear or diminish substantially in several
weeks of abstinence. This effect of cross tolerance is not applicable to
other non-opioid analgesic (nonsteroidal anti-inflammatory drugs,
analgesics…) or anaesthetics.
-
Thanks DoctorX for your reply. I do understand where you mean we
shouldn't be objective on ourselves. That's a very good point.
Cleansober,
I don't think we should take the docs advice "with a grain of salt."
Reading the responses he gives in this forum, he tends to point out the
limitations of both his knowledge and of the wider medical research.
Oh P.S. I see what you mean by the "acupuncture" I think it's a bit extreme. Blue balls are bad enough haha
-
Gunman,
I'm joking about the acupuncture but maybe it can
work and I'm sure a qualified poker has painless needle insertion.
Looked up the subject to find this:
By
pressing an acupuncture point located halfway between the anus and
scrotum, the ejaculation can be reversed into an improved orgasm and the
semen is recycled from the full prostate and reabsorbed into the blood.
I wonder if they use actual needles at that point, might be tricky spot?
Clean
DoctorX,
Cannabis can be useful for certain psychological conditions but, in general, it is not a good antidepressant.
Could
you tell us what those psychological conditions are? Want to make sure
that is why we are smoking cannabis and not some made up
foolishness.
Any comment on why certain drugs seem to
be associated with physical movement? Why is it slackliners are,
by slacklining admitting to also using weed. Each drug seems to
draw out of its users a common activity preference. I wonder if it
is better to be active and smoke weed, or inactive and not smoke?
still editing, too much happiness
Cleansober
-
DoctorX,
Cannabis can be useful for certain psychological conditions but, in general, it is not a good antidepressant.
Could
you tell us what those psychological conditions are? Want to make sure
that is why we are smoking cannabis and not some made up
foolishness.
[/quote]
Anxiety disorders,
basically. Some persons (but not all) improve their symptoms of anxiety
using cannabis. For some people cannabis has an an anxiolytic effects,
although paradoxically it can trigger anxiety in other persons. This can
be explained by differences in personality and differences in cannabis
composition. Cannabis rich in THC ( tetrahydrocannabinol) is, in
general, more psychoactive than cannabis rich in CBD ( cannabidiol),
that possess more relaxing qualities. Strains of the plant with a ratio
THC/CBD 1/1 are the most suitable for therapeutic use.
Recent studies
have shown that CBD has also antipsychotic properties. Although
cannabis use is not recommended in persons suffering psychotic disorders
it is possible that CBD has a role as a drug for management of this
disease.
-
Hi there Doc! I spammed my way to 50 posts just to come here and ask you some questions :)
I
LOVE MDMA, and clubbing without taking MDMA is, for me, like eating
cake without sugar, or something like that. That sucks, but still,
because of neurotoxicity, tolerance, depression and loss of magic, I
want to find a good stimulant replacement so I can keep MDMA for moments
which are more special. What I'm concerned about at the time of finding
this replacement, is: First, health safety (neurotoxicity, abuse
potential, addictive potential, health risks). Second, tolerance. And
third/fourth/fifth would be either of the MDMA's best effects
(empathogen, entactogen, euphoria, uninhibitedness, etc).
And as far as I researched, the best option I found seems to be 2C-B. Which leads me to some other questions:
1-
Is there any risk on doing 2C-B every weekend or even more frequently?
Maybe supposing I'll be using it specially in low doses so I can get the
stimulant effects rather than the psychedelic effects?
2- What can you suggest about redosing 2C-B and mixing with MDMA on the same short period of time (let's say, one night)?
3- Finally, is there any interaction between cannabis and 2C-B?
I think that's it for now, thank you VERY much, your help is priceless.
[EDIT: I'm in the age range of 22-27, healthy, and low weighted]
-
Dear Mr. Jackpot,
You did exactly what I did; spam to 50 and tell Fernando he is great.
What
does neurotoxicity really mean and what does clubbing mean? As FC
has pointed out earlier, the brain is a very complex
thing-a-ma-bob. Treat it kindly.
Now for the hard
part. Since there are drugs out there that can give a man a
perfect erection for two hours, why does anyone care about any other
drug? Oh wait I forgot, it's a function of age and I'm over 40.
I'm afraid to make an appointment with a real live face to face
doctor. Stop taking drugs young fellow.
Hope you
don't mind I'd like to try and guess your land of origin. England,
outside of London a wee bit? Or maybe more likely a former
colony. ha ha. Clubbing is a European term from what I know
about it. So how about Germany? of course tell me only lies to prevent
tracking, however remote the chance might be.
Clean-up-people
X,
Do
you think aggression personality disorder is in some cases treatable
with cannabis? Or do you feel there are better anxiolytics and/or
treatment modalities out there for calming our savage beasts?
If
symptoms improve for some anxiety conditions might irritability and
intolerance be a form of social anxiety or some other neurosis treatable
other ways?
Do you find an online interview is as good or worse
than the diagnostic results from an in person examination? It
seems to me that getting a real world (online or otherwise) doctor is
important to avoid problems.
Would MedissimoX sound funny or mean negative things as a translation of DoctorX,
Clean,
still
editing LCT, local computer time=1046am. I wonder if putting the
time down fires up the NSA/DEA/Policíaissimo computers? The long
arm of the law is lurking here we know that much.
-
Updated previous post at least 25 times today. Yes I need a hobby besides SR.
CS
-
First to help answer few questions then I will introduce myself to those who don't know who I am.
chakrakhan87,you surely are blessed with absence of hellish WD,I can only envy you!
To answer you a question.
Although immensely popular in USA Oxycodone is very lousy pain medicine considering high
number of people getting addicted from legit use,price and very short period of duration is main problem.
Especially if you defeat SR mechanism! Even pure pharma grade heroin is much better in any way you can count!
Since
you are O addict with such tolerance already and if your doctor won't
give you more I strongly advise you to stockpile something strong and
long lasting like Oxymorphone (Opana) and Methadone.
(have great and cheap contact for last one)
You
will probably like Opana more since it's long lasting Oxycotin on
euphoric steroids. ;-) It's my favorite rec-drug by far among opiates.
Unfortunately Oral BA is extremely low (cca. 9%) so NOT extracting is
waste of very expensive goods. Since potency ican drastically differ in
different people,sometimes nearing potency of Fent to some people don't
OD by accident! Titrate your dose slowly until you find the sweet spot.
IV for best rush in your life,IM for longer acting pain relief. Since
you are already taking almost identical molecule (oxycotin) it should be
sligtly more than 2x as potent,but still,start slowly! As much as
pinhead can kill opiate naive person!
But I prefer Methadone for non-fun use over anything since it's EXTREMLY long lasting and great oral BA.
It was my painkiller of choice when I was medic during the war.
Far
superior to morphine to whom many people are a bit allergic and best
for those who are already long on opiates,illicit or legal. Only
downside is that it can't be used IM in emergency.
-
Jackpot
Can't agree more with you on MDMA bro!
It's not a drug,but probably something Angels lost while raving! ;D
I
was MDMA cook and fanatical user for years,introduced it to countless
people and took it every week or two,until magic was gone... :(
That hurts like loosing best,cutest and sexiest girl on Earth!
I am live example that MDMA neurotoxicity is over exaggerated at least x100 times but I also
had habit of harm reduction by preloading and postloading with loads of vitamins and supplements.
Best medicine for MDMA blues is opiates,especially up to 0,5mg Buprenorphine if you are opiate naive.
To
boost MDMA effects,avoid follow up doses,return some magic and extend
experience up to 8h with single dose (at least in my case) there is one
trick...but being very risk,potentially deadly to some people I am not
comfortable sharing it publicly. It can lead to fatal Serotonine
syndrome unless you are extremely depressed and in that case resistant. I
mean depressed beyond words and resistant to all legal medicine.
If you are,then you might be safe (I know I am! Took the combo 100+ times) and feel free to PM me.
I
usually don't recommend to other people what I do cus in most cases
combos and dosages I take without consequence are fatal to ordinary Joe.
Dangerous chemicals and drugs alike!
As for fair replacement,there is something good in store: beta-ketone-MDMA (Methylone) and 4-MAR.
4-mar is obscure but piss easy to make in kitchen,just don't let subtle effect and euphoria fool you into
re-dosing
which leads to seizure and death. On the plus side it's said to be
almost entirely non-neurotoxic at normal doses,at least in animals. But
lab animals are in my experience lousy surrogate for that kind of
feedback...Same mg/kg of one chemical that will kill human won't kill 5
rats and vice versa.
No wonder totalitarian states like 3rd Reich were exponentially better in finding new and effective medicines
when their scientists had as much best possible test subjects as they pleased!
-
0,
Not sure the 3rd Reich had much good data from all their
experimentation. At least that was the story a decade or two ago
when I last looked at the history books.
Wonder if X knows this trick too?
Sober
-
I really hope you guys are sending some BTC DrX's way. He's giving
specialist, bespoke advice. Stuff that other doctors wouldn't tell you
about because they simply don't know. What you're learning here costs in
the real world, big time. So if he's helped you, do the right thing.
-
So,introduction... Why the hell do I give advice to others...
I am not Doctor of medicine like DrX who selfishly helps you with his profession and life-school but I am not that far.
Instead
telling you my life story I will be brief and just mention my
qualifications and how I gained massive experience in some fiels of
interest here:
Due the severe treatment resistant depression since early teens I tried pretty much everything psychoactive in search for cure.
I have Organic chemistry PhD,specialized in benzene compounds (pretty much all drugs are!)
Tried
to specialize bio-chemistry too,learned a lot abut drug mechanics but
never ended it,my country was attacked.Left book,grab FN FAL and I
volunteered,that was much more important than any PhD in the world!
Command
quickly realized I am good candidate for field medic,which I
passes and learned a lot about medicine there.Quickly I was stationed at
infirmary Introducing methadone as standard first-line pain killer for
my battalion and supplying it with my own money at first instead of
morphine cus of better/longer effects and less side effects.(after two
soldier died of morphine related allergy complications) Even used MDMA
on stabilized post op. patients when methadone run out,after
that,everyone wanted it! Not only is it a great pain killer but best
shock treatment and best gift imaginable to dieing individual.
Got
nickname "Angel of Mercy" by soldiers! One of the things I am most
proud in my life. After the war,instead of free and proud country there
was anarchy,poverty & misery.
Deserters and cowards became rich and war heroes bumps with skyhigh rate of suicide.
Incompetent
and malignant politicians;bad bunch of capitalists robbing us of future
and even worse bunch of commies destroying our past only cemented
social situation. So,I did what I knew best,which was pretty easy in
anarchy and became good at it,Breaking Bad good in my best period.
Don't
want to brag but anything related to MDMA and opiates,including their
unconventional use I mentioned and personal massive (ab)use until I
found harmony and self-discipline in drug use that really helped a lot
with my condition. That was my second "PhD". :)Also tried to help my
brothers in arms with PTSD using MDMA and common sense.
So,I might
not be as good as doctor of medicine selfishly helping you here here but
if my massive experience and self-experimentation and sheer luck to
survive all that can help anyone prevent death and suffering and have a
good time feel free to PM me since I am not much on the forum.
So,I
am torn in the eye of LE and psychiatry, living proof that drugs are
just a mighty tool that can give hope and heal instead of destroying
life,just with enough intelligence to use them properly and bit of
self-discipline!
-
So,introduction... Why the hell do I give advice to others...
I am not Doctor of medicine like DrX who selfishly helps you with his profession and life-school but I am not that far.
Instead
telling you my life story I will be brief and just mention my
qualifications and how I gained massive experience in some fiels of
interest here:
Due the severe treatment resistant depression since early teens I tried pretty much everything psychoactive in search for cure.
I have Organic chemistry PhD,specialized in benzene compounds (pretty much all drugs are!)
Tried
to specialize bio-chemistry too,learned a lot abut drug mechanics but
never ended it,my country was attacked.Left book,grab FN FAL and I
volunteered,that was much more important than any PhD in the world!
Command
quickly realized I am good candidate for field medic,which I
passes and learned a lot about medicine there.Quickly I was stationed at
infirmary Introducing methadone as standard first-line pain killer for
my battalion and supplying it with my own money at first instead of
morphine cus of better/longer effects and less side effects.(after two
soldier died of morphine related allergy complications) Even used MDMA
on stabilized post op. patients when methadone run out,after
that,everyone wanted it! Not only is it a great pain killer but best
shock treatment and best gift imaginable to dieing individual.
Got
nickname "Angel of Mercy" by soldiers! One of the things I am most
proud in my life. After the war,instead of free and proud country there
was anarchy,poverty & misery.
Deserters and cowards became rich and war heroes bumps with skyhigh rate of suicide.
Incompetent
and malignant politicians;bad bunch of capitalists robbing us of future
and even worse bunch of commies destroying our past only cemented
social situation. So,I did what I knew best,which was pretty easy in
anarchy and became good at it,Breaking Bad good in my best period.
Don't
want to brag but anything related to MDMA and opiates,including their
unconventional use I mentioned and personal massive (ab)use until I
found harmony and self-discipline in drug use that really helped a lot
with my condition. That was my second "PhD". :)Also tried to help my
brothers in arms with PTSD using MDMA and common sense.
So,I might
not be as good as doctor of medicine selfishly helping you here here but
if my massive experience and self-experimentation and sheer luck to
survive all that can help anyone prevent death and suffering and have a
good time feel free to PM me since I am not much on the forum.
So,I
am torn in the eye of LE and psychiatry, living proof that drugs are
just a mighty tool that can give hope and heal instead of destroying
life,just with enough intelligence to use them properly and bit of
self-discipline!
Dear 20mm,
Your
story brings a serious side into what we are learning here. What do you
mean in the last line where you say, "...just with enough intelligence
to use them properly and bit of self-discipline!"?
Are you at all afraid of LE because of your SR activities?
Csober
-
Dear Mr. Jackpot,
You did exactly what I did; spam to 50 and tell Fernando he is great.
What
does neurotoxicity really mean and what does clubbing mean? As FC
has pointed out earlier, the brain is a very complex
thing-a-ma-bob. Treat it kindly.
Now for the hard
part. Since there are drugs out there that can give a man a
perfect erection for two hours, why does anyone care about any other
drug? Oh wait I forgot, it's a function of age and I'm over 40.
I'm afraid to make an appointment with a real live face to face
doctor. Stop taking drugs young fellow.
Hope you
don't mind I'd like to try and guess your land of origin. England,
outside of London a wee bit? Or maybe more likely a former
colony. ha ha. Clubbing is a European term from what I know
about it. So how about Germany? of course tell me only lies to prevent
tracking, however remote the chance might be.
Clean,
I'm sorry but I think I didn't get your point. What do you mean when
you mention drugs that can give a man an erection? How is it related
with face to face appointments, and why do you finalize telling me to
stop taking drugs? Not questioning you, It's just that English is not my
native language, and with this I'm also popping your balloon, because
you didn't guess my land of origin ;)
Is the police really into
reading random posts in these forums? I'm not at all afraid to be caught
(but I hope that's not a mistake).
-
Hi there Doc! I spammed my way to 50 posts just to come here and ask you some questions :)
I
LOVE MDMA, and clubbing without taking MDMA is, for me, like eating
cake without sugar, or something like that. That sucks, but still,
because of neurotoxicity, tolerance, depression and loss of magic, I
want to find a good stimulant replacement so I can keep MDMA for moments
which are more special. What I'm concerned about at the time of finding
this replacement, is: First, health safety (neurotoxicity, abuse
potential, addictive potential, health risks). Second, tolerance. And
third/fourth/fifth would be either of the MDMA's best effects
(empathogen, entactogen, euphoria, uninhibitedness, etc).
And as far as I researched, the best option I found seems to be 2C-B. Which leads me to some other questions:
1-
Is there any risk on doing 2C-B every weekend or even more frequently?
Maybe supposing I'll be using it specially in low doses so I can get the
stimulant effects rather than the psychedelic effects?
2- What can you suggest about redosing 2C-B and mixing with MDMA on the same short period of time (let's say, one night)?
3- Finally, is there any interaction between cannabis and 2C-B?
I think that's it for now, thank you VERY much, your help is priceless.
[EDIT: I'm in the age range of 22-27, healthy, and low weighted]
Well…some
people seems that is difficult to find a substitute for MDMA. It
properties make it a unique experience and I don`t think there is
anything that can compare, in particular for clubbing. There is no other
drug that combines mild stimulant properties, sublte pshychedelic
effects easy to manage and a deep emotional aspect. So, instead of
searching a “replacement” I think you`d better think about exploring
other psychoactives but do not expect that they are going to give you
the same of MDMA or try to compare with it. Even you could try clubbing
sometimes without any drug and try to evoke previous experiences…Some
substances can “teach” you abilities (I´m thinking in particular about
MDMA and sociability) and it can be fun to explore this in a
non-alterated state of consciousness. Anyway, your reasonment for
choosing 2C-B is very logic in your arguments.
1.- Although there are
not too many human studies on 2C-B, neurotoxic effects or long time
toxicity seems very unlikely, according to molecular characteristics and
previous human experience. Doing 2C-B once a week or more will get to
get bored of its effects (we can call it tolerance, loss of magic or
whatever but to use a unique, magic, delicate experience as an habit or
routine leads to loss of interest sooner or later). At a stimulant rank
5-10 mg pharmacological tolerance will appear in a few weeks.
2.-
This is a very popular combination that tries to get together emotional
aspects of MDMA and psychedelics of 2C-B. First, you should have enough
experience with both substances. Total dosage used in combination should
be 20-30% below than dose used separated. A reasonable time of 1.5-2
hours between administration is required. Some people prefer to start
with MDMA, other with 2C-B. In Internet forums you will find different
opinions about the correct order to take substances but the only rule is
personal preference. From a risk perspective there are no data about
fatal or severe intoxications, but I insist in being careful with
dosages and environments. Interacting with other persons and setting is,
in general, easy with MDMA. Depending on dose of 2C-B and combination
this can be more difficult (I´m thinking, for example, in a very crowded
club). 2C-B is very dose-sensitive (effects change in the rank of 2
mg), so I suggest not to re-dose.
3.- As it happens with other drugs
with psychedelic properties, using cannabis while on 2C-B increases
hallucinogenic/psychedelic effects. For some people this can trigger
anxiety or fear, particularly if they are not regular cannabis users.
Thanks
for taking the effort to post…and don´t take too seriously cleansober
commentaries. It is difficult to know if he is talking seriously or not.
-
Dear Mr. Jackpot,
You did exactly what I did; spam to 50 and tell Fernando he is great.
What
does neurotoxicity really mean and what does clubbing mean? As FC
has pointed out earlier, the brain is a very complex
thing-a-ma-bob. Treat it kindly.
Now for the hard
part. Since there are drugs out there that can give a man a
perfect erection for two hours, why does anyone care about any other
drug? Oh wait I forgot, it's a function of age and I'm over 40.
I'm afraid to make an appointment with a real live face to face
doctor. Stop taking drugs young fellow.
Hope you
don't mind I'd like to try and guess your land of origin. England,
outside of London a wee bit? Or maybe more likely a former
colony. ha ha. Clubbing is a European term from what I know
about it. So how about Germany? of course tell me only lies to prevent
tracking, however remote the chance might be.
Clean-up-people
X,
Do
you think aggression personality disorder is in some cases treatable
with cannabis? Or do you feel there are better anxiolytics and/or
treatment modalities out there for calming our savage beasts?
If
symptoms improve for some anxiety conditions might irritability and
intolerance be a form of social anxiety or some other neurosis treatable
other ways?
Do you find an online interview is as good or worse
than the diagnostic results from an in person examination? It
seems to me that getting a real world (online or otherwise) doctor is
important to avoid problems.
Would MedissimoX sound funny or mean negative things as a translation of DoctorX,
Clean,
still
editing LCT, local computer time=1046am. I wonder if putting the
time down fires up the NSA/DEA/Policíaissimo computers? The long
arm of the law is lurking here we know that much.
There
is not pharmacological, standardized treatment for aggressive
personalities. In a clinical setting, if someone is very aggressive and
can harm himself or others the strategy is to knock-out with strong
medication (antipsychotics, incisive benzodiacepines…). But, long time,
psychology therapies are much more effective than drugs. I don`t think
cannabis plays a role here, at least for most cases.
An in-person
examination is essential to a correct medical evaluation. That is why
diagnosis can`t be made through Internet, so my advices here are general
orientation and can`t replace a complete medical evaluation
-
Hi there Doc! I spammed my way to 50 posts just to come here and ask you some questions :)
I
LOVE MDMA, and clubbing without taking MDMA is, for me, like eating
cake without sugar, or something like that. That sucks, but still,
because of neurotoxicity, tolerance, depression and loss of magic, I
want to find a good stimulant replacement so I can keep MDMA for moments
which are more special. What I'm concerned about at the time of finding
this replacement, is: First, health safety (neurotoxicity, abuse
potential, addictive potential, health risks). Second, tolerance. And
third/fourth/fifth would be either of the MDMA's best effects
(empathogen, entactogen, euphoria, uninhibitedness, etc).
And as far as I researched, the best option I found seems to be 2C-B. Which leads me to some other questions:
1-
Is there any risk on doing 2C-B every weekend or even more frequently?
Maybe supposing I'll be using it specially in low doses so I can get the
stimulant effects rather than the psychedelic effects?
2- What can you suggest about redosing 2C-B and mixing with MDMA on the same short period of time (let's say, one night)?
3- Finally, is there any interaction between cannabis and 2C-B?
I think that's it for now, thank you VERY much, your help is priceless.
[EDIT: I'm in the age range of 22-27, healthy, and low weighted]
Well…some
people seems that is difficult to find a substitute for MDMA. It
properties make it a unique experience and I don`t think there is
anything that can compare, in particular for clubbing. There is no other
drug that combines mild stimulant properties, sublte pshychedelic
effects easy to manage and a deep emotional aspect. So, instead of
searching a “replacement” I think you`d better think about exploring
other psychoactives but do not expect that they are going to give you
the same of MDMA or try to compare with it. Even you could try clubbing
sometimes without any drug and try to evoke previous experiences…Some
substances can “teach” you abilities (I´m thinking in particular about
MDMA and sociability) and it can be fun to explore this in a
non-alterated state of consciousness. Anyway, your reasonment for
choosing 2C-B is very logic in your arguments.
1.- Although there are
not too many human studies on 2C-B, neurotoxic effects or long time
toxicity seems very unlikely, according to molecular characteristics and
previous human experience. Doing 2C-B once a week or more will get to
get bored of its effects (we can call it tolerance, loss of magic or
whatever but to use a unique, magic, delicate experience as an habit or
routine leads to loss of interest sooner or later). At a stimulant rank
5-10 mg pharmacological tolerance will appear in a few weeks.
2.-
This is a very popular combination that tries to get together emotional
aspects of MDMA and psychedelics of 2C-B. First, you should have enough
experience with both substances. Total dosage used in combination should
be 20-30% below than dose used separated. A reasonable time of 1.5-2
hours between administration is required. Some people prefer to start
with MDMA, other with 2C-B. In Internet forums you will find different
opinions about the correct order to take substances but the only rule is
personal preference. From a risk perspective there are no data about
fatal or severe intoxications, but I insist in being careful with
dosages and environments. Interacting with other persons and setting is,
in general, easy with MDMA. Depending on dose of 2C-B and combination
this can be more difficult (I´m thinking, for example, in a very crowded
club). 2C-B is very dose-sensitive (effects change in the rank of 2
mg), so I suggest not to re-dose.
3.- As it happens with other drugs
with psychedelic properties, using cannabis while on 2C-B increases
hallucinogenic/psychedelic effects. For some people this can trigger
anxiety or fear, particularly if they are not regular cannabis users.
Thanks
for taking the effort to post…and don´t take too seriously cleansober
commentaries. It is difficult to know if he is talking seriously or not.
I can't thank you enough!
I
know MDMA is just unique and not replaceable. And although I think you
have already understood what I expect out of a "MDMA replacement", let's
say one night I go to some party but I just feel tired, like I need a
little boost, mood lifting, and of course MDMA is not an option. For
this, some people recommended me things as speed. What do you think of
speed in terms of safety? It's not safe enough as far as I know, but
I've been told this from a bunch of people.
Now I'm waiting for a 2C-B order, so I'll try it, but hey, It's good to have some other options.
And I think that's enough of your time for now.
Thank you again!!
EDIT:
So you say it's not a good idea to redose 2C-B after a comedown on the
same night, right? Let's say I take 10mg and I got the stimulant
effects, then I come down. If I redose with another 10, I'd be most
likely having psychedelic effects, right? Sounds awesomely versatile :)
-
@Cleansober
Both!
Drugs are tools,just like guns or
electric drill. Neither of them is "evil" or "dangerous",only the way
how some people that are not qualified,at least to say,to use them are
using them is dangerous or worse,evil manner.
Problem with drugs is that people like Dr. X are not just rare but almost non-existent,so you can rarely
learn from expert on that field who is not only educated but has life experience with that matter.
unlike those full of propaganda and ignorance.
Where people who can teach you to use guns and tools properly are available if you wish to learn.
Yes,at
first I was not comfortable about talking about my history and gory
details (believe me,I left out 90%!) but then I realized someone might
actually understand,like you did,how awesome tools
are we rejecting
cus of irrational fear,ignorance and propaganda,realizing we are no much
better than those who burned scientists in middle age!
As I said,you need someone hard to find to teach you or experiment on yourself,which can be fatal.
I survived and gained such experience only by protection of some higher force or dumb luck.
After some time of "discovering" drugs,people tend to overdo them and this is where problem starts.
Self-discipline IS possible but just hard to master.
Am
I afraid...never knew that feeling once I understood it,frankly. Not
even in war. My brain is hardwired differently. It has to do something
with hardcore depression that killed almost every normal human feeling
as form of self defense to suffer less and nasty self-inflicting
pain/injury OCD type of disorder I had before I could walk.
Closest to it I ever felt is anxiety like when order is too late or I miss the therapy.
As
for LE...they and politicians are more afraid of me because they know I
know too much about their dirty business and skeletons in closet but
they also know I am reasonable,non-violent if not provoked,quite,and
will remain so as long as I have my peace. Most of them actually worked
for me for quite a bit!
-
Dear Mr. Jackpot,
You did exactly what I did; spam to 50 and tell Fernando he is great.
What
does neurotoxicity really mean and what does clubbing mean? As FC
has pointed out earlier, the brain is a very complex
thing-a-ma-bob. Treat it kindly.
Now for the hard
part. Since there are drugs out there that can give a man a
perfect erection for two hours, why does anyone care about any other
drug? Oh wait I forgot, it's a function of age and I'm over 40.
I'm afraid to make an appointment with a real live face to face
doctor. Stop taking drugs young fellow.
Hope you
don't mind I'd like to try and guess your land of origin. England,
outside of London a wee bit? Or maybe more likely a former
colony. ha ha. Clubbing is a European term from what I know
about it. So how about Germany? of course tell me only lies to prevent
tracking, however remote the chance might be.
Clean,
I'm sorry but I think I didn't get your point. What do you mean when
you mention drugs that can give a man an erection? How is it related
with face to face appointments, and why do you finalize telling me to
stop taking drugs? Not questioning you, It's just that English is not my
native language, and with this I'm also popping your balloon, because
you didn't guess my land of origin ;)
Is the police really into
reading random posts in these forums? I'm not at all afraid to be caught
(but I hope that's not a mistake).
Dear Mr. Jackpot, and let me tell you mf's a real oz is a mfn tonne bitch.
The
real police are the ones in our minds. What limits do we adhere to
slavishly? Those are more important than any outside authorities.
Ten years from now when I'm running for political office to get an
ungodly large pension, some blogger will dig up my dealings on SR. So
much for winning that election. If they ever got hold of my secret
photo album, prison time possible, maybe.
Now on to the
important question, your land of origination. English is a second
language, you said , you also told me you popped my bubble. Maybe
USA slang but how about
Northern Europe?
Dear Mr. 20mm,
To quote you:
Am
I afraid...never knew that feeling once I understood it,frankly. Not
even in war. My brain is hardwired differently. It has to do something
with hardcore depression that killed almost every normal human feeling
as form of self defense to suffer less and nasty self-inflicting
pain/injury OCD type of disorder I had before I could walk.
Closest to it I ever felt is anxiety like when order is too late or I miss the therapy.
As
for LE...they and politicians are more afraid of me because they know I
know too much about their dirty business and skeletons in closet but
they also know I am reasonable,non-violent if not provoked,quite,and
will remain so as long as I have my peace. Most of them actually worked
for me for quite a bit!
So
you did not find MDMA to relieve your symptoms? Here we go again the
difference between symptoms and cause comes into play. If depression
means low efficiency and general poor mental health then until I write
my resume for the first time in 30 years, my opinion is low, when done
it will rise up once again.
You may be interested in a training
group I'm thinking of forming. Don't want to say too much, but I
will say all of our strippers will be pure vegans. Let me know if
you are ready for the most fun and stimulation of your life.
Simulation you say, what does that mean? Sexual healing of course. Still
working out the details of my plan. May involve the mob, not sure yet.
If I revel too much my identity will be compromised. I can wager a
big wad of money I'm the only one doing this thing. A nice bonus is I'm
almost certain it's legal in several countries. In fact even in the
countries it is against the law to do what I'm talking about, the laws
against it are rarely enforced.
Clean
-
I can't thank you enough!
I
know MDMA is just unique and not replaceable. And although I think you
have already understood what I expect out of a "MDMA replacement", let's
say one night I go to some party but I just feel tired, like I need a
little boost, mood lifting, and of course MDMA is not an option. For
this, some people recommended me things as speed. What do you think of
speed in terms of safety? It's not safe enough as far as I know, but
I've been told this from a bunch of people.
Now I'm waiting for a 2C-B order, so I'll try it, but hey, It's good to have some other options.
And I think that's enough of your time for now.
Thank you again!!
EDIT:
So you say it's not a good idea to redose 2C-B after a comedown on the
same night, right? Let's say I take 10mg and I got the stimulant
effects, then I come down. If I redose with another 10, I'd be most
likely having psychedelic effects, right? Sounds awesomely versatile :)
To
evaluate a drug in terms of safety you have to consider many factors:
dosage, frequency of use, pattern of use, pharmacological effects,
adverse effects and toxicity, setting of use and personal
characteristics of user. MDMA can be considered a safe drug if used
properly or a very dangerous substance if you eat a pill omelette
everytime you go clubbing.
MDMA, stimulants (cocaine,
amphetamine), and, to a lesser extent, GHB and ketamine are the drugs
more frequently used in recreative settings. "Legal highs" (mephedrone,
MDPV and derivatives) are not recommendable as there is no experience
with humans with these substances and risks are impredictible.
Each
drug has its own pleasurable effects (that may not be pleasurable for
everybody), risks and precautions of use. For example, a little increase
on MDMA dosage usually does not have terrible consequences, but that
increase on GHB or ketamine can ruin a night. From a pharmacological
point of view, amphetamine (speed) is a well known substance. Effects
are pleasurable for many people and risks are acceptable if you use it
properly (in dosages, frequencies and pattern of use).
Before
testing any drug it is important to have enough reliable information
about effects and risks. Erowid is one of the best sources of
information in Internet.
http://www.erowid.org/psychoactives/psychoactives.shtml
Redosing
2C-B when effects are diminishing is quite impredictible. Sometimes you
will get psychedelic effects, stimulant, a mix or just tiredness as
neurotransmissors have been liberated enough.
-
I would appreciate if commentaries, opinions, thoughts and
contributions are limited to the main theme of this thread (drugs,
health and risk reduction). All contributions, opinions and critics are
welcome, but it would be desirable more concision in commentaries to
questions and not to open paralell conversations outside the main theme
of this thread 8) 8) 8) 8) 8)
-
I have moderately high blood pressure (140/90 ). I take enalapril to
keep it in check, 10mg and it seems to do okay. There is no physical
reason for my high BP and, after doing all tests, my Doc feels it's
caused by anxiety and stress. Generally I find that MDMA makes me feel
good, but I am worried about the dangers of what I'm doing. I
weight about 200lbs and my average dose is 100mg max.
Another
question…I think I use MDMA in order to attack my depression. I do It
once or twice a month. Since I started using it my social life has
started again. I have had personal problems, I want to get rid of my
depression but I don`t want to depend on drugs my whole life
Thanks a lot doc
-
I
have moderately high blood pressure (140/90 ). I take enalapril to keep
it in check, 10mg and it seems to do okay. There is no physical reason
for my high BP and, after doing all tests, my Doc feels it's caused by
anxiety and stress. Generally I find that MDMA makes me feel good, but I
am worried about the dangers of what I'm doing. I weight about
200lbs and my average dose is 100mg max.
Another question…I think I
use MDMA in order to attack my depression. I do It once or twice a
month. Since I started using it my social life has started again. I have
had personal problems, I want to get rid of my depression but I don`t
want to depend on drugs my whole life
Thanks a lot doc
I
read an article in which they investigated the possibility to give
subpar MDMA doses everyday to treat depression. But taken once or twice a
month it's not effective I think, other than giving you a good night
out.
By my personal experience, if your depression, other than
anxiety and such, involves being weak all day, with no energy and
worrying too much about things, I couldn't recommend enough Modafinil.
It has its risks, it has not been studied a lot, but it's safer than MD I think. Do your research if you like.
Posting
this cause it really helped me a lot and I wanted to share it, but wait
the Doctor for a qualified and focused answer on what you asked.
Take care mate.
-
So,introduction... Why the hell do I give advice to others...
I am not Doctor of medicine like DrX who selfishly helps you with his profession and life-school but I am not that far.
Instead
telling you my life story I will be brief and just mention my
qualifications and how I gained massive experience in some fiels of
interest here:
Due the severe treatment resistant depression since early teens I tried pretty much everything psychoactive in search for cure.
I have Organic chemistry PhD,specialized in benzene compounds (pretty much all drugs are!)
Tried
to specialize bio-chemistry too,learned a lot abut drug mechanics but
never ended it,my country was attacked.Left book,grab FN FAL and I
volunteered,that was much more important than any PhD in the world!
Command
quickly realized I am good candidate for field medic,which I
passes and learned a lot about medicine there.Quickly I was stationed at
infirmary Introducing methadone as standard first-line pain killer for
my battalion and supplying it with my own money at first instead of
morphine cus of better/longer effects and less side effects.(after two
soldier died of morphine related allergy complications) Even used MDMA
on stabilized post op. patients when methadone run out,after
that,everyone wanted it! Not only is it a great pain killer but best
shock treatment and best gift imaginable to dieing individual.
Got
nickname "Angel of Mercy" by soldiers! One of the things I am most
proud in my life. After the war,instead of free and proud country there
was anarchy,poverty & misery.
Deserters and cowards became rich and war heroes bumps with skyhigh rate of suicide.
Incompetent
and malignant politicians;bad bunch of capitalists robbing us of future
and even worse bunch of commies destroying our past only cemented
social situation. So,I did what I knew best,which was pretty easy in
anarchy and became good at it,Breaking Bad good in my best period.
Don't
want to brag but anything related to MDMA and opiates,including their
unconventional use I mentioned and personal massive (ab)use until I
found harmony and self-discipline in drug use that really helped a lot
with my condition. That was my second "PhD". :)Also tried to help my
brothers in arms with PTSD using MDMA and common sense.
So,I might
not be as good as doctor of medicine selfishly helping you here here but
if my massive experience and self-experimentation and sheer luck to
survive all that can help anyone prevent death and suffering and have a
good time feel free to PM me since I am not much on the forum.
So,I
am torn in the eye of LE and psychiatry, living proof that drugs are
just a mighty tool that can give hope and heal instead of destroying
life,just with enough intelligence to use them properly and bit of
self-discipline!
MDMA as physical painkiller replacing morphine/methadone? Don't think so buddy. I smell troll bullshit.
DoctorX have you ever heard about such a thing?
-
I
would appreciate if commentaries, opinions, thoughts and contributions
are limited to the main theme of this thread (drugs, health and risk
reduction). All contributions, opinions and critics are welcome, but it
would be desirable more concision in commentaries to questions and not
to open paralell conversations outside the main theme of this
thread 8) 8) 8) 8) 8)
Trouble
is the subject "drugs" seems too big. Correct me if I'm wrong but
every feeling,sensation and emotion we have seems to have a drug
related component that either is on the shelf or soon to be. This
in spite of the reported fact there have been no significant new mental
health drugs for decades. Big pharma still rules. To the wealthy goes
the Ritalin.
All questions and comments should adhere to a
protocol posted in a subheading under the main thread. That way
pointless points like mine can be filtered out. We want to use X's
limited time the best way possible. Suggestions anyone else?
What
guidelines would you suggest for the questioners? I liked how
Jackpot laid his facts out on the table like a patient etherized.
What X wants and what we think he wants may be two different things. And
so...are we going to pretend everyone will read the protocol,
understand and follow the guidelines? Few will but life goes on.
Cleansober
Cleansober, editing continues to continue...I should edit out the extra cleansober and yes it should be capital Cleansober.
waiting
for the day one electrical impulse originating from anywhere can be
identified 99.99% of the time. After identification the health
system can diagnose and cure all known health issues. Better watch
out X, you gonna be looking for work soon. Oh I saw that video of
you break dancing, not bad for an older fellow. The definition of
older is a dependent variable relative to country of origination death
rates. Who lives the longest, and who lives the best? Do you
remember Finland? I wonder what happened to him? If you are
here shout out now.
Too(?) bad, all of this is on the dark
web. It would be nice to use other tools than available on
SR. Security always matters. I sometimes wonder if they will
ever bust this whole thing down? Get the small time dealer and
user but on the other side of town the post office does the delivery of
"stuff". Ironic, would you agree? I dislike when I have a
inchoate idea and I lose it. I'm almost certain inchoate is a real
word.
-
Hi DoctorX. This is such an incredibly helpful thread and I really
appreciate your time and patience in addressing our questions.
I
would like to ask you if bronchial or ventolin inhalers are of any
benefit to a person (who does not have asthma or any known health
conditions) who is experiencing some breathing difficulties due to
opiate use? I'm not referring to respiratory depression, but difficulty
drawing breath.
For example, if someone IV's heroin and then feels
like they can't inhale enough air or can't fill up their lungs. They try
to take a deep breath but this still feels unsatisfactory as if they're
not getting enough air. In this instance resting heartrate is not below
normal.
Thank you
-
I
have moderately high blood pressure (140/90 ). I take enalapril to keep
it in check, 10mg and it seems to do okay. There is no physical reason
for my high BP and, after doing all tests, my Doc feels it's caused by
anxiety and stress. Generally I find that MDMA makes me feel good, but I
am worried about the dangers of what I'm doing. I weight about
200lbs and my average dose is 100mg max.
Another question…I think I
use MDMA in order to attack my depression. I do It once or twice a
month. Since I started using it my social life has started again. I have
had personal problems, I want to get rid of my depression but I don`t
want to depend on drugs my whole life
Thanks a lot doc
It
should be important to have more information. Let´s supposse your blood
pressure is well controlled with medication, you are young, no other
diseases, and no other cardiovascular risk factors (diabetes, tobacco,
high cholesterol, obesity...), and, that your doctor thinks the cause is
stress and he hasn´t prescribed you limitations for your normal life
(you can do intense sport, for example). In this case, use of MDMA at
the doses you´ve said is probably sure and you are facing the same low
risks as other person.
In my opinion there is no pharmacological cure
for depression. It is not an organic disease, but, as you say, caused
in general by psychological distress. Antidepressives (both legal and
illegal) can releive symptoms but will not cure definetly the disease.
Medication can help to set you in a psychological situation where you
will be able to deal with the situation, but should be used as a
temporal help. And MDMA is not a good antidepressive for long-time
treatment at all. The best way to solution the problem is to seek for
psychological advice. It doesn´t matter if it is a psychiatrist or a
clinical psychologist, but someone with good technical (universitary)
formation and you feel comfortable with. It is very difficult to solve
this situations by oneself, there are parts of oneself that must be seen
from "outside", with the help of a good profesional. Sometimes this
process is painful and long in time but is the most effective way to
solve problems like yours.
-
So,introduction... Why the hell do I give advice to others...
I am not Doctor of medicine like DrX who selfishly helps you with his profession and life-school but I am not that far.
Instead
telling you my life story I will be brief and just mention my
qualifications and how I gained massive experience in some fiels of
interest here:
Due the severe treatment resistant depression since early teens I tried pretty much everything psychoactive in search for cure.
I have Organic chemistry PhD,specialized in benzene compounds (pretty much all drugs are!)
Tried
to specialize bio-chemistry too,learned a lot abut drug mechanics but
never ended it,my country was attacked.Left book,grab FN FAL and I
volunteered,that was much more important than any PhD in the world!
Command
quickly realized I am good candidate for field medic,which I
passes and learned a lot about medicine there.Quickly I was stationed at
infirmary Introducing methadone as standard first-line pain killer for
my battalion and supplying it with my own money at first instead of
morphine cus of better/longer effects and less side effects.(after two
soldier died of morphine related allergy complications) Even used MDMA
on stabilized post op. patients when methadone run out,after
that,everyone wanted it! Not only is it a great pain killer but best
shock treatment and best gift imaginable to dieing individual.
Got
nickname "Angel of Mercy" by soldiers! One of the things I am most
proud in my life. After the war,instead of free and proud country there
was anarchy,poverty & misery.
Deserters and cowards became rich and war heroes bumps with skyhigh rate of suicide.
Incompetent
and malignant politicians;bad bunch of capitalists robbing us of future
and even worse bunch of commies destroying our past only cemented
social situation. So,I did what I knew best,which was pretty easy in
anarchy and became good at it,Breaking Bad good in my best period.
Don't
want to brag but anything related to MDMA and opiates,including their
unconventional use I mentioned and personal massive (ab)use until I
found harmony and self-discipline in drug use that really helped a lot
with my condition. That was my second "PhD". :)Also tried to help my
brothers in arms with PTSD using MDMA and common sense.
So,I might
not be as good as doctor of medicine selfishly helping you here here but
if my massive experience and self-experimentation and sheer luck to
survive all that can help anyone prevent death and suffering and have a
good time feel free to PM me since I am not much on the forum.
So,I
am torn in the eye of LE and psychiatry, living proof that drugs are
just a mighty tool that can give hope and heal instead of destroying
life,just with enough intelligence to use them properly and bit of
self-discipline!
MDMA as physical painkiller replacing morphine/methadone? Don't think so buddy. I smell troll bullshit.
DoctorX have you ever heard about such a thing?
I
have never heard about that. And in all the scientific literature about
MDMA or amphetamine derivatives you will never see anything about
analgesic properties. Opiates are the most potent analgesics, that idea
is not logical neither based in scientific evidence.
-
Hi
DoctorX. This is such an incredibly helpful thread and I really
appreciate your time and patience in addressing our questions.
I
would like to ask you if bronchial or ventolin inhalers are of any
benefit to a person (who does not have asthma or any known health
conditions) who is experiencing some breathing difficulties due to
opiate use? I'm not referring to respiratory depression, but difficulty
drawing breath.
For example, if someone IV's heroin and then feels
like they can't inhale enough air or can't fill up their lungs. They try
to take a deep breath but this still feels unsatisfactory as if they're
not getting enough air. In this instance resting heartrate is not below
normal.
Thank you
Bronchodilators
as ventolin are only effective in cases of bronchial obstructions
(asthma or related conditions). It sounds a bit strange to me that
someone using heroin feels difficulty for breathing. There might be
different causes (cardiologic, neurologic, respiratory...) but bronchial
obstruction induced by opiates sounds very unlikely. So I think
bronchodilators would be useless, but the important thing should be
knowing the cause of difficulty breathing. The most likely probability
should be respiratory depression but it should be necessary to rule our
other dangerous causes.
-
I have Organic chemistry PhD,specialized in benzene compounds (pretty much all drugs are!)
That's
interesting. Benzene ring is a well known carcinogen. I would like to
ask is it possible other drugs are themselves? Could you have any
carcinogenic impurities left over in MDMA for example?
-
I have Organic chemistry PhD,specialized in benzene compounds (pretty much all drugs are!)
That's
interesting. Benzene ring is a well known carcinogen. I would like to
ask is it possible other drugs are themselves? Could you have any
carcinogenic impurities left over in MDMA for example?
One
of the problems of illegal markets is the lack of sanitary control. In
theory, everything is possible in such a market. But in real world
conditions these things have not happened. There are several scientific
publications covering the composition of MDMA pills and crystal. There
are also several NGOs and projects that analyze substances (one of them
in Spain, the NGO EnergyControl) Carcinogenic compounds or benzene
derivatives have never been found in drug testing results
-
I have a strange question that has been bothering me.
There
is some very pure Amphetimine on here I have seen post after post of
people saying 50 or 80 mg keeps them awake for 12 hours now for me to
stay up on it for 12 hours I'd need at least 300 mg - 400mg so at
least 4 x as much as them.
I only take it during the weekend so
let my body catch up with any sleep during the week but still the
amount they take does very little for me and I'd still need the 300mg.
Now
about ten years ago I used to do a lot of it for a good few years and
then settled down and gave it up for 9 years then got divorced and
started taking it again.
Would my brain after a Decade still remember how much I needed in those days which was a lot to get stimulated from it?
As
I can't work out why I need so much more than the other people taking
it as I have not caned it seems I need about 4 x as much as them or is
it just a natural high tolerance to amphetimine that I have? Like I say I
have 5 days off during the week but still need the same amount , hope
this makes some sense as it is puzzling me why I need so much more than
them.
-
I have Organic chemistry PhD,specialized in benzene compounds (pretty much all drugs are!)
That's
interesting. Benzene ring is a well known carcinogen. I would like to
ask is it possible other drugs are themselves? Could you have any
carcinogenic impurities left over in MDMA for example?
One
of the problems of illegal markets is the lack of sanitary control. In
theory, everything is possible in such a market. But in real world
conditions these things have not happened. There are several scientific
publications covering the composition of MDMA pills and crystal. There
are also several NGOs and projects that analyze substances (one of them
in Spain, the NGO EnergyControl) Carcinogenic compounds or benzene
derivatives have never been found in drug testing results
Wait just a minute here, I thought we are carbon based life forms not benzenwhateritis.
Here
is what I think. MDMA is Ecstasy and Molly is the pure form of
mdma? molly=mdma but E is made from mdma.
Question
for regular readers: What sort of questions do you want to read
here? Thanks for all thoughts and replies.
X,
Would you say unsanitary conditions is the number one problem with the illegal and compound drug markets?
Is
there any current drug or one in development that causes timed
orgasms? Take the two minute version and have a two minute orgasm,
three for three minutes and so on. If not does any drug approach
this functionality? Thanks so much.
How is it that
every now and then this thread gets 1K views in a day and then drops
down to a lesser readership? Hit statistics using Tor? At least a
weekend project, potential for a never getting the job done ending.
CS
-
hey doctorX i have a question, my girlfriend is pregnant and im
wondering if xanax is bad to take while being pregnant. does it have any
adverse effects on the fetus? im talking small doses like 1mg or
perhaps 2mg.
-
Replying so that I can follow this thread.
-
Tonic: save the doctor some bother and check out Wikipedia. It's
pretty common knowledge that pregnant women shouldn't be taking Xanax.
If she has a habit, time to switch over to Valium and start tapering, I
reckon.
-
I have Organic chemistry PhD,specialized in benzene compounds (pretty much all drugs are!)
That's
interesting. Benzene ring is a well known carcinogen. I would like to
ask is it possible other drugs are themselves? Could you have any
carcinogenic impurities left over in MDMA for example?
One
of the problems of illegal markets is the lack of sanitary control. In
theory, everything is possible in such a market. But in real world
conditions these things have not happened. There are several scientific
publications covering the composition of MDMA pills and crystal. There
are also several NGOs and projects that analyze substances (one of them
in Spain, the NGO EnergyControl) Carcinogenic compounds or benzene
derivatives have never been found in drug testing results
Thanks again DoctorX
-
I have a strange question that has been bothering me.
There
is some very pure Amphetimine on here I have seen post after post of
people saying 50 or 80 mg keeps them awake for 12 hours now for me to
stay up on it for 12 hours I'd need at least 300 mg - 400mg so at
least 4 x as much as them.
I only take it during the weekend so
let my body catch up with any sleep during the week but still the
amount they take does very little for me and I'd still need the 300mg.
Now
about ten years ago I used to do a lot of it for a good few years and
then settled down and gave it up for 9 years then got divorced and
started taking it again.
Would my brain after a Decade still remember how much I needed in those days which was a lot to get stimulated from it?
As
I can't work out why I need so much more than the other people taking
it as I have not caned it seems I need about 4 x as much as them or is
it just a natural high tolerance to amphetimine that I have? Like I say I
have 5 days off during the week but still need the same amount , hope
this makes some sense as it is puzzling me why I need so much more than
them.
One
very important thing in amphetamine dosage is purity. Amphetamine salts
for intranasal or oral administration (speed) are, in general, the most
adulterated substance in illegal drug markets. Medium purity osciles
between 2.5-15%. That´s a six-fold variation and explain why some people
react different to amphetamines. Recently, other stimulant amphetamines
are added (as 4-FA or even PMA) . And in some countries there is a
confussion between meth (far more potent and less adulterated) and
amphetamine. I think this factor is important.
On the other hand,
amphetamines generate pharmacological tolerance quickly, and this
tolerance remains weeks or months even with non-daily adiministration.
Finally, as it hapens with many other drugs, some people are more
sensitive or resistent to its effects. It is a question of personal
pharmacology :)
-
hey
doctorX i have a question, my girlfriend is pregnant and im wondering
if xanax is bad to take while being pregnant. does it have any adverse
effects on the fetus? im talking small doses like 1mg or perhaps 2mg.
Alprazolam
is in cathegory D of FDA classification of drugs and pregnancy. There
is positive evidence of human fetal risk based on adverse reaction data
from investigational or marketing experience or studies in humans. Drugs
in class D should only be administered during pregnancy evaluating if
benefits for the mother are very important and there are no other
options. Some authors think that diacepam or chlorazepoxide should be
less risky, although, in general, benzos are contraindicated during
pregnancy.
Active dosage of alprazolam is 0.125 to 2 mg. So "1 or 2
mg" is not a low dose at all. Probably the risk for the fetus in a
esporadic, ocassional use is very low. But if your gf is using
alprazolam regularlly and she is pregnant, I think she should seek
professional advice to search for another way to treat her problems
-
Hi there Doc. Thanks for your service. Couple questions if you have a moment.
1)
Have you ever come across anything about cannabis and REM sleep? I
recently quit smoking cannabis and have had the most incredible, vivid,
wierd, personal, and sometimes overwhelming dreams. I have had dreams
of this magnitude before but it seems like every single night since
cessation I've had an incredible dream sequence. I was an all day every
day smoker for about 12 years. I was wondering if this phenomenon has
ever been studied or documented that you know of.
2) Safrole is
carcinogenic, do you think unreacted precursor, byproducts, or otherwise
unpure MDMA may also be carcinogenic to any extent? i.e. MDMA
containing MDP2P, bromo-safrole, iso-safrole...might these typical
impurities be carcinogenic as well?
3) I've studied MDMA have
read that MDMA acts as both a serotonin reuptake inhibitor and as a
potent agonist of serotonergic neurons owing it's profound affects to
significant release of and sequestration of serotonin within the
synaptic cleft. In PiHKAL, Dr. Shulgin speaks about a study that was
done in the 70's where patients were administered 160mg of MDMA per day
and after 7 days could not feel any effects from the drug at all showing
MDMA a rapid tolerance. Some patients were given MDA on the 8th day and
were able to get the full effects of the drug. I recently tried MDA for
the first time but have done MDMA >20 times and found differences to
be remarkably hard to distinguish. The study suggests two completely
different mechanisms by which MDA and MDMA act in the brain. Can you
shed any light on the mechanism of MDA in the brain if there is indeed
no cross-tolerance between the two drugs?
Thank you for your service and opinions. I love references too if you have any but don't trouble youself please :)
-
Hi there Doc. Thanks for your service. Couple questions if you have a moment.
1)
Have you ever come across anything about cannabis and REM sleep? I
recently quit smoking cannabis and have had the most incredible, vivid,
wierd, personal, and sometimes overwhelming dreams. I have had dreams
of this magnitude before but it seems like every single night since
cessation I've had an incredible dream sequence. I was an all day every
day smoker for about 12 years. I was wondering if this phenomenon has
ever been studied or documented that you know of.
2) Safrole is
carcinogenic, do you think unreacted precursor, byproducts, or otherwise
unpure MDMA may also be carcinogenic to any extent? i.e. MDMA
containing MDP2P, bromo-safrole, iso-safrole...might these typical
impurities be carcinogenic as well?
3) I've studied MDMA have
read that MDMA acts as both a serotonin reuptake inhibitor and as a
potent agonist of serotonergic neurons owing it's profound affects to
significant release of and sequestration of serotonin within the
synaptic cleft. In PiHKAL, Dr. Shulgin speaks about a study that was
done in the 70's where patients were administered 160mg of MDMA per day
and after 7 days could not feel any effects from the drug at all showing
MDMA a rapid tolerance. Some patients were given MDA on the 8th day and
were able to get the full effects of the drug. I recently tried MDA for
the first time but have done MDMA >20 times and found differences to
be remarkably hard to distinguish. The study suggests two completely
different mechanisms by which MDA and MDMA act in the brain. Can you
shed any light on the mechanism of MDA in the brain if there is indeed
no cross-tolerance between the two drugs?
Thank you for your service and opinions. I love references too if you have any but don't trouble youself please :)
I
would also be interested about the sleep thing, that's actually one
thing that I look forward to, after stopping using cannabis. I rarely
remember dreams when using, but get really vivid dreams, that I
remember, after stopping.
Years ago, I read something that suggested
that cannabis use diminished REM sleep, is that true (That would explain
REM coming back with a vengeance after THC use has stopped); or, is it
just that, after thc cessation, ones sleep is not as deep as normal, so
the dreams are easier to recollect?
I know, after I read that
cannabis use reduced REM sleep, I also heard somewhere, that humans went
mad, if deprived of dreams, so I did idly consider whether the two
could be put to together and encourage insanity, lol. That's rather in
the realms of "Reefer Madness" (pun not intended) and "Cocaine Fiends",
though.
Interesting stuff though, I find that I do tend to use cannabis as a sleep aid sometimes.
-
Tonic:
save the doctor some bother and check out Wikipedia. It's pretty common
knowledge that pregnant women shouldn't be taking Xanax. If she has a
habit, time to switch over to Valium and start tapering, I reckon.
Mr. meta,
I
know what you mean but all our questions could be answered with due
diligence and wiki etc. We may become dependent on X. He
always comes up with a little twist on the stuff we get to on our
own. Nuggets of a legal sort.
Dream recording is something I
did for nine years, stopping after a major life event. Great
question about sleeping and cannabis. It is easy to have a
constant high on like I do and forget about the pure joys of regular
sleep. Work a little lucid dreaming in there and wow, let the good times
roll.
DoctorX,
You mentioned a comparison of sexual
and drug related moral injunctions as a factor in misunderstanding about
the dangers of drugs in general. Do you find very many users are
unable to reconcile their sexual selves with their recreational drug
users selves? Should we be looking for some sexual healing in
place of phama healing? For example:
If women and men can
have yogasms, then is there a drug that helps with the process?
Or, how do we learn to do this without looking for the easy way.
Maybe we just need the drugs for a while and then we can relax and
perform as desired?
http://www.thedailybeast.com/articles/2011/09/28/yogasms-on-the-rise-instructors-say-yoga-related-orgasms-are-real.html
Therefore
orgasm does not exclusively belong to pleasure. It is trans-substantial
and essentially it belongs to the immaterial spiritual nature within us
all.
:P
CS
-
Hi there Doc. Thanks for your service. Couple questions if you have a moment.
1)
Have you ever come across anything about cannabis and REM sleep? I
recently quit smoking cannabis and have had the most incredible, vivid,
wierd, personal, and sometimes overwhelming dreams. I have had dreams
of this magnitude before but it seems like every single night since
cessation I've had an incredible dream sequence. I was an all day every
day smoker for about 12 years. I was wondering if this phenomenon has
ever been studied or documented that you know of.
2) Safrole is
carcinogenic, do you think unreacted precursor, byproducts, or otherwise
unpure MDMA may also be carcinogenic to any extent? i.e. MDMA
containing MDP2P, bromo-safrole, iso-safrole...might these typical
impurities be carcinogenic as well?
3) I've studied MDMA have
read that MDMA acts as both a serotonin reuptake inhibitor and as a
potent agonist of serotonergic neurons owing it's profound affects to
significant release of and sequestration of serotonin within the
synaptic cleft. In PiHKAL, Dr. Shulgin speaks about a study that was
done in the 70's where patients were administered 160mg of MDMA per day
and after 7 days could not feel any effects from the drug at all showing
MDMA a rapid tolerance. Some patients were given MDA on the 8th day and
were able to get the full effects of the drug. I recently tried MDA for
the first time but have done MDMA >20 times and found differences to
be remarkably hard to distinguish. The study suggests two completely
different mechanisms by which MDA and MDMA act in the brain. Can you
shed any light on the mechanism of MDA in the brain if there is indeed
no cross-tolerance between the two drugs?
Thank you for your service and opinions. I love references too if you have any but don't trouble youself please :)
I
would also be interested about the sleep thing, that's actually one
thing that I look forward to, after stopping using cannabis. I rarely
remember dreams when using, but get really vivid dreams, that I
remember, after stopping.
Years ago, I read something that suggested
that cannabis use diminished REM sleep, is that true (That would explain
REM coming back with a vengeance after THC use has stopped); or, is it
just that, after thc cessation, ones sleep is not as deep as normal, so
the dreams are easier to recollect?
I know, after I read that
cannabis use reduced REM sleep, I also heard somewhere, that humans went
mad, if deprived of dreams, so I did idly consider whether the two
could be put to together and encourage insanity, lol. That's rather in
the realms of "Reefer Madness" (pun not intended) and "Cocaine Fiends",
though.
Interesting stuff though, I find that I do tend to use cannabis as a sleep aid sometimes.
YES,
I would also add that I look forward to the dreams now. It's a feeling
I've never had before about dreaming. When the dreams first came back
after cessation the intensity would sometimes shock me awake but never
scary like a nightmare, just so vivid and lucid that I would literally
realize I was dreaming so intensely that I felt a panic to wake up. Now
that I have gotten use to the intensity I do not want them to end and
almost everyday I try to go back to sleep after waking to extend the
dreams. Extension of my dreams in the morning is often the most pleasant
because I feel like I can somewhat manipulate what I was dreaming into
what I would rather change the dream into...if that makes sense. This is
not a problem just a curiosity.
-
Hello everyone. I have a couple of questions for the doctor.
I
have been using cocaine about once to twice a month for about 5 years
now. I recently had a nasty sinus infection which I believe was due to
the coke use and it lasted about two weeks.
My question is, are
there any things that I can do now that I am going off of coke for good
that may be helpful to my sinuses? I feel like they are not completely
recovered. Still congested a lot.
Also I read somewhere that 80%
of cocaine has levisamole in it. Can you confirm or deny this? From
what I understand its a nasty drug and part of the reason Im giving it
up. Thanks for your contributions to the community. I look forward to
your response.
-
[ you have any carcinogenic impurities left over in MDMA for example?
Here
is what I think. MDMA is Ecstasy and Molly is the pure form of
mdma? molly=mdma but E is made from mdma.
Would you say unsanitary conditions is the number one problem with the illegal and compound drug markets?
CS
MDMA's
most popular name, "Ecstasy", was coined in 1981 by a member of a Los
Angeles distribution network. The distributor, quoted in Bruce
Eisner's Ecstasy:The MDMA Story (1989), chose the name "Ecstasy"
because "it would sell better than calling it 'Empathy'. 'Empathy' would
be more appropriate, but how many people know what it means?". So MDMA
and "Ecstasy" are the same thing. I`m not sure about the origin of the
name "Molly" but is a recent name for MDMA.
Impurities, adulteration,
lack of access to sterile material for injectors, difficulties to
measure dosages...are very important problems associated to sanitary
conditions. The fact that drug distribution is, in many cases,
associated to crime is another significative problem.
-
Hi there Doc. Thanks for your service. Couple questions if you have a moment.
1)
Have you ever come across anything about cannabis and REM sleep? I
recently quit smoking cannabis and have had the most incredible, vivid,
wierd, personal, and sometimes overwhelming dreams. I have had dreams
of this magnitude before but it seems like every single night since
cessation I've had an incredible dream sequence. I was an all day every
day smoker for about 12 years. I was wondering if this phenomenon has
ever been studied or documented that you know of.
2) Safrole is
carcinogenic, do you think unreacted precursor, byproducts, or otherwise
unpure MDMA may also be carcinogenic to any extent? i.e. MDMA
containing MDP2P, bromo-safrole, iso-safrole...might these typical
impurities be carcinogenic as well?
3) I've studied MDMA have
read that MDMA acts as both a serotonin reuptake inhibitor and as a
potent agonist of serotonergic neurons owing it's profound affects to
significant release of and sequestration of serotonin within the
synaptic cleft. In PiHKAL, Dr. Shulgin speaks about a study that was
done in the 70's where patients were administered 160mg of MDMA per day
and after 7 days could not feel any effects from the drug at all showing
MDMA a rapid tolerance. Some patients were given MDA on the 8th day and
were able to get the full effects of the drug. I recently tried MDA for
the first time but have done MDMA >20 times and found differences to
be remarkably hard to distinguish. The study suggests two completely
different mechanisms by which MDA and MDMA act in the brain. Can you
shed any light on the mechanism of MDA in the brain if there is indeed
no cross-tolerance between the two drugs?
Thank you for your service and opinions. I love references too if you have any but don't trouble youself please :)
Hi there Doc. Thanks for your service. Couple questions if you have a moment.
1)
Have you ever come across anything about cannabis and REM sleep? I
recently quit smoking cannabis and have had the most incredible, vivid,
wierd, personal, and sometimes overwhelming dreams. I have had dreams
of this magnitude before but it seems like every single night since
cessation I've had an incredible dream sequence. I was an all day every
day smoker for about 12 years. I was wondering if this phenomenon has
ever been studied or documented that you know of.
2) Safrole is
carcinogenic, do you think unreacted precursor, byproducts, or otherwise
unpure MDMA may also be carcinogenic to any extent? i.e. MDMA
containing MDP2P, bromo-safrole, iso-safrole...might these typical
impurities be carcinogenic as well?
3) I've studied MDMA have
read that MDMA acts as both a serotonin reuptake inhibitor and as a
potent agonist of serotonergic neurons owing it's profound affects to
significant release of and sequestration of serotonin within the
synaptic cleft. In PiHKAL, Dr. Shulgin speaks about a study that was
done in the 70's where patients were administered 160mg of MDMA per day
and after 7 days could not feel any effects from the drug at all showing
MDMA a rapid tolerance. Some patients were given MDA on the 8th day and
were able to get the full effects of the drug. I recently tried MDA for
the first time but have done MDMA >20 times and found differences to
be remarkably hard to distinguish. The study suggests two completely
different mechanisms by which MDA and MDMA act in the brain. Can you
shed any light on the mechanism of MDA in the brain if there is indeed
no cross-tolerance between the two drugs?
Thank you for your service and opinions. I love references too if you have any but don't trouble youself please :)
1) There is evidence that both THC and CBD have an impact on REM sleep.
http://www.ncbi.nlm.nih.gov/pubmed/16844117
http://www.ncbi.nlm.nih.gov/pubmed/164314
Brain
adapts chronic use of cannabis diminishing oniric life, and when
cannabis regular use finishes dreams become vivid during weeks. As far
as I know this effect has not been studied but is a very common complain
of regular cannabis users that quit using it. This effect lasts several
weeks but dissapears and dreams are normalized.
2) Data from
safrole toxicity come from animal studies and its carcinogenic potential
is low. Dosages of safrole or safrole derivatives as MDMA synthesis
sub-products are far below the minimum carcinogenic dosage in animals. I
don´t think that this risk can be considered significative.
http://ec.europa.eu/food/fs/sc/scf/out116_en.pdf
3)
The difference between MDA and MDMA effects is probably related to
specific action of MDA on a subtype of serotonin receptors (5HT-2A).
Activation of these receptors has been linked to psychedelic
effects. MDMA does not act on these receptors, at least at common
dosages. The specific effect on 5HT-2A of MDA probably explains the lack
of cross-tolerance. The story you have explained is a anecdotical
experimental report by Shulgin´s team and the lack of cross-tolerance
between MDMA and MDA has been proved on animal models
http://www.lycaeum.org/research/researchpdfs/1990_zacny_1.pdf
-
:)
Thank you very much Doc. This link isn't working though. http://www.ncbi.nlm.nih.gov/pubmed/164314
Thanks for your time and references.
-
Doc, straight and simple:
What can affect the tactogen nature of MDMA? Quality? purity? setting? dosage?
Long version:
I've
tried a bit of MDMA last sunday, which I didn't weight because I had no
scale, but I guess it was around 100mg (small person, almost empty
stomach, took an antacid, 2gr vitamin C, 32mg caffeine, 325mg
aspirin and 200mg Lipoic Acid beforehand). When it went up, I was in a
cold place waiting for a bus by myself, so I didn't have all this
"loving everybody" feeling, but what I did feel was dizziness and a buzz
in all my body. When I ran to the drugstore and called a taxi to my
girlfriend's, I noticed I was speedy as hell, as I usually am when I
roll (talking very fast, and my legs moved by themselves when I
walked/ran). I didn't have this urge for rubbing my skin that I usually
feel, though; touching my skin felt normal. No jaw clenching either, no
difficulty to pee, no difficulty to ejaculate, I eventually felt hungry,
and duration was short I think (I didn't time it, actually, but it felt
short). All in all, it felt quite mild outside the 20~ minutes that the
euphoric peak lasted. This would be my first time to take MDMA in a
setting which was not in a club.
Again, thank you very much for your help!
-
Hey Dr,
I'm having hand surgery next Friday and am an
occasional heroin user (snort, don't shoot) should I stop using at some
point before surgery so I don't mess something up with the meds they
will give me for surgery?
Thanks!
-
Hello everyone. I have a couple of questions for the doctor.
I
have been using cocaine about once to twice a month for about 5 years
now. I recently had a nasty sinus infection which I believe was due to
the coke use and it lasted about two weeks.
My question is, are
there any things that I can do now that I am going off of coke for good
that may be helpful to my sinuses? I feel like they are not completely
recovered. Still congested a lot.
Also I read somewhere that 80%
of cocaine has levisamole in it. Can you confirm or deny this? From
what I understand its a nasty drug and part of the reason Im giving it
up. Thanks for your contributions to the community. I look forward to
your response.
For
nasal hygiene in intranasal drug users it is useful cleaning your nose
with isotonic saline solution (there are different commercial brands,
some of then including hyaluronic acid), or simply salted 1% clean
water. A limited cycle of intranasal corticoids (no more of one week of
intranasal 0.05% fluticasone) is helpful if there is no bacterial
infection. If this is not enough you should ask for medical evaluation,
as some complications (nasal polyps) should be ruled out.
Levamisole
is an antihelmintic (drug for parasites) that has been widely detected
in 30-70% of cocaine samples since 2009. Levamisole is added because it
has stimulant effects, and reacts as cocaine in the “bleach test,” a
quick, widely utilized street test for cocaine purity. Skin problems
(vasculitis) and blood diseases ( leukopenia, agranulocytosis) are
related to cocaine adulterated with levamisole. In general, risk depend
on dosage and occasional/sporadic use is low risk. But it depends also
in levamisole concentration, some samples of cocaine can contain up to
30-50% of levamisole. Levamisole-adulterated cocaine is one of the most
important problems with this drug since 2009.
-
Doc, straight and simple:
What can affect the tactogen nature of MDMA? Quality? purity? setting? dosage?
Long version:
I've
tried a bit of MDMA last sunday, which I didn't weight because I had no
scale, but I guess it was around 100mg (small person, almost empty
stomach, took an antacid, 2gr vitamin C, 32mg caffeine, 325mg
aspirin and 200mg Lipoic Acid beforehand). When it went up, I was in a
cold place waiting for a bus by myself, so I didn't have all this
"loving everybody" feeling, but what I did feel was dizziness and a buzz
in all my body. When I ran to the drugstore and called a taxi to my
girlfriend's, I noticed I was speedy as hell, as I usually am when I
roll (talking very fast, and my legs moved by themselves when I
walked/ran). I didn't have this urge for rubbing my skin that I usually
feel, though; touching my skin felt normal. No jaw clenching either, no
difficulty to pee, no difficulty to ejaculate, I eventually felt hungry,
and duration was short I think (I didn't time it, actually, but it felt
short). All in all, it felt quite mild outside the 20~ minutes that the
euphoric peak lasted. This would be my first time to take MDMA in a
setting which was not in a club.
Again, thank you very much for your help!
Purity
and a correct dosage are fundamental. At least you should use a
Marquis/Mecke reagent to verify that the drug you are taking is really
MDMA (if in your country you can access to a quantification technique
that would be the best). And using a scale is also very important: it
can be very difficult to distinguish between 100-150 mg without a scale
and difference of effects in this rank is very important.There are cheap
and simple scales that can be very useful.
In general,
empathogenic effect of MDMA is very specific of this drug: your story
sounds a bit strange to me, you would have to verify that your drug was
really MDMA. If this is true, differences on effects would be explained
by setting/dosage.But everytime you buy a new batch of supposed MDMA you
should verify purity before using
-
Hey Dr,
I'm
having hand surgery next Friday and am an occasional heroin user
(snort, don't shoot) should I stop using at some point before surgery so
I don't mess something up with the meds they will give me for surgery?
Thanks!
It
is unlikely that there are pharmacological interactions between most
commonly anaesthetic drugs and occasional use of heroin. A 24-48 hours
period of cleaning out is reccommended. The main problem should be
if, after surgery, you are prescribed opiates and you have developed
tolerance as a consequence of regular use of heroin. In this case you
would need higher doses of prescription opiates as analgesic.
-
Hey Dr,
I'm
having hand surgery next Friday and am an occasional heroin user
(snort, don't shoot) should I stop using at some point before surgery so
I don't mess something up with the meds they will give me for surgery?
Thanks!
It
is unlikely that there are pharmacological interactions between most
commonly anaesthetic drugs and occasional use of heroin. A 24-48 hours
period of cleaning out is reccommended. The main problem should be
if, after surgery, you are prescribed opiates and you have developed
tolerance as a consequence of regular use of heroin. In this case you
would need higher doses of prescription opiates as analgesic.
OK. Thanks so much.
-
In
general, empathogenic effect of MDMA is very specific of this drug:
your story sounds a bit strange to me, you would have to verify that
your drug was really MDMA. If this is true, differences on effects would
be explained by setting/dosage.But everytime you buy a new batch of
supposed MDMA you should verify purity before using
Lemme assk yo smtg yoou gonna want them thare thing a ma bobs other der?
Do you know English,
or only country talk and is country talk really a
language or merely a dialect of English? Clearly so I'd say if I don't
say so myself. Words strung together like pearls on a string lightly
grazing the breast of. Does anyone even read this stuff? I'd
like to offer a prize to the first person who responds in any way to
this post. But I can't due to financial restrictions. Therefore go
not gentle into the night but rage and fight until the end. These lines
are actually partially remember poems. Who can figure out what the hell
I'm talking about? I would need a team of top doctors working day and
night to figure out my mfg rubik cube. Will anyone guess what writer I'm
mimicking now? Famous strong man, clue, but not a clear cut one.
DoctorX,
Who should take this drug for their betterment and the betterment of society in general?
Who should not take this drug for whatever reason, to avoid problems greater than the possible benefits associated to mdma use?
X, do you think drugs for improving sexual performance are useful as permanent solutions to ED and so on?
You
say,"Brain adapts chronic use of cannabis diminishing oniric life, and
when cannabis regular use finishes dreams become vivid during weeks. As
far as I know this effect has not been studied but is a very common
complain of regular cannabis users that quit using it. This effect lasts
several weeks but dissapears and dreams are normalized."
Since I
rarely have non-vivid memorable dreams, could it be these dreams are
merely closer to the conscious awareness and they continue, but like
many dreamers find, they recede into the subconscious mind? Lucid
dreamers are always trying to get "into" their dreams so they can have
"fun" while sleeping. My recommendation is relax, get into the dream and
if you see Leonardo Dicaprio run for cover.
Lastly, is this sort of thing that you described as parallel conversations?
CS
How many of you deadbeats out there will buy FC's book when it comes out?
Thanks, I am afraid of bad karma true, but is no karma better than bad?
-
Doc, straight and simple:
What can affect the tactogen nature of MDMA? Quality? purity? setting? dosage?
Long version:
I've
tried a bit of MDMA last sunday, which I didn't weight because I had no
scale, but I guess it was around 100mg (small person, almost empty
stomach, took an antacid, 2gr vitamin C, 32mg caffeine, 325mg
aspirin and 200mg Lipoic Acid beforehand). When it went up, I was in a
cold place waiting for a bus by myself, so I didn't have all this
"loving everybody" feeling, but what I did feel was dizziness and a buzz
in all my body. When I ran to the drugstore and called a taxi to my
girlfriend's, I noticed I was speedy as hell, as I usually am when I
roll (talking very fast, and my legs moved by themselves when I
walked/ran). I didn't have this urge for rubbing my skin that I usually
feel, though; touching my skin felt normal. No jaw clenching either, no
difficulty to pee, no difficulty to ejaculate, I eventually felt hungry,
and duration was short I think (I didn't time it, actually, but it felt
short). All in all, it felt quite mild outside the 20~ minutes that the
euphoric peak lasted. This would be my first time to take MDMA in a
setting which was not in a club.
Again, thank you very much for your help!
Purity
and a correct dosage are fundamental. At least you should use a
Marquis/Mecke reagent to verify that the drug you are taking is really
MDMA (if in your country you can access to a quantification technique
that would be the best). And using a scale is also very important: it
can be very difficult to distinguish between 100-150 mg without a scale
and difference of effects in this rank is very important.There are cheap
and simple scales that can be very useful.
In general,
empathogenic effect of MDMA is very specific of this drug: your story
sounds a bit strange to me, you would have to verify that your drug was
really MDMA. If this is true, differences on effects would be explained
by setting/dosage.But everytime you buy a new batch of supposed MDMA you
should verify purity before using
Thank you doc!! Though I was referring to tactogen effect, as when touching things feels wonderful.
I'm
having a hard time to find a marquis locally. Doing it internationally
would take ages. And better not even think about verifying purity.
The
seller I got it from was a massive seller so I guess this MDMA is of
standard quality. I don't think it was methylone though, because the
comeback felt so clean I didn't even notice. I may have just lost the
magic or worried too much about the setting.
Anyway, I'm getting a scale tomorrow and hopefully a marquis reagent too. I'll update when I get a reagent.
EDIT:
OK;
I got a scale now and now I know how much is 100mg. I'd say, for what I
can remember, I had about 50mg, so things now make more sense; it was
impossible to get 100mg with a single fingertip -my size, of course-.
Could that have been a reason why I got all speedy but almost no tactogen effect at all?
-
Hey Dr,
I'm
having hand surgery next Friday and am an occasional heroin user
(snort, don't shoot) should I stop using at some point before surgery so
I don't mess something up with the meds they will give me for surgery?
Thanks!
It
is unlikely that there are pharmacological interactions between most
commonly anaesthetic drugs and occasional use of heroin. A 24-48 hours
period of cleaning out is reccommended. The main problem should be
if, after surgery, you are prescribed opiates and you have developed
tolerance as a consequence of regular use of heroin. In this case you
would need higher doses of prescription opiates as analgesic.
In
relation to this, I'd like to confirm something I was told about
cocaine- which my experience tended to support the apparent truth of.
A
good number of years ago, I went to the dentist to have a tooth
removed, the few days prior to this, I had indulged in quite a bit of
cocaine (quite a bit for me, that is, about 2 gram over a couple of
days). Inspite of having over 6 injections of local anesthetic, the pain
was unbearable, the dentist couldn't understand why I could still feel
the pain after so many injections, my eyes nearly popped out of my
sockets, it was so bad (I'm usually fairly pain tolerant). Years later a
pal told me, he had a similar experience, having a pin removed from
their thigh or shin, under local anesthetic, he reckoned that the use of
cocaine, the day before, and the day he was in hospital caused the
anesthetic to have limited efficiency to the point of not working.
What is the truth of this? If it is true, then prior knowledge could save someone from a very unpleasant experience!
-
Thanks Doc, keep up the good work!
-
Hi Doc,
Thanks again for answers (and again sent some spare coins your way).
Some more questions:
1.
Are there any studies for greater bioavailability for drugs absorbed
from intestines (using entering coating) versus orally taken (absorbed
from stomach)? For example, people are using MAOIs to take DMT orally --
would DMT be available orally if taken with entering coating/capsule?
(MAOIs have lots interactions). Also, the same for drugs that have very
low bioavailability orally (some opioids for example). Or would it be
roughly the same?
2. Benzodiazepines + weed -- any
contradictions? (I've read a lot of bad reports, but most of those had
also alcohol mixed -- and mixing benzos with the alcohol is stupid in
the first place). I must to keep my weed doses low because of high risk
of anxiety on stronger doses and would like to use benzos to counteract
it (if there are no indications to not do so).
3. Scopolamine --
what are physically dangerous doses (I'm talking in
"recreational"/"experience-seeking" usage range) and if there is any
method/drug to prevent anterograde amnesia while on it (to remember as
much from experience as one can)? Or is it impossible due to the
anticholinergic nature of the drug.
Also, if there are also some "safety valve" drugs for deliriants (like benzos on psychedelics)
4.
If you would strongly recommend against scopolamine use is there any
other deliriant to be used safely? (I know that all deliriants are not
really advised, but would just like to try it once).
5. Are there
any muscle relaxants that would not interfere with the psychedelic
experience? I tend to have very strong muscle tension (legs would be
most affected) during psychedelic (LSD, shrooms, 2CB etc.) experience
coming up and would like to be able to do something with it.
Also
-- if one feels this tension is it better to try to "walk it off"
(especially since there is a lot of stimulation connected with most of
psychedelics) or sit still and try to not flex muscles at all?
Thanks a lot again and take care!
EDIT:
6.
Do you know of any drugs that use nebulization administration way for
recreational use? (for example, for quicker onset or improved
bioavailability).
-
On the issue of purity of drugs, I have a question for anyone who
might know the answer. My 28 gram purchase of weed seemed much
more like a bushel-basket than an oz, however, in the interest of
science, I am slowly using this product up. After smoking a few days,
three or four times a day, I had a digestive problem, first throwing up
in the early morning and diarrhea later. Some of the best throw up
sessions I've had since stopping binge drinking or getting a good dose
of some flu like bug. This must have been a body response to the
border weed I was smoking and trying to cook up. My wife is very upset I
am so selfish as to get sick. The upset occurred again, under the same
drug use pattern about a week later, not quite as bad though. I
wonder if I am getting a tolerance built up to the cannabis or what?
Almost gone, I hope I can avoid reordering!
Sex addiction may be a
good alternative to drug use, think?Talk about tactile wonderment, I
can feel the flesh of gods or perhaps them touching me, so it seems.
Alternatively I'm touched. Perhaps sex addiction is as bad as drug
addiction but it seems like more fun, sex addiction that is.
DoctorX,
Mr. T says "EDIT:
6.
Do you know of any drugs that use nebulization administration way for
recreational use? (for example, for quicker onset or improved
bioavailability)."
What do you thing of the BHO method of using cannabis? Seems very likely to cause more than casual use, or not.
Cleansober